KEGG ENZYME: 2.4.1.369

ENZYME: 2.4.1.369

Entry

EC 2.4.1.369                Enzyme

Name

enterobactin C-glucosyltransferase;
iroB (gene name)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-glucose:enterobactin 5'-C-beta-D-glucosyltransferase (configuration-inverting)

Reaction(IUBMB)

(1) UDP-alpha-D-glucose + enterobactin = UDP + monoglucosyl-enterobactin [RN:R12469];
(2) UDP-alpha-D-glucose + monoglucosyl-enterobactin = UDP + diglucosyl-enterobactin [RN:R12470];
(3) UDP-alpha-D-glucose + diglucosyl-enterobactin = UDP + triglucosyl-enterobactin [RN:R12471]

Reaction(KEGG)

R12469 R12470 R12471

Substrate

UDP-alpha-D-glucose [CPD:C00029];
enterobactin [CPD:C05821];
monoglucosyl-enterobactin [CPD:C22180];
diglucosyl-enterobactin [CPD:C22181]

Product

UDP [CPD:C00015];
monoglucosyl-enterobactin [CPD:C22180];
diglucosyl-enterobactin [CPD:C22181];
triglucosyl-enterobactin [CPD:C22182]

Comment

The enzyme, found in pathogenic strains of the bacteria Escherichia coli and Salmonella enterica, catalyses the transfer of glucosyl groups to C-5 of one, two, or three of the 2,3-hydroxybenzoyl units of the siderophore enterobactin, forming C-glucosylated derivatives known as salmochelins.

History

EC 2.4.1.369 created 2019

Orthology

K23725

enterobactin C-glucosyltransferase

Genes

ECE:

Z1190

ECS:

ECs_1370

ECF:	ECH74115_1369

ELX:	CDCO157_1309

EOI:	ECO111_1272

EOJ:	ECO26_1324

ECOO:

ECRM13514_1270(iroB)

ECOH:

ECRM13516_1230(iroB)

ESL:

O3K_15730

ESO:

O3O_09565

ESM:

O3M_15715

EUN:	UMNK88_1247

ECP:

ECP_0306

ECV:	APECO1_O1CoBM141(iroB)

ECI:	UTI89_C1122(iroB)

EIH:	ECOK1_1111

ECZ:	ECS88_p0128(iroB)

ECC:	c1254(iroB)

ELO:	EC042_3202(mchA)

ELN:	NRG857_30008(iroB)

EAB:	ECABU_c12110(iroB)

ELU:	UM146_12295

ELC:	i14_1148(iroB)

ELD:	i02_1148(iroB)

ECOI:

ECOPMV1_01082

STY:	STY2890(iroB)

STT:	t2668(iroB)

SEX:	STBHUCCB_28080

SENT:

TY21A_13510

STM:	STM2773(iroB)

SEO:	STM14_3344(iroB)

SEV:	STMMW_27401

SEY:	SL1344_2758(iroB)

SEM:	STMDT12_C28270

SEJ:	STMUK_2761(iroB)

SEB:	STM474_2908(iroB)

SEF:	UMN798_3009(iroB)

SETU:

STU288_14040

SETC:

CFSAN001921_03215

SENR:

STMDT2_26791(iroB)

SEND:

DT104_27751(iroB)

SENI:

CY43_14500

SEEN:

SE451236_19960

SPT:	SPA2629(iroB)

SEK:

SSPA2451

SPQ:	SPAB_03444

SEI:	SPC_2813(iroB)

SEC:	SCH_2704(iroB)

SEH:	SeHA_C2949

SHB:

SU5_03260

SENH:

CFSAN002069_18400

SEEH:

SEEH1578_22680

SEE:	SNSL254_A2968

SENN:

SN31241_38610

SEW:	SeSA_A2915

SEA:	SeAg_B2885

SENS:

Q786_13310

SED:

SeD_A3071

SEG:	SG2678(iroB)

SEL:	SPUL_2765(iroB)

SEGA:

SPUCDC_2751(iroB)

SET:	SEN2619(iroB)

SENA:

AU38_13285

SENO:

AU37_13295

SENV:

AU39_13295

SENQ:

AU40_14960

SENL:

IY59_13870

SENJ:

CFSAN001992_19670

SEEC:

CFSAN002050_20150

SEEB:

SEEB0189_006315

SEEP:

I137_13190

SENB:

BN855_28060

SENE:

IA1_13235

SENC:

SEET0819_20675

SES:	SARI_00205

SALZ:

EOS98_05685

SDY:	SDY_1026(iroB)

SDZ:	Asd1617_01308

ECLE:

ECNIH2_07815

ECLY:

LI62_07670

ECLO:

ENC_19070

EHM:	AB284_18090

ECAN:

CWI88_15310

ENK:	LOC22_17650(iroB)

KPU:	KP1_3611(iroB) KP1_p028(iroB)

KPP:

A79E_1750

KPT:	VK055_5103(iroB)

KPO:	KPN2242_26226

KPNK:

BN49_pII0030(iroB)

EAE:

EAE_03270

EAR:

CCG33326

PGE:	LG71_24425

YRE:	HEC60_09565(iroB)

IZH:	FEM41_21260

GQU:	AWC35_23165

RBAD:

H2866_00495

CUW:	LH390_01880

CHIN:

J5O04_01045

NVU:	V7968_14825

SRIM:

CP984_01870

SPHV:

F9278_28325 F9278_28335 F9278_28345

SCHA:

CP983_03635 CP983_27930

SMAO:

CAG99_12165 CAG99_12170

AMYS:

CVV72_32550

KUT:	JJ691_97130

» show all

Reference

1 [PMID:15598734]

Authors

Fischbach MA, Lin H, Liu DR, Walsh CT

Title

In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase.

Journal

Proc Natl Acad Sci U S A 102:571-6 (2005)
DOI:10.1073/pnas.0408463102

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.369

IUBMB Enzyme Nomenclature:

2.4.1.369

ExPASy - ENZYME nomenclature database:

2.4.1.369

BRENDA, the Enzyme Database:

2.4.1.369

LinkDB

DBGET integrated database retrieval system