KEGG   ENZYME: 2.3.1.247
Entry
EC 2.3.1.247                Enzyme                                 

Name
3-keto-5-aminohexanoate cleavage enzyme;
kce (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
(5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase
Reaction(IUBMB)
(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate [RN:R10564]
Reaction(KEGG)
R10564
Substrate
(5S)-5-amino-3-oxohexanoate;
acetyl-CoA [CPD:C00024]
Product
L-3-aminobutanoyl-CoA [CPD:C05231];
acetoacetate [CPD:C00164]
Comment
Requires Zn2+. The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, is involved in the anaerobic fermentation of lysine.
History
EC 2.3.1.247 created 2015
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K18013  3-keto-5-aminohexanoate cleavage enzyme
Genes
KLW: DA718_19685
CBRA: A6J81_09420
CYO: CD187_16635
CPOT: FOB25_04085
CFQ: C2U38_07615
CAMA: F384_03220
CAF: AL524_19070
CFAR: CI104_07945
CIR: C2U53_17165
CTEL: GBC03_22290
XPO: XPG1_0711
VPB: VPBB_0602
VAQ: FIV01_17775(kce)
ABM: ABSDF1527
SAGA: M5M_01915
MICC: AUP74_02728(kce)
MICT: FIU95_11770(kce)
TIG: THII_3307
GAI: IMCC3135_13280(kce_2) IMCC3135_15615(kce_3)
HAM: HALO0134
HBE: BEI_0584
ENM: EBS_1707
CHAE: CH06BL_36770(kce)
RSE: F504_92
REH: H16_A1969(h16_A1969)
BTQ: BTQ_3580
BTJ: BTJ_4616
BTZ: BTL_5403
BTD: BTI_4951
BTV: BTHA_4799
BTHE: BTN_5074
BTHM: BTRA_5342
BTHA: DR62_5203
BTHL: BG87_5410
BOK: DM82_6354
BOC: BG90_4320
BCEN: DM39_6328
BUL: BW21_4479
BXB: DR64_7528
BPH: Bphy_1080
PPNO: DA70_03435
PPNM: LV28_02890
PPUL: RO07_21755
PSPU: NA29_15335
CABA: SBC2_60940(kce_6)
BPA: BPP1371
BBR: BB2437
BHO: D560_2801
BHM: D558_2781
BHZ: ACR54_02767(kce_2)
AMIM: MIM_c27280
VEI: Veis_0513
DAC: Daci_5967
APET: ToN1_41400
AZA: AZKH_1579
PCA: Pcar_2907
DOV: DSCO28_65320(kce)
ADE: Adeh_1487
MXA: MXAN_4384
HOH: Hoch_2623
MES: Meso_0174
RBS: RHODOSMS8_00063(kce)
SMD: Smed_3856
SHZ: shn_24630
BRA: BRADO6877
BBT: BBta_0673
AOL: S58_05970
BRAD: BF49_6169
RPB: RPB_3262
RPC: RPC_0635
RPD: RPD_2202
RPE: RPE_2252
RPT: Rpal_2433
XAU: Xaut_4047
AZC: AZC_2881
MOR: MOC_5882
RVA: Rvan_3446
PSF: PSE_3257
LABT: FIU93_04910(kce2) FIU93_11865(kce5)
SIL: SPOA0042
RUT: FIU92_22505(kce4)
RDE: RD1_2649
LAQU: R2C4_03715
CID: P73_1266
SPSE: SULPSESMR1_00567(kce)
RMM: ROSMUCSMR3_03759(kce)
RID: RIdsm_02185(kce_4)
ROH: FIU89_07455(kce2)
MARU: FIU81_13550(kce2)
ROT: FIV09_18950(kce)
MALU: KU6B_02930
PAMN: pAMV3p0380
PAMO: BAR1_03220
GAK: X907_0623
RCE: RC1_3529
TXI: TH3_15410
MAGQ: MGMAQ_2016
BMEG: BG04_4018
BKW: BkAM31D_23380(kce)
GTN: GTNG_2707
PASA: BAOM_3312(kce)
PSAB: PSAB_13605
ASOC: CB4_00640(kce)
PABS: JIR001_30730(kce)
CPAT: CLPA_c31500(kce)
CPAE: CPAST_c31500(kce)
CSQ: CSCA_1088
AMT: Amet_0318
STH: STH64
TTE: TTE0719
KME: H0A61_00948(kce_1) H0A61_01605(kce_2) H0A61_01689(kce_3)
STED: SPTER_15940(kce_2) SPTER_16000(kce_3) SPTER_25770(kce_4) SPTER_40640(kce_6) SPTER_46160(kce_7)
MBJ: KQ51_00861(kce)
MTV: RVBD_1718
MRA: MRA_1728
MTUR: CFBS_1811
MTD: UDA_1718
MTUE: J114_09175
MTUH: I917_12185
MTUL: TBHG_01676
MTUT: HKBT1_1810
MTUU: HKBT2_1818
MBB: BCG_1757
MBT: JTY_1732
MAF: MAF_17370
MMIC: RN08_1908
MBAI: MB901379_02355(kce)
MSHJ: MSHI_14730
MPHL: MPHLCCUG_04683(kce_2)
MMOR: MMOR_48500
MGAD: MGAD_23100
MSAR: MSAR_03700
NFA: NFA_32680
NCA: Noca_4226
KFL: Kfla_0987
TCU: Tcur_0658
FAL: FRAAL3565
NML: Namu_3440
GOB: Gobs_2519
MMAR: MODMU_5030
SEN: SACE_7114
AORI: SD37_10400
PSEA: WY02_22090
PSEE: FRP1_20600
AMI: Amir_6838
SESP: BN6_82110
KAL: KALB_8525
ALO: CRK60420
SAQ: Sare_0377
MIL: ML5_2791
MSAG: GCM10017556_19540(kce)
ASE: ACPL_7951
ACTN: L083_7745
AFS: AFR_40680
ACTS: ACWT_7820
AIH: Aiant_38100(kce)
ATL: Athai_00630(kce)
PRY: Prubr_31370(kce)
CATI: CS0771_09110(kce)
SNA: Snas_6127
RXY: Rxyl_2990
NSH: GXM_09365
TRO: trd_1744
PBF: CFX0092_A2471(kce)
FNU: FN1868
PGI: PG_1068
PGN: PGN_1164
MBAS: ALGA_2255
WIN: WPG_3396
CPC: Cpar_0847
CCH: Cag_0981
CACI: CLOAM0912(kce)
TLE: Tlet_0226
TME: Tmel_0190
TAF: THA_422
THER: Y592_02090
FNO: Fnod_0209
OCY: OSSY52_05680(kce)
PMO: Pmob_1078
MARN: LN42_02755
KOL: Kole_0965
MINF: MESINF_1634(kce)
ASAC: ATHSA_1430
MPD: MCP_0231
HHB: Hhub_3460
NPH: NP_2938A
NMG: Nmag_2346
LOKI: Lokiarch_21000(kce_1) Lokiarch_49350(kce_2)
 » show all
Reference
1  [PMID:6811551]
  Authors
Barker HA, Kahn JM, Hedrick L
  Title
Pathway of lysine degradation in Fusobacterium nucleatum.
  Journal
J Bacteriol 152:201-7 (1982)
Reference
2  [PMID:17166837]
  Authors
Kreimeyer A, Perret A, Lechaplais C, Vallenet D, Medigue C, Salanoubat M, Weissenbach J
  Title
Identification of the last unknown genes in the fermentation pathway of lysine.
  Journal
J Biol Chem 282:7191-7 (2007)
DOI:10.1074/jbc.M609829200
  Sequence
[fnu:FN1868]
Reference
3  [PMID:21632536]
  Authors
Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM.
  Title
3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.
  Journal
J Biol Chem 286:27399-405 (2011)
DOI:10.1074/jbc.M111.253260
  Sequence
[caci:CLOAM0912]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.247
IUBMB Enzyme Nomenclature: 2.3.1.247
ExPASy - ENZYME nomenclature database: 2.3.1.247
BRENDA, the Enzyme Database: 2.3.1.247
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