KEGG ENZYME: 2.3.1.247

ENZYME: 2.3.1.247

Entry

EC 2.3.1.247                Enzyme

Name

(5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase;
kce (gene name);
3-keto-5-aminohexanoate cleavage enzyme

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

(5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase

Reaction(IUBMB)

(5S)-5-amino-3-oxohexanoate + acetyl-CoA = acetoacetate + L-3-aminobutanoyl-CoA [RN:R10564]

Reaction(KEGG)

R10564

Substrate

(5S)-5-amino-3-oxohexanoate;
acetyl-CoA [CPD:C00024]

Product

acetoacetate [CPD:C00164];
L-3-aminobutanoyl-CoA [CPD:C05231]

Comment

Requires Zn2+. The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE). It is involved in the anaerobic fermentation of lysine. cf. EC 2.3.1.317, 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, EC 2.3.1.318, 3-oxoadipate:acetyl-CoA acetyltransferase, and EC 2.3.1.319, 3,5-dioxohexanoate:acetyl-CoA acetone transferase.

History

EC 2.3.1.247 created 2015, modified 2024

Pathway

ec00310

Lysine degradation

ec01100

Metabolic pathways

Orthology

K18013

3-keto-5-aminohexanoate cleavage enzyme

Genes

KLW:	DA718_19685

KAR:	LGL98_12575

KPAS:

LUW96_15355

KLC:	K7H21_19600

CBRA:

A6J81_09420

CYO:	CD187_16635

CPOT:

FOB25_04085

CFQ:	C2U38_07615

CAMA:

F384_03220

CAF:	AL524_19070

CFAR:

CI104_07945

CIR:	C2U53_17165

CTEL:

GBC03_22290

CARS:

E1B03_08745

CIB:	HF677_016245

KOU:	C0557_15940

ASUB:

NLZ15_06485

TOE:	QMG90_15515

YAS:	N0H69_04365

GQU:	AWC35_17960

DDA:	Dd703_1372

BGJ:	AWC36_10235

BRB:	EH207_03320

BNG:	EH206_14305

BIZ:	HC231_14835

PROD:

PCO85_00270

XPO:

XPG1_0711

PRAG:

EKN56_01455

PFQ:	QQ39_16150

LRI:	NCTC12151_03160

LGB:	V8L73_16865

VPF:	M634_24445

VZI:	G5S32_20505

VNP:	KW548_11610

PHOT:

L4174_018205

ABM:

ABSDF1527

HAHE:

ENC22_02610

HASO:

B2G49_09445

ORB:	IPMB12_10055

CHRO:

CXB49_05295

CRZ:	D1345_18085

CHAE:

CH06BL_36770(kce)

BYI:	BYI23_D002050

BUE:	BRPE67_DCDS03800

BPLA:

bpln_2g18490

BXE:

Bxe_C0921

BXB:

DR64_7528

BUZ:	AYM40_28240 AYM40_28280

PHS:	C2L64_12790

PTER:

C2L65_27710

PGP:	CUJ91_33320

PACS:

FAZ98_16245 FAZ98_29810

PSAA:

QEN71_35355

PLAD:

PPGU16_58610

PPK:	U875_11025

PPNO:

DA70_03435

PPNM:

LV28_02890

PRB:	X636_23675

PPUL:

RO07_21755

PSPU:

NA29_15335

PAPI:

SG18_14785 SG18_20720

PVE:	UC34_13095

POX:	MB84_17620

PFG:	AB870_00165

PNR:	AT302_19060

PFIB:

PI93_014870

PCOM:

NTU39_14695

PANN:

PanNE5_35730

PANX:

OYT13_12475

CABK:

NK8_79280

TVL:	FAZ95_29465

BTRM:

SAMEA390648702405

AXY:	AXYL_00249

AXO:	NH44784_028411

AXN:	AX27061_5475

AXX:	ERS451415_05501

ADT:	APT56_25150

AIS:	BUW96_27005

ASW:	CVS48_09975

ACHR:

C2U31_30050

ACHB:

DVB37_24805

ADY:	HLG70_24950

ACHO:

H4P35_23645

AMUI:

PE062_20425

APES:

FOC84_11560

AAEG:

RA224_01195

ASEL:

RAS12_25760

ACHM:

V6V88_24255

PUD:	G9Q38_10230

AKA:	TKWG_07525

AMIM:

MIM_c27280

NARM:

N7E01_09330

RFR:

Rfer_3885

RLH:	MIZ03_1066

ACIV:

EXV95_12200

VAP:	Vapar_0074

VPE:	Varpa_0091

VPD:	VAPA_1c00810

VBO:	CKY39_00440

VAM:	C4F17_18645

VAZ:	H7F35_12335

VAV:	IG196_31205

CTT:	CtCNB1_0216

RGE:

RGE_01310

NOK:	FAY22_04145

DOE:	DENOEST_0851 DENOEST_1136

ARES:

IWH25_08685

APET:

ToN1_41400

AZA:

AZKH_1579

AZI:	AzCIB_1071

SAME:

SAMCFNEI73_pC1548

RPC:

RPC_0635

MET:

M446_2423

MNO:

Mnod_6459

MAQU:

Maq22A_c00780

MEE:	DA075_12485

MTEA:

DK419_20340

MIND:

mvi_14970

RHZ:	RHPLAN_54170

PSIN:

CAK95_14970

LAGG:

B0E33_09765

PSTG:

E8M01_19780

CMAG:

CBW24_06465

SWI:

Swit_4921

SSY:	SLG_14250 SLG_24820

SAMI:

SAMIE_1025940

ACOB:

P0Y56_15370

RAP:

RHOA_5182

DOL:

Dole_2170

DAL:	Dalk_0258 Dalk_3351

DOV:	DSCO28_65320(kce)

DEK:	DSLASN_49370(kce)

DMP:	FAK_17300(kce) FAK_18120(kce) FAK_23450 FAK_26750 FAK_29650 FAK_39570(kce)

ADE:

Adeh_1487

ACP:	A2cp1_2468

AFW:	Anae109_2345

ANK:	AnaeK_2380

AORY:

AMOR_14180 AMOR_53320(kce)

APAU:

AMPC_09760(kce)

MXA:

MXAN_4384

MSD:	MYSTI_04873

MYM:	A176_002519

MFB:	MFUL124B02_26670

MYX:	QEG98_23510

MLAN:

JY572_02330

CCX:	COCOR_03529

MFU:	LILAB_30010

MMAS:

MYMAC_004298

PPAK:

JY651_10330

SUR:	STAUR_4744

AGE:	AA314_04550 AA314_06943

AVM:	JQX13_36730

MBD:	MEBOL_007831

VIN:	AKJ08_2025

SCL:	sce1784 sce6192

SCU:	SCE1572_11095 SCE1572_37295

CCRO:

CMC5_025210

PAUU:

E8A73_023760 E8A73_028225

MRM:	A7982_06888 A7982_13257

SAMY:

DB32_004761

LLU:	AKJ09_00844 AKJ09_10303

HOH:

Hoch_2623

BSED:

DN745_10915

PCAY:

FRD00_15175

BBAE:

FRD01_09530

BMEG:

BG04_4018

BKW:	BkAM31D_23380(kce)

BDA:	FSZ17_02380

GTN:

GTNG_2707

ASED:

IRT44_08235

VNE:	CFK40_04185

PASA:

BAOM_3312(kce)

MLIT:

KDJ21_017725

MENL:

MVE64_01685

BAYD:

BSPP4475_17735

BRUM:

NDK47_06300

PSAB:

PSAB_13605

PBJ:	VN24_22335

PDH:	B9T62_11665

PSOP:

KP014_18680

PSPN:

L1F29_24745

COHN:

KCTCHS21_27160

CCHL:

FPL14_05870

AFX:	JZ786_00690

ACUR:

JZ785_19590

ACYC:

JI721_05800

ALIC:

GI364_23745

TUM:	CBW65_05385

TAB:	CIG75_01730

SPOS:

DV702_07190

LFB:	C1X05_16280

TVU:	AB849_005250

KPUL:

GXN76_15665

KEB:	GXN75_17000

PABS:

JIR001_30730(kce)

ESS:	ATZ33_10595

FCT:	NRE15_05400 NRE15_05490

JPO:	G7058_07655

CLS:	CXIVA_02410 CXIVA_06660 CXIVA_07070 CXIVA_10680

CSR:	Cspa_c22680

CPAT:

CLPA_c31500(kce)

CPAE:

CPAST_c31500(kce)

CSQ:

CSCA_1088

CACE:

CACET_c04310(kce) CACET_c30610

CEU:	A7L45_04275

CARG:

RSJ17_19915

CFER:

D4Z93_06560

CCAA:

KQH81_17160

CRW:	CROST_000170(kce)

CFB:	CLFE_002830(kce)

CAUN:

CLAUR_029780(kce)

CTAG:

LL095_01345

CALE:

FDN13_06065 FDN13_09320

CRS:	FQB35_13630

CPRF:

K7H06_00150 K7H06_00255

CRAS:

KVH43_03060 KVH43_03185

OCW:	OW730_07265

PROQ:

P6M73_04600

FPLA:

A4U99_00635 A4U99_02450 A4U99_02930 A4U99_06985 A4U99_11325 A4U99_13675 A4U99_15495 A4U99_15680 A4U99_15875

FTK:	PXT33_001165

VFA:	MM35RIKEN_07360(kce)

VCOP:

MM50RIKEN_12230(kce_1) MM50RIKEN_22420(kce_2)

STH:

STH64

DOR:	Desor_2356

DAI:	Desaci_1864

TFR:	BR63_08260

FWA:	DCMF_21050

AACX:

DEACI_2076

ALKA:

J0B03_09535

ACAE:

HYG86_10530

IBU:	IB211_00294 IB211_00977 IB211_02342c IB211_02425c IB211_02981c IB211_03192c IB211_03205

PROM:

QO263_00265 QO263_00490

EUU:	ADJ67_07210

CCT:	CC1_10470 CC1_15150 CC1_27090 CC1_30820

BLIQ:

INP51_11485

LACY:

A4V08_13590

LXA:	OW255_13820

LUA:	D4A81_03615

LGG:	QJR73_02890

ANR:	Ana3638_09750

CBOL:

CGC65_03065

VGU:	HYG85_18515

VPY:	HZI73_18015

AMIJ:

EQM06_00105 EQM06_04540 EQM06_05495 EQM06_10715 EQM06_12635

AMIC:

Ami3637_01930

ABUT:

Ami103574_00410 Ami103574_00875 Ami103574_04915 Ami103574_06350 Ami103574_07060 Ami103574_08060

ETM:	CE91St48_04090(kce_1) CE91St48_09320(kce_2) CE91St48_13780(kce_3) CE91St48_34180(kce_4)

AMT:

Amet_0318

AOE:	Clos_2443 Clos_2597

GFE:	Gferi_09730 Gferi_10185 Gferi_11065 Gferi_11195

CSPO:

QNI18_05020 QNI18_05570

RHOM:

FRIFI_1473

TEB:	T8CH_2406(kce)

THYR:

P4S50_05125

CST:	CLOST_0198 CLOST_1384(kce)

CMIU:

B1H56_13340

TTE:

TTE0719

TWI:	Thewi_0850

THEZ:

OEI98_000852

DBC:	MFMK1_002471 MFMK1_003160

BACG:

D2962_01125

NTH:	Nther_1884 Nther_1903

HPK:	Hprae_1557

HALS:

D7D81_01265 D7D81_18045

IFN:	GM661_14610

AFT:	BBF96_12050

KME:	H0A61_00948(kce_1) H0A61_01605(kce_2) H0A61_01689(kce_3)

HPRF:

HLPR_25930

AMEI:

LV469_06375 LV469_08580

GBX:	SANA_29740

SPOA:

EQM13_03155

KPAR:

JL105_08395

CAZO:

G3A45_10605

TIZ:	RBU61_01785 RBU61_15225(kce)

SEDZ:

JYG23_14310

SEDM:

RBQ61_04745

MHW:	ACT01_12415

PUF:	UFO1_1432 UFO1_1643

PFT:	JBW_02722 JBW_04693

STED:

SPTER_15940(kce_2) SPTER_16000(kce_3) SPTER_25770(kce_4) SPTER_28480(kce_5) SPTER_40640(kce_6) SPTER_46160(kce_7)

SSPH:

SPSPH_026920(kce_1) SPSPH_040120(kce_2) SPSPH_041800(kce_3)

SSID:

SPSIL_040630(kce_1) SPSIL_052160(kce_2)

FCZ:	IMF26_07425

MANR:

MPAN_016020(kce)

MBJ:	KQ51_00861(kce)

XCL:	G4Z02_00830

TBK:	HF295_06570

TBM:	BK010_00735

TBZ:	BK011_00635

ATB:	J4859_07140

MTV:

RVBD_1718

MRA:

MRA_1728

MTF:	TBFG_11733

MTB:	TBMG_02277

MTK:	TBSG_02289

MTZ:	TBXG_002259

MTG:	MRGA327_10650

MTI:	MRGA423_10750

MTE:	CCDC5079_1594

MTUR:

CFBS_1811

MTL:	CCDC5180_1578

MTO:	MTCTRI2_1748

MTD:

UDA_1718

MTN:	ERDMAN_1887

MTJ:	J112_09165

MTUB:

MT7199_1741

MTUE:

J114_09175

MTX:	M943_08955

MTUH:

I917_12185

MTUL:

TBHG_01676

MTUT:

HKBT1_1810

MTUU:

HKBT2_1818

MTQ:	HKBS1_1814

MBO:	BQ2027_MB1746

MBB:

BCG_1757

MBT:

JTY_1732

MBM:	BCGMEX_1729

MBK:	K60_018050

MAF:

MAF_17370

MMIC:

RN08_1908

MCE:	MCAN_17291

MCQ:	BN44_20289

MCV:	BN43_30842

MCX:	BN42_21649

MCZ:	BN45_40198

MORY:

MO_001824

MKN:	MKAN_28565

MLW:	MJO58_22580

MPAG:

C0J29_14335

MBAI:

MB901379_02355(kce)

MLJ:	MLAC_16140

MSHJ:

MSHI_14730

MOT:	LTS72_11545

MPHL:

MPHLCCUG_04683(kce_2)

MMAT:

MMAGJ_45590

MGO:	AFA91_08710 AFA91_23040

NFA:

NFA_32680

NFR:	ERS450000_00808

NNO:	NONO_c50150

RER:

RER_51490

RHOD:

AOT96_05775

ROZ:	CBI38_14115

SALS:

SLNWT_0164

SCAD:

DN051_42975

SCAJ:

O1G22_43575

MIO:	AOA12_01255

HUW:	FPZ11_14540

ICA:	Intca_2943

ARS:	ADJ73_01305

TEH:	GKE56_14730

PHW:	G7075_13940

PEI:	H9L10_00100

TED:	U5C87_00325

SERW:

FY030_13290

ORN:	DV701_08540

OCP:	NF557_02660

OFA:	NF556_03395

NCA:

Noca_4226

NOY:	EXE57_14640

NOI:	FCL41_01990

NOO:	FE634_18160

NDP:	E2C04_02600

NSN:	EXE58_10700

NANO:

G5V58_19600

NMES:

H9L09_06490

NAQU:

ENKNEFLB_00763(kce)

NRO:	K8W59_15530

NOQ:	LN652_10505

NCQ:	K6T13_15365

NPS:	KRR39_22575

NRN:	SHK17_18275

NBI:	SHK19_18605

NOF:	MF408_13120

KFL:

Kfla_0987

KQI:	F1D05_24970

KSL:	OG809_16505

KRI:	OX958_32035

TCU:

Tcur_0658

AGRA:

AGRA3207_003561 AGRA3207_005241

AMAZ:

LUW76_19130

ACIR:

OG979_13325

SPIQ:

OHA34_27190

ACTQ:

OG417_46910

BLAP:

MVA48_18415

BBRG:

U6N30_26055

MMAR:

MODMU_5030

SEN:

SACE_7114

AMQ:	AMETH_2356

AORI:

SD37_10400

PBRO:

HOP40_21330

APRE:

CNX65_33810

AMI:

Amir_6838

SESP:

BN6_82110

SSYI:

EKG83_45180

SACX:

IOD16_35050

KAL:

KALB_8525

KUT:	JJ691_80710

KPHY:

AOZ06_51485

LED:	BBK82_16145

ACTA:

C1701_12125

ALO:

CRK60420

SACE:

GIY23_21560

ACTU:

Actkin_06248(kce)

CROS:

N8J89_40045

STP:	Strop_0314

SAQ:

Sare_0377

MAU:	Micau_5705

MIL:

ML5_2791

MICB:

MicB006_1753

MTUA:

CSH63_28805

MICH:

FJK98_29675

MTEM:

GCE86_23135

MCAB:

HXZ27_28490

MSAG:

GCM10017556_19540(kce)

VMA:	VAB18032_02060

MCRA:

ID554_18020

VER:	HUT12_29645

MENO:

Jiend_34200(kce)

MCHL:

PVK74_18660

MFEU:

H1D33_04425

MPRN:

Q3V37_09440

MHAW:

RMN56_14275

MCAY:

PVK37_03530

MICF:

QQG74_28985

ASE:

ACPL_7951

AMS:	AMIS_76710

ACTN:

L083_7745

ACTS:

ACWT_7820

AIH:	Aiant_38100(kce)

ACTR:

Asp14428_52490(kce)

ACTL:

L3i22_102830(kce)

ASIC:

Q0Z83_093180

AOU:	ACTOB_008286

ACTE:

ACTI_16830

AFS:

AFR_40680

PLK:	CIK06_26340

PLAB:

C6361_11370

PLAT:

C6W10_08460

PFLA:

Pflav_065980

PSUU:

Psuf_027980

ATL:	Athai_00630(kce)

ASER:

Asera_06810

PRY:	Prubr_31370(kce)

CATI:

CS0771_09110(kce)

DVC:	Dvina_03425

DFU:	Dfulv_04000

DROS:

Drose_03005

DAUR:

Daura_03100

DMAT:

Dmats_03105

DACT:

KZZ52_03635

NHY:	JQS43_24020

CCAZ:

COUCH_03300

SNA:

Snas_6127

NAV:	JQS30_07325

GLY:	K3N28_19475

AEY:	CDG81_21710

RXY:

Rxyl_2990

BSOL:

FSW04_23285

BALA:

DSM104299_04740(kce_4)

CWO:	Cwoe_1594 Cwoe_4391

PARN:

NBH00_05720

SBAE:

DSM104329_02554(kce_2) DSM104329_04556(kce_3)

TALU:

JDY09_08365

CAP:	CLDAP_25940

PBF:	CFX0092_A2471(kce)

TRO:

trd_1744

VAB:	WPS_08830(kce)

SCC:	Spico_1043

GRW:	FTO74_11760

GEP:	Q9293_15630

FNU:

FN1868

FNC:	HMPREF0946_01616

FNT:	HMPREF0405_01362

FUS:	HMPREF0409_01396

FNE:	FSDG_01973

FHW:	RN87_00405

FPD:	CTM68_06725

FVA:	FV113G1_04320 FV113G1_13760 FV113G1_17250 FV113G1_29960

FUL:	C4N20_04210 C4N20_08870 C4N20_13625 C4N20_15465

FGO:	C4N16_05135

FNF:	BSQ88_03850

FPEI:

C4N17_12360

FCI:	I6I83_03005

FHO:	H9Q81_09955

FPOL:

ERS445057_00491

IPO:	Ilyop_0142

CSOM:

MKD34_03780

AMO:	Anamo_2030

PGI:

PG_1068

PGN:

PGN_1164

PGT:	PGTDC60_1140

PAH:	Poras_0574

PCRE:

NCTC12858_01514

PCAG:

NCTC12856_01003

PEND:

LA319_06740

PSOE:

CE91St14_15600(kce)

PET:	PEIBARAKI_4151

OSP:	Odosp_3171

BUY:	D8S85_10215

BVIR:

I6J59_05615

BFH:	F1611_19365

BACC:

BRDCF_p1074

MBAS:

ALGA_2255

FBO:	J9309_08815

PROW:

OO006_09505

PROI:

OO005_08750

CACI:

CLOAM0912(kce)

THQ:	T2812B_08680

TLE:

Tlet_0226

PHY:	AJ81_05555

TME:

Tmel_0190

TAF:

THA_422

THP:	BG95_02085

THER:

Y592_02090

TFE:	JYK00_06045

FNO:

Fnod_0209

FPE:	Ferpe_0539

FIA:	NA23_03010

FRR:	IB67_05775

OCY:	OSSY52_05680(kce)

PMO:

Pmob_1078

MPZ:	Marpi_0476

MARN:

LN42_02755

MAEO:

JRV97_01890

OCS:	OF820_10895

KOL:

Kole_0965

KPF:	IX53_04760

MPG:	Theba_2113

MINF:

MESINF_1634(kce)

ASAC:

ATHSA_1430

HDL:	HALDL1_15910

HHB:

Hhub_3460

HNO:	LT974_14100

HLU:	LT972_00540 LT972_06520

HJE:	HacjB3_10425

HDO:	MUK72_07175

HALX:

M0R89_00440

HAXZ:

M0R88_01105

HAXY:

NGM07_05615

HALJ:

G9465_01310 G9465_10725 G9465_13925 G9465_24225

NPH:

NP_2938A

NHO:	HWV23_00435 HWV23_15080 HWV23_15145

NSAL:

HWV07_02080 HWV07_02130

HALI:

BV210_00545 BV210_19060

HSN:	DV733_03480

HRR:	HZS55_12685

HPEL:

HZS54_16610

HLT:	I7X12_01275

SSAI:

N0B31_04995 N0B31_19240

HAAD:

MW046_00080 MW046_18070

HAER:

DU502_10385

HALP:

DOS48_10000

HALQ:

Hrr1229_007895

HSS:	J7656_02505

HSAI:

HPS36_07860

SRUB:

C2R22_04265

HALN:

B4589_001425 B4589_004885

HALG:

HUG10_03230

HALU:

HUG12_08300 HUG12_20315

HMP:	K6T50_01305

HRE:	K6T36_01105

HRM:	K6T25_00175

HACB:

Hbl1158_08250

HAH:	Halar_1559

HAKZ:

J0X25_14125

NMG:

Nmag_2346

NAY:	HYG81_16520

SAWL:

NGM29_01205

HALV:

NGM15_10810

NAJ:	B1756_13425

NAG:	AArcMg_3082

NAN:	AArc1_2987

NBG:	DV706_17370

NAS:	GCU68_19320 GCU68_20075

HDA:	BB347_14420

LOKI:

Lokiarch_21000(kce_1) Lokiarch_49350(kce_2)

LOB:	NEF87_002601

PSYT:

DSAG12_00568

» show all

Reference

1 [PMID:6811551]

Authors

Barker HA, Kahn JM, Hedrick L

Title

Pathway of lysine degradation in Fusobacterium nucleatum.

Journal

J Bacteriol 152:201-7 (1982)

Reference

2 [PMID:17166837]

Authors

Kreimeyer A, Perret A, Lechaplais C, Vallenet D, Medigue C, Salanoubat M, Weissenbach J

Title

Identification of the last unknown genes in the fermentation pathway of lysine.

Journal

J Biol Chem 282:7191-7 (2007)
DOI:10.1074/jbc.M609829200

Sequence

[fnu:FN1868]

Reference

3 [PMID:21632536]

Authors

Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM.

Title

3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.

Journal

J Biol Chem 286:27399-405 (2011)
DOI:10.1074/jbc.M111.253260

Sequence

[caci:CLOAM0912]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.247

IUBMB Enzyme Nomenclature:

2.3.1.247

ExPASy - ENZYME nomenclature database:

2.3.1.247

BRENDA, the Enzyme Database:

2.3.1.247

LinkDB

DBGET integrated database retrieval system