KEGG   ENZYME: 2.3.1.279
Entry
EC 2.3.1.279                Enzyme                                 
Name
long-chain-acyl-CoA---trehalose acyltransferase;
papA3 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
long-chain-fatty acyl-CoA:alpha,alpha-trehalose 2-acyltransferase
Reaction(IUBMB)
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose = a 2-(long-chain-fatty acyl)-trehalose + CoA [RN:R12287]
Reaction(KEGG)
R12287
Substrate
long-chain-fatty acyl-CoA [CPD:C02843];
alpha,alpha-trehalose [CPD:C01083]
Product
2-(long-chain-fatty acyl)-trehalose [CPD:C22061];
CoA [CPD:C00010]
Comment
The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains. The enzyme catalyses two successive activities - it first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase).
History
EC 2.3.1.279 created 2018
Orthology
K23156  mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase / long-chain-acyl-CoA---trehalose acyltransferase
Genes
LBQCKQ53_00740
LPOPI6N93_03610
ZPLZBT109_1554
CTIpRALTA_0573
MFBMFUL124B02_11305
SAMESAMCFNEI73_pB0404
BSYMCIT39_22775
BELBE61_77300
MTURv1182(papA3)
MTVRVBD_1182
MTCMT1219
MRAMRA_1192(papA3)
MTFTBFG_11206
MTBTBMG_02800
MTKTBSG_02814
MTZTBXG_002780
MTGMRGA327_07450
MTECCDC5079_1093
MTURCFBS_1260(papA3)
MTLCCDC5180_1086
MTOMTCTRI2_1213(papA3)
MTDUDA_1182(papA3)
MTNERDMAN_1324(papA3)
MTJJ112_06385
MTUBMT7199_1211
MTUCJ113_08295
MTUEJ114_06385
MTXM943_06190
MTUHI917_08405
MTULTBHG_01165
MTUTHKBT1_1258(papA3)
MTUUHKBT2_1264(papA3)
MTQHKBS1_1262(papA3)
MBOBQ2027_MB1214(papA3)
MBBBCG_1244(papA3)
MBTJTY_1217(papA3)
MBMBCGMEX_1216(papA3)
MBKK60_012740
MBXBCGT_1013
MAFMAF_12010(papA3)
MMICRN08_1326
MCEMCAN_11931(papA3)
MCQBN44_11321(papA)
MCVBN43_30249(papA)
MCXBN42_21047(papA)
MCZBN45_30244(papA)
MLEML1230(papA3)
MLBMLBr01230(papA3)
MPAMAP_2231(papA3) MAP_3721 MAP_3763c(papA3)
MAOMAP4_0048 MAP4_1593 MAP4_3872
MAVIRC58_00225 RC58_07935 RC58_19220
MAVURE97_00230 RE97_07935 RE97_19270
MAVMAV_1762 MAV_4883
MITOCO_18180 OCO_47930
MIAOCU_18360 OCU_47860
MIDMIP_02565 MIP_07251
MYOOEM_16190 OEM_48100
MCHIAN480_08940 AN480_24900
MIROCQ_15790 OCQ_48950
MMALCKJ54_07815 CKJ54_22825 CKJ54_22835
MLPMLM_2749
MMANMMAN_23420 MMAN_36120 MMAN_40010(papA3)
MSAMycsm_00207
MULMUL_1531(papA3)
MMCMmcs_0245 Mmcs_3118
MKMMkms_0255 Mkms_3178
MJLMjls_0235 Mjls_3129
MMIMMAR_0087 MMAR_2343 MMAR_2355(papA3)
MMAEMMARE11_00800 MMARE11_22650 MMARE11_22770(papA3)
MMMW7S_07745 W7S_24030
MLIMULP_00074 MULP_03269(papA3)
MKNMKAN_27535 MKAN_27610
MYVG155_01575 G155_14370
MYEAB431_02010 AB431_13675
MGOAFA91_08980 AFA91_16880 AFA91_22635
MHADB586_07470 B586_12980
MDXBTO20_18245 BTO20_34435
MSHGMSG_03264 MSG_03826(papA3)
MFJMFLOJ_45790 MFLOJ_52900
MSTOMSTO_49700 MSTO_54060 MSTO_57010
MSIMMSIM_42160
MSAKMSAS_03080(papA3_1) MSAS_16200 MSAS_21090(papA3_2)
MKUI2456_11550 I2456_18040
MGROFZ046_08055 FZ046_18575
MNVMNVI_38120
MPAGC0J29_20850
MGORH0P51_12600 H0P51_12615 H0P51_18890
MCOOMCOO_14710
MBAIMB901379_02178(papA2) MB901379_02191(papA1)
MSEOMSEO_22230 MSEO_24770 MSEO_43720
MPSEMPSD_00770 MPSD_23880
MSHOMSHO_31370 MSHO_35730
MLJMLAC_13990(papA3) MLAC_14010(papA2)
MBRDMBRA_33990
MSHJMSHI_16720(papA2) MSHI_16740(papA3)
MDFK0O62_02035 K0O62_13850
MMAMK3U93_10750 K3U93_15990
MHOLK3U96_05125 K3U96_25255
MSENK3U95_01625 K3U95_12065
MPAEK0O64_01645 K0O64_13480
MSPGF6B93_01470 F6B93_09730
MOTLTS72_12605 LTS72_12670
MLMMLPF_1674(papA3)
MVMMJO54_23315
MRFMJO55_01280
MPAAMKK62_08600
MCROMI149_02190 MI149_14305
MSMMSMEG_0409 MSMEG_4728
MSGMSMEI_0399(papA3) MSMEI_4611
MSBLJ00_02035 LJ00_23390
MSNLI99_02035 LI99_23395
MSHLI98_02035 LI98_23400
MVAMvan_0270
MGIMflv_0404
MSPMspyr1_03510
MCBMycch_0237
MNED174_03070 D174_13550
MYNMyAD_03000 MyAD_13300
MFTXA26_03380 XA26_29750
MPHLMPHLCCUG_00973(papA3_1) MPHLCCUG_04852(papA3_2)
MVQMYVA_0272
MLLB1R94_01625 B1R94_15670
MRHMycrhN_2273
MTHN4412656_01985(papA1)
MDUMDUV_40530
MCHTMCHIJ_06870
MDRMDOR_22950
MAUUNCTC10437_00273(papA1) NCTC10437_02583(papA2)
MMAGMMAD_05470(papA3) MMAD_26460
MMORMMOR_12060
MFXMFAL_06690
MAICMAIC_24560 MAIC_52950
MIJMINS_17880 MINS_24730
MALVMALV_32520
MTYMTOK_44810
MARZMARA_13110 MARA_35290
MHEVMHEL_18590 MHEL_49060
MSARMSAR_19040 MSAR_43810
MANYMANY_11070 MANY_44020
MAUBMAUB_03850 MAUB_05850 MAUB_36870
MPOFMPOR_08100
MPHUMPHO_06840 MPHO_08990 MPHO_33530
MMUCC1S78_001325 C1S78_013710 C1S78_014920
MMATMMAGJ_18030 MMAGJ_61730
MBOKMBOE_15660 MBOE_44840
MFGK6L26_17660 K6L26_29830
MSEIMSEDJ_38500
MFLVNCTC10271_04865(papA3)
MCEEMCEL_29780
MABMAB_0852 MAB_0938c MAB_3147c
MMVMYCMA_0438 MYCMA_0490 MYCMA_1726
MABBMASS_0863 MASS_0922 MASS_3090
MABLMMASJCM_0798 MMASJCM_0855 MMASJCM_3150
MCHEBB28_03970 BB28_04245 BB28_15930
MIZBAB75_04760 BAB75_05045
MSTEMSTE_00784 MSTE_00844 MSTE_03124
MSAOMYCSP_03545 MYCSP_03820 MYCSP_14310
MSALDSM43276_00716(papA2) DSM43276_00773(papA3_1) DSM43276_02932(papA3_2)
MMINMMIN_17130(papA3)
MHIBMHIB_35860(papA3)
MPAKMIU77_05275
CKPckrop_0207
CVACVAR_2563
CTERA606_10850
CFNCFAL_11485
CGYCGLY_00745 CGLY_02255
CPRECsp1_03780(papA3)
CUOCUROG_10195(papA3)
NBRO3I_015370 O3I_026865 O3I_026875
NSLBOX37_05985 BOX37_10765 BOX37_10775 BOX37_16845 BOX37_16915
NTPCRH09_17250 CRH09_26800
NOZDMB37_05765 DMB37_05775
NAHF5544_26520 F5544_26530
NADNCTC11293_03792(papA2_1) NCTC11293_03816(papA2_2)
NWLNWFMUON74_32000 NWFMUON74_32020
NIEKV110_26050
NTCKHQ06_37420
NYALTV02_36640
RHARHA1_ro06283
RERRER_21220 RER_21250 RER_47370 RER_47390
REYO5Y_10130 O5Y_10145 O5Y_22390 O5Y_22400
REBXU06_10355 XU06_10370 XU06_22500 XU06_22510
RQIC1M55_10795 C1M55_10810 C1M55_23855 C1M55_23865
ROPROP_63460 ROP_63500
ROAPd630_LPD02946
REQREQ_33910
RPYY013_07790
RBYCEJ39_18710
RHBNY08_1709 NY08_1714
RAVAAT18_17375
RFAA3L23_00070(papA3_1) A3L23_00075(papA3_3)
RHSA3Q41_02149(papA3_1) A3Q41_03338(papA3_2) A3Q41_03343(papA3_4)
RHWBFN03_04340
RRZCS378_06910
RHUA3Q40_02056(papA3_1) A3Q40_02058(papA2) A3Q40_02063(papA3_2)
RHQIM25_22105
RHODAOT96_03890 AOT96_20975 AOT96_20990
RRT4535765_01198 4535765_03380(papA2)
RCRNCTC10994_03880(papA2)
RTMG4H71_17610
RKOJWS14_34190
RGOKYT97_07945
ROZCBI38_19335
GBRGbro_1833
GPOGPOL_c06650 GPOL_c06670 GPOL_c17240 GPOL_c42910
GORKTR9_0874 KTR9_0876 KTR9_1771 KTR9_1820 KTR9_1822
GOQACH46_06775
GTABCM27_05390 BCM27_05400 BCM27_09560 BCM27_09805 BCM27_09815
GOCCXX93_08180 CXX93_15815
GITC6V83_07140 C6V83_14895
GRUGCWB2_04595(papA1) GCWB2_08990(papA4)
GOMD7316_01431(papA3_1) D7316_01433(papA1_2) D7316_01436(papA3_2) D7316_01834(papA3_3) D7316_01836(papA3_4)
GAVC5O27_18800
GODGKZ92_04245 GKZ92_04255 GKZ92_08585
GAMGII34_08110 GII34_19450 GII34_21240
GPDGII33_03410 GII33_07580
GJIH1R19_04315 H1R19_08895
GOILK459_01295 LK459_01540
GHNMVF96_09210
GAMIIHQ52_07190 IHQ52_11885
TPRTpau_0205 Tpau_1032
TSMASU32_01725 ASU32_17900
SRTSrot_0561 Srot_0563 Srot_0652 Srot_0654
DIZCT688_15405
DPCA6048_16170
SCBSCAB_62191
SHYSHJG_5667
SHOSHJGH_5428
SDVBN159_5568
SALSSLNWT_4090 SLNWT_4093 SLNWT_6964
SCIB446_21325
SLVSLIV_15895
SAMBSAM23877_4294
SRWTUE45_05074(papA2)
SPAVSpa2297_18815
STRTA8713_01955
SGSAVL59_41160
SKYD0C37_30800
SCADDN051_24910
SPLULK06_013055
STRDNI25_16465
SPUNBFF78_18430 BFF78_26990
SALFSMD44_04889 SMD44_05403
SALJSMD11_2920
SRJSRO_3188
SGDELQ87_07690
SCYAEJ357_26835
SGZC0216_18305
SVNCP980_30345
SHAWCEB94_23665
SRKFGW37_01785
SAQUEJC51_18800
SGFHEP81_03398
SSEOD0Z67_16675
SSUBCP968_30340
SPHVF9278_13490
SCINCP977_30915
SPACB1H29_15960
SCHACP983_18285
SCOECP976_25030
SBROGQF42_25360
SHUNDWB77_06868(papA3)
SDDD9753_15005
MIMAKG07_00880
MCWA8L33_02555
MICRBMW26_05430
MSFIT882_14675
CPHYB5808_08295
LTREVS81_05265
ARHAHiyo8_52980
GARAOZ07_17300
KRSEQG70_03445
RKRI6G21_00825
NAEBHE16_11855
BSAUDWV08_08845
BRRC1N80_07740
JTEASJ30_03220
JLIEXU32_01140
JMEEEW87_015820
SERJSGUI_2570
BCAUI6G59_08605
PBOPACID_26890
AACIASQ49_08605
RAINRai3103_09085
NOIFCL41_00210
NSNEXE58_19155
NPIG7071_16605
AERAERYTH_07440
NGVCDO52_05030
PSEAWY02_28115
PSEHXF36_14880
 » show all
Reference
1  [PMID:19276083]
  Authors
Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, Lin FL, Carlson BL, Kumar P, Leary JA, Bertozzi CR
  Title
PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis.
  Journal
J Biol Chem 284:12745-51 (2009)
DOI:10.1074/jbc.M809088200
  Sequence
[mtu:Rv1182]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.279
IUBMB Enzyme Nomenclature: 2.3.1.279
ExPASy - ENZYME nomenclature database: 2.3.1.279
BRENDA, the Enzyme Database: 2.3.1.279
LinkDB

DBGET integrated database retrieval system