KEGG ENZYME: 2.4.1.46

ENZYME: 2.4.1.46

Entry

EC 2.4.1.46                 Enzyme

Name

monogalactosyldiacylglycerol synthase;
uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase;
UDP-galactose:diacylglycerol galactosyltransferase;
MGDG synthase;
UDP galactose-1,2-diacylglycerol galactosyltransferase;
UDP-galactose-diacylglyceride galactosyltransferase;
UDP-galactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase;
1beta-MGDG;
1,2-diacylglycerol 3-beta-galactosyltransferase;
UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase

Reaction(IUBMB)

UDP-alpha-D-galactose + a 1,2-diacyl-sn-glycerol = UDP + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol [RN:R02691]

Reaction(KEGG)

R02691

Substrate

UDP-alpha-D-galactose [CPD:C00052];
1,2-diacyl-sn-glycerol [CPD:C00641]

Product

UDP [CPD:C00015];
1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol

Comment

This enzyme adds only one galactosyl group to the diacylglycerol; EC 2.4.1.241, digalactosyldiacylglycerol synthase, adds a galactosyl group to the product of the above reaction. There are three isoforms in Arabidopsis that can be divided into two types, A-type (MGD1) and B-type (MGD2 and MGD3). MGD1 is the isoform responsible for the bulk of monogalactosyldiacylglycerol (MGDG) synthesis in Arabidopsis [4].

History

EC 2.4.1.46 created 1972, modified 2003, modified 2005

Pathway

ec00561

Glycerolipid metabolism

ec01100

Metabolic pathways

Orthology

K03715

1,2-diacylglycerol 3-beta-galactosyltransferase

Genes

ATH:	AT2G11810(MGDC) AT4G31780(MGD1) AT5G20410(MGD2)

ALY:	9305384 9308006 9319839

CRB:	17878480 17882958 17892650

CSAT:

104700063 104706388 104717012 104721659 104730134 104736117 104748635 104767934 104770420

EUS:	EUTSA_v10013431mg EUTSA_v10022676mg EUTSA_v10024883mg

BRP:	103837651 103851349 103851545 103862083

BNA:	106354743 106366315 106368692 106375399 106392218 106420497 106425766

BOE:	106301258 106316128 106316193 106325403

RSZ:	108824363 108842169 108843682 108853953 130511690

THJ:	104808956 104811011 104819949

CPAP:

110808254 110826136

CIT:	102614331 102616808 102624996

CIC:	CICLE_v10007936mg CICLE_v10008213mg CICLE_v10010220mg

PVY:	116108379 116108383 116138108

MINC:

123194445 123195049 123199903

TCC:	18587678 18588847

GRA:	105770833 105773757 105776111 105781160

GHI:	107901653 107953724 107961718 121212595 121217451 121225007 121229214 121232004

GAB:	108463142 108477428 108486783

HSYR:

120126550 120177598 120197448 120218989

DZI:	111284770 111286736 111299430 111303304

EGR:	104436070 104438405 104438611

RARG:

115750978 115751005 115752585

GMX:	100794727 100804814 100806325 547469(MGD1)

GSJ:	114374435 114385082 114392744 114394029

PVU:	137807594 137816689

VRA:	106762909 106766883

VAR:	108323869 108338531

VUN:	114175823 114194729

VUM:	124835426 124837578

CCAJ:

109808150 109817751

APRC:

113846505 113874985

MTR:	11428752 11439263 25500699

TPRA:

123881899 123916063

CAM:	101510704 101515157

PSAT:

127073476 127092901

VVO:	131596322 131633100

LJA:	130711977 130718253

ADU:	107461393 107470593 107495613

AIP:	107605453 107623603 107640550

AHF:	112697606 112701499 112716006 112723333 112755834 112783732

LANG:

109326041 109328766 109339323 109343788 109345964 109354684

PCIN:

129298458 129308040 129320635

QSA:	O6P43_002454 O6P43_015794 O6P43_019192 O6P43_023960

FVE:	101295108 101304410

AANS:

126783125 126805544

RCN:	112173289 112188707

PPER:

18770365 18793552

PMUM:

103320709 103341171

PAVI:

110752682 110762666

PDUL:

117633726 117635731

MDM:	103401643 103417972 103440567 103442345

MSYL:

126602362 126602396 126611893 126632819

PXB:	103949172 103949703 103949750 103953356 103953874

PCOX:

137713816 137717499 137735928 137747640

ZJU:	107407197 107419930

MNT:	21396532 21407637

CSAV:

115695927 115707728

CSV:	101209030 101215352

CMO:	103488358 103496946

BHJ:	120075858 120079310

MCHA:

111004707 111013024

CMAX:

111465534 111493715 111496183

CMOS:

111444335 111450318 111454498

CPEP:

111798450 111799315 111806023

RCU:	8263869 8274155

MEAN:

126665018 126667570

JCU:	105637529 105641265

HBR:	110636479 110657369 110671192 110671419

MESC:

110600030 110604125 110611819

POP:	18099909 18111074 7465432 7468702

PEU:	105121074 105122665 105130558 105134120

PALZ:

118032612 118050172 118051142 118052055

PNZ:	133673708 133674929 133688892 133690206

JRE:	108995671 109000998 109005204 109008297

CILL:

122305199 122308429 122316603 122318578

CAVE:

132165589 132189765

AGLU:

133857694 133871117

QSU:	111998614 112024357 136064790

QLO:	115974813 115977130

TWL:	119993637 119997838

VVI:	100247378 100248939

VRI:	117912821 117924660

SLY:	101246362 101259856 101263085

SPEN:

107007576 107026350 107028612

SOT:	102578822 102588275 102600797 102600922

SSTN:

125842124 125855119 125875926

SDUL:

129870409 129888914 129889452 129891437

CANN:

107840795 107848737 107877723

LBB:	132603111 132609443 132636984

NTA:	107758934 107778411 107787940(NtMGD1) 107796922 107814929 107815856

NSY:	104220710 104239147 104244772

NTO:	104091472 104102546 104108525

NAU:	109207107 109208351 109234432

INI:	109147300 109168378 109169926 109178727

ITR:	116001911 116007458 116012054 116023241

SIND:

105162237 105164881 105166432

OEU:	111374436 111388678 111398224 111399376 111407920

EGT:	105960665 105975327

SSPL:

121748721 121751961 121752090 121783436 121801630 121805604 121808305

SMIL:

130988223 130989229 131015096

SHIS:

125187479 125193157 125194428 125214688

APAN:

127239996 127251388 127255782 127266408

HAN:	110877347 110899401 110928684 110930343

ECAD:

122599393 122600251

LSV:	111877804 111908547

CCAV:

112501081 112507778 112529284

DCR:	108201943 108206444 108211851 108215641

CSIN:

114256679 114266251 114284431

RVL:	131299857 131317884 131320271

AEW:	130756615 130790928 130793391 130796304

DLT:	127794081 127806870 127809361 127813690

BVG:	104887802 104901921

SOE:	110791699 110805894

CQI:	110708023 110712165 110723048 110725562

ATRI:

130816002 130817586

MOF:	131149884 131150440 131158174

NNU:	104586160 104589849 104592530 104605433

MING:

122066766 122073030 122082450

TSS:	122646141 122652759 122655935 122666759

PSOM:

113282742 113301280 113306106 113355890

OSA:	4331045(MGD3) 4345212(MGD2) 4347099(MGD1)

DOSA:

Os02g0802700 Os08g0299400

OBR:	102704776 102712378 102717644

OGL:	127762694 127781561 127784191

BDI:	100822971 100838296 100844719

ATS:	109741872 109755152 109769532

TDC:	119286449 119293432 119301677 119309621 119318371 119323792

TAES:

123082162 123094585 123099670 123112071 123121603 123128831 123139279 123145979 542965

TUA:	125509420 125515215 125553653

LPER:

127301516 127305230 127331070

LRD:	124652455 124678127 124678568 124689013 124693403

SBI:	8055186 8055993 8084656

ZMA:	100274282 100281388 100383973

MFLO:

136467927 136472704 136472816 136475112 136501610 136541962

SITA:

101760868 101764122 101764643

SVS:	117841430 117844563 117860076

PVIR:

120645267 120657513 120660703 120679264 120695685 120711695

PHAI:

112873981 112882799 112896381

PAUA:

133897349 133899221 133901688 133920017 133920772

PDA:	103706476 103707463 103710116 103715894

EGU:	105033793 105039544 105049423 105050115

MUS:	103985478 103997383 103999153 135609918 135617590

ZOF:	121970519 121970748 121970955 121975592 121975845 121992261 121996202 122002492 122006748 122029369 122042030 122043366 122046547 122047891 122050454

DCT:	110103531 110103945 110104020

PEQ:	110023378 110026955

AOF:	109820101 109841163 109844529

MSIN:

131217073 131254857 131258383

ACAK:

137941051 137949935

NCOL:

116250941 116253683 116261104

ATR:	18435298 18442588

CJF:	131070656 131070658

SMO:	SELMODRAFT_271007(MGD)

PPP:	112295608 112296119

CRE:	CHLRE_13g585301v5

VCN:	VOLCADRAFT_58564

MNG:

MNEG_3776

CSL:	COCSUDRAFT_35261

OLU:	OSTLU_119506(mgdA)

OTA:	OT_ostta02g01930

BPG:	Bathy14g01530(MGDG)

MIS:	MICPUN_107335(MGDA)

MPP:	MICPUCDRAFT_45255

CME:	CYME_CMI271C

GSL:	Gasu_39500

CCP:	CHC_T00008381001 CHC_T00008619001 CHC_T00009002001

PTI:	PHATRDRAFT_14125 PHATRDRAFT_9619 PHATR_43938

FCY:	FRACYDRAFT_198887 FRACYDRAFT_275442

TPS:	THAPSDRAFT_264013 THAPSDRAFT_264314 THAPS_263200

NGD:	NGA_0081800(MGD)

AAF:	AURANDRAFT_1716 AURANDRAFT_24670

EHX:	EMIHUDRAFT_414703 EMIHUDRAFT_467938 EMIHUDRAFT_470522 EMIHUDRAFT_73870

GTT:	GUITHDRAFT_118033 GUITHDRAFT_146693 GUITHDRAFT_156659

» show all

Reference

1 [PMID:4838219]

Authors

Veerkamp JH.

Title

Biochemical changes in Bifidobacterium bifidum var. pennsylvanicus after cell-wall inhibition. VI. Biosynthesis of the galactosyldiglycerides.

Journal

Biochim Biophys Acta 348:23-34 (1974)
DOI:10.1016/0005-2760(74)90089-7

Reference

2 [PMID:5681471]

Authors

Wenger DA, Petitpas JW, Pieringer RA.

Title

The metabolism of glyceride glycolipids. II. Biosynthesis of monogalactosyl diglyceride from uridine diphosphate galactose and diglyceride in brain.

Journal

Biochemistry 7:3700-7 (1968)
DOI:10.1021/bi00850a049

Reference

3 [PMID:10518794]

Authors

Miege C, Marechal E, Shimojima M, Awai K, Block MA, Ohta H, Takamiya K, Douce R, Joyard J

Title

Biochemical and topological properties of type A MGDG synthase, a spinach chloroplast envelope enzyme catalyzing the synthesis of both prokaryotic and eukaryotic MGDG.

Journal

Eur J Biochem 265:990-1001 (1999)
DOI:10.1046/j.1432-1327.1999.00801.x

Sequence

[ag:CAB56218]

Reference

4 [PMID:15590685]

Authors

Benning C, Ohta H.

Title

Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants.

Journal

J Biol Chem 280:2397-400 (2005)
DOI:10.1074/jbc.R400032200