KEGG   ENZYME: 2.4.1.202
Entry
EC 2.4.1.202                Enzyme                                 
Name
2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase;
uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase;
BX8;
BX9;
benzoxazinoid glucosyltransferase;
DIMBOA glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-beta-D-glucosyltransferase
Reaction(IUBMB)
(1) UDP-alpha-D-glucose + 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one = UDP + (2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [RN:R04579];
(2) UDP-alpha-D-glucose + 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one = UDP + (2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [RN:R07426]
Reaction(KEGG)
R04579 R07426
Substrate
UDP-alpha-D-glucose [CPD:C00029];
2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one [CPD:C04720];
2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one [CPD:C15770]
Product
UDP [CPD:C00015];
(2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [CPD:C04831];
(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [CPD:C15772]
Comment
The enzyme is involved in the detoxification of the benzoxazinoids DIBOA (2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one) and DIMBOA (2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) which are stored as the respective non-toxic glucosides in the vacuoles in some plants, most commonly from the family of Poaceae (grasses). Benzoxazinoids are known to exhibit antimicrobial, antifeedant, and antiinsecticidal effects and are involved in the interaction of plants with other plants, insects, or microorganisms.
History
EC 2.4.1.202 created 1992, modified 2012
Pathway
ec00402  Benzoxazinoid biosynthesis
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13227  UDP-glucosyltransferase BX8/BX9
Genes
OSA: 4334628 4342809 4350429
OBR: 102699351 102716206
OGL: 127754441 127766058 127780103
BDI: 100830404 100830893
ATS: 109735346 109736907 109754422 109779844
TDC: 119312581 119314690 119315414 119328279 119330805 119334371 119336035 119336866 119340106 119341052 119349903 119349904
TAES: 100682422 123114056 123123546 123147887 123150283 123150314 123159126 123160005 123167683 123172831
TUA: 125511240 125523142 125523860
LPER: 127292054 127330662
LRD: 124671666 124681485
SBI: 110430107 8069138 8079707 8079708
ZMA: 100274317 100277344 103632152 109943562
MFLO: 136481097 136481105 136520960 136532876 136537698 136549539
SITA: 101752637 101753321 101778310 101780325 101784691 101785893
SVS: 117836233 117836591 117859511
PVIR: 120644461 120644612 120649240 120684540 120684928 120691830 120696099
PHAI: 112873443 112897861
 » show all
Reference
1  [PMID:16666853]
  Authors
Bailey BA, Larson RL
  Title
Hydroxamic Acid glucosyltransferases from maize seedlings.
  Journal
Plant Physiol 90:1071-6 (1989)
DOI:10.1104/pp.90.3.1071
  Sequence
[zma:100274317]
Reference
2  [PMID:11851909]
  Authors
von Rad U, Huttl R, Lottspeich F, Gierl A, Frey M.
  Title
Two glucosyltransferases are involved in detoxification of benzoxazinoids in maize.
  Journal
Plant J 28:633-42 (2001)
DOI:10.1046/j.1365-313x.2001.01161.x
  Sequence
[zma:100277344 100274317]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.202
IUBMB Enzyme Nomenclature: 2.4.1.202
ExPASy - ENZYME nomenclature database: 2.4.1.202
BRENDA, the Enzyme Database: 2.4.1.202
CAS: 122544-56-3
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