Entry
Name
D-inositol-3-phosphate glycosyltransferase;
mycothiol glycosyltransferases;
MshA;
UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP [RN:
R09634 ]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:
C00043 ];
1D-myo-inositol 3-phosphate [CPD:
C04006 ]
Product
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate [CPD:
C19761 ];
UDP [CPD:
C00015 ]
Comment
The enzyme, which belongs to the GT-B fold superfamily, catalyses the first dedicated reaction in the biosynthesis of mycothiol [1]. The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate [2]. A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate [3].
History
EC 2.4.1.250 created 2010
Orthology
K15521 D-inositol-3-phosphate glycosyltransferase
Genes
BUE : BRPE67_ECDS00300 BRPE67_ECDS01490
AXX : ERS451415_04217(mshA_3)
MASS : CR152_16740 CR152_19275
ULI : ETAA1_07230(mshA_3) ETAA1_63180(mshA_9)
AGV : OJF2_28890(cotSA_2) OJF2_33150(mshA_4)
PBAP : Pla133_24650(pimB_8)
MAVI : RC58_02620 RC58_20345
MAVM : MAA44156_04106(mshA_4)
MBAI : MB901379_00694(mshA_1)
MHEK : JMUB5695_04173(mshA)
MKY : IWGMT90018_08150(mshA)
MPHL : MPHLCCUG_04512(mshA_2)
MTHN : 4412656_00583(mshA_1)
MAUU : NCTC10437_00686(mshA_2)
MPSC : MPSYJ_02550(mshA) MPSYJ_37250
MPOF : MPOR_11710(mshA) MPOR_32860
MFLV : NCTC10271_04486(mshA_2)
MGRO : FZ046_09615(mshA) FZ046_09880
MBUG : MU0053_004006(mshA)
MYQ : TUM20985_50560(mshA)
MPAT : MPNTM1_00571(mshA_1)
MSAL : DSM43276_03879(mshA)
MTER : 4434518_00470(mshA_1) 4434518_03068(mshA_2)
CDIP : ERS451417_00310(mshA)
COI : CPCIP5297_01380(mshA)
CUN : Cul210932_0316(mshA)
CUQ : Cul210931_0304(mshA)
CUJ : CUL131002_0302(mshA)
CMIN : NCTC10288_02245(mshA)
CRL : NCTC7448_01129(mshA_2)
CCYS : SAMEA4530656_2186(mshA_2)
NFR : ERS450000_04691(mshA_3)
NAD : NCTC11293_00121(mshA_1)
NWL : NWFMUON74_66080(mshA)
NSPU : IFM12276_57710(mshA)
RER : RER_15810 RER_16170(mshA)
REB : XU06_07765 XU06_07960
RQI : C1M55_08015 C1M55_08190(mshA)
ROP : ROP_17450(mshA) ROP_18330
ROA : Pd630_LPD06250 Pd630_LPD06293
RAV : AAT18_19425 AAT18_23145
RHW : BFN03_12755 BFN03_12910
RHOD : AOT96_18390 AOT96_18565
RRT : 4535765_03708(mshA_1)
RCR : NCTC10994_03552(mshA_3)
RANT : RHODO2019_01600(mshA)
RFA : A3L23_00964(mshA_1) A3L23_02775(mshA_3)
RHS : A3Q41_00585(mshA_1) A3Q41_02388(mshA_3)
TPUL : TPB0596_06290(mshA)
SCO : SCO4204(2SCD46.18) SCO6185(SC2G5.06)
SSX : SACTE_3644 SACTE_6037
SHO : SHJGH_2019 SHJGH_4651
STRP : F750_1038 F750_3943(mshA)
SCI : B446_01245 B446_04870 B446_17845 B446_34050
SCW : TU94_17975 TU94_26545
SAMB : SAM23877_3492(mshA)
SPRI : SPRI_1885 SPRI_4052
SCX : AS200_22770 AS200_24960 AS200_42265
SRW : TUE45_01023(mshA_2) TUE45_04740(mshA_4)
SLE : sle_14930(sle_14930) sle_38490(sle_38490)
SRN : A4G23_00217(mshA_1) A4G23_02492(mshA_4)
SGM : GCM10017557_38500(mshA)
SPHW : NFX46_24620 NFX46_38195(mshA)
SGRS : V9K83_06255 V9K83_17885(mshA)
SLX : SLAV_09105(mshA1) SLAV_17730(mshA2)
SGE : DWG14_00393(mshA_1) DWG14_04601(mshA_3)
SGD : ELQ87_20915(mshA) ELQ87_38410
SCYA : EJ357_07030 EJ357_21025(mshA)
SAST : CD934_05570 CD934_13655(mshA)
SHAW : CEB94_02325 CEB94_18825(mshA)
SSUB : CP968_02050 CP968_18445(mshA)
SCIN : CP977_01795 CP977_19015(mshA)
SCHA : CP983_23180(mshA) CP983_39665(mshA)
SGX : H4W23_21905(mshA) H4W23_22735
SCOE : CP976_20300(mshA) CP976_34435 CP976_40815
STUI : GCM10017668_31870(mshA) GCM10017668_56740
SHUN : DWB77_03632(mshA_1)
SCYG : S1361_03760(mshA1) S1361_18580(mshA4)
SFEU : IM697_03180(mshA) IM697_16445(mshA)
SDD : D9753_19245(mshA) D9753_32765
SACT : DMT42_18020(mshA) DMT42_30455
SGOB : test1122_07615 test1122_10690(mshA)
SRUG : F0345_15825(mshA) F0345_26105
STAA : LDH80_18005(mshA) LDH80_18665(mshA)
SCAE : IHE65_02280(mshA) IHE65_24480(mshA)
SXT : KPP03845_104150(mshA_3)
SARG : HKX69_18795 HKX69_31740
SINN : ABB07_20585 ABB07_34430
STPB : QR97_16420 QR97_28560
SCAJ : O1G22_22835(mshA) O1G22_39905(mshA)
STRW : QHG49_19095(mshA) QHG49_31550
STSD : HEP87_05695(mshA) HEP87_25565(mshA)
SABD : N8I86_05170 N8I86_21080(mshA)
SSTO : ACE1OC_22090(mshA) ACE1OC_34875(mshA)
STGO : KBP30_19355(mshA) KBP30_36695
STSG : B6R96_05505 B6R96_19530
SSEC : ABZO29_24045(mshA) ABZO29_40065(mshA)
KIT : CFP65_0979 CFP65_3319 CFP65_6027
KCH : O1G21_03925(mshA) O1G21_21500(mshA)
KIC : KCMC57_up36350(mshA)
RTC : APU90_02210 APU90_06955
RTN : A6122_0944 A6122_2392
RIA : C7V51_01390 C7V51_14990
RFS : C1I64_10190 C1I64_12780
RTE : GSU10_02680 GSU10_05315
CART : PA27867_2304 PA27867_3163
MANT : BHD05_07725 BHD05_07870 BHD05_11795
ARTH : C3B78_02145 C3B78_13905(mshA)
AAGI : NCTC2676_1_03036(mshA_5)
ASUF : MNQ99_03345 MNQ99_10650(mshA)
AOD : Q8Z05_01360(mshA) Q8Z05_09850
PAGO : IRJ34_00495 IRJ34_14480(mshA)
APN : Asphe3_04630 Asphe3_27440
PSNI : NIBR502771_02835 NIBR502771_11220(mshA)
PDEL : JCQ34_02025 JCQ34_13190(mshA)
POK : SMD14_02375 SMD14_14145(mshA)
PSLS : KTR40_02305 KTR40_13020(mshA)
PQA : WHH00_05370(mshA) WHH00_16365
PSNB : NIBR502770_12085(mshA)
GCR : GcLGCM259_1393 GcLGCM259_2538
KVR : CIB50_0000024(mshA_1)
SATK : SA2016_0690 SA2016_2813
ACRY : AC20117_03440 AC20117_18480
YIM : J5M86_03755 J5M86_12460(mshA)
XYL : ET495_10845(mshA) ET495_12880
XYA : ET471_03295(mshA) ET471_05180
DCO : SAMEA4475696_0882(mshA)
PAUS : NCTC13651_00188(mshA)
TLA : TLA_TLA_01919(mshA_2)
NBE : Back2_09760 Back2_13320(mshA)
NAQU : ENKNEFLB_00888(mshA_1)
MGG : MPLG2_0103 MPLG2_3560(mshA)
AGRA : AGRA3207_005269(mshA)
AWS : ACN3XK_08645(mshA) ACN3XK_09120(mshA)
FRE : Franean1_0851 Franean1_5882 Franean1_6162 Franean1_6548
FSY : FsymDg_1059 FsymDg_4081
FRI : FraEuI1c_6082 FraEuI1c_6341
AMQ : AMETH_0128 AMETH_0421
AMYC : CU254_01010(mshA) CU254_17790
AMYZ : HUW46_03333(mshA_4)
ABAR : AMYBAR_000408(mshA)
SESP : BN6_81180(gtuS4-21)
PMAD : BAY61_01880 BAY61_08260
ACTU : Actkin_06095(mshA_3)
STP : Strop_0331 Strop_1762 Strop_3722
MAU : Micau_5263 Micau_5680
MTUA : CSH63_28930(mshA) CSH63_31095
MICH : FJK98_10425 FJK98_27485 FJK98_29570(mshA)
MTEM : GCE86_20925 GCE86_23020(mshA)
MCAB : HXZ27_10625 HXZ27_11530 HXZ27_26425 HXZ27_28380(mshA)
MSAG : GCM10017556_15180 GCM10017556_19330(mshA) GCM10017556_43340 GCM10017556_45680
VMA : VAB18032_00060 VAB18032_01930 VAB18032_14340
MCRA : ID554_02665 ID554_18340(mshA)
VER : HUT12_10460 HUT12_27345 HUT12_29495(mshA)
MENO : Jiend_34430(mshA) Jiend_38440
MCHL : PVK74_16545 PVK74_18545(mshA)
MFEU : H1D33_01795 H1D33_04310(mshA)
MHAW : RMN56_14415(mshA) RMN56_16555
MCAY : PVK37_01270 PVK37_03400(mshA)
MICN : WHN02_00605 WHN02_02280(mshA)
ASE : ACPL_2650 ACPL_6582 ACPL_7885
AMS : AMIS_50140 AMIS_63450 AMIS_76040(mshA)
ACTN : L083_4595 L083_6112 L083_7672
ACTS : ACWT_2896 ACWT_6451 ACWT_7754
ACTR : Asp14428_53180(mshA)
PLAB : C6361_11465(mshA) C6361_14520
PLAT : C6W10_08560(mshA) C6W10_10635
PSUU : Psuf_007810 Psuf_027800(mshA)
PRY : Prubr_31560(mshA) Prubr_48060 Prubr_56830 Prubr_58330
CAI : Caci_5074 Caci_6395 Caci_7644 Caci_8224
ACTT : DDD63_00520 DDD63_00525
ABAM : B1s21122_05810(mshA)
AQZ : KSP35_06620 KSP35_17465
CMP : Cha6605_0855 Cha6605_0857 Cha6605_5458
CYN : Cyan7425_1751 Cyan7425_2924
CEP : Cri9333_3742 Cri9333_4344
LEN : LEP3755_01000 LEP3755_07970 LEP3755_28800
LET : O77CONTIG1_02192(mshA_1) O77CONTIG1_03884(mshA_7)
LBO : LBWT_24300 LBWT_5330
THEU : HPC62_13675 HPC62_22375
GLP : Glo7428_1199 Glo7428_3980
HAO : PCC7418_1738 PCC7418_2984
CYC : PCC7424_1935 PCC7424_3257
CYJ : Cyan7822_0598 Cyan7822_0795
OXY : HCG48_00920 HCG48_16470 HCG48_21320
OAC : Oscil6304_0821 Oscil6304_2012 Oscil6304_2973
MIC : Mic7113_0204 Mic7113_1043 Mic7113_5881 Mic7113_5916
GLJ : GKIL_0944(gmhA) GKIL_4105(mshA)
NPU : Npun_R1558 Npun_R4579
NON : NOS3756_22520 NOS3756_39620
NED : HUN01_30795 HUN01_32560 HUN01_33275
NLK : NIES25_35120 NIES25_55340
NOST : GJB62_04905 GJB62_21970
NOSU : JYQ62_13650 JYQ62_16625
ANN : EH233_06180 EH233_24450
NSPH : BDGGKGIB_00910(mshA_2)
CALO : Cal7507_5994 Cal7507_6027
CALN : NIES2098_23480 NIES2098_47410
SCYT : SAMD_32020 SAMD_54120
SCYS : NIES4073_19600 NIES4073_58980
BSEN : DP114_08070 DP114_21915
BOX : DP113_08025 DP113_21835
NCN : BZZ01_18090 BZZ01_29935
CTHE : Chro_2260 Chro_2932
PLP : Ple7327_1732 Ple7327_3145 Ple7327_3305
SCS : Sta7437_0828 Sta7437_0877
STAN : STA3757_05160 STA3757_10340
DTB : BH720_000465 BH720_036275
» show all
Taxonomy
Reference
Authors
Newton GL, Koledin T, Gorovitz B, Rawat M, Fahey RC, Av-Gay Y
Title
The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).
Journal
Sequence
Reference
Authors
Newton GL, Ta P, Bzymek KP, Fahey RC
Title
Biochemistry of the initial steps of mycothiol biosynthesis.
Journal
Sequence
Reference
Authors
Vetting MW, Frantom PA, Blanchard JS
Title
Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.250
LinkDB
All DBs