KEGG   ENZYME: 2.3.1.323
Entry
EC 2.3.1.323                Enzyme                                 
Name
stemmadenine O-acetyltransferase;
SAT (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:stemmadenine O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + stemmadenine = CoA + stemmadenine acetate [RN:R13343]
Reaction(KEGG)
R13343
Substrate
acetyl-CoA [CPD:C00024];
stemmadenine [CPD:C11691]
Product
CoA [CPD:C00010];
stemmadenine acetate [CPD:C22933]
Comment
The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a pathway that leads to the production of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine, which are used as anticancer drugs.
History
EC 2.3.1.323 created 2024
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K27791  stemmadenine O-acetyltransferase
Reference
1  [PMID:29511102]
  Authors
Qu Y, Easson MEAM, Simionescu R, Hajicek J, Thamm AMK, Salim V, De Luca V
  Title
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine.
  Journal
Proc Natl Acad Sci U S A 115:3180-3185 (2018)
DOI:10.1073/pnas.1719979115
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.323
IUBMB Enzyme Nomenclature: 2.3.1.323
ExPASy - ENZYME nomenclature database: 2.3.1.323
BRENDA, the Enzyme Database: 2.3.1.323
LinkDB

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