KEGG   ENZYME: 2.4.1.47
Entry
EC 2.4.1.47                 Enzyme                                 
Name
N-acylsphingosine galactosyltransferase;
UGT8 (gene name);
CGT (gene name);
UDP galactose-N-acylsphingosine galactosyltransferase;
uridine diphosphogalactose-acylsphingosine galactosyltransferase;
UDP-galactose:N-acylsphingosine D-galactosyltransferase;
UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase;
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:N-acylsphingosine beta-D-galactosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + a ceramide = UDP + a beta-D-galactosylceramide [RN:R01500 R06277]
Reaction(KEGG)
R01500 R06277(G) > R04322;
(other) R10804
Substrate
UDP-alpha-D-galactose [CPD:C00052];
ceramide [CPD:C00195]
Product
UDP [CPD:C00015];
beta-D-galactosylceramide
Comment
This membrane-bound, endoplasmic reticulum-located enzyme catalyses the last step in the synthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. It has a strong preference for ceramides that contain hydroxylated fatty acids.
History
EC 2.4.1.47 created 1972
Pathway
ec00565  Ether lipid metabolism
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04628  ceramide galactosyltransferase
Genes
HSA7368(UGT8)
PTR461446(UGT8)
PPS100985864(UGT8)
GGO101137553(UGT8)
PON100437492(UGT8)
NLE100607960(UGT8)
MCC702979(UGT8)
MCF102126400(UGT8)
CSAB103236153(UGT8)
CATY105571468(UGT8)
PANU101011998(UGT8)
TGE112624639(UGT8)
RRO104675972(UGT8)
RBB108527094(UGT8)
TFN117085818(UGT8)
PTEH111547934(UGT8)
CJC100396627(UGT8)
SBQ101036737(UGT8)
CSYR103261614(UGT8)
MMUR105879492(UGT8)
OGA100958105(UGT8)
MMU22239(Ugt8a)
MCAL110291396(Ugt8)
MPAH110320435(Ugt8)
RNO50555(Ugt8)
MCOC116093746(Ugt8)
MUN110554355
CGE100772408
PLEU114684609(Ugt8)
NGI103731259(Ugt8)
HGL101702896(Ugt8)
CPOC100718939(Ugt8)
CCAN109677276(Ugt8)
DORD105991238(Ugt8)
DSP122123194(Ugt8)
NCAR124994017
OCU100341450(UGT8)
OPI101523880(UGT8)
TUP102480796(UGT8)
CFA487910(UGT8)
VVP112930967(UGT8)
VLG121493881(UGT8)
AML100465291(UGT8)
UMR103661766(UGT8)
UAH113255592(UGT8)
UAR123793338(UGT8)
ELK111156987
LLV125093308
MPUF101693531(UGT8)
ORO101383800(UGT8)
EJU114203048 114203049 114222677(UGT8)
ZCA113924512(UGT8)
MLX118027111(UGT8)
FCA101097722(UGT8)
PYU121030616(UGT8)
PBG122476845(UGT8)
PTG102965984(UGT8)
PPAD109248503(UGT8)
AJU106977315(UGT8)
HHV120225123(UGT8)
BTA281566(UGT8)
BOM102269259(UGT8)
BIU109560234(UGT8)
BBUB102409846(UGT8)
CHX102174638(UGT8)
OAS101113069(UGT8)
ODA120861700(UGT8)
CCAD122422350(UGT8)
SSC100511825(UGT8)
CFR102522568(UGT8)
CBAI105067140(UGT8)
CDK105089918(UGT8)
VPC102525011(UGT8)
BACU103004850(UGT8)
LVE103073438(UGT8)
OOR101289765(UGT8)
DLE111186063(UGT8)
PCAD102993924(UGT8)
PSIU116754771(UGT8)
ECB100072587(UGT8)
EPZ103557103(UGT8)
EAI106842868(UGT8)
MYB102252842(UGT8)
MMYO118652966(UGT8)
MLF102442855(UGT8)
MNA107527850(UGT8)
PKL118726050(UGT8)
HAI109390271(UGT8)
DRO112312608(UGT8)
SHON118980012(UGT8)
AJM119037686(UGT8)
PDIC114503128(UGT8)
PHAS123814153(UGT8)
MMF118616083(UGT8)
RFQ117038197(UGT8)
PALE102881397(UGT8)
PGIG120589341(UGT8)
PVP105309073
RAY107510863(UGT8)
MJV108409879(UGT8)
TOD119242760(UGT8)
SARA101551134(UGT8)
LAV100665032(UGT8)
TMU101352658
DNM101410626(UGT8)
MDO100010696(UGT8)
GAS123253133(UGT8)
SHR100927545(UGT8)
PCW110218601(UGT8)
OAA100076336(UGT8)
GGA374033(UGT8) 428949(UGT8L)
PCOC116231252(UGT8) 116234480
MGP100539821 100541199(UGT8)
CJO107313583(UGT8) 107315928
NMEL110399157(UGT8) 110400413
APLA101794817 101799126(UGT8)
ACYG106029878 106038627(UGT8)
AFUL116489127(UGT8) 116491423
TGU100228968 100231902(UGT8)
LSR110471176(UGT8) 110480032
SCAN103813974 103815551(UGT8)
PMOA120502064 120502813(UGT8)
OTC121331975(UGT8) 121341851
PRUF121349178(UGT8) 121350254
GFR102031520(UGT8) 102040819
FAB101807254 101809664(UGT8)
PHI102107687(UGT8) 102108262
PMAJ107203102(UGT8) 107206597
CCAE111928999(UGT8) 111931100
CCW104696845(UGT8) 104697059
ETL114054721 114068337(UGT8)
ZAB102062618(UGT8) 102066639
FPG101914948(UGT8) 101924669
FCH102047748 102051681(UGT8)
CLV102089904(UGT8) 102097199
EGZ104127441 104129123 104135946
NNI104019136(UGT8) 104019447
ACUN113479767(UGT8) 113481588
TALA104362911 104366712(UGT8)
PADL103915563 103926098(UGT8)
ACHC115344526(UGT8) 115348607
AAM106492128(UGT8) 106498896
AROW112967517 112974891 112977284
NPD112943430(UGT8) 112957115
DNE112980201 112986157(UGT8)
ASN102382334(UGT8) 102384980
AMJ102574992 106737104(UGT8)
CPOO109309361(UGT8) 109324295
GGN109287412 109301099(UGT8)
PSS102457655 102462979
CMY102936934(UGT8) 102941238
CPIC101945157 101952125(UGT8)
TST117877789(UGT8) 117881007
CABI116823594 116825360(UGT8)
MRV120406330(UGT8) 120408926
ACS100551810(ugt8)
PVT110083901(UGT8)
SUND121930338(UGT8)
PBI103055483(UGT8)
PMUR107296372(UGT8)
TSR106556413(UGT8)
PGUT117679964(UGT8)
VKO123022823(UGT8)
PMUA114597016 114604195 114604507
ZVI118083636(UGT8) 118096504
GJA107110289(UGT8) 107122753
STOW125440230(UGT8)
XLA108706712(ugt8.S) 108710441(ugt8.L)
XTR779534(ugt8)
NPR108792209(UGT8)
RTEM120918452(UGT8)
BBUF120989896(UGT8)
BGAR122946095 122946158
DRE553508(ugt8)
SRX107745064 107750420
SANH107656191 107702381
SGH107548345(ugt8) 107591551
CCAR109045590 109058520(ugt8) 109105396
CAUA113044224 113106881
PPRM120493749(ugt8)
MAMB125272607(ugt8)
IPU108260842(ugt8)
PHYP113544363(ugt8)
SMEO124381495(ugt8)
TFD113660716(ugt8)
AMEX103043793(ugt8)
EEE113586472(ugt8)
TRU101064956(ugt8)
TNGGSTEN00007473G001
LCO104929353(ugt8)
NCC104955311(ugt8)
CGOB115012015(ugt8)
ELY117255548(ugt8)
PLEP121942478(ugt8)
SLUC116052239(ugt8)
ECRA117959889(ugt8)
PFLV114546530(ugt8)
GAT120825483(ugt8)
PPUG119218134(ugt8)
MSAM119899023(ugt8)
CUD121509021(ugt8)
MZE101473219(ugt8)
ONL100696128(ugt8)
OAU116329078(ugt8)
OLA101156303(ugt8)
OML112157358(ugt8)
XMA102221616(ugt8)
XCO114144945(ugt8)
XHE116720325(ugt8)
PRET103467322(ugt8)
PFOR103137882(ugt8) 103137940
PLAI106943362 106947345(ugt8)
PMEI106923498 106928604(ugt8)
GAF122829438(ugt8)
CVG107085760(ugt8)
CTUL119772592(ugt8)
GMU124868442(ugt8)
NFU107375211(ugt8)
KMR108231012(ugt8)
ALIM106517139(ugt8)
NWH119408100(ugt8)
AOCE111568569(ugt8)
CSEM103383812(ugt8)
POV109637829(ugt8)
SSEN122771324(ugt8)
HHIP117763218(ugt8)
LCF108896622(ugt8)
SDU111231488(ugt8)
SLAL111664066(ugt8)
XGL120799673(ugt8)
HCQ109519902(ugt8)
BPEC110165331(ugt8)
MALB109961392(ugt8)
OTW121844288
OMY110512130 110516863
OGO124021864
ELS105009093(ugt8)
SFM108924325(ugt8)
PKI111837341(ugt8)
AANG118227920(ugt8)
LOC102684913(ugt8)
PSPA121295410 121322782
ARUT117409393
LCM102350700 102364207(UGT8)
CMK103181594 103188741(ugt8) 121851509
RTP109916958 109928089
BFO118417462
BBEL109473946
APLC110976680 110983599 110983924
SKO100369397 100369825 100369971 100370117 100376206 100377334 100377471 100377621 102800741 102801407 102802771 102802804 102802916 102809864
DER6541458
DSIDsimw501_GD10375(Dsim_GD10375)
DPODpse_GA24594
DPE6590768
DMN108160067
DMODmoj_GI11922
DAZ108614624
DNV108651678
DHE111605641
MDE101892333
AME411298
BIM100744553
OBB114872868
ACEP105619733
CFO105255889
LHU105673022
PGC109853431
OBO105284682
BMOR100862844(UGT50A1)
BMAN114244370
PMAC106719871
ZCE119832801
TNL113504541
SLIU111354804
BTAB109038550
FCD110844391
DPXDAPPUDRAFT_49730
HAZT108673810 108673814
HROHELRODRAFT_177639 HELRODRAFT_186053 HELRODRAFT_85113
HRF124124286 124125061
HRJ124272888
PMAX117314629 117344882
OBI106870503
LAK106160069 106160895 106164760 106177649 112041410
EPA110231822 110231830 110242043 110243724
ATEN116308303
ADF107331984 107342096
AMIL114961539 114967941
PDAM113676364
TADTRIADDRAFT_22477 TRIADDRAFT_23179 TRIADDRAFT_2420 TRIADDRAFT_2560 TRIADDRAFT_3259 TRIADDRAFT_33822 TRIADDRAFT_53582 TRIADDRAFT_57718 TRIADDRAFT_62077 TRIADDRAFT_62078 TRIADDRAFT_62405
AQU105315706 109581221
MNGMNEG_2496 MNEG_4536 MNEG_4537 MNEG_7078
CSLCOCSUDRAFT_47003
CVRCHLNCDRAFT_140490
APROF751_1121
PPEIPpBr36_04956
SREPTSG_05600
PIFPITG_05764
PSOJPHYSODRAFT_517093
 » show all
Reference
1  [PMID:5807218]
  Authors
Fujino Y, Nakano M.
  Title
Enzymic synthesis of cerebroside from ceramide and uridine diphosphate galactose.
  Journal
Biochem J 113:573-5 (1969)
DOI:10.1042/bj1130573
Reference
2  [PMID:5793706]
  Authors
Morell P, Radin NS.
  Title
Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid.
  Journal
Biochemistry 8:506-12 (1969)
DOI:10.1021/bi00830a008
Reference
3  [PMID:5497154]
  Authors
Morell P, Costantino-Ceccarini E, Radin NS
  Title
The biosynthesis by brain microsomes of cerebrosides containing nonhydroxy fatty  acids.
  Journal
Arch Biochem Biophys 141:738-48 (1970)
DOI:10.1016/0003-9861(70)90192-X
Reference
4  [PMID:5090043]
  Authors
Basu S, Schultz AM, Basu M, Roseman S.
  Title
Enzymatic synthesis of galactocerebroside by a galactosyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 246:4272-9 (1971)
Reference
5  [PMID:762114]
  Authors
Akanuma H, Kishimoto Y
  Title
Synthesis of ceramides and cerebrosides containing both alpha-hydroxy and nonhydroxy fatty acids from lignoceroyl-CoA by rat brain microsomes.
  Journal
J Biol Chem 254:1050-60 (1979)
Reference
6  [PMID:7306007]
  Authors
Koul O, Jungalwala FB
  Title
UDP-galactose:ceramide galactosyltransferase of rat central-nervous-system myelin.
  Journal
Biochem J 194:633-7 (1981)
DOI:10.1042/bj1940633
Reference
7  [PMID:7694285]
  Authors
Schulte S, Stoffel W
  Title
Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression.
  Journal
Proc Natl Acad Sci U S A 90:10265-9 (1993)
DOI:10.1073/pnas.90.21.10265
  Sequence
[rno:50555]
Reference
8  [PMID:9748263]
  Authors
Sprong H, Kruithof B, Leijendekker R, Slot JW, van Meer G, van der Sluijs P
  Title
UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum.
  Journal
J Biol Chem 273:25880-8 (1998)
DOI:10.1074/jbc.273.40.25880
Reference
9  [PMID:15998297]
  Authors
Fewou SN, Bussow H, Schaeren-Wiemers N, Vanier MT, Macklin WB, Gieselmann V, Eckhardt M
  Title
Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase.
  Journal
J Neurochem 94:469-81 (2005)
DOI:10.1111/j.1471-4159.2005.03221.x
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.47
IUBMB Enzyme Nomenclature: 2.4.1.47
ExPASy - ENZYME nomenclature database: 2.4.1.47
BRENDA, the Enzyme Database: 2.4.1.47
CAS: 37277-56-8
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