Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy

4-coumaroyl-CoA:feruloylacetyl-CoA feruloyltransferase (demethoxycurcumin-forming)

(1) 4-coumaroyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + demethoxycurcumin + CO2 [RN:R08809];
(2) 4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H2O = 2 CoA + bisdemethoxycurcumin + CO2 [RN:R08807]

R08807 R08809
Reaction

4-coumaroyl-CoA [CPD:C00223];
feruloylacetyl-CoA [CPD:C17741];
H2O [CPD:C00001];
(4-coumaroyl)acetyl-CoA [CPD:C17740]

A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217, curcumin synthase), CURS3 can accept 4-coumaroyl-CoA equally well [1].

EC 2.3.1.219 created 2013

1  [PMID:19622354]