KEGG   ENZYME: 2.3.1.207
Entry
EC 2.3.1.207                Enzyme                                 
Name
beta-ketodecanoyl-[acyl-carrier-protein] synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
octanoyl-CoA:malonyl-[acyl-carrier protein] C-heptanoylltransferase (decarboxylating, CoA-forming)
Reaction(IUBMB)
octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2 [RN:R10172]
Reaction(KEGG)
R10172
Substrate
octanoyl-CoA [CPD:C01944];
malonyl-[acyl-carrier protein] [CPD:C01209]
Product
3-oxodecanoyl-[acyl-carrier protein] [CPD:C05753];
CoA [CPD:C00010];
CO2 [CPD:C00011]
Comment
This enzyme, which has been characterized from the bacterium Pseudomonas aeruginosa PAO1, catalyses the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via beta-oxidation, with malonyl-[acp], forming 3-oxodecanoyl-[acp], an intermediate of the fatty acid elongation cycle. The enzyme provides a shunt for beta-oxidation degradation intermediates into de novo fatty acid biosynthesis.
History
EC 2.3.1.207 created 2012
Orthology
K16872  beta-ketodecanoyl-[acyl-carrier-protein] synthase
Genes
PSHISAMEA2665130_0711(fabH_1)
PAEPA3286
PAEVN297_3403
PAEIN296_3403
PAUPA14_21540(fabH-2)
PAPPSPA7_1833
PAGPLES_17791
PAFPAM18_1682
PNCNCGM2_4414(fabH-2)
PAEBNCGM1900_2994(fabH-2)
PDKPADK2_07865
PSGG655_08355
PRPM062_17545
PAEPPA1S_08920
PAERPA1R_gp1123
PAEMU769_08425
PAELT223_08920
PAESSCV20265_1765
PAEUBN889_03647
PAEGAI22_24960
PAECM802_3401
PAEOM801_3268
PMYPmen_1545
PMKMDS_1612
PREPCA10_41510
PPSEBN5_2858(fabH)
PFUWKF707C_14460
PALCA0T30_15710
PCQPcP3B5_15030(fabH)
PMUIG4G71_09895
PPUPP_4545
PPFPput_1345
PPGPputGB1_4052
PPWPputW619_3839
PPTPPS_3891
PPBPPUBIRD1_1353
PPIYSA_07809
PPXT1E_0854
PPUHB479_19325
PPUTL483_24815
PPUNPP4_12760
PPUDDW66_4329
PFVPsefu_3003
PMONX969_18985
PMOTX970_18620
PMOSO165_002365
PPJRK21_00603
PORAPT59_08215
PMOLCLJ08_19695
PSTPSPTO_4094
PSBPsyr_3830
PSYRN018_06355
PSPPSPPH_1429
PSAVPSA3335_06760
PAMGBKM19_022705
PCIPCH70_39070
PAVLBKM03_22200
PVDCFBP1590__1466
PCABJGS08_19765
PCOFPOR16_06205
PFLPFL_1532(fabH_1)
PPRCPFLCHA0_c15710(fabH1)
PPROPPC_1586
PFEPSF113_1472
PFNHZ99_25360
PFOPfl01_1421
PFSPFLU_4539
PFCPflA506_3851(fabH_2)
PPZH045_13580
PFBVO64_4996
PMANOU5_1920
PTVAA957_22120
PCGAXG94_22865
PVRPverR02_23125
PAZOAYR47_29415
POIBOP93_18765
PRXHRH33_19790
PFWPF1751_v1c40400(fabH)
PFFPFLUOLIPICF715990
PFXA7318_19440
PENPSEEN3967
PSAPST_2842
PSZPSTAB_2866
PSRPSTAA_2980
PSCA458_14880
PSJPSJM300_05230
PSHPsest_1462
PSTUUIB01_06745
PSTTCH92_15640
PCHLLLJ08_06470
PBMCL52_14015
PLULFOB45_11465
PBAPSEBR_a1396
PBCCD58_07805
PPUUPputUW4_03987(fabH2)
PDRH681_18170
PSVPVLB_18090
PSKU771_23650
PKCPKB_1532
PCHEY04_07085
PCZPCL1606_45860
PCPJM49_22775
PFZAV641_15760
PLQAA042_17850
PALKPSAKL28_38900
PRHLT40_05475
PSWLK03_00320
PPVNJ69_03115
PSESPSCI_3097
PSEMTO66_07595
PSECCCOS191_3925
PPSYAOC04_13085
PSOSPOS17_1538
PKRAYO71_09745
PFKPFAS1_18770
PANRA7J50_4221
PPSLBJP27_23125
PSETTHL1_4087
PSILPMA3_22160
PYMAK972_4423
PSEDDM292_04520
PKEDLD99_07850
PALLUYA_08105
PUMHGP31_07690
POJPtoMrB4_15040
PGGFX982_00306
PPSHG5J76_19320
PGYAWU82_23490
PLALFXN65_07165
PSEJHNQ25_16645
PVKEPZ47_07575
PEZHWQ56_06425
PBZGN234_10850
PKHJLK41_08055
PTYJWV26_18400
PMAOPMYSY11_1368
PATAJWU58_20500
PDWBV82_0728
PZEHU754_008620
PMOEHV782_008085
PCAMHNE05_03920
PSEPC4K39_1603
PVWHU752_008660
PTRTHU722_0021365
PXAKSS93_22450
PSAMHU731_007800
PTZHU718_008280
PQIKH389_07735
PSHHHU773_007860
PXNHU772_017840
PHVHU739_010490
PPRGHU725_016665
PNNKEM63_07400
PANHHU763_017675
PASGKSS96_21015
PFAKKSS94_19880
PMUYKSS95_20665
PMAMKSS90_07270
PAZEKSS91_21495
PALVKSS97_21530
PPHABVH74_14505
PORYEJA05_20730
PWZJ7655_14125
PTKEXN22_08565
PTWTUM18999_15410
PZAHU749_008555
PIEHU724_007825
PWYHU734_018685
PTAENCTC10697_03045(fabH1)
PGFJ0G10_08395
PCAVD3880_16070
PBBAKN87_10845
PAGRE2H98_17925
HPEGEAO82_11790
HAESLO767_06295
MAQMaqu_1591
MHCMARHY1693
MADHP15_1862
MBSMRBBS_2153(fabH)
MSRAU15_07375
MSXAU14_01285
MPQABA45_10195
MARIACP86_21685
MLQASQ50_00485
MSQBKP64_04835
MARAD0851_02805
MARJMARI_12640
PARPsyc_1052
PCRPcryo_1412
PRWPsycPRwf_1458
PSOPSYCG_07410
PURAOC03_01835
PALIA3K91_1404
PSPGAK823_07495
PSYGAK825_07600
PSYCDABAL43B_1409(fabH)
PSYAAOT82_465
PSYYDLE54_06735
PSYPE5677_06365
ACBA1S_1208
ABMABSDF1494
ABYABAYE2562
ABCACICU_01185
ABNAB57_1343
ABBABBFA_02340(fabH)
ABXABK1_1640
ABZABZJ_01344
ABRABTJ_02521
ABDABTW07_1372
ABHM3Q_1564
ABADABD1_12170(fabH)
ABJBJAB07104_01355
ABABBJAB0715_01367
ABAJBJAB0868_01303
ABAZP795_11450
ABKLX00_05815
ABAUIX87_04610
ABAAIX88_08110
ABWBL01_13795
ABALABLAC_20260
ACCBDGL_000459(fabH)
ANORR32_12290
ALCOTEC02_13020
ACALBUM88_05760
ASEII8T81_13035
ACDAOLE_13370
ACIACIAD2101
ATTAMQ28_01845
AEIAOY20_10730
AJORZ95_05750
ACWA0J50_11670
ACVAMD27_06060
AHLAHTJS_09590
AJNBVL33_08520
ASOLBEN76_04135
ALABFG52_09120
ASJAsACE_CH01748
AIDCTZ23_05620
ADVDJ533_11365
ARJDOM24_08795
AWUBEN71_07160
ACUMC9E88_013845
AGUAS4_13670(fabH)
AUGURS_3197
ALWFOB21_03275
ADSFPL17_03295
ABERBSR55_07300
ATNFM020_10610
ACHICDG60_11535
ALJG8D99_09690
AWGGFH30_07845
ASHAG8E00_06475
ATGJ4G44_10020
AVBRYU24_12160(fabH)
ABOUACBO_12060(fabH)
MCTMCR_0863(fabH)
MCSDR90_1016
MCATMC25239_00867(fabH)
MOIMOVS_05090
MOSAXE82_02790
MBLAAX09_04565
MBOIDQF64_06170
MCUNNCTC10297_01441(fabH)
MNNI6G26_06355
MBAHHYN46_08005
SONSO_2901
SDNSden_2519
SFRSfri_2467
SAZSama_1510
SBMShew185_2683
SBNSbal195_2762
SBPSbal223_1701
SBTSbal678_2767
SBBSbal175_1683
SPCSputcn32_2368
SHPSput200_2393
SHEShewmr4_1502
SHMShewmr7_1569
SHNShewana3_1563
SHWSputw3181_1641
SHFCEQ32_01970
SJASJ2017_2623
SBJCF168_12950
SHEWCKQ84_17010
SALGBS332_16455
SLJEGC82_08745
SMAIEXU30_02115
SPOLFH971_07420
SKHSTH12_01153(fabH_2)
SAESHBH39_06790
SLITJQC75_07420
SCAATUM17387_17790
SCYPJYB88_10785
SSEMJYB85_11010
SGLAFJ709_07250
SINVK8B83_10540
SXMMKD32_07880
CPSCPS_1068
COMCMT41_04120
COZA3Q34_12290
LSDEMK97_06945
PATPatl_3297
PSYMJ1N51_02875
AMCMADE_1015285
AMHI633_15745
AMAAamad1_15230
AMALI607_14530
AMAEI876_14825
AMAOI634_14770
AMADI636_14645
AMAII635_15200
AMAGI533_14350
AMACMASE_14315 MASE_14365
AMBAMBAS45_14835
AMGAMEC673_14640
AMKAMBLS11_14165
ALTambt_02095
AALEP13_14570
AAUSEP12_15130
ASPAOR13_405
ASQAVL57_16475
AAWAVL56_15395
ALRDS731_15765
ALEAV939_15415
ALZAV940_15165
APELCA267_004290
SALMD0Y50_14800
SALKFBQ74_04335
SMAAIT774_03460
GAGGlaag_1054
GNIGNIT_2715(fabH)
GPSC427_1538
PMESFX988_03632
LALAT746_14670
SALHHMF8227_00784
HMIsoil367_10030
PAEWKIH87_05150
MVSMVIS_1220
MYAMORIYA_4315
MMAAFR932_11705
SAGAM5M_09995
ZALAZF00_06700
OSGBST96_13640
MTHDA3224_01690
MICCAUP74_01244(fabH)
MAGAMag101_16260
MIIBTJ40_02020
MICTFIU95_01695(fabH)
MHYDGTQ55_02070
MCELLPW13_17145
MICZGL2_09940
HJABST95_11875
HALCEY643_10540
KIMG3T16_02195
AFUSEYZ66_07325
RHHE0Z06_06235
HCHHCH_02649
HAHEENC22_18345
CSACsal_1470
HELHELO_2120
HCSFF32_12265
HAKKO116_01721
HAMHALO1885
HHUAR456_07155
HCOLOKO_02597(fabH)
HSIBOX17_13380
HALOBWR19_13410
HHHCLM76_12880
HAGBB497_14845
HAFC8233_08385
HALKCUU95_17880
HVNEI420_06695
HOLHORIV_43560
HSRHSBAA_41330
HMDCTT34_06660
HAXIHAALTHF_44790n
HTTHZS52_13975
HCAMI4484_07970
HPIZGYM47_06370
HSXHNO51_07380
HSVHNO53_08010
HTXEKK97_08400
CMAIBFX80_14420
CAMHLCW13_02810
PAURFGL86_10940
ABOABO_1520(fabB)
ADIB5T_02481(fabB2)
APACS7S_07835
ALNAS19_15710
AXEP40_12045
KAKKalk_20585
MMWMmwyl1_2158
MMEMarme_2044
MPCMar181_1830
MPRIMP3633_1937
MARDIBG28_10440
MFOIJSY38_00220
MPRFJ8N69_16465
TOLTOL_2727
TORR615_03995
OAIOLEAN_C32910
BSANCHH28_00510
NCUF0U83_07185
NJPNEJAP_2083
NIKF5I99_11450
BMARHF888_06135
VCWGJQ55_03230
OMEOLMES_3328(fabH)
ENWMJO57_09505
AHAAHA_3035
AHYAHML_16360
AHDAI20_04220
AHRV428_16925
AHPV429_16960
AHJV469_06335
AHHRY45_15660
AHIVU14_06490
AAJBOQ57_15555
ASAASA_3056
AEOO23A_p2321
AVRB565_2885
AVOAMS64_17195
AMEDB224_3784
ASRWL1483_4593
ADHCK627_10605
ACAVVI35_14685
AEMCK911_11155
AEAC2U39_15735
ARVC7N77_10150
AESC2U30_21310
AELNCTC12917_03044(fabH_2)
ASIMFE240_04080
AALLI6G90_00605
AJDI6H43_04315
ARIVKYK33_06630
SOKD0B54_10180
SINIGT972_00600
FCEJN531_013785
SALNSALB1_3236
PSPIPS2015_1343
GPBHDN1F_33740(fabH)
NSGH3L94_11320
NAWLVJ86_01815
VITADP71_23510
VSTLVJ81_02290
PTESJQU52_13415
USULVJ78_02580
UTELVJ83_10965
CVICV_1096
CVCBKX93_18540
CHROCXB49_16705
CHRIDK842_13010
CHRBDK843_18470
CRZD1345_17615
CHRMFYK34_01110
CHAECH06BL_35820
PSENH8B_3422(fabH)
AQLBXU06_12575
AMAHDLM_3217
AQSDKK66_10995
VOGLCH97_09450
RSORSp0194
RSLRPSI07_mp0145
RSNRSPO_m00190(fabH)
RSMCMR15_mp10168
RSEF504_3635
RSYRSUY_35280
RPIRpic_4712
RPFRpic12D_3635
RMNTK49_17800
RINACS15_5027
RPUCDC45_18575
RSGJK151_05025
PLGNCTC10937_04148(fabH1)
LIMNHKT17_04505
CARIFNU76_06965
RFRRfer_2770
RSBRS694_15410
RACRA876_07370
RHGEXZ61_16210
ACIDCBP33_03270
ACIPCBP36_03690
ACINCBP34_03215
ACISCBP35_15250
CKEB5M06_03820
CAQTKAQ61_14185
RTARta_04890
KIAG8A07_11305
JAGGJA_5154
JAZYQ44_25935
JALBZG29_02095
JSVCNX70_02185
JASFJQ89_19230
JLVG3257_02080
MNRACZ75_18380
MASWAM586_01590
MASSCR152_02600
MASZC9I28_02590
MTIMDIR46_13255
MASYDPH57_19395
MALIEYF70_28075
MUMFCL38_21505
MFLAGO485_16745
MPLIE1742_15355
MANCIV454_08670
DUGHH213_11915
UPVEJN92_06270
UPIEJG51_009705
NOKFAY22_18375
RGERGE_18370
RBNRBXJA2T_11256
RDPRD2015_2779
PKTAT984_09555
MIUABE85_11345
AONDEH84_12365
IDCLRM40_07840
ARESIWH25_02590
NIVJY500_12880
APPCAP2UW1_0979
DOVDSCO28_31800
DALKDSCA_26130
CCROCMC5_066050(fabH)
HOHHoch_0130
MLOmll1602
MLNA9174_18240
MCIMesci_3118
MOPMesop_3500
MAMMesau_03386
MAMOA6B35_23150
MESWA9K65_016910
MESMEJ066_26935
MESPC1M53_22220
MHUAMCHK_3220
MJREB229_18505
MERDEB233_15845
MESRFGU64_06425
MESOBSQ44_16600
MESMeso_2031
AAKAA2016_2776 AA2016_5202
AMIHCO731_02758(fabH_1) CO731_04799(fabH_4)
PHTBLM14_14320
RPODE0E05_02495
NIYFQ775_02560 FQ775_15415
NKIKW403_01975
ORMHTY61_12890
PLAPlav_0744
PMOBHG718_09905
RBSRHODOSMS8_00289
RPARPA1298
RPBRPB_4123
RPCRPC_2800
RPDRPD_3969
RPERPE_0742
RPTRpal_1489
RPXRpdx1_4153
HDNHden_3439
HDTHYPDE_41113
HMCHYPMC_4843
RVARvan_1310
CCRCC_1442
CCSCCNA_01509
CAKCaul_2904
CSECseg_1924
CHQAQ619_09625
CMBCSW64_14135
CFHC1707_19970
CAUFCSW63_13125
CAULKCG34_24160
PZUPHZ_c1369
PHBHYN04_08805
BSBBresu_2763
BRDJL11_15585
BNEDA69_02320
BRGA4249_01005
BRLBZG35_06230
BVCCEP68_03760
BDMEQG53_16755
BRFE4M01_12635
BREVE7T10_13670
BMEDGYM46_12445
BVYNCTC9239_00693(fabH_2)
BNDKWG56_00505
BPONIFE19_12035
BGOEIFJ75_02435
BVITJIP62_13205
TSVDSM104635_02587(fabH_2)
SILSPO0918(fabH-1)
SITTM1040_0628
RUAD1823_00090
RUTFIU92_12885(fabH2)
JANJann_3320
RDERD1_3492(fabH)
RLIRLO149_c026950
RPONG3256_14040
PGAPGA1_c24640
PGLPGA2_c22640
PGDGal_00929
PHPPhaeoP97_02334
PPICPhaeoP14_02249
PHQD1820_07205
OATOAN307_c09920
OTMOSB_23750(fabH_2)
OCTFTO60_13005
REDroselon_02001
CIDP73_0926
CMARIMCC12053_1455
CEHCEW89_09135
SUAMBOO69_04160
SULZC1J03_04650
SULIC1J05_16630
SULDB5M07_13570
SPOTG6548_13060
SMEDJNX03_09455
SINLDSM14862_00711
SPSESULPSESMR1_02370
TOMBWR18_11295
RMMROSMUCSMR3_02379
ROKRAK1035_0803
RIDRIdsm_04132(fabH_2)
ROMEI983_03590
ROHFIU89_03260(fabH1)
AHTANTHELSMS3_00724
SAGUCDO87_08365
THAACFI11_06860
ROTFIV09_03825(fabH1)
MALUKU6B_02820
TGLHFZ77_14175
TMDKUV46_09695
HATRC74_01035
PALXGQA70_01770
RCPRCAP_rcc01145(fabH1)
RHPLPB142_04595
RMBK529_010235
DONBSK21_12115
THWBMG03_06790
TECAKL02_005660
LVSLOKVESSMR4R_00463
SEDIEBB79_15820
BOOE2K80_00395
PAEDG5B38_10305
MONG8E03_06245
PAMOBAR1_14660
POZI0K15_04580
PPAFI8N54_04050
CACTHZ995_02870
RBZB9057_01505
THASC6Y53_02615
GCEKYE46_06050
MMRMmar10_0802
GAKX907_1389
HYTHXX25_07785 HXX25_07790
HNEHNE_0857
HBAHbal_3184
CBOTATE48_16525
HBCAEM38_06190
NGFFRF71_11630
SALSala_3145
SPHKSKP52_02190
SPHPLH20_01175
SMAGAN936_00550
SMAZLH19_00555
STERAOA14_09105
SGISGRAN_3682
SPHQBWQ93_14390
SPHOC3E99_13780
SPHXE5675_18585
SPHUSPPYR_3162
SECHB18_29430
SLANGV829_01990
CIJWG74_12650
SPHGAZE99_09405
SFLASPHFLASMR4Y_00515
SPHYCHN51_13590
SPHLLPB140_05430
BLASBSY18_2210
BFWB5J99_02620
PARJJ4G78_03840
PHAOHF685_04750
SANDH3309_04115
AEPAMC99_00679
ALHG6N82_02980
AMXAM2010_725
ADOA6F68_02576(fabH_2)
TFVIDJ81_08545
EFVCHH26_10695
ELIELI_03745
ELQGa0102493_112919
ERKCD351_07820
ERRDVR09_07685
ERFFIU90_07780(fabH2)
EMVHQR01_07295
PNSA9D12_10490
PORLBG023_111576
PHZCHX26_08455
POTE2E27_13790
RAPRHOA_4394
PBRPB2503_02542
MAIMICA_879
MANA11S_795
PARHI5S86_21950
ECOUM1R54_01755
AYMYM304_41580(fabH)
 » show all
Reference
1  [PMID:22753057]
  Authors
Yuan Y, Leeds JA, Meredith TC
  Title
Pseudomonas aeruginosa directly shunts beta-oxidation degradation intermediates into de novo fatty acid biosynthesis.
  Journal
J Bacteriol 194:5185-96 (2012)
DOI:10.1128/JB.00860-12
  Sequence
[pae:PA3286]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.207
IUBMB Enzyme Nomenclature: 2.3.1.207
ExPASy - ENZYME nomenclature database: 2.3.1.207
BRENDA, the Enzyme Database: 2.3.1.207
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