KEGG ENZYME: 2.3.1.331

ENZYME: 2.3.1.331

Entry

EC 2.3.1.331                Enzyme

Name

phenylglycine N-acetyltransferase;
natA (gene name)

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:L-phenylgylcine N-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + L-phenylglycine = (2S)-2-acetylamino-2-phenylacetic acid + CoA [RN:R13515]

Reaction(KEGG)

R13515

Substrate

acetyl-CoA [CPD:C00024];
L-phenylglycine [CPD:C18623]

Product

(2S)-2-acetylamino-2-phenylacetic acid [CPD:C23053];
CoA [CPD:C00010]

Comment

The enzyme has been isolated from the bacterium Chryseobacterium sp. 5-3B. Reduced activity has been observed with L-2-phenylglycine methyl ester, L-2-chlorophenylglycine and L-4-hydroxyphenylglycine.

History

EC 2.3.1.331 created 2025

Orthology

K28317

phenylglycine N-acetyltransferase

Genes

CHZ:

CHSO_0604

CGN:	OK18_07375

CIO:	CEQ15_17860

CHRY:

CEY12_14150

CPIP:

CJF12_14640

CARH:

EGY05_21400

CNK:	EG343_13715

CJT:	EG359_14380

CCAU:

EG346_06790

CBEN:

EG339_05240

CGLE:

NCTC11432_03238(yvbK_2)

CLAC:

EG342_05070

CCAO:

H5J24_23125

CCAB:

PFY12_09220

CHRJ:

CHRYMOREF3P_2819

CORA:

N0B40_16220

CCUC:

JNG87_05465

CHRD:

KYG33_14370

» show all

Reference

1 [PMID:23479412]

Authors

Takenaka S, Honma Y, Yoshida K, Yoshida K.

Title

Enantioselective N-acetylation of 2-phenylglycine by an unusual N-acetyltransferase from Chryseobacterium sp.

Journal

Biotechnol Lett 35:1053-9 (2013)
DOI:10.1007/s10529-013-1172-z

Reference

2 [PMID:24375143]

Authors

Takenaka S, Yoshida K, Tanaka K, Yoshida K.

Title

Molecular characterization of a novel N-acetyltransferase from Chryseobacterium sp.

Journal

Appl Environ Microbiol 80:1770-6 (2014)
DOI:10.1128/AEM.03449-13

Sequence

[ag:BAO31626]

Reference

3 [PMID:28721586]

Authors

Takenaka S, Ozeki T, Tanaka K, Yoshida KI.

Title

Homology modeling and prediction of the amino acid residues participating in the transfer of acetyl-CoA to arylalkylamine by the N-acetyltransferase from Chryseobacterium sp.

Journal

Biotechnol Lett 39:1699-1707 (2017)
DOI:10.1007/s10529-017-2399-x

Sequence

[ag:BAO31626]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.331

IUBMB Enzyme Nomenclature:

2.3.1.331

ExPASy - ENZYME nomenclature database:

2.3.1.331

BRENDA, the Enzyme Database:

2.3.1.331

LinkDB

DBGET integrated database retrieval system