KEGG ENZYME: 2.4.1.62

ENZYME: 2.4.1.62

Entry

EC 2.4.1.62                 Enzyme

Name

ganglioside galactosyltransferase;
UDP-galactose---ceramide galactosyltransferase;
uridine diphosphogalactose-ceramide galactosyltransferase;
UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase;
UDP-galactose-GM2 galactosyltransferase;
uridine diphosphogalactose-GM2 galactosyltransferase;
uridine diphosphate D-galactose:glycolipid galactosyltransferase;
UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase;
UDP-galactose-GM2 ganglioside galactosyltransferase;
GM1-synthase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine 3-beta-D-galactosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-galactose:N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase

Reaction(IUBMB)

UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04631 R05941]

Reaction(KEGG)

R04631 R05941(G);
(other) R05110 R05111 R05948(G) R05953(G) R05956(G)

Substrate

UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Product

UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Comment

The substrate is also known as gangloside GM2, the product as gangloside GM1a

History

EC 2.4.1.62 created 1972, modified 2013

Pathway

ec00604

Glycosphingolipid biosynthesis - ganglio series

ec01100

Metabolic pathways

Orthology

K00715

ganglioside galactosyltransferase

K02175

beta-1,3-galactosyltransferase / beta-1,3-N-acetylglucosaminyltransferase

Genes

HSA:	8705(B3GALT4)

PTR:	746800(B3GALT4)

PPS:	100990558(B3GALT4)

GGO:	101147230(B3GALT4)

PON:	100431810(B3GALT4)

NLE:	100581961(B3GALT4)

MCC:	718178(B3GALT4)

MCF:	101867339(B3GALT4)

MTHB:

126952774

CSAB:

103221668(B3GALT4)

CATY:

105593488(B3GALT4)

PANU:

101023708(B3GALT4)

TGE:	112623234(B3GALT4)

RRO:	104657975(B3GALT4)

RBB:	108540279(B3GALT4)

TFN:	117087042(B3GALT4)

PTEH:

111542919(B3GALT4)

CANG:

105514228(B3GALT4)

CJC:	100386867(B3GALT4)

SBQ:	101045208(B3GALT4)

CSYR:

103262599(B3GALT4)

MMUR:

105886003(B3GALT4)

LCAT:

123631830(B3GALT4)

PCOQ:

105821666(B3GALT4)

OGA:	100964044(B3GALT4)

MMU:	54218(B3galt4)

MCAL:

110284218(B3galt4)

MPAH:

110335875(B3galt4)

RNO:	171079(B3galt4)

MCOC:

116074540(B3galt4)

MUN:	110543490(B3galt4)

CGE:	100751197(B3galt4)

MAUA:

101834936(B3galt4)

PLEU:

114706130(B3galt4)

MORG:

121435266(B3galt4)

MFOT:

126499731

AAMP:

119823302(B3galt4)

NGI:	103739707(B3galt4)

HGL:	101722054(B3galt4)

CPOC:

100731582(B3galt4)

CCAN:

109686699(B3galt4)

DORD:

105999846(B3galt4)

DSP:	122111356(B3galt4)

NCAR:

124989520

OCU:

100353929

OPI:	101534884(B3GALT4)

TUP:	102493328(B3GALT4)

GVR:	103597944(B3GALT4)

CFA:	481737(B3GALT4)

CLUD:

112641398(B3GALT4)

VVP:	112913882(B3GALT4)

VLG:	121498347(B3GALT4)

AML:	100474436(B3GALT4)

UMR:	103665497(B3GALT4)

UAH:	113243802(B3GALT4)

UAR:	123790926(B3GALT4)

ELK:

111152171

LLV:

125102664

MPUF:

101682074(B3GALT4)

ORO:	101375875(B3GALT4)

EJU:	114222148(B3GALT4)

ZCA:	113927263(B3GALT4)

MLX:	118001290(B3GALT4)

NSU:	110575576(B3GALT4)

LWW:	102728743(B3GALT4)

FCA:	101087480 111556175(B3GALT4)

PYU:	121029280(B3GALT4)

PBG:	122489398(B3GALT4)

LRUF:

124528317

PTG:	102968511(B3GALT4)

PPAD:

109271436(B3GALT4)

AJU:	106976084(B3GALT4)

HHV:	120238195(B3GALT4)

BTA:	768038(B3GALT4)

BOM:	102287503(B3GALT4)

BIU:	109576550(B3GALT4)

BBUB:

102398556(B3GALT4)

BBIS:

104994994(B3GALT4)

CHX:	102182551(B3GALT4)

OAS:	101111585(B3GALT4)

ODA:	120869846(B3GALT4)

CCAD:

122429442(B3GALT4)

SSC:	100155431(B3GALT4)

CFR:	102504152(B3GALT4)

CBAI:

105064226(B3GALT4)

CDK:	105101388(B3GALT4)

VPC:	102532667(B3GALT4)

BACU:

103004913(B3GALT4)

LVE:	103073598(B3GALT4)

OOR:	101285679(B3GALT4)

DLE:	111178678(B3GALT4)

PCAD:

102984198(B3GALT4)

PSIU:

116762685(B3GALT4)

ECB:	100052704(B3GALT4)

EPZ:	103567107(B3GALT4)

EAI:	106834597(B3GALT4)

MYB:	102253194(B3GALT4)

MYD:	102766372(B3GALT4)

MMYO:

118679522(B3GALT4)

MLF:	102437857(B3GALT4)

MNA:	107541603(B3GALT4)

PKL:	118705663(B3GALT4)

HAI:	109392428(B3GALT4)

DRO:	112302286(B3GALT4)

SHON:

118991483(B3GALT4)

AJM:	119041188(B3GALT4)

PDIC:

114495132(B3GALT4)

PHAS:

123815910(B3GALT4)

MMF:	118621058(B3GALT4)

RFQ:	117018064(B3GALT4)

PALE:

102882787(B3GALT4)

PGIG:

120597652(B3GALT4)

PVP:	105300984(B3GALT4)

RAY:	107511980(B3GALT4)

MJV:	108396197(B3GALT4)

TOD:	119252336(B3GALT4)

SARA:

101557558(B3GALT4)

LAV:	100662423(B3GALT4)

TMU:

101340682

ETF:	101653267(B3GALT4)

DNM:	101447995(B3GALT4)

MDO:	100618101(B3GALT4)

GAS:	123244584(B3GALT4)

SHR:	100932392 105750445(B3GALT4)

PCW:	110217176(B3GALT4)

OAA:	114807618(B3GALT4)

PCOC:

116241646

OTC:

121347883

PHI:

102110936

ETL:

114073638

ACHC:

115338495(B3GALT4)

HLE:	104833328(B3GALT4)

AROW:

112963739(B3GALT4)

ASN:	102386365(B3GALT4)

AMJ:	106737709(B3GALT4)

CMY:	114021730(B3GALT4)

CPIC:

101953116(B3GALT4)

CABI:

116829512(B3GALT4)

MRV:	120394906(B3GALT4)

ACS:	103280835 103280836 103281647

PVT:	110091025(B3GALT4)

SUND:

121921237(B3GALT4)

PBI:

112543393

PMUR:

107299593

CTIG:

120318402 120318403

TSR:	106551469 106551472

PGUT:

117673480 117673484

VKO:	123022486(B3GALT4)

ZVI:	118078050 118078811

GJA:	107115678(B3GALT4)

STOW:

125424808 125424812

XLA:	108698545(b3galt4.L)

XTR:	100489366(b3galt4)

NPR:	108788356(B3GALT4)

RTEM:

120914313(B3GALT4)

BBUF:

121009481(B3GALT4)

BGAR:

122919701(B3GALT4)

DRE:	101883911 101886595(b3galt4)

SRX:

107706538

SANH:

107667941

SGH:

107549558

CCAR:

109078046 109078053 109078403

CAUA:

113107881

PPRM:

120481244(b3galt4)

MAMB:

125280481(b3galt4)

IPU:	108265547(b3galt4)

PHYP:

113533653(b3galt4)

SMEO:

124400434(b3galt4)

TFD:	113656030(b3galt4)

AMEX:

103044102

EEE:	113584319(b3galt4)

TRU:	101065804(b3galt4)

TNG:	GSTEN00033258G001

LCO:	104938595(b3galt4)

NCC:

104957801

CGOB:

115010910

ELY:	117257944(b3galt4)

EFO:	125891516(b3galt4)

PLEP:

121947253(b3galt4)

SLUC:

116062207(b3galt4)

ECRA:

117948189(b3galt4)

PFLV:

114559268

GAT:	120829380(b3galt4)

PPUG:

119222017(b3galt4)

MSAM:

119905345(b3galt4)

CUD:	121517185(b3galt4)

ALAT:

119022167(b3galt4)

MZE:	101480560(b3galt4)

ONL:

102079080

OAU:	116331206(b3galt4)

OLA:	101168709(b3galt4)

OML:	112159750(b3galt4)

XMA:

102221914

XCO:

114144870

XHE:

116728650

PRET:

103467526(b3galt4)

PFOR:

103145033

PLAI:

106934922

PMEI:

106905585

GAF:	122834805(b3galt4)

CVG:

107090384

CTUL:

119774046(b3galt4)

GMU:	124876018(b3galt4)

NFU:	107391227(b3galt4)

KMR:	108231973(b3galt4)

ALIM:

106522851

NWH:	119416772(b3galt4)

AOCE:

111570403(b3galt4)

MCEP:

125006590(b3galt4)

CSEM:

103385519

POV:	109635031(b3galt4)

SSEN:

122776599(b3galt4)

HHIP:

117764937(b3galt4)

HSP:	118111246(b3galt4)

LCF:

108898093

SDU:

111217361

SLAL:

111667144

XGL:	120804126(b3galt4)

HCQ:

109528392

BPEC:

110156371 110158064(b3galt4)

MALB:

109966040(b3galt4)

BSPL:

114858315(b3galt4)

SASA:

106571873

STRU:

115166337 115168435(b3galt4)

OTW:	112215736 112222246(b3galt4)

OMY:	110492437(b3galt4) 110531971

OGO:	124045667(b3galt4)

ONE:	115101626 115131850

SALP:

111966177 111977194

SNH:	120058757 120061656(b3galt4)

CCLU:

121537296 121545378(b3galt4)

ELS:	105024940(b3galt4)

SFM:

108940259

PKI:	111847794(b3galt4)

AANG:

118208491(b3galt4)

PSPA:

121304341(b3galt4)

ARUT:

117434196

CIN:	100186979 101242046

SCLV:

120330808 120332756 120332862 120346279

DME:	Dmel_CG4934(brn)

DER:

6550969

DSE:

6612539

DSI:	Dsimw501_GD16669(Dsim_GD16669)

DYA:	Dyak_GE16330

DAN:

6503467

DSR:

110183066

DPO:

4815306

DPE:

6602768

DMN:

108164862

DWI:

6653050

DGR:

6566045

DMO:	Dmoj_GI16397

DAZ:

108618591

DNV:

115564488

DHE:

111593000

DVI:

6633706

CCAT:

101462189

BOD:

106617507

RZE:

108354177

MDE:	101894401 101894886

SCAC:

106083036

LCQ:

111688695

LSQ:

119604076

AGA:	AgaP_AGAP002097

ACOZ:

120950790

AARA:

120895926

ASTE:

118504340

AAG:

5576338

AALB:

109411046 115256312

CQU:	CpipJ_CPIJ018702

CPII:

120417065

CNS:

116345449

BCOO:

119072048 119080657

AME:

551589

ACER:

108001212

ALAB:

122710430

BIM:

100749675

BBIF:

117209512

BVK:

117234434

BVAN:

117158415

BTER:

100648600

BPYO:

122571423

CCAL:

108627205

OBB:

114878178

MGEN:

117223432

NMEA:

116426077

CGIG:

122402555

SOC:

105203637

MPHA:

105835019

AEC:

105143285

ACEP:

105623352

PBAR:

105432777

VEM:

105560864

HST:

105184588

DQU:

106744767

CFO:

105250101

FEX:

115241693

LHU:

105678723

PGC:

109859477

OBO:

105278266

PCF:

106791384

PFUC:

122523580

VPS:

122629979

NVI:

100679450

CSOL:

105367310

TPRE:

106660382

MDL:

103572997

CGLO:

123269520

FAS:

105265973

DAM:

107041937

AGIF:

122852204

CCIN:

107272322

TCA:

661418

DPA:

109543621

SOY:

115891535

ATD:

109594188

CSET:

123317488 123317489

AGB:

108907869

LDC:

111514425

NVL:

108568068

APLN:

108733038 112904194

PPYR:

116168189

OTU:	111427886 111427954

BMOR:

733133(Bm_Bre5)

BMAN:

114244639

MSEX:

115451835

DPL:	KGM_215053

BANY:

112046556

PMAC:

106718256

PXU:	106116218 106119123

PRAP:

110996374 110997620 110998479

PBX:

123712649

ZCE:

119832244

CCRC:

123695538

HZE:

124633483

TNL:

113492219

SLIU:

111351040 111359277 111359853

OFU:

114356139

PXY:	105389814 105390413(bre-5)

API:

100164641

DNX:

107166093

AGS:

114124984

RMD:

113553214

BTAB:

109035846

DCI:

103510227

CLEC:

106665695

HHAL:

106682910

NLU:

111054451

PHU:	Phum_PHUM278100

FOC:

113211952

TPAL:

117646735

ZNE:

110836445

CSEC:

111875172

FCD:	110845484 110845485 110846305 110856195 110862185

DPX:	DAPPUDRAFT_66289

DMK:	116922454 123466382 123471529 123471540

PVM:

113814456

PJA:

122263616

PCHN:

125032776 125042967

HAME:

121876189

PCLA:

123764163 123765523

PTRU:

123503416 123515942

HAZT:

108665864

EAF:

111704047

PPOI:

119108919 119108920 119108923

ISC:	IscW_ISCW005339 IscW_ISCW007178 IscW_ISCW007342 IscW_ISCW010896 IscW_ISCW013734 IscW_ISCW014983 IscW_ISCW014984

DSV:	119432928 119448348 119455931

RSAN:

119378880 119404949

RMP:	119162043 119162045 119172723 119187537

VDE:	111247359 111249037 111249712 111252487

VJA:	111263934 111266965 111273729

TUT:

107369713

DPTE:

113797676

DFR:

124491063

CSCU:

111641196

PTEP:

107439835

SDM:

118196228

CEL:	CELE_T12G3.8(bre-5)

CBR:	CBG_06216(Cbr-bre-5)

BMY:	BM_BM5757(Bma-bre-5)

LOA:	LOAG_09610

NAI:	NECAME_07961

HRO:	HELRODRAFT_84672

PCAN:

112553274 112569600

BGT:

106051264

CRG:	105317293 105322782 105331369 105332568 105334278 109620855 117680769 117684511 117684906 117692837

MYI:	110440246 110440864 110443682 110443698 110444412 110445052 110445909 110449420 110449421 110451039 110451742 110451752 110451782 110452065 110452229 110452234 110452238 110453247 110453258 110456350 110456822 110457161 110457668 110457671 110458134 110459672 110461148 110461707 110464579

PMAX:

117314790 117315091 117315382 117315401 117315822 117317336 117319939 117321246 117322795 117323873 117325181 117325182 117325183 117326096 117329749 117332397 117332555 117332783 117337888 117339598 117339809 117340743 117342078 117342795

OSN:

115224367

LAK:

106180776

SMM:	Smp_014260 Smp_014280 Smp_151210

SHX:	MS3_00007254(B3GALT1_3) MS3_00007265

OVI:	T265_07747 T265_08677 T265_14897

EGL:	EGR_10081 EGR_11071

EPA:

110246985

ATEN:

116300017

HMG:

100202706

» show all

Reference

1 [PMID:5842076]

Authors

Basu S, Kaufman B, Roseman S.

Title

Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase.

Journal

J Biol Chem 240:4115-7 (1965)

Reference

2 [PMID:4987145]

Authors

Yip GB, Dain JA.

Title

The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain.

Journal

Biochim Biophys Acta 206:252-60 (1970)
DOI:10.1016/0005-2744(70)90108-7

Reference

3 [PMID:5484669]

Authors

Yip MC, Dain JA.

Title

Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceram ide galactosyltransferase.

Journal

Biochem J 118:247-52 (1970)
DOI:10.1042/bj1180247

Other DBs

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