| Entry |
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| Name |
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
benzoyl-CoA:ecgonine methyl ester O-benzoyltransferase
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| Reaction(IUBMB) |
benzoyl-CoA + ecgonine methyl ester = CoA + cocaine [RN: R08430]
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| Reaction(KEGG) |
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| Substrate |
benzoyl-CoA [CPD: C00512];
ecgonine methyl ester [CPD: C12448]
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| Product |
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| Comment |
Isolated from the plant Erythoxylum coca. Cinnamoyl-CoA can substitute for benzoyl-CoA.
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| History |
EC 2.3.1.334 created 2025
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| Pathway |
| ec00960 | Tropane, piperidine and pyridine alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
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| Reference |
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| Authors |
Schmidt GW, Jirschitzka J, Porta T, Reichelt M, Luck K, Torre JC, Dolke F, Varesio E, Hopfgartner G, Gershenzon J, D'Auria JC. |
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| Title |
The last step in cocaine biosynthesis is catalyzed by a BAHD acyltransferase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.334 |
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| LinkDB |
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