KEGG   ENZYME: 2.3.1.291
Entry
EC 2.3.1.291                Enzyme                                 
Name
sphingoid base N-palmitoyltransferase;
mammalian ceramide synthase 5;
CERS5 (gene name);
LASS5 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
palmitoyl-CoA:sphingoid base N-palmitoyltransferase
Reaction(IUBMB)
palmitoyl-CoA + a sphingoid base = an N-(palmitoyl)-sphingoid base + CoA
Reaction(KEGG)
(other) R01496 R06517
Substrate
palmitoyl-CoA [CPD:C00154];
sphingoid base
Product
N-(palmitoyl)-sphingoid base;
CoA [CPD:C00010]
Comment
Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.
History
EC 2.3.1.291 created 2019, modified 2019
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K23727  sphingoid base N-palmitoyltransferase
Genes
HSA253782(CERS6) 91012(CERS5)
PTR451891(CERS5) 741293(CERS6)
PPS100980816(CERS5) 100985038(CERS6)
GGO101126713(CERS6) 101131185(CERS5)
PON100452162(CERS6) 100454836(CERS5)
NLE100580966(CERS5) 100606355(CERS6)
MCC704953(CERS6) 713449(CERS5)
MCF101926756(CERS6) 102116993(CERS5)
CSAB103217252(CERS6) 103238299(CERS5)
CATY105576085 105580163(CERS6) 105580356(CERS5)
PANU101007470(CERS5) 101010164(CERS6)
TGE112635263(CERS5) 112635963(CERS6)
RRO104655030(CERS6) 104679692(CERS5)
RBB108520506(CERS6) 108543894(CERS5)
TFN117090138(CERS5) 117094902(CERS6)
PTEH111523514(CERS6) 111542010(CERS5)
CJC100400191(CERS5) 100406593(CERS6)
SBQ101031310(CERS5) 101042109(CERS6)
CSYR103259017 103264586(CERS5) 103275446(CERS6)
MMUR105869901(CERS5) 105880675(CERS6)
LCAT123640385(CERS5) 123643926(CERS6)
OGA100944197(CERS5) 100965109(CERS6)
MMU241447(Cers6) 71949(Cers5)
MCAL110285303(Cers6) 110310406(Cers5)
MPAH110318337(Cers6) 110334738(Cers5)
RNO366065(Cers6) 366984(Cers5)
MCOC116079726(Cers5) 116090263(Cers6)
MUN110547416(Cers5) 110547789(Cers6)
CGE100761613(Cers6) 100774213(Cers5)
MAUA101835560(Cers5) 101842471(Cers6)
PLEU114696680(Cers5) 114701812(Cers6)
MORG121433167(Cers6) 121441512(Cers5)
AAMP119819939(Cers6) 119823323(Cers5)
NGI103737993(Cers6) 103746545(Cers5)
HGL101701089(Cers5) 101713278(Cers6)
CPOC100713053(Cers6) 100713687(Cers5)
CCAN109689224(Cers6) 109695422(Cers5)
DORD105987427(Cers5) 105994475(Cers6)
DSP122106337(Cers5) 122120081(Cers6)
NCAR124980060 124983009
OCU100339974(CERS5) 100344726(CERS6)
OPI101516066(CERS6) 101531778(CERS5) 105942315
TUP102474397(CERS5) 102484493(CERS6)
CFA477611(CERS5) 488387(CERS6)
CLUD112668042(CERS6) 112678319(CERS5)
VVP112916440(CERS6) 112921132(CERS5)
VLG121471816(CERS6) 121480093(CERS5)
AML100473865(CERS6) 100474398(CERS5)
UMR103659527(CERS6) 103675475(CERS5)
UAH113250813(CERS6) 113257628(CERS5)
UAR123781107(CERS6) 123794754(CERS5)
ELK111145572 111157957
LLV125095680 125106796
MPUF101679078(CERS5) 101689555(CERS6)
ORO101373517(CERS6) 101384709(CERS5)
EJU114223534(CERS6) 114225788(CERS5)
ZCA113919738(CERS6) 113922517(CERS5)
MLX118008859(CERS5) 118012363(CERS6)
FCA101084386(CERS6) 101087243(CERS5)
PYU121030655(CERS6) 121038586(CERS5)
PBG122473381(CERS5) 122481418(CERS6)
PTG102948771(CERS6) 102961799(CERS5)
PPAD109249101(CERS5) 109272468(CERS6)
AJU106969231(CERS5) 106970310(CERS6)
HHV120237896(CERS5) 120242834(CERS6)
BTA530776(CERS5) 616901(CERS6)
BOM102271413(CERS5)
BIU109559116(CERS5) 109575183(CERS6) 109575194
BBUB102394124(CERS5) 102412267(CERS6)
CHX102170388 102170747(CERS5) 102176466(CERS6)
OAS101117661(CERS5) 101122252(CERS6)
ODA120854885(CERS6) 120858190(CERS5)
CCAD122427691(CERS5) 122453803(CERS6)
SSC100126279(CERS6) 110260661(CERS5)
CFR102507747(CERS5) 102509169(CERS6)
CBAI105076226(CERS5) 105081974(CERS6)
CDK105091057(CERS6) 105097208(CERS5)
VPC102527280(CERS6) 102542785(CERS5)
BACU103007274(CERS5) 103008265(CERS6)
LVE103076535(CERS6) 103088889(CERS5)
OOR101282056(CERS6) 101282990(CERS5)
DLE111172828(CERS6) 111174012(CERS5)
PCAD102983287(CERS6) 112064695(CERS5)
PSIU116756288(CERS6) 116760255(CERS5)
ECB100052305(CERS6) 100059999(CERS5)
EPZ103546204(CERS5) 103567735(CERS6)
EAI106843426(CERS6) 106845048(CERS5)
MYB102246479(CERS6) 102262839(CERS5)
MYD102760303(CERS5) 102772688(CERS6)
MMYO118650380(CERS5) 118661337(CERS6)
MLF102436571(CERS5) 102440851(CERS6)
MNA107527415(CERS6) 107528263(CERS5)
PKL118709783(CERS6) 118729927(CERS5)
HAI109390309(CERS6) 109393272(CERS5)
DRO112318384(CERS5) 112322198(CERS6)
SHON118976441(CERS5) 118985744(CERS6)
AJM119042790(CERS5) 119045847(CERS6)
PDIC114494743(CERS6) 114512942(CERS5)
PHAS123813037(CERS5) 123823852(CERS6)
MMF118624460(CERS5) 118625117(CERS6)
RFQ117026070(CERS6) 117029327(CERS5)
PALE102880099(CERS5) 102896376(CERS6)
PGIG120597041(CERS6) 120618175(CERS5)
PVP105290776(CERS6) 105297590(CERS5)
RAY107514286(CERS5) 107521030(CERS6)
MJV108385188(CERS6) 108406540(CERS5)
TOD119247907(CERS5) 119255898(CERS6)
SARA101551440(CERS6) 101558293(CERS5)
LAV100660076(CERS6) 100674871(CERS5)
TMU101353143 101360537
DNM101413515(CERS5) 101434663(CERS6)
MDO100024030(CERS6)
GAS123242227(CERS6) 123249238(CERS5)
SHR100924117(CERS6) 100929507(CERS5)
PCW110193982(CERS5) 110211536(CERS6)
OAA100083235(CERS6) 114814501(CERS5)
GGA426879(CERS5) 771503(CERS6)
PCOC116232888(CERS6) 116239661(CERS5)
MGP100544401(CERS6) 104913603(CERS5)
CJO107316742(CERS6) 107325704(CERS5)
NMEL110389242(CERS5) 110400020(CERS6)
APLA101789541(CERS5) 101804816(CERS6)
ACYG106029829(CERS6) 106047737(CERS5)
AFUL116490567(CERS6) 116499847(CERS5)
TGU100225623(CERS6) 100231332(CERS5)
LSR110472763(CERS6) 110478539(CERS5)
SCAN103814409(CERS6) 103823883(CERS5)
PMOA120498351(CERS6) 120500684(CERS5)
OTC121333717(CERS5) 121335462(CERS6)
PRUF121353965(CERS5) 121356581(CERS6)
GFR102038365(CERS5) 102041033(CERS6)
FAB101816156(CERS5) 101818852(CERS6)
PHI102105774(CERS5) 102111990(CERS6)
PMAJ107207352(CERS6) 107215686(CERS5)
CCAE111932124(CERS6) 111940481(CERS5)
CCW104694173(CERS6)
CBRC103613219(CERS5) 103616649(CERS6)
ETL114069957(CERS5) 114073750(CERS6)
ZAB102062883(CERS6) 102070566(CERS5)
ACHL103797040(CERS5) 103810631(CERS6)
FPG101913508(CERS5) 101920423(CERS6)
FCH102052030(CERS5) 102052115(CERS6)
CLV102089975(CERS6) 102090443(CERS5)
EGZ104127999(CERS6) 104132784(CERS5)
NNI104010021(CERS6) 104011985(CERS5)
PLET104619430(CERS6) 104626983(CERS5)
PCRI104032713(CERS5) 104035165(CERS6)
ACUN113482330(CERS6) 113491052(CERS5)
TALA104360950(CERS5) 104365809(CERS6)
PADL103914717(CERS5) 103918187(CERS6)
ACHC115343159(CERS6) 115350995(CERS5)
HALD104311178(CERS5) 104322568(CERS6)
CCRI104161428 104162691(CERS5)
CSTI104561729(CERS5)
EHS104511671(CERS5) 104513181
CMAC104487460(CERS5)
MUI104538151 104548789(CERS5)
FGA104076342(CERS5)
GSTE104252040(CERS5)
LDI104340808(CERS5) 104351137(CERS6)
MNB103778648(CERS5)
OHA104326608(CERS5) 104329048(CERS6)
AAM106499105(CERS6) 106499436(CERS5)
AROW112974982(CERS6) 112975208(CERS5)
NPD112947661(CERS6) 112950288(CERS5)
DNE112979643(CERS6) 112991671(CERS5)
ASN102380256(CERS6) 102383725(CERS5)
AMJ102562554(CERS6) 102569929(CERS5)
CPOO109322838(CERS6) 109324422(CERS5)
GGN109293341(CERS5) 109301529(CERS6)
PSS102452005(CERS5) 102460649(CERS6)
CMY102935736(CERS6) 102939527(CERS5)
CPIC101938783(CERS5) 101947382(CERS6)
TST117884876(CERS6) 117888487(CERS5)
CABI116819314(CERS6) 116825906(CERS5)
MRV120374746(CERS6) 120391341(CERS5)
ACS100552770(cers5) 100563712(cers6)
PVT110074286(CERS5) 110076893(CERS6)
SUND121919678(CERS6) 121922289(CERS5)
PBI103050325(CERS5) 103062842(CERS6)
PMUR107287846(CERS6) 107302713(CERS5)
TSR106545288(CERS5) 106546629(CERS6)
PGUT117662796(CERS5) 117671124(CERS6)
VKO123016992(CERS6) 123019263(CERS5)
PMUA114586906(CERS5) 114606000(CERS6)
ZVI118081592(CERS5) 118093633(CERS6)
GJA107119688(CERS6) 107122515(CERS5)
STOW125426129(CERS6) 125429405(CERS5)
XLA108701361 108702983 399185(cers5.L) 495501(cers5.S)
XTR100101657(cers5) 100489264(cers6)
NPR108789979(CERS5) 108796981(CERS6)
RTEM120929081(CERS5) 120944047(CERS6)
BBUF120996226(CERS5) 121008458(CERS6)
BGAR122932495(CERS5) 122944931(CERS6)
DRE323020(cers5) 564867(cers6)
SRX107707597 107708313 107712190 107718462
SANH107677898 107694004 107698577
SGH107564136 107566328 107566751 107590873
CCAR109096437 109101475 109102223
CAUA113039395 113040386 113052943(cers6) 113080556 113100953 113108267
PPRM120486726(cers5) 120487022(cers6)
MAMB125263379(cers5) 125270740(cers6)
IPU108255109(cers5) 108266969(cers6)
PHYP113526149(cers6) 113537857(cers5)
SMEO124383158(cers6) 124402259(cers5)
TFD113639059(cers5) 113654356(cers6)
AMEX103028461(cers6) 103035123(cers5)
EEE113577516(cers6) 113580588(cers5)
TRU101069548(cers5) 101069883(cers6) 105416273
TNGGSTEN00033223G001 GSTEN00033850G001 GSTEN00034621G001
LCO104924188(cers6) 104928376(cers5) 104935436
NCC104956311 104961144 104967145(cers5)
CGOB115008103(cers5) 115011230 115026753(cers6)
ELY117251840(cers6) 117257181(cers5) 117258080
EFO125889337(cers5) 125891306 125899476(cers6)
PLEP121946445 121949499(cers6) 121959331(cers5)
SLUC116048950(cers6) 116051423(cers5) 116062012
ECRA117942945(cers5) 117947484 117952532(cers6)
ESP116688268(cers5) 116693172 116697638(cers6)
PFLV114553897(cers5) 114558757 114564086(cers6)
GAT120828931 120833686(cers6) 120835436(cers5)
PPUG119222399 119228533(cers6) 119229875(cers5)
MSAM119886324(cers5) 119904068(cers6) 119905629
CUD121505618(cers5) 121517503 121523085(cers6)
ALAT119021569(cers5) 119022413 119026496(cers6)
MZE101465150 101466824(cers6) 101466872(cers5)
ONL100693585 100695512(cers5) 100700285(cers6)
OAU116319368(cers5) 116323067(cers6) 116324792
OLA101156449(cers6) 101166550 101175231(cers5)
OML112144547(cers5) 112155476(cers6) 112159097
XMA102228308(cers5) 102231596 102234372(cers6)
XCO114135628(cers5) 114143560 114148177(cers6)
XHE116708203 116710701(cers5) 116722749(cers6)
PRET103461713(cers6) 103464664(cers5) 103467553
PFOR103134348(cers6) 103134554(cers5) 103145066
PLAI106939936 106948004 106959521(cers5)
PMEI106926443(cers6) 106928826 106929006(cers5)
GAF122828957 122834553(cers5) 122839969(cers6)
CVG107082007(cers6) 107097563 107101127(cers5)
CTUL119774092 119780272(cers6) 119788651(cers5)
GMU124856671(cers5) 124870794(cers6) 124874118
NFU107385395 107390055(cers6) 107391072
KMR108231679(cers5) 108232041 108240800(cers6)
ALIM106512928(cers6) 106517657 106523186 106536835(cers5)
NWH119411855(cers5) 119416757 119419127(cers6)
AOCE111572807(cers6) 111576050(cers5) 111588345
MCEP125007024(cers5) 125017914 125018172(cers6)
CSEM103385495 103386746(cers5) 103392228(cers6)
POV109631475(cers6) 109635146 109635609(cers5)
SSEN122765528(cers6) 122768432(cers5) 122777674
HHIP117754754(cers6) 117761336(cers5) 117765323
HSP118103435(cers5) 118110575 118120188(cers6)
LCF108884121 108886075 108888662(cers6) 108889493
SDU111217339 111218344(cers6) 111233599(cers5)
SLAL111648435(cers5) 111654505(cers6) 111667195
XGL120801585(cers6) 120803324 120807600(cers5)
HCQ109507970(cers5) 109526957(cers6) 109528680
BPEC110155830(cers5) 110158056 110163953(cers6)
MALB109957097(cers6) 109964292 109964621
BSPL114847408(cers6) 114855110(cers5) 114858540
SASA106566192 106566664 106581790(cers6) 106583695 106583702 106586203
OTW112222046 112222283 112225207(cers6) 112236284 112246295(cers5)
OMY110492480 110494816 110501482(cers6) 110520083 110528577(cers5)
OGO124003996 124018470 124042801(cers6) 124043845 124045635
ONE115102035 115108751 115124173 115131870(cers5) 115145419(cers6)
SALP111959739 111970771(cers5) 111974822 111976765 112071209
SNH120057836 120058239 120061373 120064402(cers6) 120065488
CCLU121536805 121538600 121545346 121552238(cers6) 121574729
ELS105016697(cers5) 105022463(cers6) 109614588
SFM108920298 108931341(cers5)
PKI111835271(cers5) 111836391(cers6) 111852288
AANG118208513 118211526(cers5) 118223886(cers6)
LOC102694432(cers6) 102696759(cers5)
PSPA121301802 121308831(cers5) 121321532 121323660
ARUT117401105 117404579 117426584 117433315 117966995
LCM102345762(CERS5) 102354959(CERS6)
CMK103176381(cers6) 103190303
RTP109915855 109926491(cers6)
BFO118424561
BBEL109478803
CIN778662 778663(lag1-like1)
SCLV120332580 120332645 120347204
SPU115926214 582683
APLC110973426
SKO100373352
DMEDmel_CG3576(schlank)
DER6551335
DSE6612295
DSIDsimw501_GD28007(Dsim_GD28007)
DYADyak_GE16474
DAN26514187
DSR110181935
DPO4814776
DPE6603077
DMN108164752
DWI6648628
DGR6565933
DMODmoj_GI21529
DAZ108618444
DNV108655797
DHE111598102
DVI6634510
CCAT101462193
BOD106623226
MDE101890389
SCAC106081429
LCQ111685485
LSQ119600467
HIS119656157
AGAAgaP_AGAP001761
ACOZ120953999
AARA120893705
ASTE118504466
AAG5571461
AALB109432412
CQUCpipJ_CPIJ012963
CPII120414849
CNS116349858
BCOO119084431
AME727350
ACER107992919
ALAB122719222
BIM100742830
BBIF117214553
BVK117242673
BVAN117156442
BTER100650450
BPYO122572179
CCAL108621905 108623525
OBB114878598
MGEN117229463
NMEA116432360
CGIG122400982
SOC105202455 105202760
MPHA105834422
AEC105147584
ACEP105623188
PBAR105429305
VEM105558072
HST105190345
DQU106748799
CFO105251260
FEX115242037
LHU105679186
PGC109859190
OBO105276915
PCF106788439 106790267
PFUC122513576 122513581 122513582 122515260 122522526
VPS122634726
NVI100124217
CSOL105361245
TPRE106659191
MDL103573253
CGLO123267428
FAS105273287
DAM107046384
AGIF122856851
LHT122510284
CCIN107270358
TCA103313757 103314249 656365 656449
DPA109544248
SOY115883107
ATD109604206
CSET123320817
AGB108906836
LDC111515909
NVL108563163
APLN108745073
PPYR116161117 116162415 116168852 116169757 116177087
OTU111416207
BMOR101735559 101746948
MSEX115441317 115441318 115441319
DPLKGM_206860
BANY112045917 112053654
PMAC106712959 106712960 106712961
PPOT106107812 106107830
PXU106117619 106118032
PRAP110997056 110997057
ZCE119833225 119833241
HAW110380732 110380734
HZE124639677 124639879
TNL113502767 113502772
SLIU111360032 111360375 111360450
OFU114358327 114361483 114361490 114363875
PXY105391568
API100164476 100168238
DNX107162818
AGS114120474
RMD113551978
BTAB109034368 109036148 109036156 109036161 109036176 109036278 109036335
CLEC106662291
HHAL106683384
NLU111064616
PHUPhum_PHUM115780
FOC113202527
TPAL117640517
ZNE110827521
CSEC111864128
FCD110845774 110848678 110855638
DPXDAPPUDRAFT_202055 DAPPUDRAFT_220106 DAPPUDRAFT_309267
DMK116919551 116922943 116922982
PVM113808182 113815250 113815251 113819878 113819881 113819882 113819883 113819885
PJA122259873 122260028 122260091 122260102 122260122
PCHN125041733 125042092 125042093 125042094 125042183
HAME121877662 121877663 121880097 121880098 121880198
PCLA123757625 123757630 123757685 123760054 123760291 123760507
PTRU123520078 123520079 123520080
HAZT108664530 108664543 108672980 108679150 108680560 108680697 108680703 108680708 108680710
EAF111700142 111709730 111711161 111711434
LSM121116035
PPOI119096296
ISCIscW_ISCW005009 IscW_ISCW018120 IscW_ISCW018121
DSV119442028
RSAN119387907
RMP119159735
VDE111252683
VJA111259237
TUT107361924
DPTE113795595
DFR124496419
CSCU111642175
PTEP107453820
SDM118190732
CELCELE_C09G4.1(hyl-1) CELE_K02G10.6(hyl-2)
CBRCBG_14524(Cbr-hyl-2) CBG_15635(Cbr-hyl-1)
BMYBM_BM4772(Bm4772)
LOALOAG_08632
NAINECAME_16352
TSPTsp_02045
HROHELRODRAFT_131704 HELRODRAFT_82517
LGILOTGIDRAFT_219624 LOTGIDRAFT_226091
PCAN112564114 112565008
BGT106074898 106079942
GAE121380469 121380788
HRF124121261 124121268 124123088
HRJ124273151 124276679 124276681
CRG105332957 105335972 117683888
MYI110442549 110449442 110449450 110449461 110463359 110463365
PMAX117343242 117343783 117344169 117344187 117344188 117344192
MMER123531411 123532052 123532472 123532663
OBI106870521 106872705 106882761
OSN115219755 115225548 115230564
LAK106153017 106153023
SMMSmp_042440
OVIT265_11353
EGLEGR_07006
NVE5511770 5515822
EPA110239328 110239732
ATEN116291181 116302865
ADF107356367
AMIL114965228
PDAM113665414
SPIS111326256
DGT114517562 114522109
XEN124440805 124440809
HMG100197598 101237570
ECUECU08_1350
EINEint_081340
EHEEHEL_081340
EROEROM_081360
NCENCER_100162
SMINv1.2.016704.t1(symbB.v1.2.016704.t1) v1.2.016704.t2(symbB.v1.2.016704.t2)
NGRNAEGRDRAFT_68950 NAEGRDRAFT_81765
 » show all
Reference
1  [PMID:16100120]
  Authors
Lahiri S, Futerman AH
  Title
LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.
  Journal
J Biol Chem 280:33735-8 (2005)
DOI:10.1074/jbc.M506485200
  Sequence
[hsa:91012]
Reference
2  [PMID:15772421]
  Authors
Xu Z, Zhou J, McCoy DM, Mallampalli RK
  Title
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia.
  Journal
J Lipid Res 46:1229-38 (2005)
DOI:10.1194/jlr.M500001-JLR200
  Sequence
[mmu:71949]
Reference
3  [PMID:15823095]
  Authors
Mizutani Y, Kihara A, Igarashi Y
  Title
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
  Journal
Biochem J 390:263-71 (2005)
DOI:10.1042/BJ20050291
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.291
IUBMB Enzyme Nomenclature: 2.3.1.291
ExPASy - ENZYME nomenclature database: 2.3.1.291
BRENDA, the Enzyme Database: 2.3.1.291
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