Entry
Name
ganglioside galactosyltransferase;
UDP-galactose---ceramide galactosyltransferase;
uridine diphosphogalactose-ceramide galactosyltransferase;
UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase;
UDP-galactose-GM2 galactosyltransferase;
uridine diphosphogalactose-GM2 galactosyltransferase;
uridine diphosphate D-galactose:glycolipid galactosyltransferase;
UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase;
UDP-galactose-GM2 ganglioside galactosyltransferase;
GM1-synthase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:
R04631 R05941 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:
C00052 ];
N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:
C00015 ];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
The substrate is also known as gangloside GM2, the product as gangloside GM1a
History
EC 2.4.1.62 created 1972, modified 2013
Pathway
ec00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
ec00604 Glycosphingolipid biosynthesis - ganglio series
Orthology
K00715 ganglioside galactosyltransferase
K02175 beta-1,3-galactosyltransferase / beta-1,3-N-acetylglucosaminyltransferase
Genes
SHR : 100932392 105750445(B3GALT4)
ACS : 103280835 103280836 103281647
ASAO : 132766300(B3GALT4) 132766301 132766303 132780113
CTIG : 120318402 120318403
PCAE : 139309770 139311708
APRI : 131192785 131192788 131192789 131192792
PTEX : 113450372 113452891 113455095
PRAF : 128409556(B3GALT4) 128409557
STOW : 125424808 125424812
XLA : 108698545(b3galt4.L)
ACAT : 141107463 141107465 141107466
CCAR : 109078053 109078403(b3galt4)
BPEC : 110156371 110158064(b3galt4)
STRU : 115166337 115168435(b3galt4)
OTW : 112215736 112222246(b3galt4)
OMY : 110492437(b3galt4) 110531971
OKE : 118361425 118370697(b3galt4)
OMM : 135504702 135527953(b3galt4)
OCLA : 139368815 139417211
SALP : 111966177 111977194
SNH : 120058757 120061656(b3galt4)
CCLU : 121537296 121545378(b3galt4)
SCLV : 120330808 120332862
DSI : Dsimw501_GD16669(Dsim_GD16669)
AALB : 109411046 115256312
ASUA : 134203214 134219275
CSET : 123317488 123317489
HAXR : 123682916 123682917
APLN : 108733038 112904194
MCIX : 123656879 123665532
PRAP : 110996374 110997620 110998479
LSIN : 126969642 126969804
SLIU : 111351040 111359277 111359853
FCD : 110845485 110846305 110856195 110862185
DMK : 116922454 123471529 123471540
PCHN : 125032776 125042967
PTRU : 123503416 123515942
PPOI : 119108919 119108920 119108923
DSV : 119432928 119448348 119455931
RSAN : 119378880 119404949
RMP : 119162043 119162045 119172723 119187537
VDE : 111247359 111249037 111249712 111252487
VJA : 111263934 111266965 111273729
CBR : CBG_06216(Cbr-bre-5)
BMY : BM_BM5757(Bma-bre-5)
CRG : 105322782 105331369 105332568 105334278 109620855 117684906 117692837
CANU : 128167023 128167578 128168344 128174851 128176387 128184818 128189687 128189818 128190103
CVN : 111118220 111134324 111135186
OED : 125648428 125651108 125655361 125655380 125665301 125669998 125671241 125683699
MYI : 110440246 110440864 110443682 110443698 110444412 110445052 110445909 110449420 110449421 110451039 110451742 110451752 110451782 110452065 110452229 110452234 110452238 110453247 110453258 110456350 110456822 110457161 110457668 110457671 110458134 110459672 110461148 110461707 110464579
PMAX : 117314790 117315091 117315382 117315401 117315822 117317336 117319939 117321246 117322795 117323873 117325181 117325182 117325183 117326096 117329749 117332397 117332555 117332783 117337888 117339598 117339809 117340743 117342078 117342795
AIRR : 138306137 138306195 138306217 138306276 138306292 138306625 138306687 138306953 138307092 138307212 138307290 138307367 138307619 138307646 138307722 138307774 138307854 138308215 138309849 138310507 138310541 138310970 138315135 138315206 138317203 138317601 138319927 138320029 138320905 138323024 138324430 138325743 138326078 138326281 138326282 138326283 138326326 138326328 138326329 138326330 138326332 138328464 138328465 138328467 138328468 138330768 138330855 138330856 138331238 138332324 138334548 138335199 138335271
SMM : Smp_014260 Smp_014280 Smp_151210
SHX : MS3_00007254(B3GALT1_3) MS3_00007265
OVI : T265_07747 T265_08677 T265_14897
LLON : 135498597 135498632 135501690 135503124
» show all
Taxonomy
Reference
Authors
Basu S, Kaufman B, Roseman S.
Title
Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase.
Journal
J Biol Chem 240:4115-7 (1965)
Reference
Authors
Yip GB, Dain JA.
Title
The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain.
Journal
Reference
Authors
Yip MC, Dain JA.
Title
Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceram ide galactosyltransferase.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.62
ExPASy - ENZYME nomenclature database: 2.4.1.62
LinkDB
All DBs