KEGG   ENZYME: 2.4.99.20
Entry
EC 2.4.99.20                Enzyme                                 
Name
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase;
diphosphopyridine nucleosidase (ambiguous);
CD38 (gene name);
BST1 (gene name)
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
NADP+:nicotinate ADP-ribosyltransferase
Reaction(IUBMB)
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide (overall reaction) [RN:R00119];
(1a) NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide [RN:R10631];
(1b) 2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate [RN:R10632]
Reaction(KEGG)
Substrate
NADP+ [CPD:C00006];
nicotinate [CPD:C00253];
2'-phospho-cyclic ADP-ribose [CPD:C20742]
Product
nicotinate-adenine dinucleotide phosphate [CPD:C13051];
nicotinamide [CPD:C00153];
2'-phospho-cyclic ADP-ribose [CPD:C20742]
Comment
This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
History
EC 2.4.99.20 created 2014
Pathway
ec00760  Nicotinate and nicotinamide metabolism
Orthology
K01242  ADP-ribosyl cyclase 1
K18152  ADP-ribosyl cyclase 2
Genes
HSA683(BST1) 952(CD38)
PTR461126(BST1) 745433(CD38)
PPS100972434(BST1) 100974952(CD38)
GGO101145401(BST1) 101149825(CD38)
PON100174150(BST1) 100457558(CD38)
NLE100606064(BST1) 100606960(CD38)
MCC714399(CD38) 722848(BST1)
MCF101926698(BST1) 102126394(CD38)
CSAB103246326(CD38) 103246328(BST1)
CATY105579036(CD38) 105579041(BST1)
PANU101017008(BST1) 101022305(CD38)
TGE112624454(CD38) 112625503(BST1)
RRO104658167(BST1) 104658170(CD38)
RBB108531741(CD38) 108531746(BST1)
TFN117085172(BST1) 117085174(CD38)
PTEH111539163(BST1) 111539166(CD38)
CJC100387937(CD38) 100402445(BST1)
SBQ101035567(BST1) 101036203(CD38)
CSYR103269336(BST1)
MMUR105856078(CD38) 105856080(BST1)
LCAT123637314(BST1) 123637315(CD38)
OGA100948063(CD38) 100949639(BST1)
MMU12182(Bst1) 12494(Cd38)
MCAL110294333(Bst1) 110294426(Cd38)
MPAH110330967(Cd38) 110330979(Bst1)
RNO25668(Cd38) 81506(Bst1)
MCOC116070677(Bst1) 116070680(Cd38)
MUN110559148(Cd38) 110559149(Bst1)
CGE100773187(Cd38) 100773468(Bst1)
MAUA101825392(Cd38) 101829693(Bst1)
PLEU114687856 114709224(Bst1) 114709225(Cd38)
MORG121436384(Cd38) 121436585(Bst1)
AAMP119803349(Bst1) 119804718(Cd38)
NGI103728882(Cd38) 103728884(Bst1)
HGL101713685(Bst1) 101720283(Cd38)
CPOC100726264(Bst1) 100726537(Cd38) 100735470 106026535
CCAN109691561(Cd38) 109691564(Bst1)
DORD105980149(Bst1) 105980338(Cd38)
DSP122104071(Bst1) 122104097(Cd38)
NCAR124994506 124994678
OCU100009409(CD38) 100351817(BST1)
OPI101533232(CD38) 101533472(BST1)
TUP102468679(BST1) 102480083(CD38)
CFA403756(CD38)
VVP112919977(BST1) 112919984(CD38)
VLG121489283(BST1) 121489687(CD38)
AML100463977(BST1) 100481326(CD38)
UMR103658313(BST1) 103658362(CD38)
UAH113266702(BST1) 113266704(CD38)
UAR123775810(BST1) 123775823(CD38)
ELK111149117 111149296
LLV125093560 125093561
MPUF101684892(BST1) 101685175(CD38)
ORO101364829(CD38) 101365133(BST1)
EJU114196716(CD38) 114198536(BST1)
ZCA113924284(CD38) 113924929(BST1)
MLX118010687(CD38) 118010690(BST1)
FCA101101052(BST1) 101101308(CD38)
PYU121038074(CD38) 121038087(BST1)
PBG122479020(CD38) 122479021(BST1)
PTG102955186(CD38) 102962771(BST1)
PPAD109269635(CD38) 109269636(BST1)
AJU106975627(BST1) 106975653(CD38)
HHV120237985(CD38) 120237994(BST1)
BTA327677(CD38) 616757(BST1)
BOM102271683(BST1) 102273331(CD38)
BIU109560088(BST1) 109560687(CD38)
BBUB102400853(BST1) 102401480(CD38)
CHX102169848(BST1) 102172881(CD38)
OAS101116575(BST1) 105614340(CD38) 114115250 114115251 114115349
ODA120861630(CD38) 120861770(BST1)
CCAD122428274(CD38) 122428330(BST1)
SSC100511702(CD38) 100625942(BST1)
CFR102508026(CD38) 102508256(BST1)
CBAI105083238(BST1) 105083239(CD38)
CDK105098338(BST1) 105098339(CD38)
VPC102538089(BST1) 102538359(CD38)
BACU103000954(BST1) 103020545(CD38)
LVE103087769(CD38) 103088314(BST1)
OOR101284537(CD38) 101284786(BST1)
DLE111171401(CD38) 111171425(BST1)
PCAD102981972(CD38) 102982819(BST1)
PSIU116754512(CD38) 116754525(BST1)
ECB100068959(CD38) 100068968(BST1)
EPZ103565758(BST1) 103565759(CD38)
EAI106827091(CD38) 106827092(BST1)
MYB102252244(CD38) 102252530(BST1)
MYD102759158(CD38) 102770056(BST1)
MMYO118666927(BST1) 118666935(CD38)
MLF102434861(CD38) 102437542(BST1)
PKL118708737(CD38) 118725690(BST1)
HAI109372167(CD38) 109372831(BST1)
DRO112316691(BST1) 112316692(CD38)
SHON118986595(CD38) 118989556(BST1)
AJM119035514(CD38) 119035581(BST1)
PDIC114491309(CD38) 114493375(BST1)
PHAS123815823(CD38) 123815824(BST1)
MMF118615378(BST1) 118641660(CD38)
RFQ117021922 117021923 117022444(BST1)
PALE102884937(BST1) 102889755(CD38)
PGIG120582708(BST1) 120582820(CD38)
PVP105295961(BST1) 105295966(CD38)
RAY107507351(CD38) 107507352(BST1)
MJV108403411(BST1) 108408183(CD38)
TOD119260627 119260628 119260630 119260888(BST1) 119261103 119261298
SARA101539895(BST1) 101540160(CD38)
LAV100659997(BST1) 100660287(CD38)
TMU101346112 101346368
DNM101429299(BST1) 101429735(CD38)
MDO100015733(BST1) 103094598(CD38)
GAS123252450(BST1) 123252910(CD38)
SHR100915627(BST1) 105751033(CD38)
PCW110212831(BST1) 110212844(CD38)
OAA100074315(CD38) 100079912(BST1)
GGA422827(CD38) 422828(BST1)
PCOC116225809(BST1) 116225812
MGP100546297 100548136(CD38)
CJO107313950(BST1) 107313951(CD38)
NMEL110398571(CD38) 110398576
APLA101799363(BST1)
ACYG106033418(CD38) 106035386(BST1)
AFUL116489206 116489217(CD38)
TGU100224783(BST1) 101232999(CD38)
LSR110484008 110484039
SCAN103824309(BST1) 103824319
PMOA120497359 120497360(CD38)
OTC121335091 121335188
PRUF121348778(BST1) 121365982(CD38)
GFR102032481(BST1) 102032646(CD38)
FAB101808664(BST1) 101813225(CD38)
PHI102100836(CD38) 102101014(BST1)
PMAJ107203272 107203546
CCAE111928170 111928172
CCW104690721 104690901(CD38)
ETL114061133(BST1) 114061141
ZAB102061886 102065942
FPG101912278(CD38) 101917967(BST1)
FCH102048375 102048871
CLV102089855(BST1)
EGZ104134476(BST1) 104134477(CD38)
NNI104010763(CD38) 104010764(BST1)
PLET104613827(CD38) 104619105(BST1)
PCRI104026992(CD38) 104030339(BST1)
ACUN113479380 113479383(BST1)
TALA104357985(CD38) 104360998(BST1)
PADL103916996(CD38) 103916997(BST1)
ACHC115341987(BST1) 115342015(CD38)
CCRI104161112(CD38) 104163056(BST1)
AAM106498697 106498751
AROW112970832 112970833
NPD112958511 112958546
DNE112996520 112996530
ASN102376962(BST1)
AMJ102559494(BST1)
CPOO109322214(BST1) 109322366(CD38)
GGN109303956 109304108
PSS102444728(BST1) 102444963(CD38)
CMY102933631(BST1) 102933862(CD38)
CPIC101935271 101935553
TST117878308 117878553
CABI116821059(CD38) 116821061(BST1)
MRV120405962 120405963
ACS100566030(cd38)
PVT110085956(CD38)
SUND121932151(CD38)
PBI103059310
PMUR107292463
TSR106543891(CD38)
PGUT117660712
VKO123017189(CD38)
PMUA114604446
ZVI118084020(CD38)
GJA107120012(CD38)
STOW125439720
XLA100036901(cd38.L) 101027297(bst1.L)
XTR101733556 496666(cd38)
NPR108799310(BST1) 108799313
RTEM120924334(CD38) 120924335
BBUF120990331 120990332
BGAR122931523 122940253(BST1)
DRE101886891
SANH107693813
SGH107568972
CAUA113075268
PPRM120495013
IPU108256685 108259605
PHYP113532851 113546708
SMEO124375480 124380174
TFD113634204 113659789
AMEX103029242
EEE113582404 113582405
TRU101074837 101075059 105418447
TNGGSTEN00025533G001 GSTEN00025534G001
LCO104933795 104933796 104933803
NCC104942392 104946571 104946574
CGOB115025235 115025547 115025767
ELY117264480 117264955 117265032 117265088
PLEP121940397 121960727 121961001
SLUC116048591 116048593 116048594 116048595
ECRA117937835 117937841
PFLV114549402 114549422 114549480 114549609
GAT120811807 120811890 120811891
PPUG119198455 119198456 119198459
MSAM119912040 119912049
CUD121527044 121527105 121527134 121527530 121527535 121527555 121527566 121527740
ALAT119008641 119008766 119008934 119009095 119013827
MZE101478770 101479062 101479335
ONL100696855 100709482 100710024 102077908 102078110 106098852 109194449
OAU116329626 116329633 116329643 120441989 120442012 120442076
OLA101168159 101168658 101168676
OML112151048 112151449
XMA102227962 102228215 106699822
XCO114136499 114136564 114137010
XHE116711401 116711499 116711986
PRET103456798 103456800 103456801
PFOR103147559 103147560 103147569
PLAI106951163 106951164 106951165
PMEI106912836 106912857 106912868
GAF122823991 122823992
CVG107085442 107085455 107099405 107099407
CTUL119798421 119798436 119798439
GMU124857890 124858222 124858405
NFU107382594 107382595
KMR108230245 108230355 108230372
ALIM106515510 106515511
NWH119426679 119426680
AOCE111587679 111587684
MCEP124996073 125024413
CSEM103377367 103377368
POV109629467 109629469
SSEN122766606 122766860
HHIP117753607 117753609
HSP118098756 118098758
LCF108900033 108900035
SDU111224346 111224354
SLAL111673629 111673631 111673659
XGL120789958 120790041
HCQ109517521
BPEC110165536 110165581
BSPL114853868 114854305 114854614 114854615
SASA106590199 106590200
OTW112227553 112245218
OMY110489876 110489879
OGO124039734 124039735
ONE115130320 115131105
SALP111953730
SNH120051110 120051113
ELS105031580
SFM108922735 108922775
PKI111850018 111850115
AANG118226015 118226024 118226025
LOC102689984 102690185
PSPA121324556 121324563 121324571 121329920
ARUT117408506 117420417 117421343 117421345 117421349
LCM102364780 106706579
RTP109917306 109917325
BFO118405736
BBEL109465410
SPU100126187(arc3) 100859964(arc4) 115918149 115918151 115922770 576085(arc2) 580868(arc1)
APLC110977913 110981710
SKO100370260
HROHELRODRAFT_179637 HELRODRAFT_193621
LGILOTGIDRAFT_150043 LOTGIDRAFT_218611
PCAN112555169 112555726 112555871
GAE121367392 121373590
HRF124117015 124117016 124117017 124117019 124122531
HRJ124262792 124262799 124262800 124262801 124267312
CRG105319809
MYI110451407 110458378
PMAX117342638 117342726
MMER123529931 123545671 123554407 123554776 123556012 123564280
LAK106153853 106155009 106155798 106159481 106159482 106169313 106180219
OVIT265_08021 T265_08022
NVE116618638 5503859 5505197
EPA110246357 110251379
ATEN116291709 116302029 116302620
ADF107339424 107340996
AMIL114948060 114961589
PDAM113669069 113675387
SPIS111329655
DGT114519185
XEN124439014
HMG100199121 100199929 100211840 101234797 101241800
TADTRIADDRAFT_19184 TRIADDRAFT_36890 TRIADDRAFT_51409
AQU105312071 105312710
SREPTSG_13238
 » show all
Reference
1  [PMID:11829748]
  Authors
Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H
  Title
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
  Journal
Biochem J 362:125-30 (2002)
DOI:10.1042/0264-6021:3620125
  Sequence
[mmu:12494]
Reference
2  [PMID:16690024]
  Authors
Moreschi I, Bruzzone S, Melone L, De Flora A, Zocchi E
  Title
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.
  Journal
Biochem Biophys Res Commun 345:573-80 (2006)
DOI:10.1016/j.bbrc.2006.04.096
  Sequence
[hsa:952]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.20
IUBMB Enzyme Nomenclature: 2.4.99.20
ExPASy - ENZYME nomenclature database: 2.4.99.20
BRENDA, the Enzyme Database: 2.4.99.20
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