Entry
Name
(5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase;
kce (gene name);
3-keto-5-aminohexanoate cleavage enzyme
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
(5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase
Reaction(IUBMB)
(5S)-5-amino-3-oxohexanoate + acetyl-CoA = acetoacetate + L-3-aminobutanoyl-CoA [RN:
R10564 ]
Reaction(KEGG)
Substrate
(5S)-5-amino-3-oxohexanoate;
acetyl-CoA [CPD:
C00024 ]
Product
acetoacetate [CPD:
C00164 ];
L-3-aminobutanoyl-CoA [CPD:
C05231 ]
Comment
Requires Zn2+. The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE). It is involved in the anaerobic fermentation of lysine. cf. EC
2.3.1.317 , 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, EC
2.3.1.318 , 3-oxoadipate:acetyl-CoA acetyltransferase, and EC
2.3.1.319 , 3,5-dioxohexanoate:acetyl-CoA acetone transferase.
History
EC 2.3.1.247 created 2015, modified 2024
Pathway
Orthology
K18013 3-keto-5-aminohexanoate cleavage enzyme
Genes
BUZ : AYM40_28240 AYM40_28280
PACS : FAZ98_16245 FAZ98_29810
PAPI : SG18_14785 SG18_20720
DOE : DENOEST_0851 DENOEST_1136
DMP : FAK_17300(kce) FAK_18120(kce) FAK_23450 FAK_26750 FAK_29650 FAK_39570(kce)
AORY : AMOR_14180 AMOR_53320(kce)
AGE : AA314_04550 AA314_06943
SCU : SCE1572_11095 SCE1572_37295
PAUU : E8A73_023760 E8A73_028225
MRM : A7982_06888 A7982_13257
LLU : AKJ09_00844 AKJ09_10303
FCT : NRE15_05400 NRE15_05490
CLS : CXIVA_02410 CXIVA_06660 CXIVA_07070 CXIVA_10680
CACE : CACET_c04310(kce) CACET_c30610
CALE : FDN13_06065 FDN13_09320
CPRF : K7H06_00150 K7H06_00255
CRAS : KVH43_03060 KVH43_03185
FPLA : A4U99_00635 A4U99_02450 A4U99_02930 A4U99_06985 A4U99_11325 A4U99_13675 A4U99_15495 A4U99_15680 A4U99_15875
VFA : MM35RIKEN_07360(kce)
VCOP : MM50RIKEN_12230(kce_1) MM50RIKEN_22420(kce_2)
IBU : IB211_00294 IB211_00977 IB211_02342c IB211_02425c IB211_02981c IB211_03192c IB211_03205
PROM : QO263_00265 QO263_00490
CCT : CC1_10470 CC1_15150 CC1_27090 CC1_30820
AMIJ : EQM06_00105 EQM06_04540 EQM06_05495 EQM06_10715 EQM06_12635
ABUT : Ami103574_00410 Ami103574_00875 Ami103574_04915 Ami103574_06350 Ami103574_07060 Ami103574_08060
ETM : CE91St48_04090(kce_1) CE91St48_09320(kce_2) CE91St48_13780(kce_3) CE91St48_34180(kce_4)
GFE : Gferi_09730 Gferi_10185 Gferi_11065 Gferi_11195
CSPO : QNI18_05020 QNI18_05570
CST : CLOST_0198 CLOST_1384(kce)
DBC : MFMK1_002471 MFMK1_003160
NTH : Nther_1884 Nther_1903
HALS : D7D81_01265 D7D81_18045
KME : H0A61_00948(kce_1) H0A61_01605(kce_2) H0A61_01689(kce_3)
AMEI : LV469_06375 LV469_08580
TIZ : RBU61_01785 RBU61_15225(kce)
STED : SPTER_15940(kce_2) SPTER_16000(kce_3) SPTER_25770(kce_4) SPTER_28480(kce_5) SPTER_40640(kce_6) SPTER_46160(kce_7)
SSPH : SPSPH_026920(kce_1) SPSPH_040120(kce_2) SPSPH_041800(kce_3)
SSID : SPSIL_040630(kce_1) SPSIL_052160(kce_2)
MBAI : MB901379_02355(kce)
MPHL : MPHLCCUG_04683(kce_2)
MGO : AFA91_08710 AFA91_23040
NAQU : ENKNEFLB_00763(kce)
AGRA : AGRA3207_003561 AGRA3207_005241
MSAG : GCM10017556_19540(kce)
ACTR : Asp14428_52490(kce)
BALA : DSM104299_04740(kce_4)
SBAE : DSM104329_02554(kce_2) DSM104329_04556(kce_3)
FVA : FV113G1_04320 FV113G1_13760 FV113G1_17250 FV113G1_29960
FUL : C4N20_04210 C4N20_08870 C4N20_13625 C4N20_15465
PSOE : CE91St14_15600(kce)
HLU : LT972_00540 LT972_06520
HALJ : G9465_01310 G9465_10725 G9465_13925 G9465_24225
NHO : HWV23_00435 HWV23_15080 HWV23_15145
NSAL : HWV07_02080 HWV07_02130
HALI : BV210_00545 BV210_19060
SSAI : N0B31_04995 N0B31_19240
HAAD : MW046_00080 MW046_18070
HALN : B4589_001425 B4589_004885
HALU : HUG12_08300 HUG12_20315
NAS : GCU68_19320 GCU68_20075
LOKI : Lokiarch_21000(kce_1) Lokiarch_49350(kce_2)
» show all
Taxonomy
Reference
Authors
Barker HA, Kahn JM, Hedrick L
Title
Pathway of lysine degradation in Fusobacterium nucleatum.
Journal
J Bacteriol 152:201-7 (1982)
Reference
Authors
Kreimeyer A, Perret A, Lechaplais C, Vallenet D, Medigue C, Salanoubat M, Weissenbach J
Title
Identification of the last unknown genes in the fermentation pathway of lysine.
Journal
Sequence
Reference
Authors
Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM.
Title
3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.247
LinkDB
All DBs