KEGG   ENZYME: 2.3.1.140
Entry
EC 2.3.1.140                Enzyme                                 
Name
rosmarinate synthase;
rosmarinic acid synthase;
caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase;
4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase;
RAS (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
caffeoyl-CoA:(R)-3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase
Reaction(IUBMB)
caffeoyl-CoA + (R)-3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate [RN:R03374]
Reaction(KEGG)
R03374
Substrate
caffeoyl-CoA [CPD:C00323];
(R)-3-(3,4-dihydroxyphenyl)lactate [CPD:C22038]
Product
CoA [CPD:C00010];
rosmarinate [CPD:C01850]
Comment
Involved, with EC 1.1.1.237 (hydroxyphenylpyruvate reductase) in the biosynthesis of rosmarinic acid. Characterized from the plant Melissa officinalis L. (lemon balm).
History
EC 2.3.1.140 created 1992, modified 2013
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K21425  rosmarinate synthase
Genes
SSPL: 121747317 121753299
SMIL: 131005049
SHIS: 125188612
Reference
1
  Authors
Petersen M, Alfermann AW.
  Title
Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.
  Journal
Z Naturforsch C: Biosci 43:501-504 (1988)
Reference
2
  Authors
Petersen M S.
  Title
Characterization of rosmarinic acid synthase from cell cultures of Coleus blumei.
  Journal
Phytochemistry 30:2877-2881 (1991)
Reference
3  [PMID:21354582]
  Authors
Weitzel C, Petersen M
  Title
Cloning and characterisation of rosmarinic acid synthase from Melissa officinalis L.
  Journal
Phytochemistry 72:572-8 (2011)
DOI:10.1016/j.phytochem.2011.01.039
  Sequence
[ag:CBW35684]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.140
IUBMB Enzyme Nomenclature: 2.3.1.140
ExPASy - ENZYME nomenclature database: 2.3.1.140
BRENDA, the Enzyme Database: 2.3.1.140
CAS: 117590-80-4
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