Entry
Name
alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase;
MGAT4C (gene name);
N-acetylglucosaminyltransferase VI;
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI;
uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI;
mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase;
GnTVI;
GlcNAc-T VI;
UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->2)]-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] [RN:
R05992 ]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:
C00043 ];
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Product
UDP [CPD:
C00015 ];
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Comment
Requires a high concentration of Mn2+ for maximal activity. The enzyme, characterized from hen oviduct membranes, participates in the processing of N-glycans in the Golgi apparatus. It transfers GlcNAc in beta1-4 linkage to a D-mannose residue that already has GlcNAc residues attached at positions 2 and 6 by beta linkages. No homologous enzyme appears to exist in mammals.
History
EC 2.4.1.201 created 1992, modified 2001, modified 2018
Pathway
Orthology
K13748 alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase C
Genes
MCC : 700450(MGAT4C) 705617
MCF : 101866242(MGAT4C) 102131925
CSAB : 103230293 103238817(MGAT4C)
PANU : 101006452(MGAT4C) 103878644
RBB : 108535046(MGAT4C) 108545046
TFN : 117074698 117089664(MGAT4C)
PTEH : 111522678 111537602(MGAT4C)
HGL : 101708499 101725010(Mgat4c)
OCU : 100339976(MGAT4C) 100340174
CFA : 100682872 475418(MGAT4C)
VVP : 112914890(MGAT4C) 112934545
CHX : 102169257(MGAT4C) 102172500
ODA : 120855467 120858418(MGAT4C)
ECB : 100051064(MGAT4C) 100065011
EPZ : 103555117 103558210(MGAT4C)
EAI : 106838333(MGAT4C) 106840148
MYB : 102240623 102253362(MGAT4C)
MYD : 102757109 102769462(MGAT4C)
MNA : 107526839(MGAT4C) 107536007
DRO : 112304367(MGAT4C) 112318900
SHON : 118974878(MGAT4C) 119003929
AJM : 119059021(MGAT4C) 119060798
LAV : 100654846(MGAT4C) 104845928
MDO : 100015496 100020942(MGAT4C) 103102801
GAS : 123247432 123250138(MGAT4C)
SHR : 100932381(MGAT4C) 105750316
PCW : 110213170(MGAT4C) 110219622
OAA : 100081053(MGAT4C) 100091422
GGA : 395415(MGAT4C) 427873(MGAT4C)
PCOC : 116226659(MGAT4C) 116238699
MGP : 100541955(MGAT4C) 100550363
CJO : 107311189(MGAT4C) 107324722
NMEL : 110388150 110397617(MGAT4C)
APLA : 101791726(MGAT4C) 101799353
ACYG : 106041520(MGAT4C) 106045877
AFUL : 116498846 116502268(MGAT4C)
LSR : 110469164 110469371(MGAT4C)
SCAN : 103813418(MGAT4C) 103822368
PMOA : 120497272 120499839(MGAT4C)
OTC : 121338661(MGAT4C) 121345499
PRUF : 121357264(MGAT4C) 121365391
GFR : 102034112(MGAT4C) 102043367
FAB : 101809036(MGAT4C) 101815032
PHI : 102103698 102110314(MGAT4C)
PMAJ : 107205204(MGAT4C) 107214888
CCAE : 111933425(MGAT4C) 111939621
CCW : 104692465 104698425(MGAT4C)
ETL : 114064493(MGAT4C) 114068544
ZAB : 102060851(MGAT4C) 102065237
FPG : 101914300(MGAT4C) 101916943
FCH : 102045721(MGAT4C) 102049618
CLV : 102088784(MGAT4C) 102089679
EGZ : 104121996 104132945(MGAT4C)
NNI : 104011085 104022863(MGAT4C)
ACUN : 113488971 113491133(MGAT4C)
TALA : 104358634(MGAT4C) 104368412
PADL : 103916497 103918099(MGAT4C)
ACHC : 115334914 115336341(MGAT4C)
AAM : 106485644 106488510(MGAT4C)
AROW : 112965031(MGAT4C) 112965061
NPD : 112956234(MGAT4C) 112959176
DNE : 112981455(MGAT4C) 112983858
ASN : 102374657(MGAT4C) 102376706 102378177
AMJ : 102560247 102563452 102575494(MGAT4C)
CPOO : 109315437(MGAT4C) 109317586 109320931
GGN : 109295775(MGAT4C) 109299068
PSS : 102446260(MGAT4C) 102460254 102462087
CMY : 102934016 102938060 102941733(MGAT4C)
CPIC : 101936161 101937266 101947319(MGAT4C)
TST : 117869141(MGAT4C) 117876834
CABI : 116831643 116837314 116838998(MGAT4C)
MRV : 120395885(MGAT4C) 120404645 120405061
ACS : 100556708 100561638(mgat4c) 100562892
PVT : 110070064(MGAT4C) 110073381 110080923
SUND : 121919615 121927656 121930305(MGAT4C)
PBI : 103052083(MGAT4C) 103056592 103067082
PMUR : 107289197(MGAT4C) 107289270 107291092
TSR : 106543329 106545375 106548707(MGAT4C)
PGUT : 117655823(MGAT4C) 117663738 117665346
VKO : 123021414 123031944 123036175(MGAT4C)
PMUA : 114599446 114605745(MGAT4C)
ZVI : 118087646 118089492 118091132(MGAT4C)
GJA : 107107839 107111720 107123105(MGAT4C)
XLA : 108710250(mgat4c.L) 108713740(mgat4g.L) 108715280(mgat4g.S)
XTR : 100486336(mgat4c) 100489718
NPR : 108785666 108792416(MGAT4C)
RTEM : 120916984 120932064(MGAT4C)
BBUF : 120980409 120983210(MGAT4C)
BGAR : 122920881 122925844(MGAT4C)
DRE : 100333333(mgat4c) 492796(zgc:101663)
SRX : 107709235 107730506(mgat4c) 107740326 107746337
SANH : 107672194 107673483 107686247(mgat4c) 107697032
SGH : 107553950 107554219 107566074 107583810
CCAR : 109076300 109099101 109100200 109109693
CAUA : 113041006 113061513 113094049 113118293
PPRM : 120473933(zgc:101663) 120493289(mgat4c)
IPU : 108263961 108275769(zgc:101663) 124627963
PHYP : 113534472(mgat4c) 113545614
SMEO : 124395386(mgat4c) 124399071(zgc:101663)
TFD : 113650708(zgc:101663) 113652306(mgat4c)
AMEX : 103027198(mgat4c) 103036431
EEE : 113587801 113592123(mgat4c)
TRU : 101064767 101066579(mgat4c) 105418847
TNG : GSTEN00012385G001 GSTEN00025653G001 GSTEN00025676G001
LCO : 104922610(mgat4c) 104925119 104933748
CGOB : 115009692 115010151(mgat4c) 115010597
ELY : 117258290(zgc:101663) 117262063 117262816(mgat4c)
PLEP : 121946530(zgc:101663) 121950129 121950657(mgat4c)
SLUC : 116046844(mgat4c) 116046857 116058000
ECRA : 117947186(zgc:101663) 117949041(mgat4c)
PFLV : 114558668 114560033 114560790(mgat4c)
GAT : 120809353 120809461(mgat4c) 120828980
PPUG : 119196245(mgat4c) 119196346 119223297
MSAM : 119894451(mgat4c) 119905770
CUD : 121515449(mgat4c) 121515710 121516959
MZE : 101472188 101483483 106675125(mgat4c)
ONL : 100693195 100694611 100704471
OAU : 116314008 116314030 116322804(zgc:101663)
OLA : 101156719(mgat4c) 101173858 101175155
OML : 112152399 112152418 112159708(zgc:101663)
XMA : 102218707 102222649(mgat4c) 102226325
XCO : 114146072 114150652 114162050(mgat4c)
XHE : 116708141(mgat4c) 116724208 116737181
PRET : 103465731 103465750(mgat4c) 103466943
PFOR : 103147598(mgat4c) 103147605 103150232
PLAI : 106946939(mgat4c) 106952455 106955720
PMEI : 106920731 106930831(mgat4c) 106932588
GAF : 122831579 122835165(mgat4c) 122835691
CVG : 107093796 107099730(mgat4c) 107100989
CTUL : 119775468 119798056(mgat4c) 119799214
GMU : 124858877(mgat4c) 124876318 124879350
NFU : 107388342(mgat4c) 107391540 107395515
KMR : 108244220 108244231(mgat4c) 108249187(zgc:101663)
ALIM : 106523019 106526858(mgat4c) 106529854
NWH : 119415392 119415443(mgat4c) 119417207(zgc:101663)
AOCE : 111571046(mgat4c) 111576346 111582021
CSEM : 103380004 103384716 103398884(mgat4c)
POV : 109623979 109624028(mgat4c) 109630602
SSEN : 122775946 122776438(mgat4c) 122776933
HHIP : 117762789 117763482(mgat4c) 117765390
LCF : 108880860 108880875 108899620
SDU : 111222525(mgat4c) 111229827 111237016
SLAL : 111647753 111659931 111672170(mgat4c)
XGL : 120793480 120793483 120803652
HCQ : 109528599 109530880 109530900(mgat4c)
BPEC : 110155136(mgat4c) 110162118
MALB : 109956382 109956477(mgat4c) 109969969
SASA : 106561603 106573111 106573155
OTW : 112218868(mgat4c) 112219151 112221479 112252660 112253389
OMY : 110492713 110499683(mgat4c) 110499798 110524434 110524488
OGO : 123997662 124004004 124018217 124018671 124033449
ONE : 115108992 115109671 115115583 115122670 115133953
SALP : 111952907 111952978 111962732 111962745
SNH : 120053306 120053529 120061718 120065888 120065895
ELS : 105007116 105026418 105030750
SFM : 108918691 108928190 108931472
PKI : 111835193(mgat4c) 111855285
AANG : 118207630 118215556 118218736 118232199(mgat4c)
LOC : 102687023(mgat4c) 102690465
PSPA : 121299730 121300191 121318495(mgat4c) 121320295 121330096
ARUT : 117414479 117419564(mgat4c) 117428212 117965983
LCM : 102346343 102347820(MGAT4C)
CMK : 103175065 103179072 103185333(mgat4c)
RTP : 109910955(mgat4c) 109914242 109915501
BFO : 118413034 118413212 118413214
BBEL : 109469451 109469461 109469462 109474455 109474456 109474458 109474568
APLC : 110974061 110984449 110984711 110984722 110985805 110985807 110985808
PCAN : 112559553 112575653
HRF : 124126230 124152739 124152785
HRJ : 124255965 124255977 124262739
CRG : 105320882 105324375 105324376 105325491 105330470 105338504 105338576 105340894 105342679 117680994 117683793 117683794 117683795 117683796
MYI : 110443458 110447857 110453151 110454675 110459894 110463378 110463896
PMAX : 117329199 117335820 117335983 117336373 117336392 117336407 117336523 117336524 117341467
MMER : 123535723 123536079 123536118 123536693 123536846 123537118
LAK : 106152265 106160495 106164659 106172365 106172639 106174249 106176399
NVE : 5503815 5513696 5517229 5517300 5521811
EPA : 110232308 110243200 110244311
ATEN : 116288335 116305189 116305197
ADF : 107328532 107333160 107333161 107336078 107344550 107347979 107348679 107352963
AMIL : 114947664 114949509 114959622 114969084 114969085 114969910 114971341
PDAM : 113678682 113681400 113681963 113682042 113682084 113686241
SPIS : 111319180 111325502 111325529 111328500 111328729
DGT : 114517430 114519996 114519998 114524837 114527166 114542530
XEN : 124441719 124441720 124442975 124443219 124443220 124443221 124446286
TAD : TRIADDRAFT_32367 TRIADDRAFT_51821 TRIADDRAFT_55928 TRIADDRAFT_61341
SMIN : v1.2.033022.t1(symbB.v1.2.033022.t1)
» show all
Taxonomy
Reference
Authors
Brockhausen I, Hull E, Hindsgaul O, Schachter H, Shah RN, Michnick SW, Carver JP.
Title
Control of glycoprotein synthesis. Detection and characterization of a novel branching enzyme from hen oviduct, UDP-N-acetylglucosamine:GlcNAc beta 1-6 (GlcNAc beta 1-2)Man alpha-R (GlcNAc to Man) beta-4-N-acetylglucosaminyltransferase VI.
Journal
J Biol Chem 264:11211-21 (1989)
Reference
Authors
Taguchi T, Ogawa T, Inoue S, Inoue Y, Sakamoto Y, Korekane H, Taniguchi N
Title
Purification and characterization of UDP-GlcNAc: GlcNAcbeta 1-6(GlcNAcbeta 1-2)Manalpha 1-R [GlcNAc to Man]-beta 1, 4-N-acetylglucosaminyltransferase VI from hen oviduct.
Journal
Sequence
Reference
Authors
Sakamoto Y, Taguchi T, Honke K, Korekane H, Watanabe H, Tano Y, Dohmae N, Takio K, Horii A, Taniguchi N
Title
Molecular cloning and expression of cDNA encoding chicken UDP-N-acetyl-D-glucosamine (GlcNAc): GlcNAcbeta 1-6(GlcNAcbeta 1-2)- manalpha 1-R[GlcNAc to man]beta 1,4N-acetylglucosaminyltransferase VI.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.201
LinkDB
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