ENZYME: 2.3.1.334
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Entry
EC 2.3.1.334 Enzyme
Name
cocaine synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
benzoyl-CoA:ecgonine methyl ester O-benzoyltransferase
Reaction(IUBMB)
benzoyl-CoA + ecgonine methyl ester = CoA + cocaine [RN:
R08430
]
Reaction(KEGG)
R08430
Reaction
Substrate
benzoyl-CoA [CPD:
C00512
];
ecgonine methyl ester [CPD:
C12448
]
Product
CoA [CPD:
C00010
];
cocaine [CPD:
C01416
]
Comment
Isolated from the plant Erythoxylum coca. Cinnamoyl-CoA can substitute for benzoyl-CoA.
History
EC 2.3.1.334 created 2025
Orthology
K28301
cocaine synthase
Reference
1 [PMID:
25406120
]
Authors
Schmidt GW, Jirschitzka J, Porta T, Reichelt M, Luck K, Torre JC, Dolke F, Varesio E, Hopfgartner G, Gershenzon J, D'Auria JC.
Title
The last step in cocaine biosynthesis is catalyzed by a BAHD acyltransferase.
Journal
Plant Physiol 167:89-101 (2015)
DOI:
10.1104/pp.114.248187
Sequence
[ag:
AGT56097
]
Other DBs
ExplorEnz - The Enzyme Database:
2.3.1.334
IUBMB Enzyme Nomenclature:
2.3.1.334
ExPASy - ENZYME nomenclature database:
2.3.1.334
BRENDA, the Enzyme Database:
2.3.1.334
LinkDB
All DBs
DBGET
integrated database retrieval system
