Entry
Name
N-acylsphingosine galactosyltransferase;
UGT8 (gene name);
CGT (gene name);
UDP galactose-N-acylsphingosine galactosyltransferase;
uridine diphosphogalactose-acylsphingosine galactosyltransferase;
UDP-galactose:N-acylsphingosine D-galactosyltransferase;
UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase;
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acylsphingosine beta-D-galactosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + a ceramide = UDP + a beta-D-galactosylceramide [RN:
R01500 R06277 ]
Reaction(KEGG)
Substrate
Product
UDP [CPD:
C00015 ];
beta-D-galactosylceramide
Comment
This membrane-bound, endoplasmic reticulum-located enzyme catalyses the last step in the synthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. It has a strong preference for ceramides that contain hydroxylated fatty acids.
History
EC 2.4.1.47 created 1972
Pathway
Orthology
K04628 ceramide galactosyltransferase
Genes
EJU : 114203048 114203049 114222677(UGT8)
GGA : 374033(UGT8) 428949(UGT8L)
PCOC : 116231252(UGT8) 116234480
MGP : 100539821 100541199(UGT8)
CJO : 107313583(UGT8) 107315928
TPAI : 128077990 128080106(UGT8)
LMUT : 125691974(UGT8) 125693947
NMEL : 110399157(UGT8) 110400413
APLA : 101794817 101799126(UGT8)
ACYG : 106029878 106038627(UGT8)
CATA : 118243154 118244232(UGT8)
AFUL : 116489127(UGT8) 116491423
TGU : 100228968 100231902(UGT8)
LSR : 110471176(UGT8) 110480032
SCAN : 103813974 103815551(UGT8)
PMOA : 120502064 120502813(UGT8)
OTC : 121331975(UGT8) 121341851
PRUF : 121349178(UGT8) 121350254
GFR : 102031520(UGT8) 102040819
FAB : 101807254 101809664(UGT8)
OMA : 130252607(UGT8) 130254856
PHI : 102107687(UGT8) 102108262
PMAJ : 107203102(UGT8) 107206597
CCAE : 111928999(UGT8) 111931100
CCW : 104696845(UGT8) 104697059
CBRC : 103613199(UGT8) 103624465
ETL : 114054721 114068337(UGT8)
ZAB : 102062618(UGT8) 102066639
ZLE : 135447016(UGT8) 135449503
ACHL : 103803439(UGT8) 103804160
SVG : 106855308 106860196(UGT8)
MMEA : 130578784 130581403(UGT8)
HRT : 120752805(UGT8) 120755845
SATI : 136360797(UGT8) 136364540
FPG : 101914948(UGT8) 101924669
FCH : 102047748 102051681(UGT8)
CCRI : 104160879 104161821(UGT8)
SHAB : 115605542(UGT8) 115608919
ACUN : 113479767(UGT8) 113481588
TALA : 104362911 104366712(UGT8)
ACHC : 115344526(UGT8) 115348607
HLE : 104831885 104836800(UGT8)
AGEN : 126042735 126044880
MNB : 103768724(UGT8) 103769785
DPUB : 104297688 104310337(UGT8)
PPUS : 135176503 135178705(UGT8)
AVIT : 104273583 104276343 104281458
BRHI : 104492239 104499174(UGT8)
EGZ : 104127441 104129123 104135946
NNI : 104019136(UGT8) 104019447
PCAO : 104047043(UGT8) 104051037
PADL : 103915563 103926098(UGT8)
AFOR : 103897613 103901699(UGT8)
FGA : 104070646 104075856(UGT8)
GSTE : 104259532(UGT8) 104264940
CLV : 102089904(UGT8) 102097199
MUI : 104536489(UGT8) 104543684
PGUU : 104459329(UGT8) 104466261
PLET : 104615011(UGT8) 104622396
EHS : 104504187(UGT8) 104514948
CMAC : 104476709 104487754
CUCA : 104059087(UGT8) 104067908
TEO : 104370543 104376593(UGT8)
BREG : 104630313 104635471 104637738
OHA : 104334458 104336717(UGT8)
ACAR : 104518558 104521111
CPEA : 104391481 104393373(UGT8)
CVF : 104289747 104295651(UGT8)
RTD : 128910444(UGT8) 128911321
AAM : 106492128(UGT8) 106498896
AROW : 112967517 112974891 112977284
NPD : 112943430(UGT8) 112957115
TGT : 104569610(UGT8) 104573043
DNE : 112980201 112986157(UGT8)
SCAM : 104138032(UGT8) 104141791
ASN : 102382334(UGT8) 102384980
AMJ : 102574992 106737104(UGT8)
CPOO : 109309361(UGT8) 109324295
GGN : 109287412 109301099(UGT8)
CMY : 102936934(UGT8) 102941238
CCAY : 125635522(UGT8) 125640339
DCC : 119855314(UGT8) 119859521
CPIC : 101945157 101952125(UGT8)
TST : 117877789(UGT8) 117881007
CABI : 116823594 116825360(UGT8)
MRV : 120406330(UGT8) 120408926
PMUA : 114597016 114604195 114604507
PRAF : 128413684 128421200(UGT8)
ZVI : 118083636(UGT8) 118096504
HCG : 128327900(UGT8) 128349455
GJA : 107110289(UGT8) 107122753
EMC : 129332432 129336897(UGT8)
XLA : 108706712(ugt8.S) 108710441(ugt8.L)
BGAR : 122946095 122946158
MUO : 115462257 115462725(UGT8)
SANH : 107656191 107702381
SGH : 107548345(ugt8) 107591551
CCAR : 109045590 109058520(ugt8) 109105396
CAUA : 113044224 113106881
CGIB : 127949701 127960912
MASI : 127444375 127444494
PFOR : 103137882(ugt8) 103137940
PLAI : 106943362 106947345(ugt8)
PMEI : 106923498 106928604(ugt8)
STRU : 115184006 115184007
OKE : 127926863 127927878(ugt8)
CCLU : 121562104(ugt8) 121563379
PSPA : 121295410 121322782
PSEX : 120533017(ugt8) 120538937
LCM : 102350700 102364207(UGT8)
CMK : 103181594 103188741(ugt8) 121851509
RTP : 109916958 125483505(ugt8)
CPLA : 122541891 122553344(ugt8)
HOC : 132820409(ugt8) 132834939
LERI : 129700342(ugt8) 129712892
APLC : 110976680 110983599 110983924
ARUN : 117298736 117301574 117301724
SKO : 100369397 100369825 100369971 100370117 100376206 100377334 100377471 100377621 102800741 102801407 102802771 102802804 102802916 102809864
DSI : Dsimw501_GD10375(Dsim_GD10375)
HAZT : 108673810 108673814
HRO : HELRODRAFT_177639 HELRODRAFT_186053
PMAX : 117314629 117344882
LAK : 106160069 106160895 106164760 106177649 112041410
LLON : 135483170 135487876 135488784 135489995 135489996 135489997 135489998 135490915 135492325 135492449 135499602 135500205 135500322 135500323
EPA : 110231822 110231830 110242043 110243724
AMIL : 114961539 114967941
TAD : TRIADDRAFT_22477 TRIADDRAFT_23179 TRIADDRAFT_2420 TRIADDRAFT_2560 TRIADDRAFT_3259 TRIADDRAFT_33822 TRIADDRAFT_53582 TRIADDRAFT_57718 TRIADDRAFT_62077 TRIADDRAFT_62078 TRIADDRAFT_62405
MNG : MNEG_2496 MNEG_4536 MNEG_4537 MNEG_7078
» show all
Taxonomy
Reference
Authors
Fujino Y, Nakano M.
Title
Enzymic synthesis of cerebroside from ceramide and uridine diphosphate galactose.
Journal
Reference
Authors
Morell P, Radin NS.
Title
Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid.
Journal
Reference
Authors
Morell P, Costantino-Ceccarini E, Radin NS
Title
The biosynthesis by brain microsomes of cerebrosides containing nonhydroxy fatty acids.
Journal
Reference
Authors
Basu S, Schultz AM, Basu M, Roseman S.
Title
Enzymatic synthesis of galactocerebroside by a galactosyltransferase from embryonic chicken brain.
Journal
J Biol Chem 246:4272-9 (1971)
Reference
Authors
Akanuma H, Kishimoto Y
Title
Synthesis of ceramides and cerebrosides containing both alpha-hydroxy and nonhydroxy fatty acids from lignoceroyl-CoA by rat brain microsomes.
Journal
J Biol Chem 254:1050-60 (1979)
Reference
Authors
Koul O, Jungalwala FB
Title
UDP-galactose:ceramide galactosyltransferase of rat central-nervous-system myelin.
Journal
Reference
Authors
Schulte S, Stoffel W
Title
Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression.
Journal
Sequence
Reference
Authors
Sprong H, Kruithof B, Leijendekker R, Slot JW, van Meer G, van der Sluijs P
Title
UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum.
Journal
Reference
Authors
Fewou SN, Bussow H, Schaeren-Wiemers N, Vanier MT, Macklin WB, Gieselmann V, Eckhardt M
Title
Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.47
ExPASy - ENZYME nomenclature database: 2.4.1.47
LinkDB
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