KEGG   ENZYME: 2.4.1.134
Entry
EC 2.4.1.134                Enzyme                                 
Name
galactosylxylosylprotein 3-beta-galactosyltransferase;
galactosyltransferase II;
uridine diphosphogalactose-galactosylxylose galactosyltransferase;
UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [RN:R05927]
Reaction(KEGG)
R05927(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
Product
UDP [CPD:C00015];
[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [CPD:C04825]
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.134 created 1984, modified 2002
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ec01100  Metabolic pathways
Orthology
K00734  galactosylxylosylprotein 3-beta-galactosyltransferase
Genes
HSA126792(B3GALT6)
PTR457187(B3GALT6)
PPS100971409(B3GALT6)
PON112135480(B3GALT6)
NLE115833053(B3GALT6)
MCC703713(B3GALT6)
MCF102115188(B3GALT6)
CSAB103225816(B3GALT6)
CATY105572458(B3GALT6)
PANU101003310(B3GALT6)
TGE112625398(B3GALT6)
RRO104673226(B3GALT6)
RBB108544195(B3GALT6)
TFN117093480(B3GALT6)
PTEH111526850(B3GALT6)
CJC100387131(B3GALT6)
MMUR105877638(B3GALT6)
OGA100958919(B3GALT6)
MMU117592(B3galt6)
MCAL110292468(B3galt6)
MPAH110322882(B3galt6)
RNO298690(B3galt6)
MCOC116097170(B3galt6)
MUN110560227(B3galt6)
CGE100767598(B3galt6)
PLEU114708248(B3galt6)
NGI103749737(B3galt6)
HGL101721217(B3galt6)
CPOC100730778(B3galt6)
CCAN109681028(B3galt6)
DORD106002935(B3galt6)
DSP122127349(B3galt6)
NCAR124963718
OCU103351814(B3GALT6)
OPI101521287(B3GALT6)
TUP102502785(B3GALT6)
CFA664717(B3GALT6)
VVP112926057(B3GALT6)
VLG121500774(B3GALT6)
AML100473227(B3GALT6)
UMR103682080(B3GALT6)
UAH113270686(B3GALT6)
UAR123796089(B3GALT6)
ELK111154922
LLV125097488
MPUF101677593(B3GALT6)
ORO101364618(B3GALT6)
EJU114213404(B3GALT6)
ZCA113928681(B3GALT6)
MLX118020133(B3GALT6)
FCA105259949(B3GALT6)
PYU121017977(B3GALT6)
PBG122479773(B3GALT6)
PTG102964488(B3GALT6)
PPAD109273914(B3GALT6)
AJU106978137 113599162(B3GALT6)
HHV120242505(B3GALT6)
BTA522406(B3GALT6)
BOM102265005(B3GALT6)
BIU109570568(B3GALT6)
BBUB102406953(B3GALT6)
CHX102191357(B3GALT6)
OAS101105768(B3GALT6)
ODA120862075 120880627(B3GALT6)
CCAD122452078(B3GALT6)
SSC100523125(B3GALT6)
CFR102522264(B3GALT6)
CBAI105071076(B3GALT6)
CDK105105583(B3GALT6)
LVE103085660(B3GALT6)
OOR101276763(B3GALT6)
DLE111187245(B3GALT6)
PCAD112065327(B3GALT6)
PSIU116756707(B3GALT6)
ECB100146417(B3GALT6)
EPZ103558570(B3GALT6)
EAI106845197(B3GALT6)
MMYO118655568(B3GALT6)
MNA107543692(B3GALT6)
PKL118731977(B3GALT6)
HAI109391146(B3GALT6)
SHON118998221(B3GALT6)
AJM119050524(B3GALT6)
PDIC114497174(B3GALT6)
PHAS123831877(B3GALT6)
MMF118643408(B3GALT6)
RFQ117026943(B3GALT6)
PALE102879449(B3GALT6)
PGIG120614084(B3GALT6)
RAY107503893 107510710(B3GALT6)
MJV108409072(B3GALT6)
TOD119236531(B3GALT6)
SARA101551557(B3GALT6)
LAV100659349(B3GALT6)
TMU101342110
DNM101412993(B3GALT6)
MDO100024991(B3GALT6)
GAS123240111(B3GALT6)
SHR116422871(B3GALT6)
PCW110201068(B3GALT6)
OAA100074836(B3GALT6)
GGA428185(B3GALT6)
PCOC116242558(B3GALT6)
MGP104914138(B3GALT6)
CJO107323501(B3GALT6)
NMEL110408704(B3GALT6)
APLA101798225(B3GALT6)
ACYG106044272(B3GALT6)
AFUL116497597(B3GALT6)
TGU100225099(B3GALT6)
LSR110474385(B3GALT6)
SCAN103820901(B3GALT6)
PMOA120511127(B3GALT6)
OTC121344105(B3GALT6)
PRUF121358335(B3GALT6) 121358342
FAB101808759(B3GALT6)
PHI102108353(B3GALT6)
PMAJ107213734(B3GALT6)
CCAE111938482(B3GALT6)
CCW104693401(B3GALT6)
ETL114071242(B3GALT6)
ZAB102062738(B3GALT6)
FPG101913380(B3GALT6)
FCH102056999(B3GALT6)
CLV102096830(B3GALT6)
EGZ104133398(B3GALT6)
NNI104009059(B3GALT6)
ACUN113487982(B3GALT6)
TALA104355594(B3GALT6)
PADL103918023(B3GALT6)
ACHC115343036(B3GALT6)
AAM106495555(B3GALT6)
AROW112970105(B3GALT6)
NPD112957393(B3GALT6)
DNE112983500(B3GALT6)
ASN102373206(B3GALT6)
AMJ102571760(B3GALT6)
CPOO109314423(B3GALT6)
GGN109293554(B3GALT6)
PSS102452076(B3GALT6)
CMY102942046(B3GALT6)
CPIC101943011(B3GALT6)
TST117867974(B3GALT6)
CABI116824600(B3GALT6)
MRV120387825(B3GALT6)
PVT110073136(B3GALT6)
SUND121937204(B3GALT6)
PBI103049964(B3GALT6)
PMUR107298347(B3GALT6)
TSR106541052(B3GALT6)
PGUT117675860(B3GALT6)
VKO123030942(B3GALT6)
PMUA114602507(B3GALT6)
ZVI118087931(B3GALT6)
GJA107110843(B3GALT6)
XLA108696563(b3galt6.L) 108697636(b3galt6.S)
XTR548849(b3galt6)
NPR108784315(B3GALT6)
RTEM120915404(B3GALT6)
BBUF121004783(B3GALT6)
BGAR122926567(B3GALT6)
DRE572324(b3galt6)
SRX107714504 107751019
SANH107680432 107699339
SGH107555998 107592565
CCAR109066899 109098579
CAUA113055100 113069397
PPRM120473396(b3galt6)
IPU108255271(b3galt6)
PHYP113539477(b3galt6)
SMEO124402544(b3galt6)
TFD113661931(b3galt6)
AMEX103027814(b3galt6)
EEE113585544(b3galt6)
TRU777996(b3galt6)
LCO104939272(b3galt6)
NCC104942072(b3galt6)
CGOB115008833(b3galt6)
ELY117256359(b3galt6)
PLEP121953859(b3galt6)
SLUC116067467(b3galt6)
ECRA117943739(b3galt6)
PFLV114554241(b3galt6)
GAT120835278(b3galt6)
PPUG119229718(b3galt6)
MSAM119886187(b3galt6)
CUD121529149(b3galt6)
MZE101485514(b3galt6)
ONL100693145(b3galt6)
OAU116326550(b3galt6)
OLA100049392(b3galt6)
OML112145073(b3galt6)
XMA102230525(b3galt6)
XCO114136114(b3galt6)
XHE116710500(b3galt6)
PRET103464912(b3galt6)
PFOR103144356(b3galt6)
PLAI106955120(b3galt6)
PMEI106917398(b3galt6)
GAF122833643(b3galt6)
CVG107101435(b3galt6)
CTUL119791815(b3galt6)
GMU124856092(b3galt6)
NFU107385557(b3galt6)
KMR108246845(b3galt6)
ALIM106513334(b3galt6)
NWH119411667(b3galt6)
AOCE111587882(b3galt6)
CSEM103386136(b3galt6)
POV109629160(b3galt6)
SSEN122767632(b3galt6)
HHIP117761446(b3galt6)
LCF108884066(b3galt6)
SDU111221818(b3galt6)
SLAL111667675(b3galt6)
XGL120807316(b3galt6)
HCQ109522223(b3galt6)
BPEC110165823(b3galt6)
MALB109956258(b3galt6)
SASA106582684 106593203
OTW112221817 112254159
OMY110494759 110527712
OGO124002933 124021082
ONE115143517 115145326
SALP111970598 112080947
SNH120023840 120064928
ELS105007424(b3galt6)
SFM108938192(b3galt6)
PKI111853658(b3galt6)
AANG118210577(b3galt6)
LOC102694517(b3galt6)
PSPA121329263 121329297
ARUT117425319 117972756
LCM102355255(B3GALT6)
CMK103187433(b3galt6)
RTP109918536(b3galt6)
BFO118410806 118411359 118430418
BBEL109464793 109466855 109479943
CIN778996(b3galt6)
SCLV120341313
SPU115921698 115924557 753784
APLC110979066 110979076
SKO100367674
DMEDmel_CG8734(beta3GalTII)
DER6543072
DSE6608207
DSIDsimw501_GD27981(Dsim_GD27981)
DYADyak_GE22868(Dyak_beta3galt6)
DSR110182817
DPODpse_GA28758(Dpse_beta3galt6)
DPE6597933
DMN108162389
DWI6644411
DGR6566393
DMODmoj_GI17485
DAZ108610340
DNV115562853
DHE111592079
DVI6627305
CCAT101456591
BOD106615736
MDE101899820
SCAC106084399
LCQ111679243
AGAAgaP_AGAP009175
ACOZ120959582
AARA120901636
AAG5568811
AALB109419591
CQUCpipJ_CPIJ010407
CPII120425909
CNS116341215
AME102655877
ACER108003457
ALAB122711455
BIM100740262
BBIF117214488
BVK117242628
BVAN117161233
BTER100644667
BPYO122576443
CCAL108622599
OBB114880076
MGEN117222654
NMEA116425873
CGIG122403002 122403764
SOC105194992
MPHA105829197
AEC105155005
ACEP105626882
PBAR105426350
VEM105566820
HST105186112
DQU106745352
CFO105255994
FEX115243790
LHU105669725
PGC109857902
OBO105284463
PCF106788423
PFUC122522484
VPS122634692
NVI100680242
CSOL105359846
TPRE106659421
MDL103571274
CGLO123261645
FAS105270274
DAM107035758
AGIF122859047
CCIN107266373
TCA656431
DPA109534754
SOY115889543
ATD109599054
CSET123311551
AGB108910758
LDC111509085
NVL108563522
APLN108735776
PPYR116170377
OTU111424934
BMOR101740645
BMAN114247960
MSEX115449198
DPLKGM_203077
BANY112045668
PMAC106712341
PPOT106107973
PXU106117241
PRAP111001912
ZCE119830168
HAW110383736
TNL113493565
SLIU111354696
OFU114352165
PXY105386738
API100168819 100574538
DNX107164501
AGS114128883 114128889
RMD113556535 113559464
BTAB109035941
DCI103514882
CLEC106670905
HHAL106686435
NLU111047956
PHUPhum_PHUM361650
FOC113218242
ZNE110831323
CSEC111867039
FCD110850766
DPXDAPPUDRAFT_65862
DMK116916453
PVM113821037 113821051
PJA122248394
PCHN125029043
HAME121879271
PCLA123756098
PTRU123517004
HAZT108667009
EAF111700018
ISCIscW_ISCW012863
DSV119446461 119446463
RSAN119389641 119389643
RMP119180578 119180586
VDE111249317
VJA111270592
TUT107368691
DPTE113794377
DFR124497317
CSCU111625572
PTEP107448329
SDM118186131
CELCELE_Y110A2AL.14(sqv-2)
CBRCBG_19617(Cbr-sqv-2)
BMYBM_BM7274(Bma-sqv-2)
LOALOAG_03680
NAINECAME_13336
HROHELRODRAFT_169080
LGILOTGIDRAFT_125392
PCAN112556227
BGT106065403
GAE121390616
HRF124111204
HRJ124265859
CRG105340554
MYI110450118
PMAX117344584
MMER123527630
OBI106882295
OSN115224526
LAK106161537
NVE5501668 5520673 5521149
EPA110240882 110244990 110245377
ATEN116288021 116295030 116295325 116295768 116297253 116299259 116303361 116306154 116308444
ADF107328872 107333361 107335697 107347461
AMIL114954815 114957105 114957161 114961431 114971432
PDAM113671392 113671524 113675377 113681807
SPIS111320722 111330874 111336902 111340050
DGT114517942 114526059
XEN124444309 124444315 124444999 124445001 124446513 124456616 124457527 124457591 124457933 124458026
HMG100208936
AQU100637620 100640622 105313401 105313426 105316663
PALZ118058471
CRECHLRE_12g513000v5
VCNVOLCADRAFT_116659
GSLGasu_09650
VALVDBG_05778
MBRMONBRDRAFT_23896
SREPTSG_02498
FCYFRACYDRAFT_267815
EHXEMIHUDRAFT_196600 EMIHUDRAFT_213995 EMIHUDRAFT_243705
 » show all
Reference
1  [PMID:3924029]
  Authors
Robinson JA, Robinson HC.
  Title
Initiation of chondroitin sulphate synthesis by beta-D-galactosides. Substrates for galactosyltransferase II.
  Journal
Biochem J 227:805-14 (1985)
DOI:10.1042/bj2270805
Reference
2  [PMID:1150655]
  Authors
Schwartz NB, Roden L.
  Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
  Journal
J Biol Chem 250:5200-7 (1975)
Reference
3  [PMID:11551958]
  Authors
Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD
  Title
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).
  Journal
J Biol Chem 276:48189-95 (2001)
DOI:10.1074/jbc.M107339200
  Sequence
[hsa:126792] [mmu:117592]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.134
IUBMB Enzyme Nomenclature: 2.4.1.134
ExPASy - ENZYME nomenclature database: 2.4.1.134
BRENDA, the Enzyme Database: 2.4.1.134
CAS: 56626-21-2 56626-19-8
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