KEGG   ENZYME: 2.4.1.222
Entry
EC 2.4.1.222                Enzyme                                 
Name
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;
O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase;
fringe;
UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:[protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + [protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) = UDP + [protein with EGF-like domain]-3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl]-(L-serine/L-threonine) [RN:R09296]
Reaction(KEGG)
R09296(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
[protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine)
Product
UDP [CPD:C00015];
[protein with EGF-like domain]-3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl]-(L-serine/L-threonine)
Comment
The enzyme, found in animals and plants, is involved in the biosynthesis of the tetrasaccharides alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc and alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc, which are attached to L-Ser or L-Thr residues within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys in EGF-like domains in Notch and Factor-X proteins, respectively. The substrate is provided by EC 2.4.1.221, peptide-O-fucosyltransferase.
History
EC 2.4.1.222 created 2002, modified 2022
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K05948  fringe
Genes
HSA: 3955(LFNG) 4242(MFNG) 5986(RFNG)
PTR: 458811(MFNG) 472272(LFNG) 747153(RFNG)
PPS: 100977920(LFNG) 100980961(RFNG) 100995551(MFNG)
GGO: 101145692(LFNG) 101150690(RFNG) 129529495(MFNG)
PON: 100433262(MFNG) 100453406(RFNG) 100457821(LFNG)
PPYG: 129016842(RFNG) 129023409(MFNG) 129040263(LFNG)
NLE: 100590152(LFNG) 100599575(MFNG) 100603704(RFNG)
HMH: 116458583(MFNG) 116462859(LFNG) 116483004(RFNG)
SSYN: 129461436(RFNG) 129467868(MFNG) 129472418(LFNG)
MCC: 100428736(LFNG) 699530(MFNG) 719330(RFNG)
MCF: 101865860(RFNG) 102122259(LFNG) 102132366(MFNG)
MTHB: 126939112 126951486 126963749
MNI: 105464487(MFNG) 105469329(RFNG) 105483398(LFNG)
CSAB: 103223279(MFNG) 103243752(RFNG) 103246864(LFNG)
CATY: 105571746(LFNG) 105575827(MFNG) 105588569(RFNG)
PANU: 101011968(LFNG) 101013421(RFNG) 101018492(MFNG)
TGE: 112610374(RFNG) 112621031(LFNG) 112633581(MFNG)
MLEU: 105537347(LFNG) 105539034(MFNG) 105552392(RFNG)
RRO: 104654981(RFNG) 104664990 104682508(MFNG)
RBB: 108512800(MFNG) 108534090(RFNG) 108543803(LFNG)
TFN: 117066370(RFNG) 117070066(MFNG) 117072008(LFNG)
PTEH: 111523718(LFNG) 111527644(RFNG) 111549040(MFNG)
CANG: 105500659(RFNG) 105522438(LFNG) 105527803(MFNG)
CJC: 100394244(RFNG) 100397083(MFNG) 100397710(LFNG)
SBQ: 101028632(MFNG) 101031267(RFNG) 101052656(LFNG)
CIMI: 108289452(MFNG) 108293013(LFNG) 108301635(RFNG)
ANAN: 105707558(LFNG) 105717461(RFNG) 105721768(MFNG)
CSYR: 103251328(RFNG) 103269780(MFNG) 103273020
MMUR: 105868435(LFNG) 105878072(RFNG) 105883754(MFNG)
LCAT: 123632569(LFNG) 123639288(MFNG) 123650730(RFNG)
PCOQ: 105805200(MFNG) 105806080(LFNG) 105820019(RFNG)
OGA: 100947634(RFNG) 100956337(MFNG) 100965012(LFNG)
MMU: 16848(Lfng) 17305(Mfng) 19719(Rfng)
MCAL: 110294717(Lfng) 110304960(Rfng) 110310660(Mfng)
MPAH: 110312801(Lfng) 110331255(Rfng) 110334897(Mfng)
RNO: 170905(Lfng) 315119(Mfng) 60433(Rfng)
MCOC: 116068671(Lfng) 116075628(Mfng) 116077482(Rfng)
ANU: 117698372(Lfng) 117711743(Rfng) 117718792(Mfng)
ASYL: 127667710(Mfng) 127672936(Lfng) 127693675(Rfng)
MUN: 110548858(Rfng) 110554724(Lfng) 110558853(Mfng)
CGE: 100762397(Lfng) 100762875(Mfng) 100771257(Rfng)
MAUA: 101825685(Lfng) 101831994(Mfng) 101835058(Rfng)
PROB: 127220540(Rfng) 127225760(Mfng) 127237151(Lfng)
PLEU: 114694235(Mfng) 114703908(Rfng) 114705506(Lfng)
MORG: 121444099 121444594 121446582 121461287(Mfng) 121464623
MFOT: 126500390 126514322 126515816
AAMP: 119811847(Rfng) 119823893(Mfng) 119825059(Lfng)
NGI: 103730070(Rfng) 103748612(Mfng) 103748675(Lfng)
HGL: 101699763(Lfng) 101722987(Mfng) 101725480(Rfng)
CPOC: 100715492(Rfng) 100722901 100727311 100730084 100731745(Mfng)
CCAN: 109683509(Lfng) 109697229(Mfng) 109702741(Rfng)
DORD: 105990865(Lfng) 105991967(Mfng)
DSP: 122098337(Rfng) 122113852(Lfng) 122119310(Mfng)
PLOP: 125339212(Lfng) 125358592(Mfng) 125365470(Rfng)
NCAR: 124970295 124978941 124983959
MMMA: 107139661(Mfng) 107157674(Rfng) 107161091(Lfng)
ITI: 101968352(Rfng) 101968882(Lfng) 101973137(Mfng)
OCU: 100355921 100357457
OPI: 101528974(RFNG) 101531267(MFNG) 101532339(LFNG)
TUP: 102491172(LFNG) 102493487(RFNG) 102497808(MFNG)
GVR: 103585714(LFNG) 103588151(MFNG) 103593319(RFNG)
CFA: 483376(RFNG) 489891(LFNG) 610303(MFNG)
CLUD: 112640204(LFNG) 112668421(MFNG) 112672966(RFNG)
VVP: 112920916(RFNG) 112929107(MFNG) 112929356(LFNG)
VLG: 121472707(RFNG) 121488152(LFNG) 121491363(MFNG)
NPO: 129503081(RFNG) 129512035(MFNG) 129520131(LFNG)
AML: 100468722(RFNG) 100470247(MFNG) 100479208(LFNG)
UMR: 103666011(RFNG) 103670070(LFNG) 103676401(MFNG)
UAH: 113241808(MFNG) 113244483(RFNG) 113247705(LFNG)
UAR: 123777908(RFNG) 123780761(MFNG) 123802560(LFNG)
ELK: 111146201 111157518 111160292
LLV: 125087730 125090538 125106480
MPUF: 101677000(LFNG) 101678112(MFNG) 101687676(RFNG)
MNP: 132003411(RFNG) 132019249(MFNG) 132026436(LFNG)
MLK: 131815853(RFNG) 131819211(LFNG) 131839443(MFNG)
NVS: 122891374(MFNG) 122895654(LFNG) 122905869(RFNG)
ORO: 101370080(LFNG) 101373562(RFNG) 101384739(MFNG)
EJU: 114199923(LFNG) 114216196(RFNG) 114218332(MFNG)
ZCA: 113922684(MFNG) 113933221(LFNG) 113939623(RFNG)
MLX: 117998712(MFNG) 117999295(LFNG) 118024152(RFNG)
NSU: 110571887(LFNG) 110572417(RFNG) 110578117(MFNG)
LWW: 102732306(MFNG) 102738454(LFNG) 102747107(RFNG)
FCA: 101080753(RFNG) 101092320(LFNG) 101097256(MFNG)
PYU: 121018138(RFNG) 121040390(MFNG)
PCOO: 112863852(MFNG) 112864629(RFNG)
PBG: 122471220(LFNG) 122472714(MFNG) 122485976(RFNG)
PVIV: 125151658(RFNG) 125154755(LFNG) 125169770(MFNG)
LRUF: 124502536 124519176 124522500
LGF: 123589628(LFNG) 123592176(MFNG) 123604166(RFNG)
AJU: 106984500 106986348 113602730
PTG: 102956076(RFNG) 102961069(MFNG) 102962200(LFNG)
PPAD: 109251132(LFNG) 109265536(MFNG) 109276754(RFNG)
PUC: 125919575 125926226 125928431
PLEZ: 122206247(RFNG) 122209847(LFNG) 122225100(MFNG)
HHV: 120227953(LFNG) 120228186(RFNG) 120241170(MFNG)
BTA: 505267(MFNG) 516209(LFNG) 532242(RFNG)
BOM: 102276513(MFNG) 102286691(RFNG) 102288229(LFNG)
BIU: 109559537(MFNG) 109573332(RFNG)
BBUB: 102394903(RFNG) 102410037(LFNG) 102415597(MFNG)
BBIS: 105000596(RFNG) 105003417(MFNG)
CHX: 102169449(LFNG) 102178013(RFNG) 102178708(MFNG)
OAS: 101103554(MFNG) 101106785(RFNG) 101112372(LFNG)
BTAX: 128047748(MFNG) 128064569(RFNG) 128070865(LFNG)
CSUM: 138076442(LFNG) 138078160(MFNG) 138083787(RFNG)
ODA: 120858553 120861176 120866874(RFNG) 120883260(LFNG)
CCAD: 122423402(MFNG) 122433209(LFNG)
MREE: 136149102(RFNG) 136158398(LFNG) 136170826(MFNG)
OVR: 110136748(LFNG) 110144163(MFNG) 110145941(RFNG)
MBEZ: 129536464(MFNG) 129544588(RFNG) 129545786(LFNG)
SSC: 100524978(LFNG) 102161832(MFNG) 110255925(RFNG)
CFR: 102506111(LFNG) 102509192(RFNG) 102518312(MFNG)
CBAI: 105073150(MFNG) 105078190(LFNG)
CDK: 105091974(MFNG) 105102217(RFNG) 105105769(LFNG)
VPC: 102527071(LFNG) 102542233(MFNG) 102546125(RFNG)
BACU: 103005287(MFNG) 103009108(LFNG) 103019781(RFNG)
BMUS: 118882085(LFNG) 118886459(RFNG) 118901493(MFNG)
LVE: 103075553(MFNG) 103076301(RFNG) 103089921(LFNG)
OOR: 101270479(MFNG) 101278665(RFNG) 101282067(LFNG)
LALB: 132504667(LFNG) 132511231(RFNG) 132528634(MFNG)
DLE: 111169357(LFNG) 111182674(RFNG) 111186217(MFNG)
PCAD: 102977711(RFNG) 102989837(MFNG) 102990636(LFNG)
PSIU: 116740198(LFNG) 116746374(RFNG) 116760549(MFNG)
NASI: 112410532(RFNG) 112410776(MFNG) 112412047(LFNG)
ECB: 100057395(RFNG) 100069766(MFNG) 100147464(LFNG)
EPZ: 103551123(RFNG) 103566953(LFNG) 103567118(MFNG)
EAI: 106834776(LFNG) 106837591(MFNG) 106846141(RFNG)
MYB: 102238965(MFNG)
MYD: 102764930(LFNG) 102767457(MFNG)
MMYO: 118651215(MFNG) 118658757(LFNG) 118671602(RFNG)
MLF: 102420819(MFNG) 102421262(RFNG)
MDT: 132227001(MFNG) 132236046(LFNG)
MYUM: 138994351(RFNG) 139007532(MFNG) 139010155(LFNG)
PKL: 118704530(RFNG) 118711340(LFNG) 118729310(MFNG)
EFUS: 103288889(MFNG) 103298337(RFNG) 103299200(LFNG)
MNA: 107537047(LFNG) 107539057(RFNG) 107545234(MFNG)
DRO: 112298814(RFNG) 112319527(LFNG) 112321833(MFNG)
SHON: 118995038(LFNG) 119002171(MFNG) 119002771(RFNG)
AJM: 119043787(LFNG) 119058575(RFNG) 119060375(MFNG)
PDIC: 114503244(RFNG) 114509647(LFNG) 114513460(MFNG)
PHAS: 123809608(LFNG) 123816238(MFNG) 123817111(RFNG)
MMF: 118616306(LFNG) 118624274(MFNG) 118634311(RFNG)
PPAM: 129063387(LFNG) 129071247(MFNG) 129086615(RFNG)
HAI: 109380238(LFNG) 109393064(RFNG) 109394533(MFNG)
RFQ: 117014026(RFNG) 117016784(LFNG) 117029352(MFNG)
PALE: 102879652(RFNG) 102885010(MFNG) 102892443(LFNG)
PGIG: 120600325(RFNG) 120614843(MFNG) 120615783(LFNG)
PVP: 105294596(LFNG) 105301167(RFNG) 105311554(MFNG)
RAY: 107519247(MFNG) 107520206(RFNG) 107521424(LFNG)
MJV: 108392670(MFNG) 108395246(RFNG) 108398746(LFNG)
TOD: 119231057(RFNG) 119241419(LFNG) 119248239(MFNG)
SARA: 101541708(MFNG) 101545521(LFNG) 101554530(RFNG)
SFUM: 130024913(RFNG) 130036601(LFNG) 130044916(MFNG)
SETR: 126006372(MFNG) 126013596(RFNG) 126030441(LFNG)
LAV: 100655946(LFNG) 100669607(MFNG)
TMU: 101356202
ETF: 101656253(MFNG) 101659758(RFNG) 101663521(LFNG)
DNM: 101437450(MFNG)
MDO: 100012518(LFNG) 100025532(MFNG) 100029839(RFNG)
GAS: 123231173(LFNG) 123245018(RFNG) 123248955(MFNG)
SHR: 100914846(MFNG) 100930580(LFNG)
AFZ: 127538201 127560603 127563813
PCW: 110200103(LFNG) 110205752(MFNG) 110218311(RFNG)
TVP: 118834941(LFNG) 118848522(RFNG) 118851504(MFNG)
PBRV: 138142912(RFNG) 138156650(MFNG) 138158672(LFNG)
OAA: 100078922(LFNG) 100088145(RFNG) 100093244(MFNG)
TACU: 119923440(RFNG) 119936867(MFNG) 119942194(LFNG)
GGA: 395789(RFNG) 395790(LFNG) 418042(MFNG)
PCOC: 116232573(RFNG) 116233313(MFNG) 116237377(LFNG)
MGP: 100539077(MFNG) 100544514(RFNG) 100549739(LFNG)
CJO: 107313900(MFNG) 107320761(LFNG) 107322080(RFNG)
TPAI: 128073644(MFNG) 128078840(LFNG) 128083201(RFNG)
LMUT: 125700498(LFNG) 125702011(RFNG) 125703448(MFNG)
NMEL: 110393122(MFNG) 110405902(LFNG)
APLA: 101790022(MFNG) 101797427(LFNG) 101800803(RFNG)
ACYG: 106033576(LFNG) 106035911(MFNG) 106046760(RFNG)
CATA: 118249275(LFNG) 118250685(MFNG) 118259236(RFNG)
AFUL: 116495399(LFNG) 116496547(RFNG) 116501050(MFNG)
TGU: 100218383(LFNG) 100232033(MFNG) 100232663(RFNG)
LSR: 110472408(RFNG) 110475488(LFNG) 110483830(MFNG)
SCAN: 103813595(MFNG) 103817861(LFNG) 103819909(RFNG)
PMOA: 120505628(RFNG) 120510115(MFNG) 120513080(LFNG)
OTC: 121334479(LFNG) 121338240(RFNG) 121342381(MFNG)
PRUF: 121350779(LFNG) 121352781(RFNG) 121361163(MFNG)
ATRC: 139587991(MFNG) 139598053(LFNG) 139602016(RFNG)
GFR: 102032502(MFNG) 102045456(LFNG) 102045657(RFNG)
FAB: 101808008(MFNG) 101818865(LFNG) 101819642(RFNG)
OMA: 130248458(MFNG) 130259279(LFNG) 130260474(RFNG)
PHI: 102103333(RFNG) 102104211(LFNG) 102107617(MFNG)
PMAJ: 107205151(MFNG) 107211349(LFNG) 107212318(RFNG)
CCAE: 111931257 111936281(LFNG) 111937595(RFNG)
CCW: 104685032(LFNG) 104696299(MFNG) 104698221(RFNG)
CBRC: 103613391(RFNG) 103615584(LFNG) 103618073(MFNG)
ACOE: 138104084(MFNG) 138118627(LFNG) 138120009(RFNG)
ETL: 114055408(MFNG) 114060198(LFNG) 114060327(RFNG)
ZAB: 102061325(LFNG) 102072860(RFNG) 102073191(MFNG)
ZLE: 135454195(LFNG) 135455354(RFNG) 135457527(MFNG)
ACHL: 103799200(LFNG) 103809214(MFNG) 103809842(RFNG)
SVG: 106849627(LFNG) 106858539(MFNG) 106859950(RFNG)
MMEA: 130575731(LFNG) 130581992(RFNG) 130586894(MFNG)
HRT: 120751995(MFNG) 120759597(LFNG) 120760850(RFNG)
SATI: 136361911(MFNG) 136367908(LFNG) 136369414(RFNG)
CCIC: 134043190(MFNG) 134050493(LFNG) 134052071(RFNG)
FPG: 101914835(RFNG) 101916406(MFNG) 101916735(LFNG)
FCH: 102047108(LFNG) 102054672(RFNG) 102059881(MFNG)
CCRI: 104159202(LFNG) 104163981(MFNG) 104165081(RFNG)
NNT: 104400482(RFNG) 104402227(LFNG) 104409284(MFNG)
SHAB: 115605671(MFNG) 115607142(LFNG) 115616603(RFNG)
ACUN: 113485767(LFNG) 113486842(RFNG) 113491499(MFNG)
TALA: 104355857(RFNG) 104361276(LFNG) 104363928(MFNG)
ACHC: 115335909(LFNG) 115340956(RFNG) 115352646(MFNG)
HALD: 104311826(RFNG) 104317748
HLE: 104832144(RFNG) 104833560(LFNG) 104842815(MFNG)
AGEN: 126034071 126043783 126048097
HHAR: 128134874(LFNG) 128143605(MFNG) 128151316(RFNG)
GCL: 127022533 127024075 127029652
CSTI: 104549475(LFNG) 104550454(RFNG) 104560035(MFNG)
LDI: 104343194(RFNG) 104350611(LFNG) 104351065(MFNG)
MNB: 103777044(RFNG) 103778708(MFNG)
DPUB: 104297148(LFNG) 104297993(RFNG) 104302038(MFNG)
PPUS: 135179267(RFNG) 135180863(LFNG) 135181861(MFNG)
AVIT: 104268049 104276059(MFNG) 104280226(LFNG)
BRHI: 104488369(RFNG) 104494085(LFNG) 104495836(MFNG)
EGZ: 104131255(RFNG) 104132617(LFNG) 104134305(MFNG)
NNI: 104014390(RFNG) 104015089(LFNG) 104021594(MFNG)
PCRI: 104024855(LFNG) 104034087(RFNG) 104038599(MFNG)
PCAO: 104040088(RFNG) 104042638 104050867(MFNG)
PADL: 103913573(LFNG) 103917468(RFNG) 103924151(MFNG)
AFOR: 103899066(RFNG) 103904993(LFNG) 103907847(MFNG)
FGA: 104070916(RFNG) 104074135(MFNG) 104081624(LFNG)
GSTE: 104251598(RFNG) 104254882(MFNG) 104258205
CLV: 102084027(LFNG) 102092690(MFNG) 102094918(RFNG)
MUI: 104545376(LFNG) 104545859(RFNG) 104548783(MFNG)
PGUU: 104457445(MFNG) 104459214(RFNG) 104461925(LFNG)
PLET: 104615066(RFNG) 104622433(MFNG) 104626940(LFNG)
EHS: 104516807(MFNG)
CMAC: 104473466(MFNG) 104474295(RFNG) 104478516
CUCA: 104057614(RFNG) 104059220(LFNG) 104065868(MFNG)
TEO: 104370477(RFNG) 104371524
BREG: 104630444(RFNG) 104637706(LFNG) 104642326(MFNG)
OHA: 104327767(RFNG) 104331237(LFNG) 104332371(MFNG)
ACAR: 104517408(MFNG) 104521722(RFNG) 104527619(LFNG)
CPEA: 104385272(LFNG) 104396057(MFNG) 104398572(RFNG)
CVF: 104283128(RFNG) 104283642(MFNG) 104287706(LFNG)
RTD: 128904191(MFNG) 128914178(LFNG) 128917829(RFNG)
CRID: 134509623(MFNG) 134519690(LFNG) 134523363(RFNG)
AAM: 106487094(RFNG) 106488480(MFNG) 106496125
AROW: 112969355(MFNG) 112974227(LFNG) 112974799(RFNG)
NPD: 112945271(RFNG) 112947759(MFNG) 112959927(LFNG)
TGT: 104565619(LFNG) 104570229(RFNG) 104576737(MFNG)
DNE: 112990701(MFNG) 112990972(RFNG) 112992921(LFNG)
SCAM: 104137849(MFNG) 104140219(RFNG)
ASN: 102381094(LFNG) 102386399(RFNG) 102388348(MFNG)
AMJ: 102566885(LFNG) 102567014(MFNG) 102571352(RFNG)
CPOO: 109314720(LFNG) 109316646(MFNG) 109324495(RFNG)
GGN: 109286886(RFNG) 109294538(LFNG) 109296045(MFNG)
PSS: 102443867(LFNG) 102455692 102458358(MFNG)
CMY: 102931854(LFNG) 102932974(RFNG) 122461360(MFNG)
CCAY: 125621196(RFNG) 125628299(MFNG) 125644288(LFNG)
DCC: 119842957(RFNG) 119847050(MFNG) 119862776(LFNG)
CPIC: 101934811(MFNG) 101940585(RFNG) 101950276(LFNG)
TST: 117880716(MFNG) 117886896(RFNG)
CABI: 116815821(RFNG) 116824111(MFNG) 116832951(LFNG)
MRV: 120371489(MFNG) 120373583(LFNG) 120383181(RFNG)
ACS: 100561637(mfng) 100565009(lfng) 100567901(rfng)
ASAO: 132768691(RFNG) 132775916(MFNG) 132782161(LFNG)
PVT: 110075969(MFNG) 110090776(RFNG) 110091685(LFNG)
SUND: 121914534(LFNG) 121922810(RFNG) 121932279(MFNG)
PBI: 103060821 103063742(RFNG)
PMUR: 107288860(RFNG) 107290633(LFNG)
CTIG: 120308369(RFNG) 120315874(LFNG)
TSR: 106551147(RFNG)
PGUT: 117663058(RFNG) 117677573(LFNG)
APRI: 131185219(LFNG) 131190086(RFNG)
PTEX: 113437080(RFNG) 113438811(LFNG)
NSS: 113412013(RFNG) 113423708(LFNG)
VKO: 123018127(RFNG) 123025021(LFNG) 123028880(MFNG)
PMUA: 114584152(LFNG) 114589787(RFNG) 114605544(MFNG)
PRAF: 128401407(LFNG) 128407395(RFNG) 128422708(MFNG)
ZVI: 118079763(RFNG) 118091383(MFNG) 118092778(LFNG)
HCG: 128327444(MFNG) 128336738(LFNG) 128344466(RFNG)
GJA: 107105918(MFNG) 107118125(RFNG) 107122012(LFNG)
STOW: 125430294(RFNG) 125430632(LFNG) 125434181(MFNG)
EMC: 129328938(RFNG) 129335987(MFNG) 129338837(LFNG)
XLA: 100036937(lfng.L) 394282(rfng.L) 397855(lfng.S)
XTR: 100486895(rfng) 549805(lfng)
NPR: 108786198(LFNG) 108791320(RFNG)
RTEM: 120918908(RFNG) 120943397(LFNG)
BBUF: 121004641(RFNG) 121007811(LFNG)
BGAR: 122944905(LFNG)
PWL: 138261201(LFNG) 138292657(MFNG)
MUO: 115471556(RFNG) 115474676(MFNG) 115476246(LFNG)
GSH: 117345841(LFNG) 117353689(MFNG) 117368492(RFNG)
DRE: 30158(lfng) 414848(rfng) 493633(mfng)
SRX: 107708990 107715074 107753450(lfng) 107757470 107758333
SANH: 107653613 107665528 107674646 107693671(rfng) 107703400
SGH: 107561915 107562029 107581707(lfng) 107600994
CCAR: 109046565 109047918 109063455(lfng) 109083482(mfng) 122133996(rfng)
CAUA: 113040249 113050147 113050483 113056435(rfng) 113064821 113092142
CGIB: 127943399 127952174 127953246 127988084 128025091
PTET: 122327250 122327883(mfng) 122333358(rfng) 122341706(lfng)
LROH: 127153757(mfng) 127163071(lfng) 127174236(rfng)
OMC: 131530089(mfng) 131538022(lfng) 131551304(rfng)
PPRM: 120468972 120469034 120486334(mfng) 120489737(lfng)
RKG: 130080628(rfng) 130089323(mfng) 130095028(lfng)
MAMB: 125250987(mfng) 125255023(rfng) 125269763(lfng)
CIDE: 127508372 127521405 127523901
CERY: 137007907(rfng) 137017793(lfng) 137027677(mfng)
MASI: 127422798 127427398 127437931 127439033 127450195 127452348
TROS: 130549105(mfng) 130561990(lfng) 130569427(rfng)
TDW: 130426761(lfng) 130430725(mfng) 130439360(rfng)
MANU: 129420852(rfng) 129432408(lfng) 129453865(mfng)
PDAB: 135726753(mfng) 135734602 135737611 135739349 135743513
IPU: 108257411 108259517(mfng) 108273644
IFU: 128600127(lfng) 128603059(mfng) 128617227(rfng)
PHYP: 113527078(rfng) 113536168(lfng)
SMEO: 124376366(lfng) 124379746(mfng) 124389136(rfng)
TFD: 113647081(mfng) 113653605(rfng) 113660403(lfng)
TVC: 132838924(mfng) 132841540(rfng) 132864128(lfng)
CGAR: 128519294(mfng) 128519342(lfng) 128541749(rfng)
NGRA: 132875276(mfng) 132898065(rfng) 132900787(lfng)
TRN: 134303839(mfng) 134306807(lfng) 134321196(rfng)
AMEX: 103025168(lfng) 103035856(mfng) 103037421(rfng)
CMAO: 118803822(mfng) 118805732(lfng) 118809798(rfng)
EEE: 113571376(lfng) 113574297 113589668
CHAR: 105890720(lfng) 105891205(rfng) 105900239
SPIL: 134070210(rfng) 134077377(lfng) 134090329(mfng)
TRU: 101066309 101067911(lfng) 101073166 101073848
TFS: 130514991(lfng) 130526900 130527076(mfng) 130538931(rfng)
TNG: GSTEN00005496G001 GSTEN00006372G001 GSTEN00015727G001 GSTEN00034798G001
LCO: 104918731(lfng) 104921160 104925295 104929533(rfng)
NCC: 104940897 104964482(lfng)
TBEN: 117474096(rfng) 117482090(mfng) 117482395 117493663(lfng)
CGOB: 115006363 115012806(lfng) 115025014(rfng)
PGEO: 117449709 117451449(mfng) 117451485(lfng) 117464938(rfng)
GACU: 117534031(mfng) 117537671(rfng) 117548769(lfng) 117555343
EMAC: 134864128 134864169(mfng) 134871173(rfng) 134878650(lfng)
ELY: 117247195(rfng) 117254949 117255462(mfng) 117268911(lfng)
EFO: 125879880(lfng) 125881008(rfng) 125885945(mfng) 125886200
PLEP: 121941589 121942114 121956644(lfng) 121958539(rfng)
SLUC: 116042554(mfng) 116043029 116059588(lfng) 116067493(rfng)
ECRA: 117937138(rfng) 117937768 117958377(lfng) 117960572(mfng)
ESP: 116671531 116697601 116703169(lfng) 116704611
PFLV: 114548122(rfng) 114551702 114569526 114569561 114570318
GAT: 120815096(mfng) 120819026(rfng) 120825560 120828401(lfng)
PPUG: 119213257(rfng) 119217993 119218007(mfng) 119220927(lfng)
AFB: 129093196(rfng) 129095550(mfng) 129095864 129098334(lfng)
CLUM: 117735637(lfng) 117736090 117748604(rfng)
PSWI: 130189254(lfng) 130190598 130190749(mfng) 130203282(rfng)
CANA: 137787051(lfng) 137789950(rfng) 137792942
CVE: 137867887(mfng) 137867954(lfng)
MSAM: 119881907 119892040(lfng) 119898584(mfng) 119898693 119915967(rfng)
SCHU: 122867492(rfng) 122868369(lfng) 122873444(mfng) 122873651
CUD: 121503818(lfng) 121508129(mfng) 121508164 121528288(rfng)
SPUL: 138593984(rfng) 138594472 138595281(mfng) 138602681(lfng)
LMIX: 132953888(lfng) 132955241(rfng) 132987020(mfng) 132987910
ALAT: 119009645(rfng) 119014792(lfng) 119017298 119026242(mfng)
ASTR: 137599737 137599821(mfng) 137610233(lfng) 137614199(rfng)
MZE: 101466218(rfng) 101467699 101469344 101485425
ONL: 100696743(rfng) 100697735 100707701 100708834
OAU: 116312496(lfng) 116317355(mfng) 116320071(rfng) 116323527
OLA: 101155324 101156689(rfng) 101169038(lfng) 101174979
OML: 112137176 112141692(mfng) 112146906(lfng) 112162334(rfng)
CSAI: 133419848 133421930(lfng) 133442136 133442954(mfng)
XMA: 102219280(rfng) 102225648 102230356(lfng)
XCO: 114145337 114150882(rfng) 114160037(lfng)
XHE: 116720163 116726860(rfng) 116735665(lfng)
PRET: 103468664(lfng) 103480636 103482187(rfng)
PFOR: 103136457 103142244(lfng) 103142448(rfng)
PLAI: 106936426 106957747 106960501(lfng)
PMEI: 106909996 106923349 106925146
GAF: 122821475(lfng) 122823239(rfng) 122830348(mfng)
PPRL: 129352231(rfng) 129352564(lfng) 129376825(mfng)
CVG: 107084259 107084747(lfng) 107087619(rfng) 107099338
CTUL: 119778848(lfng) 119783681 119786990(mfng) 119796121(rfng)
GMU: 124863519 124863705 124868493 124869218(mfng) 124875060(rfng)
NFU: 107372602 107378430(lfng) 107389966 107391332
KMR: 108237295(mfng) 108245159(rfng) 108245271 108246120(lfng)
ALIM: 106522721(lfng) 106527238 106532938 106537334
NWH: 119421400(lfng) 119422929(mfng) 119422971 119423737(rfng)
AOCE: 111565184(rfng) 111566263 111569841(mfng) 111581680(lfng)
EJA: 138197800(lfng) 138209315 138209419(mfng)
BFRE: 138615735(mfng) 138615815 138626865(rfng) 138630394(lfng)
MCEP: 124998144(lfnG) 125003989(mfnG) 125004537 125022843(rfnG)
CSEM: 103381663(rfng) 103383433 103383472 103392616
POV: 109627033 109639604(lfng) 109640166 109646450
SSEN: 122759731(rfng) 122760876 122771443 122771619(mfng) 122784823(lfng)
SSOE: 131448667(rfng) 131466484(mfng) 131467323 131475919(lfng)
HHIP: 117752504(rfng) 117766531(lfng) 117770457
HSP: 118099116(mfng) 118100757(rfng) 118123731(lfng) 118124381
PPLT: 128427154 128427155 128436509 128437433(mfng) 128458427(lfng)
SMAU: 118287609(rfng) 118289228(lfng) 118312020(mfng) 118312946
LCF: 108876800 108880842(mfng) 108894766 108900781
SDU: 111216706 111217747(lfng) 111235903 111237097(rfng)
SLAL: 111657941 111660595(lfng) 111664402(rfng) 111672994
XGL: 120788454(lfng) 120794139(rfng) 120799844(mfng) 120799895
HCQ: 109511290 109511291 109513832(lfng) 109529290
SSCV: 125968477 125969011(mfng) 125983877(lfng) 125991072(rfng)
SBIA: 133495263(rfng) 133506510 133506668(mfng) 133514420(lfng)
PEE: 133404014 133404386(mfng) 133415241(lfng) 133418121(rfng)
PTAO: 133466289(lfng) 133469611(rfng) 133476636 133476805(mfng)
BPEC: 110154327(rfng) 110165650 110167656(lfng)
ENY: 140358283(lfng) 140369041(rfng) 140377443(mfng) 140378121
MALB: 109964190(lfng) 109966694(rfng) 109970347 109973279
BSPL: 114845974(rfng) 114859896 114860343(lfng) 114861345(mfng)
SJO: 128365057 128365321 128379635(lfng) 128381022(rfng)
SSCO: 133990843 133997186(mfng) 133999291(lfng) 134003622(rfng)
GMH: 115531389(rfng) 115535960(lfng) 115539888 115541001
SASA: 106589611(rfng) 106593718 106594217 106601125 106607332 106610281
STRU: 115147657 115147658 115152889 115171151 115191205 115191206 115198390 115201410(rfng)
OTW: 112224491(rfng) 112226024(lfng) 112240162(mfng) 112245978 112259205
OMY: 110486296 110487259 110499227(rfng) 110503025 110513416 110538231(lfng) 118936550 118940346
OGO: 124000378 124015978 124018423 124018428 124018624 124018638 124022298 124040219(rfng)
ONE: 115104164 115110309 115115732 115123394 115127654 115144263(rfng)
OKI: 109870037(rfng) 109877455 109880963 109888170 109891936 109900061 116360195 116372050
OKE: 118365292 118370993 118382903(mfng) 118384510 118402903(rfng) 127920114 127922906
OMM: 135511932 135523615 135535717 135535850 135535854 135554076 135555683
OCLA: 139364702 139376774 139381932 139394168 139395863 139401961 139402034 139421202 139424065
SALP: 111980694 111981123 112070915 112080424(rfng)
SNH: 120023829 120028006(mfng) 120029725 120034371 120039995 120044539 120046806
CCLU: 121547559 121550607 121553934 121553961(mfng) 121569548 121577674
ELS: 105005737 105013213(lfng) 109614596 109614605(rfng)
OEP: 134007755(lfng) 134016361(mfng) 134016856 134030763(rfng)
SFM: 108922521 108926351 108927511 108939756(rfng)
PKI: 111832910 111845285(mfng) 111845492 111853276
AANG: 118217299(lfng) 118220755(rfng) 118221534 118221624(mfng)
AROT: 135243341(lfng) 135248183 135248456(rfng) 135248770(mfng)
CCOG: 133114607(lfng) 133117098(rfng) 133121689 133122430(mfng)
LOC: 102684219(rfng) 102690142 102693167
PSPA: 121295762 121296349 121300883(lfng) 121306163 121331145
ARUT: 117417826 117423338 117424071 117431085
PSEX: 120517484(rfng) 120536984 120542082(lfng)
LCM: 102347945(LFNG) 102350505(MFNG) 102362901(RFNG)
CMK: 103175474(rfng) 103186827(lfng) 103189782
RTP: 109917090(lfng) 109930933(rfng)
CPLA: 122542250 122560476(lfng) 122562136
HOC: 132825545(lfng) 132828037(rfng) 132831161
LERI: 129706717(lfng) 129708426(rfng) 129713935
PMRN: 116937575 116955103 116956645
LRJ: 133339065 133348015 133358695
BFO: 118428905
BBEL: 109484277
CIN: 113474334 778622 778624 778625 778626
SCLV: 120342216 120344217
SPU: 578181
LPIC: 129263772 129269081 129276506
AJJ: 139978263
APLC: 110981883 110989661
ARUN: 117292183 117293135
AAMU: 139943862 139943973
AFIL: 140164697 140165102
AJC: 117111154
SKO: 100653401(fng)
PFLL: 139151957
DME: Dmel_CG10580(fng)
DER: 6546161
DSE: 6616375
DSI: Dsimw501_GD28062(Dsim_GD28062)
DYA: Dyak_GE22371 Dyak_GE28150
DAN: 6493073
DSR: 110189997
DPO: 4813082
DPE: 6604426
DMN: 108153338
DGR: 6558607
DMO: Dmoj_GI16838
DAZ: 108614550
DNV: 108650377
DHE: 111592962
DVI: 6624162(fng)
CCAT: 101448383
BOD: 106621397
BDR: 105221842
RZE: 108375725 108376345 108377593 108378635
AOQ: 129241282
ALUD: 128861451
TDA: 119667636 119672261
MDE: 101890371
LCQ: 111676980
LSQ: 119607960
CVJ: 135953517(fng)
GFS: 119645008
ECOE: 129944346
CLON: 129606778
HIS: 119649228
AGA: 1277047
ACOZ: 120949945
AARA: 120893923
AMER: 121593002
ASTE: 118509600
AMAP: 126563642
AFUN: 125771984
AMOU: 128301193
AMRS: 128716242
ACOS: 131263910
AAG: 5574115
AALB: 109623129
ASUA: 134218409
CQU: CpipJ_CPIJ010821 CpipJ_CPIJ010824
CPII: 120423174
CNS: 116339100 116341591
BCOO: 119080341 119080342
LLL: 129792435
PPAP: 129804434
AME: 551501
ACER: 107995872
ALAB: 122718255
ADR: 102673211
AFLR: 100870819
BIM: 100741335
BBIF: 117212676
BVK: 117231280
BVAN: 117156684
BHUN: 126863638
BTER: 100648290
BAFF: 126918052
BPYO: 122572420
BPAS: 132907199
CCAL: 108624015
OBB: 114878915
OLG: 117602041
MGEN: 117229939
NMEA: 116428209
CGIG: 122397305
SOC: 105201656
MPHA: 105832301
AEC: 105145067
ACEP: 105624750
PBAR: 105422509
VEM: 105562750
COBS: 139110067(Fng)
TLN: 139823353(Fng)
HST: 105185424
DQU: 106741484
CFO: 105251037
FEX: 115232699
PMEC: 138939978(Fng)
LHU: 105675165(fng)
PGC: 109851939
OBO: 105276314
PCF: 106790982
PFUC: 122523658
VPS: 122630114
VCRB: 124425748
VVE: 124949176
NVI: 100678242
CSOL: 105361405
TPRE: 106653420 111693900
LHT: 122504358
LBD: 127288455
MDL: 103571993 106693367
CGLO: 123269289
FAS: 105267675
DAM: 107044117
AGIF: 122855200
CINS: 118064376
VCAN: 122407331
CCIN: 107272544
DSM: 124407895
NPT: 124216974(fng)
NFB: 124181658
NLO: 107222775
NVG: 124304102
TCA: 100141773
TMOL: 138127197(fng)
DPA: 109540120
ESIM: 136416659(fng)
EFOR: 136349481(fng)
SOY: 115876239
AGRG: 126746517
ATD: 109598146
CSET: 123314170
HAXR: 123679797
AGB: 108907799
LDC: 111504163
DVV: 126882394
NVL: 108560087 108566740
APLN: 108745264
PPYR: 116176682 116176726 116177203 116177362 116181885
OTU: 111421150
BMOR: 100144549(Fng)
BMAN: 114243226
MSEX: 115445284
DPL: KGM_202101
BANY: 112056524
MJU: 123880995
NIQ: 126770049
VCD: 124533750
MCIX: 123653662
PMAC: 106718445
PPOT: 106105228
PXU: 106128246
BPHI: 137930422(fng)
PRAP: 110995650
PBX: 123708887
PNAP: 125049669
ZCE: 119835035
CCRC: 123691321
LSIN: 126964812
AAGE: 121732089
HAW: 110371554
HZE: 124631448
TNL: 113504560
SLIU: 111352092
OFU: 114350631
ONU: 135071712
ATRA: 106134492
GMW: 113517457
PXY: 105390350
PGW: 126367483
LGLY: 125228117
CSTB: 134742489
CFEL: 113376605 113378720
CCRN: 123296156
API: 100160830
DNX: 107164992
AGS: 114126629
RMD: 113553865
ACOO: 126845017
DVT: 126897063
BTAB: 109037881
DCI: 103505607
CLEC: 106661495
HHAL: 106685149(fng)
NLU: 111048523
HVI: 124367354
MQU: 128991345
PHU: Phum_PHUM014770
FOC: 113202473
TPAL: 117651573
ZNE: 110830882
CSEC: 111865356
SGRE: 126270700
BROR: 134532540
IEL: 124165063
HAMR: 139696330(fng)
FCD: 110847136
DPX: DAPPUDRAFT_93561
DMK: 116919626
DPZ: 124342010
AFRA: 136039873 136043735
PVM: 113807163(fng)
PJA: 122254503
PCHN: 125047451
PMOO: 119596405
HAME: 121864231
PCLA: 123745420(fng)
CQD: 128685453(fng)
PTRU: 123499121
ESN: 127008863
MNZ: 135207911
MRJ: 136830726(fng)
PORN: 139762296(fng)
HAZT: 108669222
EAF: 111699063 111703992 111706808
LSM: 121119428 121121774
TCF: 131879374 131882153 131889136
PPOI: 119090919 119090983 119095094 119109545 119112358 119113221 119114546
DSV: 119453617
RSAN: 119399349
RMP: 119179851
VDE: 111244994 111247283
VJA: 111258969 111264582
TUT: 107360014
DPTE: 113793628
DFR: 124493845
CSCU: 111617733 111619390
CVS: 136984793 136989261
PTEP: 107441830
ABRU: 129984599
UDV: 129225679
SDM: 118183468
LPOL: 106460922 106460923 106469670
PMEO: 129580839 129590124 129599678
LGI: LOTGIDRAFT_93476
PVUL: 126809664
PCAN: 112561686
LSAX: 138959265
BGT: 106053876
GAE: 121378484
HRF: 124132242
HRJ: 124286678
HASI: 137285261
HCRA: 139468349
CRG: 105321777
CVN: 111118946
MYI: 110453003
PMAX: 117327462
AIRR: 138324084
MCAF: 127708623
MMER: 123564022
RPHI: 132748108
DPOL: 127868751
MAEA: 128213234
OBI: 106871323
OSN: 115215667
LJP: 135462192
LAK: 106168328
LLON: 135494051
NVE: 116603670
EPA: 110237675
ADF: 107346687
AMIL: 114964698
MCAZ: 138059251
MFOO: 137970056
PDAM: 113678576
SPIS: 111340325
AQU: 100632073 100632325 100637378 100637506 100637631 105314240 105314592
TVA: TVAG_2v0379720
 » show all
Reference
1  [PMID:10935626]
  Authors
Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, Wang Y, Stanley P, Irvine KD, Haltiwanger RS, Vogt TF.
  Title
Fringe is a glycosyltransferase that modifies Notch.
  Journal
Nature 406:369-75 (2000)
DOI:10.1038/35019000
  Sequence
[dme:Dmel_CG10580] [hsa:4242]
Reference
2  [PMID:10935637]
  Authors
Bruckner K, Perez L, Clausen H, Cohen S.
  Title
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.
  Journal
Nature 406:411-5 (2000)
DOI:10.1038/35019075
Reference
3  [PMID:16221665]
  Authors
Rampal R, Li AS, Moloney DJ, Georgiou SA, Luther KB, Nita-Lazar A, Haltiwanger RS.
  Title
Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats.
  Journal
J Biol Chem 280:42454-63 (2005)
DOI:10.1074/jbc.M509552200
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.222
IUBMB Enzyme Nomenclature: 2.4.1.222
ExPASy - ENZYME nomenclature database: 2.4.1.222
BRENDA, the Enzyme Database: 2.4.1.222
CAS: 299203-70-6
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