KEGG   ENZYME: 2.3.1.80
Entry
EC 2.3.1.80                 Enzyme                                 
Name
cysteine-S-conjugate N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:S-substituted L-cysteine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an L-cysteine-S-conjugate = CoA + an N-acetyl-L-cysteine-S-conjugate [RN:R04950]
Reaction(KEGG)
R04950
Substrate
acetyl-CoA [CPD:C00024];
L-cysteine-S-conjugate [CPD:C02882]
Product
CoA [CPD:C00010];
N-acetyl-L-cysteine-S-conjugate
Comment
S-Benzyl-L-cysteine and, in decreasing order of activity, S-butyl-L-cysteine, S-propyl-L-cysteine, O-benzyl-L-serine and S-ethyl-L-cysteine, can act as acceptors.
History
EC 2.3.1.80 created 1984
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K20838  N-acetyltransferase 8
Genes
HSA9027(NAT8)
PTR470406(NAT8) 739241(NAT8B)
PPS100967484(NAT8) 100971190
GGO101133830 109025735(NAT8)
PON100173062(NAT8) 100435458 100436198
NLE100606331 100606676
MCC706820(NAT8)
MCF102119614(NAT8)
CSAB103220050
CATY105576587
PANU101009924(NAT8)
TGE112604608(NAT8)
RRO104661367(NAT8)
RBB108532437(NAT8)
TFN117062027(NAT8)
PTEH111550503(NAT8)
CJC100394433(NAT8) 100407076
SBQ101032039(NAT8)
CSYR103270032(NAT8)
MMUR105866750 105884612
OGA100948530 100949350 111721719
MMU100043497(Nat8f7) 100504710(Nat8f6) 66116(Nat8f1) 68396(Nat8) 69049(Nat8f5) 93673(Nat8f2) 93674(Nat8f3)
MCAL110296074 110296552 110296554 110296685 110296691
MPAH110316573 110316574(Nat8) 110317018 110317030 110317113 110317171
RNO102549803(Nat8f4) 113892(Nat8f3) 114020(Nat8f5) 500237(Nat8f2) 59300(Nat8f1) 64570(Nat8)
MCOC116098219(Nat8) 116098220 116098221 116099166 116099167 116099169 116099949
MUN110547154 110547165 110547168 110547169 110547171 110547186
CGE100767690 100767982 100771416 100771708 113837001 113837005 113837015 113837953
PLEU114685558 114685560 114688544 114688545 114688549 114688551
NGI103749950(Nat8b)
HGL101720890
CPOC100714111 100714389 100714665 100714943 100715229
CCAN109679392 109679393 109692614 109699979 109702888 109702890 109702891
DORD106000492 106000493 106000497 106000498 106000499 106000512
DSP122125133 122125135 122125153 122125159
NCAR124962937 124962938 124962939 124962940 124963647
OCU100352648 100352904 100353153
OPI101516522(NAT8)
TUP102482811(NAT8)
CFA100856478(NAT8)
VVP112916821(NAT8)
VLG121491024(NAT8)
AML100481005(NAT8)
UMR103671389
UAH113243903(NAT8)
UAR123786058(NAT8)
ELK111148203
LLV125109058
MPUF101692477(NAT8B)
ORO101363205(NAT8B)
EJU114218970(NAT8)
ZCA113937264(NAT8)
MLX118007970(NAT8)
FCA101098621(NAT8)
PYU121019250(NAT8)
PBG122497015(NAT8)
PTG102957307(NAT8B)
PPAD109262891(NAT8)
AJU106967787(NAT8)
HHV120237022(NAT8)
BTA101902604(NAT8)
BOM102278525(NAT8)
BIU109565932(NAT8)
BBUB102392037(NAT8)
CHX102181787(NAT8)
OAS101104899(NAT8)
ODA120851256(NAT8)
CCAD122441406(NAT8)
SSC100516363(NAT8)
CFR102507921(NAT8) 116669040
CBAI105078088 105082464
CDK105085749 116157529
VPC102532352(NAT8)
BACU103001786(NAT8) 103011589(NAT8B)
OOR101283003(NAT8B)
DLE111167883(NAT8)
PCAD112067510(NAT8)
PSIU116764085(NAT8)
ECB100058571 100058847
EPZ103542782
EAI106828286 106828287(NAT8)
MYB102238886(NAT8B) 102258540 102264232(NAT8)
MYD102759258 102760011 102772700
MMYO118668852(TPRKB) 118668853 118674545
MLF102421789 102426829
MNA107529202 107529203 107537368
PKL118717542 118717543
HAI109371189 109371193
DRO112303117(NAT8)
SHON118988517(NAT8)
AJM119038406(NAT8)
PDIC114500389(NAT8) 114500391
PHAS123811987(NAT8)
MMF118630912(NAT8)
RFQ117032749(NAT8)
PALE102895046 102895288 102896662
PGIG120594618(NAT8) 120611045
PVP105290779(NAT8) 105311326
RAY107502947
MJV108389752
TOD119238577 119259071 119259860
SARA101550682 101550950
LAV100669016 100669295 100669579
TMU101353867
MDO100021822 100022265 100022287 100022311 100022341 100022462 100027946 103094600
GAS123233125 123234509 123234510 123234514 123234515 123242189 123251307
SHR100927631 100933401 100935099 105749210(NAT8)
PCW110218372 110218391 110218393(NAT8) 110218423 110221068 110223576
OAA100076893(NAT8) 100083900 100086348 100091934 114805410
GGA107056278 429762(NAT8) 776932(NAT8B)
PCOC116225638 116225639 116241588
MGP104916712
CJO107306852 107306853 107306860
NMEL110390949 110390950 110390953
TGU115494848(NAT8)
LSR110469863(NAT8)
PMOA120509254(NAT8)
OTC121335083(NAT8)
PRUF121356940(NAT8)
PHI102103115
PMAJ107199384(NAT8)
ETL114070483
FPG101923652 101923830
FCH102052756 102052929
CLV110365702
NNI104011623 104011626
ACHC115338093 115338094
AAM106485319
ASN102374866 102375188
AMJ102570938 102572312
PSS102454462 102460069
CMY102930433 102947988(NAT8)
CPIC101931009 101931016 101932235 101935729 101935906 101940281 101941653 101944101 101946392 101946587 101953511 101953710
TST117870377 117870378
CABI116829277(NAT8) 116829278
MRV120406350 120406354 120406356 120406357
ACS100565860 100566062 103281262
PVT110086606 110086612 110086613
SUND121931876(NAT8) 121931877
PBI103050100 103053349
PMUR107287842 107287863
TSR106545778 106555384
VKO123022809 123023014 123023015
PMUA114604315 114604606(NAT8)
ZVI118077537 118077548
GJA107115846 107125475
XLA108696285(nat8.1.L) 108696290(nat8.2.L) 108697419(nat8.5.L) 108705738(nat8.7.S) 108719400(nat8.3.L) 108719408(nat8.6.L) 373623(nat8.6.S) 414583(nat8.1.S)
XTR100124951(nat8.1) 100145252(nat8.7) 100489204(nat8.2) 100489358(nat8.3) 100489520(nat8.5) 100489681 100489847(nat8.9) 101731538(nat8.6) 493291(nat8.4)
NPR108796050 108796051 108796057 108796941 108796942 108796943 108796955 108796956 108798959 108798962 108798963
RTEM120917942 120924304 120924316 120924336 120924478 120924504 120924516 120924523 120924575 120924588 120924605 120924614 120924770 120924771 120924772 120924774 120924775 120924776
BBUF120982821 120982822 120990545 120990548 120990549 120990551 120991106 120991107 120991854 120991855 120991858 120991859 120991860
BGAR122924386 122933993 122934015 122934025 122934036 122934054 122934069 122934080 122934093 122934128
DRE100002956(si:ch211-195e19.1) 100004652(nat8l2)
SRX107733671 107733716 107744405 107747598 107758781
SANH107664162 107666411 107666562 107667058 107696411
SGH107560502 107562255 107580815 107585290 107587650 107587914
CCAR109048520 109057670 109069999 109070000 109084742 109086990 109087021
CAUA113051076 113051077 113057103 113065360 113076083 113078344 113078346 113112814
PPRM120479462(nat8) 120493384(nat8l2)
IPU100528621(cmlo) 108271756(nat8l2)
PHYP113537203 113543984
SMEO124377245(nat8) 124393567(nat8l2) 124401823
TFD113642683(nat8l2) 113644995(nat8)
AMEX103027576 103035650 103037014 103037654 103041541 111193667 111193668
EEE113571638 113585848 113585855
TRU101061992 101068639 101071337(nat8) 101077733 105418616
TNGGSTEN00038389G001
LCO104923878 104932474(nat8) 104935383
NCC104950447 104952185 104952196 104962577
CGOB115007748 115011241 115027023(nat8)
ELY117256715 117257323 117257433 117258832 117266763
PLEP121946499 121950294 121955196 121955213 121963702(nat8)
SLUC116043752 116051432 116057583(nat8) 118492926
ECRA117935776(nat8) 117943980 117943982 117948297
PFLV114546333(nat8) 114554526 114554838
GAT120828685 120833091(nat8) 120835658(nat8l2)
PPUG119194184(nat8l2) 119222708 119227272
MSAM119886117(nat8l2) 119905082 119910379
CUD121517538 121525780 121525781 121528410(nat8l2)
MZE101465996(nat8) 101475129 101486240 106676491 112429980 112429981 112434796 112434827 112434830
ONL100691576 100693555 100694594(nat8) 100703402 109202228 109202229
OAU116315189(nat8) 116319325 116319467 116319474 116321972
OLA101159785 101160033 101160718 101173140 101173383 101173914
OML112145217 112145245 112145690(nat8l2) 112159627
XMA102216856 102222280 102225553 102228442
XCO114133745 114134804 114134960 114140321
XHE116708613 116708614 116719670
PRET103458191 103458195 103464674 103467845
PFOR103134572 103150063 103150064 103150962
PLAI106952056 106952057 106960248 106962796
PMEI106912905 106919286 106919301 106932893
GAF122833041 122834765(nat8l2) 122846155 122846157
CVG107083706 107096798 107096799 107097103
CTUL119777220 119779708 119779709 119788653(nat8l2)
GMU124855153(nat8) 124855633 124875078
NFU107385408 107390441 107391881 107391882
KMR108229320(nat8) 108237615
ALIM106527420 106536673 106536674 106536675
NWH119416705 119427278(nat8)
AOCE111566213 111578760 111578761 111579626 111579628
CSEM103381413 103381421 103385248 103386735
POV109635574 109636400 109640482
SSEN122767715(nat8l2) 122777586 122783219(nat8)
HHIP117756335(nat8) 117761448(nat8l2) 117764580
LCF108873565 108876605(nat8) 108892940
SDU111225478 111233597 111234875
SLAL111644242 111660675 111672808(nat8)
XGL120783050(nat8l2) 120795010 120804435
HCQ109513340 109528151
BPEC110154604 110157443 110171160 110171190
MALB109962441(nat8) 109970779 109971435
SASA106567325 106572644 106583684 106591868 106607815
OTW112221405 112226697(nat8) 112255536(nat8l2) 112256967 121846867
OMY110492903 110498316(nat8) 110505940 110528564(nat8l2)
OGO124001187 124018552(nat8l2) 124045143 124046829(nat8)
ONE115101688 115120942
SALP111970525 111977091 112074940
SNH120023112 120060110 120061125 120064658(nat8l2)
ELS105013642 105015843(nat8) 105016676
SFM108930887 108935794 108936586
PKI111835899 111845766 111845802 111845803 111853952
AANG118210912 118227525 118231241
LOC102685310
PSPA121294220 121302749
ARUT117408398 117420953 117421097
LCM102349209 102349485 102349767 102351352 102360089
RTP109919252
BFO118417186 118419854 118427483
BBEL109464417 109471269 109473416 109473417
SCLV120339126
SKO102801948 102804750 102807544
LDC111513548
PJA122251805 122261856
HAME121865169
HAZT108672794
EAF111714301
BGT106072930
HRF124136965
OBI106868182
LAK106159074 106159075 106159098 106174736 112042394
NVE5507724 5507725
EPA110234338
ATEN116293235 116307908 116307913
ADF107355193
AMIL114947431 114968931
PDAM113664653 113673068 113673069 113673081 113673086 113673088 113677701 113677707
SPIS111333733 111333875 111333876 111333883 111333889 111333899 111337850 111346407
LBCLACBIDRAFT_293252 LACBIDRAFT_315392
MRRMoror_15052
MOREE1B28_002879 E1B28_005684 E1B28_005685 E1B28_005701 E1B28_006773 E1B28_009367
CCICC1G_12505
ACANACA1_044750
TETTTHERM_00304180
PSOJPHYSODRAFT_375526
 » show all
Reference
1  [PMID:6892478]
  Authors
Duffel MW, Jakoby WB.
  Title
Cysteine S-conjugate N-acetyltransferase from rat kidney microsomes.
  Journal
Mol Pharmacol 21:444-8 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.80
IUBMB Enzyme Nomenclature: 2.3.1.80
ExPASy - ENZYME nomenclature database: 2.3.1.80
BRENDA, the Enzyme Database: 2.3.1.80
CAS: 81725-80-6
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