KEGG   ENZYME: 2.4.3.3
Entry
EC 2.4.3.3                  Enzyme                                 
Name
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Sialyltransferases
Sysname
CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
Reaction(KEGG)
(other) R05911(G) R05914(G) R06273(G) R12704(G)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
Product
CMP [CPD:C00055];
glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
Comment
N-acetyl-alpha-D-galactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.
History
EC 2.4.3.3 created 1984 as EC 2.4.99.3, modified 1986, transferred 2022 to EC 2.4.3.3
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03479  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A)
K06616  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7B)
Genes
HSA10610(ST6GALNAC2) 55808(ST6GALNAC1)
PTR449513(ST6GALNAC2) 449516(ST6GALNAC1)
PPS100990954 100991286(ST6GALNAC2)
GGO101131207(ST6GALNAC2) 101131564(ST6GALNAC1)
PON100436103(ST6GALNAC2) 100437242(ST6GALNAC1)
NLE100582235(ST6GALNAC2) 100582568(ST6GALNAC1)
MCC707237(ST6GALNAC2) 707339(ST6GALNAC1)
MCF102131184(ST6GALNAC1) 102131833(ST6GALNAC2)
CSAB103242996(ST6GALNAC2) 103242998(ST6GALNAC1)
CATY105575033 105577679(ST6GALNAC2) 105577682(ST6GALNAC1)
PANU100998137(ST6GALNAC1) 101023130(ST6GALNAC2)
TGE112609123(ST6GALNAC2) 112609345(ST6GALNAC1)
RRO104681265(ST6GALNAC1) 104681267(ST6GALNAC2)
RBB108537385(ST6GALNAC1) 108537420(ST6GALNAC2)
TFN117066728(ST6GALNAC1) 117066729(ST6GALNAC2)
PTEH111542380(ST6GALNAC2) 111542573(ST6GALNAC1)
CJC100394846(ST6GALNAC1) 100408276(ST6GALNAC2)
SBQ101052905(ST6GALNAC1) 101053227(ST6GALNAC2)
CSYR103249571(ST6GALNAC1) 103249572(ST6GALNAC2)
MMUR105878982(ST6GALNAC2) 105878983(ST6GALNAC1)
OGA100950503(ST6GALNAC1) 100964755(ST6GALNAC2)
MMU20445(St6galnac1) 20446(St6galnac2)
MCAL110287813 110306090(St6galnac2) 110306209(St6galnac1)
MPAH110331893 110332431(St6galnac2) 110332478
RNO287920(St6galnac1) 303692(St6galnac2)
MCOC116077832(St6galnac1) 116078540(St6galnac2)
MUN110566009(St6galnac1) 110566010(St6galnac2)
CGE100763224 113836687 113836690
PLEU114707078 114707079 114707085(St6galnac2)
NGI103732779(St6galnac1) 103732780(St6galnac2)
HGL101716098(St6galnac2) 101716443(St6galnac1)
CPOC100722416(St6galnac1) 100725069(St6galnac2)
CCAN109685592(St6galnac1) 109685593(St6galnac2)
DORD106001289(St6galnac1) 106001296(St6galnac2)
DSP122128362(St6galnac1) 122128396(St6galnac2)
NCAR124980575 124981220
OCU100357022(ST6GALNAC1) 103345771(ST6GALNAC2)
OPI101520854(ST6GALNAC1) 101521094(ST6GALNAC2)
TUP102470254(ST6GALNAC2) 102502337(ST6GALNAC1)
CFA100049002(ST6GALNAC1) 100049005(ST6GALNAC2)
VVP112920614(ST6GALNAC1) 112920833(ST6GALNAC2)
VLG121473474(ST6GALNAC1) 121473747(ST6GALNAC2)
AML100483101(ST6GALNAC2) 100483351(ST6GALNAC1)
UMR103665769(ST6GALNAC1) 103665953(ST6GALNAC2)
UAH113244589(ST6GALNAC1) 113244590(ST6GALNAC2)
UAR123802968(ST6GALNAC2) 123803220(ST6GALNAC1)
ELK111160366 111160465
LLV125087282 125088079
MPUF101671804(ST6GALNAC2) 101686919(ST6GALNAC1)
ORO101373308(ST6GALNAC1) 101373602(ST6GALNAC2)
EJU114216103(ST6GALNAC2) 114216186(ST6GALNAC1)
ZCA113939380(ST6GALNAC2) 113939753(ST6GALNAC1)
MLX118024234(ST6GALNAC2) 118024445(ST6GALNAC1)
FCA101085418(ST6GALNAC1) 101098908(ST6GALNAC2)
PYU121017957(ST6GALNAC2) 121017962(ST6GALNAC1)
PBG122486124(ST6GALNAC2) 122486128(ST6GALNAC1)
PTG102954578(ST6GALNAC1) 102967529(ST6GALNAC2)
PPAD109276888(ST6GALNAC1) 109276890(ST6GALNAC2)
AJU106987765(ST6GALNAC2) 106987766(ST6GALNAC1)
HHV120228158(ST6GALNAC2) 120228285(ST6GALNAC1)
BTA511690(ST6GALNAC2) 618655(ST6GALNAC1)
BOM102281107(ST6GALNAC2) 102285967(ST6GALNAC1)
BIU109573345(ST6GALNAC1) 109573998(ST6GALNAC2)
BBUB102415174(ST6GALNAC2) 102415715(ST6GALNAC1)
CHX102184000(ST6GALNAC1) 102190459(ST6GALNAC2)
OAS101103907(ST6GALNAC2) 101116588(ST6GALNAC1)
ODA120866741(ST6GALNAC1) 120866753(ST6GALNAC2)
CCAD122437142(ST6GALNAC2) 122437155(ST6GALNAC1)
SSC100518510(ST6GALNAC2) 100622490(ST6GALNAC1)
CFR102521946(ST6GALNAC1) 102522194(ST6GALNAC2)
CBAI105065618(ST6GALNAC2) 105065792(ST6GALNAC1)
CDK105092179(ST6GALNAC1) 105092180(ST6GALNAC2)
VPC102534047(ST6GALNAC2) 102534303(ST6GALNAC1)
BACU103011965(ST6GALNAC2) 103012251(ST6GALNAC1)
LVE103069368(ST6GALNAC2) 103071465(ST6GALNAC1)
OOR101280670(ST6GALNAC2) 101286810(ST6GALNAC1)
DLE111182785(ST6GALNAC2) 111182936(ST6GALNAC1)
PCAD102983183(ST6GALNAC2)
PSIU116745798(ST6GALNAC2)
ECB100050960(ST6GALNAC2) 100058687(ST6GALNAC1)
EPZ103565524(ST6GALNAC1) 103565526(ST6GALNAC2)
EAI106830336(ST6GALNAC2) 106830340(ST6GALNAC1)
MYB102245384 102253368(ST6GALNAC2) 102256773(ST6GALNAC1)
MYD102756729(ST6GALNAC2) 102763652(ST6GALNAC1)
MMYO118669386 118671255(ST6GALNAC1) 118671256(ST6GALNAC2)
MLF102418540(ST6GALNAC2) 102440368(ST6GALNAC1)
MNA107536586(ST6GALNAC2) 107536587(ST6GALNAC1)
PKL118704534(ST6GALNAC1) 118704586(ST6GALNAC2)
HAI109383649(ST6GALNAC1) 109383653(ST6GALNAC2)
DRO112298676(ST6GALNAC2) 112298677(ST6GALNAC1)
SHON118982634 118999928(ST6GALNAC1) 119000022(ST6GALNAC2)
AJM119058670(ST6GALNAC1) 119058672(ST6GALNAC2) 119059852
PDIC114500778 114503462(ST6GALNAC2) 114503952(ST6GALNAC1)
PHAS123811293 123817021(ST6GALNAC2) 123817714(ST6GALNAC1)
MMF118631226 118634925(ST6GALNAC2) 118634950(ST6GALNAC1)
RFQ117013049(ST6GALNAC1) 117013050(ST6GALNAC2) 117033332
PALE102898342(ST6GALNAC1) 102898585(ST6GALNAC2)
PGIG120599987(ST6GALNAC2)
PVP105293436(ST6GALNAC2) 105293437(ST6GALNAC1)
RAY107510029(ST6GALNAC1) 107510041(ST6GALNAC2)
MJV108398661(ST6GALNAC1) 108398668(ST6GALNAC2)
TOD119230971(ST6GALNAC1) 119231777(ST6GALNAC2) 119259876
SARA101552923(ST6GALNAC1) 101553188(ST6GALNAC2)
LAV100667338(ST6GALNAC1) 100673802(ST6GALNAC2)
TMU101348933 101353137
DNM101415658(ST6GALNAC1) 101426363(ST6GALNAC2)
MDO100026506(ST6GALNAC2)
GAS123245008(ST6GALNAC2)
SHR100913684(ST6GALNAC1) 100914208(ST6GALNAC2)
PCW110219273(ST6GALNAC2)
OAA100076453(ST6GALNAC1) 100087307(ST6GALNAC2)
GGA396159(ST6GALNAC2) 396168(ST6GALNAC1) 422075(ST6GALNAC2L)
PCOC116232515 116232619(ST6GALNAC2) 116232679(ST6GALNAC1)
MGP100549131(ST6GALNAC1) 100549285(ST6GALNAC2) 100550511
CJO107322110(ST6GALNAC1) 107322111(ST6GALNAC2) 107322294
NMEL110407367 110407369(ST6GALNAC1) 110407371(ST6GALNAC2)
APLA101797291(ST6GALNAC1) 101799102(ST6GALNAC2)
ACYG106034632(ST6GALNAC1) 106034805(ST6GALNAC2)
AFUL116496391(ST6GALNAC1) 116496471(ST6GALNAC2) 116496697
TGU100224588(ST6GALNAC2) 100227473(ST6GALNAC1)
LSR110479610(ST6GALNAC1) 110479617(ST6GALNAC2)
SCAN103819877(ST6GALNAC2) 103820005(ST6GALNAC1)
PMOA120505616(ST6GALNAC2) 120505661(ST6GALNAC1)
OTC121338348(ST6GALNAC2) 121338422(ST6GALNAC1)
PRUF121363843(ST6GALNAC2) 121363863(ST6GALNAC1)
GFR102034795(ST6GALNAC2) 102044354(ST6GALNAC1)
FAB101816531(ST6GALNAC1) 101816852(ST6GALNAC2)
PHI102104528(ST6GALNAC1) 102107675(ST6GALNAC2)
PMAJ107212525(ST6GALNAC1) 107212603(ST6GALNAC2)
CCAE111937266(ST6GALNAC1) 111937267(ST6GALNAC2)
CCW104694336(ST6GALNAC1) 104694396(ST6GALNAC2)
ETL114058601(ST6GALNAC1) 114058606(ST6GALNAC2)
ZAB102064328(ST6GALNAC1) 102074249(ST6GALNAC2)
FPG101917798(ST6GALNAC2) 101917973(ST6GALNAC1)
FCH102046464(ST6GALNAC2) 102046634(ST6GALNAC1)
CLV102092944(ST6GALNAC2) 102096307(ST6GALNAC1)
EGZ104125305(ST6GALNAC2) 104125375(ST6GALNAC1)
NNI104022834(ST6GALNAC2) 104022870(ST6GALNAC1)
ACUN113486705(ST6GALNAC1) 113486926(ST6GALNAC2)
TALA104368225(ST6GALNAC1) 116964070(ST6GALNAC2)
PADL103921017(ST6GALNAC2) 103921018(ST6GALNAC1)
ACHC115341193(ST6GALNAC2) 115342282(ST6GALNAC1)
AAM106485387(ST6GALNAC2) 106485391(ST6GALNAC1) 106492263
AROW112973738 112977746(ST6GALNAC2) 112977772(ST6GALNAC1)
NPD112945294 112957665(ST6GALNAC2) 112957693(ST6GALNAC1)
DNE112985341(ST6GALNAC2) 112985345(ST6GALNAC1) 112994287
ASN102379898(ST6GALNAC2) 102380149(ST6GALNAC1) 102388548
AMJ102567931(ST6GALNAC1) 102568170(ST6GALNAC2) 102575229
CPOO109314908 109315110(ST6GALNAC2) 109315222(ST6GALNAC1)
GGN109287708(ST6GALNAC1) 109287716(ST6GALNAC2) 109295883
PSS102455769(ST6GALNAC2)
CMY102934815(ST6GALNAC1) 102939328(ST6GALNAC2) 102945850
CPIC101942154 101951888(ST6GALNAC2) 101952335(ST6GALNAC1)
TST117887671 117887781(ST6GALNAC1) 117887782(ST6GALNAC2)
CABI116832225(ST6GALNAC2) 116832291(ST6GALNAC1) 116834890
MRV120383309(ST6GALNAC1) 120383310(ST6GALNAC2) 120383782
ACS100552576(st6galnac1) 100552771(st6galnac2)
PVT110085897(ST6GALNAC1) 110085907(ST6GALNAC2)
SUND121923493(ST6GALNAC2) 121923650(ST6GALNAC1)
PBI103048388(ST6GALNAC2) 103049161(ST6GALNAC1)
PMUR107300752(ST6GALNAC2) 107300765(ST6GALNAC1)
TSR106546339 106547963(ST6GALNAC2)
PGUT117660466(ST6GALNAC1) 117660468(ST6GALNAC2)
VKO123035597(ST6GALNAC2) 123035648(ST6GALNAC1)
PMUA114590658(ST6GALNAC2) 114590659(ST6GALNAC1)
ZVI118079868(ST6GALNAC2) 118079869(ST6GALNAC1)
GJA107118138(ST6GALNAC1) 107118143(ST6GALNAC2)
STOW125429378(ST6GALNAC1) 125430228(ST6GALNAC2)
XLA108700986(abo2.L) 108701135(st6galnac2.L) 108701136 108702706(abo2.S) 108702826(st6galnac2.S) 108702827
XTR100489217(abo2) 101733431(st6galnac1) 395053(st6galnac2)
NPR108786396(ST6GALNAC1) 108797161
RTEM120918495(ST6GALNAC1) 120919010(ST6GALNAC2)
BBUF121003929(ST6GALNAC2) 121004739(ST6GALNAC1) 121006139
BGAR122941155(ST6GALNAC1) 122941255 122941557(ST6GALNAC2)
DRE100001225(st6galnac2) 407706(st6galnac) 564336(st6galnac1.1) 799868(st6galnac1.2)
SRX107721981 107721986 107734167 107734198 107743031(st6galnac2) 107753281 107755459
SANH107660869 107660870 107666010(st6galnac2) 107684137 107690941 107692092 107692094
SGH107548689(st6galnac2) 107561819 107577723 107578269 107584072 107584073
CCAR109054194 109054206 109080850 109100113 109105181 109105186 109105532 109110781
CAUA113046546(st6galnac2) 113046593 113055985 113056073 113056538 113073460 113111647 113112096 113112097
PPRM120463930(st6galnac1.1) 120464580(st6galnac2) 120471569(st6galnac1.2) 120471576 120474706(st6galnac)
MAMB125255307(st6galnac) 125255409(st6galnac1.2) 125255410(st6galnac1.1) 125266234(st6galnac2)
IPU108273438 108273718(st6galnac)
PHYP113527194(st6galnac2) 113527195 113527221(st6galnac1)
SMEO124389081 124389082 124389433
TFD113640966 113653493 113653503 125145288
AMEX103028114 103031766(st6galnac2) 111196612
EEE113572794 113576805(st6galnac2) 113579268 113582980
TRU445974 445975
TNGGSTEN00022328G001
LCO104935881(st6galnac2) 104936231 104937002 104937003
NCC104956443 104965389
CGOB115024167 115024617
ELY117247139(st6galnac) 117247283 117247284 117247568 117268036(st6galnac2)
PLEP121956376 121956377(st6galnac2) 121958436
SLUC116050009(st6galnac2) 116061086(st6galnac) 116061210
ECRA117936449 117936685(st6galnac)
PFLV114548220 114548559 114548560 114570228(st6galnac2)
GAT120819337 120819338 120819339 120819650(st6galnac)
PPUG119212481 119213294(st6galnac)
MSAM119887876 119915506 119915571(st6galnac) 119915996 119915997 119916524
CUD121522563 121527839 121528392 121528394 121528395 121528619
MZE101474318 101474872 101475163 101481664 101483915 112430022
ONL100690385 100691173(st6galnac2) 100691443 100691711 100691981 100692518 100698116 100708495 100708765 100709034 106097985 109203140 112847711
OAU116310550 116310551 116310571 116312955(st6galnac2) 116322712 116323485(st6galnac) 116330443 116335876 116335878 120441393 120441401 120441471 120441507
OLA100049382(st6galnac2) 101164026
OML112153961(st6galnac)
XMA102225407 102225672 102230432 102232301
XCO114151667 114151756 114152135 114152366
XHE116727455 116727707 116727722 116727723
PRET103481510 103481511 103481513 103481773
PFOR103145160 103145161 103145162 103152734 103153088(st6galnac2)
PLAI106942040 106962610 106964094 106964096 106964097
PMEI106915353 106927457 106927480 106927481 106932759
GAF122823307 122823308 122823339(st6galnac) 122823388
CVG107088933 107089181 107089188 107093984 107096872
CTUL119774889 119774900 119775975(st6galnac) 119789999(st6galnac2) 119793613
GMU124863470 124864954 124874903 124875161(st6galnac) 124875380 124875472 124875604
NFU107387266 107387721 107387723 107387725 107396531
KMR108245597(st6galnac) 108246104 108246110 108249294
ALIM106516657 106516659 106516660 106529039
NWH119423538 119424055 119424058 119424207(st6galnac)
AOCE111578131 111583259
CSEM103381823(st6galnac2) 103382295
POV109641162 109643035
SSEN122759505(st6galnac) 122769459
HHIP117752651(st6galnac) 117753398
LCF108876231 108876842 108882387(st6galnac2)
SDU111219599(st6galnac1) 111219706
SLAL111655373(st6galnac2) 111664312 111673497(st6galnac1)
XGL120788330(st6galnac2) 120793982(st6galnac) 120794673
HCQ109516217 109516279 109518603
BPEC110165448 110165451 110166304
MALB109953680 109959622(st6galnac2) 109962782
SASA106570212 106589847 106589898 106601434 106601522(st6galnac2) 106611954
OTW112229175 112229683 112235036 112238292 112257755(st6galnac)
OMY100135821(rtst6galnac) 110486578 110488217 110499425 110502786 110538981
OGO123999027 124038469 124040394 124040410 124043415
ONE115104302 115112982 115121789 115131502 115144442
SALP111968151 111975296 111978119 111980257
SNH120026841 120029378 120029706 120034115 120046751(st6galnac)
ELS105008325 105009376 105012912(st6galnac2)
SFM108930263 108937017(st6galnac2) 108940103
PKI111846578 111848248 111852860 111856727
AANG118216489 118216644(st6galnac2) 118216802 118219460 118221231(st6galnac)
LOC102689937 102690138 102690342 102692491
PSPA121295260 121295299 121295433 121295434 121295435 121295914(st6galnac2) 121307652
ARUT117422896 117422897(st6galnac2) 117423165 117423268 117423623 117423789 117424102(st6galnac)
LCM102352533 102354852(ST6GALNAC2)
CMK103175572 103175574
RTP109939003(st6galnac2)
 » show all
Reference
1  [PMID:447688]
  Authors
Sadler JE, Rearick JI, Hill RL.
  Title
Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands.
  Journal
J Biol Chem 254:5934-41 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.3.3
IUBMB Enzyme Nomenclature: 2.4.3.3
ExPASy - ENZYME nomenclature database: 2.4.3.3
BRENDA, the Enzyme Database: 2.4.3.3
CAS: 71124-50-0
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