KEGG   ENZYME: 2.4.1.60
Entry
EC 2.4.1.60                 Enzyme                                 
Name
CDP-abequose:alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase;
wbaV (gene name);
rfbV (gene name);
trihexose diphospholipid abequosyltransferase;
abequosyltransferase (ambiguous);
CDP-alpha-D-abequose:Man(alpha1->4)Rha(alpha1->3)Gal(beta-1)-diphospholipid D-abequosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
CDP-alpha-D-abequose:alpha-D-mannopyranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 3III-alpha-abequosyltransferase (configuration retaining)
Reaction(IUBMB)
CDP-alpha-D-abequose + alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und = CDP + alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und [RN:R04581]
Reaction(KEGG)
R04581
Substrate
CDP-alpha-D-abequose [CPD:C01788];
alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und [CPD:C04724]
Product
CDP [CPD:C00112];
alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und [CPD:C04808]
Comment
The enzyme from Salmonella participates in the biosynthesis of the repeat unit of O antigens produced by strains that belong to the A, B and D1-D3 groups. The enzyme is able to transfer abequose, paratose, or tyvelose, depending on the availability of the specific dideoxyhexose in a particular strain.
History
EC 2.4.1.60 created 1972, modified 2012, modified 2021
Orthology
K13005  O-antigen biosynthesis alpha-1,3-abequosyltransferase
Genes
STYSTY2296(rfbV)
STTt0786(rfbV)
SEXSTBHUCCB_8380
SENTTY21A_03985
STMSTM2087(rfbV)
SEOSTM14_2581(rfbV)
SEVSTMMW_21181
SEYSL1344_2064(rfbV)
SEMSTMDT12_C21090
SEJSTMUK_2117(rfbV)
SEBSTM474_2172(rfbV)
SEFUMN798_2255(rfbV)
SETUSTU288_06820
SETCCFSAN001921_06345
SENRSTMDT2_20611(rfbV)
SENDDT104_21461(rfbV)
SENICY43_11260
SEENSE451236_16645
SPTSPA0780(rfbV) SPA0782(rfbV) SPA0784(rfbV)
SEKSSPA0734
SPQSPAB_00943
SEHSeHA_C2313
SHBSU5_02681
SENHCFSAN002069_21385
SEEHSEEH1578_19715
SEWSeSA_A2320
SEASeAg_B2212
SENSQ786_10305
SEDSeD_A2426
SEGSG2117(rfbV)
SELSPUL_0811(rfbV)
SEGASPUCDC_0811(rfbV)
SETSEN2085A(rfbV)
SENAAU38_10525
SENOAU37_10535
SENVAU39_10535
SENQAU40_11790
SENLIY59_10820
SENJCFSAN001992_00995
SEEPI137_03645
KIENCTC12125_00630
YPQDJ40_1354
YPRBZ20_1041
YENYE3083(wbcC)
YEWCH47_2458
SERASer39006_021565
SERQCWC46_21575
PAKHB0X70_24670
PLUICE143_24710
XBUHGO23_18955
POLBpro_3993
JABVN23_20265
IDCLRM40_13110
NIMW01_22130(wbcC)
SEMEMIZ01_2639
NIVJY500_12240
HYONNO_0326
GEFFO488_01040 FO488_03040
GEOGeob_2130
GBMGbem_0854
MROSEHO51_05130
SLUTH9L13_06530
FTJFTUN_8108
PCORKS4_00810(rfbV)
EPOEpro_0326(rfbV)
MUHHYN43_018200
PMXPERMA_1998
MAEMaeo_0390
 » show all
Reference
1  [PMID:4297268]
  Authors
Osborn MJ, Weiner IM.
  Title
Biosynthesis of a bacterial lipopolysaccharide. VI. Mechanism of incorporation of abequose into the O-antigen of Salmonella typhimurium.
  Journal
J Biol Chem 243:2631-9 (1968)
  Sequence
[stm:STM2087]
Reference
2  [PMID:7541787]
  Authors
Liu D, Lindqvist L, Reeves PR
  Title
Transferases of O-antigen biosynthesis in Salmonella enterica: dideoxyhexosyltransferases of groups B and C2 and acetyltransferase of group C2.
  Journal
J Bacteriol 177:4084-8 (1995)
DOI:10.1128/JB.177.14.4084-4088.1995
  Sequence
[stm:STM2087]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.60
IUBMB Enzyme Nomenclature: 2.4.1.60
ExPASy - ENZYME nomenclature database: 2.4.1.60
BRENDA, the Enzyme Database: 2.4.1.60
CAS: 37277-67-1
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