Entry
Name
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase;
diphosphopyridine nucleosidase (ambiguous);
CD38 (gene name);
BST1 (gene name)
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
NADP+:nicotinate ADP-ribosyltransferase
Reaction(IUBMB)
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide (overall reaction) [RN:
R00119 ];
(1a) NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide [RN:
R10631 ];
(1b) 2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate [RN:
R10632 ]
Reaction(KEGG)
Substrate
Product
nicotinate-adenine dinucleotide phosphate [CPD:
C13051 ];
nicotinamide [CPD:
C00153 ];
2'-phospho-cyclic ADP-ribose [CPD:
C20742 ]
Comment
This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC
3.2.2.6 , ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
History
EC 2.4.99.20 created 2014
Pathway
ec00760 Nicotinate and nicotinamide metabolism
Orthology
Genes
PTR : 461126(BST1) 745433(CD38)
PPS : 100972434(BST1) 100974952(CD38)
GGO : 101145401(BST1) 101149825(CD38)
PON : 100174150(BST1) 100457558(CD38)
NLE : 100606064(BST1) 100606960(CD38)
MCC : 714399(CD38) 722848(BST1)
MCF : 101926698(BST1) 102126394(CD38)
CSAB : 103246326(CD38) 103246328(BST1)
CATY : 105579036(CD38) 105579041(BST1)
PANU : 101017008(BST1) 101022305(CD38)
TGE : 112624454(CD38) 112625503(BST1)
RRO : 104658167(BST1) 104658170(CD38)
RBB : 108531741(CD38) 108531746(BST1)
TFN : 117085172(BST1) 117085174(CD38)
PTEH : 111539163(BST1) 111539166(CD38)
CJC : 100387937(CD38) 100402445(BST1)
SBQ : 101035567(BST1) 101036203(CD38)
MMUR : 105856078(CD38) 105856080(BST1)
LCAT : 123637314(BST1) 123637315(CD38)
OGA : 100948063(CD38) 100949639(BST1)
MMU : 12182(Bst1) 12494(Cd38)
MCAL : 110294333(Bst1) 110294426(Cd38)
MPAH : 110330967(Cd38) 110330979(Bst1)
RNO : 25668(Cd38) 81506(Bst1)
MCOC : 116070677(Bst1) 116070680(Cd38)
MUN : 110559148(Cd38) 110559149(Bst1)
CGE : 100773187(Cd38) 100773468(Bst1)
MAUA : 101825392(Cd38) 101829693(Bst1)
PLEU : 114687856 114709224(Bst1) 114709225(Cd38)
MORG : 121436384(Cd38) 121436585(Bst1)
AAMP : 119803349(Bst1) 119804718(Cd38)
NGI : 103728882(Cd38) 103728884(Bst1)
HGL : 101713685(Bst1) 101720283(Cd38)
CPOC : 100726264(Bst1) 100726537(Cd38) 100735470 106026535
CCAN : 109691561(Cd38) 109691564(Bst1)
DORD : 105980149(Bst1) 105980338(Cd38)
DSP : 122104071(Bst1) 122104097(Cd38)
NCAR : 124994506 124994678
OCU : 100009409(CD38) 100351817(BST1)
OPI : 101533232(CD38) 101533472(BST1)
TUP : 102468679(BST1) 102480083(CD38)
VVP : 112919977(BST1) 112919984(CD38)
VLG : 121489283(BST1) 121489687(CD38)
AML : 100463977(BST1) 100481326(CD38)
UMR : 103658313(BST1) 103658362(CD38)
UAH : 113266702(BST1) 113266704(CD38)
UAR : 123775810(BST1) 123775823(CD38)
MPUF : 101684892(BST1) 101685175(CD38)
ORO : 101364829(CD38) 101365133(BST1)
EJU : 114196716(CD38) 114198536(BST1)
ZCA : 113924284(CD38) 113924929(BST1)
MLX : 118010687(CD38) 118010690(BST1)
FCA : 101101052(BST1) 101101308(CD38)
PYU : 121038074(CD38) 121038087(BST1)
PBG : 122479020(CD38) 122479021(BST1)
PTG : 102955186(CD38) 102962771(BST1)
PPAD : 109269635(CD38) 109269636(BST1)
AJU : 106975627(BST1) 106975653(CD38)
HHV : 120237985(CD38) 120237994(BST1)
BTA : 327677(CD38) 616757(BST1)
BOM : 102271683(BST1) 102273331(CD38)
BIU : 109560088(BST1) 109560687(CD38)
BBUB : 102400853(BST1) 102401480(CD38)
CHX : 102169848(BST1) 102172881(CD38)
OAS : 101116575(BST1) 105614340(CD38) 114115250 114115251 114115349
ODA : 120861630(CD38) 120861770(BST1)
CCAD : 122428274(CD38) 122428330(BST1)
SSC : 100511702(CD38) 100625942(BST1)
CFR : 102508026(CD38) 102508256(BST1)
CBAI : 105083238(BST1) 105083239(CD38)
CDK : 105098338(BST1) 105098339(CD38)
VPC : 102538089(BST1) 102538359(CD38)
BACU : 103000954(BST1) 103020545(CD38)
LVE : 103087769(CD38) 103088314(BST1)
OOR : 101284537(CD38) 101284786(BST1)
DLE : 111171401(CD38) 111171425(BST1)
PCAD : 102981972(CD38) 102982819(BST1)
PSIU : 116754512(CD38) 116754525(BST1)
ECB : 100068959(CD38) 100068968(BST1)
EPZ : 103565758(BST1) 103565759(CD38)
EAI : 106827091(CD38) 106827092(BST1)
MYB : 102252244(CD38) 102252530(BST1)
MYD : 102759158(CD38) 102770056(BST1)
MMYO : 118666927(BST1) 118666935(CD38)
MLF : 102434861(CD38) 102437542(BST1)
PKL : 118708737(CD38) 118725690(BST1)
HAI : 109372167(CD38) 109372831(BST1)
DRO : 112316691(BST1) 112316692(CD38)
SHON : 118986595(CD38) 118989556(BST1)
AJM : 119035514(CD38) 119035581(BST1)
PDIC : 114491309(CD38) 114493375(BST1)
PHAS : 123815823(CD38) 123815824(BST1)
MMF : 118615378(BST1) 118641660(CD38)
RFQ : 117021922 117021923 117022444(BST1)
PALE : 102884937(BST1) 102889755(CD38)
PGIG : 120582708(BST1) 120582820(CD38)
PVP : 105295961(BST1) 105295966(CD38)
RAY : 107507351(CD38) 107507352(BST1)
MJV : 108403411(BST1) 108408183(CD38)
TOD : 119260627 119260628 119260630 119260888(BST1) 119261103 119261298
SARA : 101539895(BST1) 101540160(CD38)
LAV : 100659997(BST1) 100660287(CD38)
DNM : 101429299(BST1) 101429735(CD38)
MDO : 100015733(BST1) 103094598(CD38)
GAS : 123252450(BST1) 123252910(CD38)
SHR : 100915627(BST1) 105751033(CD38)
PCW : 110212831(BST1) 110212844(CD38)
OAA : 100074315(CD38) 100079912(BST1)
GGA : 422827(CD38) 422828(BST1)
PCOC : 116225809(BST1) 116225812
MGP : 100546297 100548136(CD38)
CJO : 107313950(BST1) 107313951(CD38)
NMEL : 110398571(CD38) 110398576
ACYG : 106033418(CD38) 106035386(BST1)
AFUL : 116489206 116489217(CD38)
TGU : 100224783(BST1) 101232999(CD38)
SCAN : 103824309(BST1) 103824319
PMOA : 120497359 120497360(CD38)
PRUF : 121348778(BST1) 121365982(CD38)
GFR : 102032481(BST1) 102032646(CD38)
FAB : 101808664(BST1) 101813225(CD38)
PHI : 102100836(CD38) 102101014(BST1)
PMAJ : 107203272 107203546
CCAE : 111928170 111928172
CCW : 104690721 104690901(CD38)
ETL : 114061133(BST1) 114061141
FPG : 101912278(CD38) 101917967(BST1)
EGZ : 104134476(BST1) 104134477(CD38)
NNI : 104010763(CD38) 104010764(BST1)
PLET : 104613827(CD38) 104619105(BST1)
PCRI : 104026992(CD38) 104030339(BST1)
ACUN : 113479380 113479383(BST1)
TALA : 104357985(CD38) 104360998(BST1)
PADL : 103916996(CD38) 103916997(BST1)
ACHC : 115341987(BST1) 115342015(CD38)
CCRI : 104161112(CD38) 104163056(BST1)
AROW : 112970832 112970833
CPOO : 109322214(BST1) 109322366(CD38)
PSS : 102444728(BST1) 102444963(CD38)
CMY : 102933631(BST1) 102933862(CD38)
CPIC : 101935271 101935553
CABI : 116821059(CD38) 116821061(BST1)
XLA : 100036901(cd38.L) 101027297(bst1.L)
XTR : 101733556 496666(cd38)
NPR : 108799310(BST1) 108799313
RTEM : 120924334(CD38) 120924335
BBUF : 120990331 120990332
BGAR : 122931523 122940253(BST1)
PHYP : 113532851 113546708
SMEO : 124375480 124380174
TRU : 101074837 101075059 105418447
TNG : GSTEN00025533G001 GSTEN00025534G001
LCO : 104933795 104933796 104933803
NCC : 104942392 104946571 104946574
CGOB : 115025235 115025547 115025767
ELY : 117264480 117264955 117265032 117265088
PLEP : 121940397 121960727 121961001
SLUC : 116048591 116048593 116048594 116048595
ECRA : 117937835 117937841
PFLV : 114549402 114549422 114549480 114549609
GAT : 120811807 120811890 120811891
PPUG : 119198455 119198456 119198459
MSAM : 119912040 119912049
CUD : 121527044 121527105 121527134 121527530 121527535 121527555 121527566 121527740
ALAT : 119008641 119008766 119008934 119009095 119013827
MZE : 101478770 101479062 101479335
ONL : 100696855 100709482 100710024 102077908 102078110 106098852 109194449
OAU : 116329626 116329633 116329643 120441989 120442012 120442076
OLA : 101168159 101168658 101168676
XMA : 102227962 102228215 106699822
XCO : 114136499 114136564 114137010
XHE : 116711401 116711499 116711986
PRET : 103456798 103456800 103456801
PFOR : 103147559 103147560 103147569
PLAI : 106951163 106951164 106951165
PMEI : 106912836 106912857 106912868
CVG : 107085442 107085455 107099405 107099407
CTUL : 119798421 119798436 119798439
GMU : 124857890 124858222 124858405
KMR : 108230245 108230355 108230372
ALIM : 106515510 106515511
AOCE : 111587679 111587684
MCEP : 124996073 125024413
CSEM : 103377367 103377368
SSEN : 122766606 122766860
HHIP : 117753607 117753609
SLAL : 111673629 111673631 111673659
BPEC : 110165536 110165581
BSPL : 114853868 114854305 114854614 114854615
SASA : 106590199 106590200
AANG : 118226015 118226024 118226025
PSPA : 121324556 121324563 121324571 121329920
ARUT : 117408506 117420417 117421343 117421345 117421349
SPU : 100126187(arc3) 100859964(arc4) 115918149 115918151 115922770 576085(arc2) 580868(arc1)
APLC : 110977913 110981710
HRO : HELRODRAFT_179637 HELRODRAFT_193621
LGI : LOTGIDRAFT_150043 LOTGIDRAFT_218611
PCAN : 112555169 112555726 112555871
HRF : 124117015 124117016 124117017 124117019 124122531
HRJ : 124262792 124262799 124262800 124262801 124267312
PMAX : 117342638 117342726
MMER : 123529931 123545671 123554407 123554776 123556012 123564280
LAK : 106153853 106155009 106155798 106159481 106159482 106169313 106180219
OVI : T265_08021 T265_08022
NVE : 116618638 5503859 5505197
ATEN : 116291709 116302029 116302620
AMIL : 114948060 114961589
PDAM : 113669069 113675387
HMG : 100199121 100199929 100211840 101234797 101241800
TAD : TRIADDRAFT_19184 TRIADDRAFT_36890 TRIADDRAFT_51409
» show all
Taxonomy
Reference
Authors
Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H
Title
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
Journal
Sequence
Reference
Authors
Moreschi I, Bruzzone S, Melone L, De Flora A, Zocchi E
Title
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.99.20
LinkDB
All DBs