KEGG   ENZYME: 2.4.99.20
Entry
EC 2.4.99.20                Enzyme                                 
Name
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase;
diphosphopyridine nucleosidase (ambiguous);
CD38 (gene name);
BST1 (gene name)
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
NADP+:nicotinate ADP-ribosyltransferase
Reaction(IUBMB)
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide (overall reaction) [RN:R00119];
(1a) NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide [RN:R10631];
(1b) 2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate [RN:R10632]
Reaction(KEGG)
Substrate
NADP+ [CPD:C00006];
nicotinate [CPD:C00253];
2'-phospho-cyclic ADP-ribose [CPD:C20742]
Product
nicotinate-adenine dinucleotide phosphate [CPD:C13051];
nicotinamide [CPD:C00153];
2'-phospho-cyclic ADP-ribose [CPD:C20742]
Comment
This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
History
EC 2.4.99.20 created 2014
Pathway
ec00760  Nicotinate and nicotinamide metabolism
Orthology
K01242  ADP-ribosyl cyclase 1
K18152  ADP-ribosyl cyclase 2
Genes
HSA683(BST1) 952(CD38)
PTR461126(BST1) 745433(CD38)
PPS100972434(BST1) 100974952(CD38)
GGO101145401(BST1) 101149825(CD38)
PON100174150(BST1) 100457558(CD38)
PPYG129035217(CD38) 129035583(BST1)
NLE100606064(BST1) 100606960(CD38)
HMH116456838(CD38) 116456971(BST1)
SSYN129464963(BST1) 129464964(CD38)
MCC714399(CD38) 722848(BST1)
MCF101926698(BST1) 102126394(CD38)
MTHB126955270 126955271
MNI105487906(CD38) 105487910(BST1)
CSAB103246326(CD38) 103246328(BST1)
CATY105579036(CD38) 105579041(BST1)
PANU101017008(BST1) 101022305(CD38)
TGE112624454(CD38) 112625503(BST1)
MLEU105542530(CD38) 105542551(BST1)
RRO104658167(BST1) 104658170(CD38)
RBB108531741(CD38) 108531746(BST1)
TFN117085172(BST1) 117085174(CD38)
PTEH111539163(BST1) 111539166(CD38)
CANG105516574(CD38) 105516575(BST1)
CJC100387937(CD38) 100402445(BST1)
SBQ101035567(BST1) 101036203(CD38)
CIMI108282733(BST1) 108282737(CD38)
ANAN105730927(CD38)
CSYR103269336(BST1)
MMUR105856078(CD38) 105856080(BST1)
LCAT123637314(BST1) 123637315(CD38)
PCOQ105805514(BST1) 105805529(CD38)
OGA100948063(CD38) 100949639(BST1)
MMU12182(Bst1) 12494(Cd38)
MCAL110294333(Bst1) 110294426(Cd38)
MPAH110330967(Cd38) 110330979(Bst1)
RNO25668(Cd38) 81506(Bst1)
MCOC116070677(Bst1) 116070680(Cd38)
ANU117701559 117712457(Cd38) 117712864(Bst1)
MUN110559148(Cd38) 110559149(Bst1)
CGE100773187(Cd38) 100773468(Bst1)
MAUA101825392(Cd38) 101829693(Bst1)
PROB127233691(Bst1) 127233692(Cd38)
PLEU114687856 114709224(Bst1) 114709225(Cd38)
MORG121436384(Cd38) 121436585(Bst1)
MFOT126506474 126506475
AAMP119803349(Bst1) 119804718(Cd38)
NGI103728882(Cd38) 103728884(Bst1)
HGL101713685(Bst1) 101720283(Cd38)
CPOC100726264(Bst1) 100726537(Cd38) 100735470 106026535
CCAN109691561(Cd38) 109691564(Bst1)
DORD105980149(Bst1) 105980338(Cd38)
DSP122104071(Bst1) 122104097(Cd38)
PLOP125364481(Bst1) 125364801(Cd38)
NCAR124994506 124994678
MMMA107139141(Bst1) 107139142(Cd38)
OCU100009409(CD38) 100351817
OPI101533232(CD38) 101533472(BST1)
TUP102468679(BST1) 102480083(CD38)
GVR103601094(CD38) 103606370(BST1)
CFA403756(CD38)
CLUD112653383(CD38) 125752080(BST1)
VVP112919977(BST1) 112919984(CD38)
VLG121489283(BST1) 121489687(CD38)
NPO129510115(CD38) 129510478(BST1)
AML100463977(BST1) 100481326(CD38)
UMR103658313(BST1) 103658362(CD38)
UAH113266704(CD38)
UAR123775810(BST1) 123775823(CD38)
ELK111149117 111149296
LLV125093560 125093561
MPUF101684892(BST1) 101685175(CD38)
MNP132004743(BST1) 132004751(CD38)
MLK131825764(CD38) 131825787(BST1)
NVS122890459(CD38) 122890462(BST1)
ORO101364829(CD38) 101365133(BST1)
EJU114196716(CD38) 114198536(BST1)
ZCA113924284(CD38) 113924929(BST1)
MLX118010687(CD38) 118010690(BST1)
NSU110571283(CD38) 110581065(BST1)
LWW102748690(CD38) 102748987(BST1)
FCA101101052(BST1) 101101308(CD38)
PYU121038074(CD38) 121038087(BST1)
PCOO112858650(BST1) 112858986(CD38)
PBG122479020(CD38) 122479021(BST1)
PVIV125164260(CD38) 125164330(BST1)
LRUF124520126 124521280
PTG102955186(CD38) 102962771(BST1)
PPAD109269635(CD38) 109269636(BST1)
PUC125922651 125922652
AJU106975627 106975653
HHV120237985(CD38) 120237994(BST1)
BTA327677(CD38) 616757(BST1)
BOM102271683(BST1) 102273331(CD38)
BIU109560088(BST1) 109560687(CD38)
BBUB102400853(BST1) 102401480(CD38)
BBIS104982242 105001132(CD38) 105001197(BST1)
CHX102169848(BST1) 102172881(CD38)
OAS101116575(BST1) 105614340 114115250
BTAX128049684(BST1) 128049963(CD38)
ODA120861630(CD38) 120861770(BST1)
CCAD122428274(CD38) 122428330(BST1)
SSC100511702(CD38) 100625942(BST1)
CFR102508026(CD38) 102508256(BST1)
CBAI105083238(BST1) 105083239(CD38)
CDK105098338(BST1) 105098339(CD38)
VPC102538089(BST1) 102538359(CD38)
BACU103000954(BST1) 103020545(CD38)
BMUS118895218(CD38) 118895232(BST1)
LVE103087769(CD38) 103088314(BST1)
OOR101284537(CD38) 101284786(BST1)
DLE111171401(CD38) 111171425(BST1)
PCAD102981972(CD38) 102982819(BST1)
PSIU116754512(CD38) 116754525(BST1)
NASI112397560(CD38) 112397568(BST1)
ECB100068959(CD38) 100068968(BST1)
EPZ103565758(BST1) 103565759(CD38)
EAI106827091(CD38) 106827092(BST1)
MYB102252244(CD38) 102252530(BST1)
MYD102759158(CD38) 102770056(BST1)
MMYO118666927(BST1) 118666935(CD38)
MLF102434861(CD38) 102437542(BST1)
PKL118708737(CD38) 118725690(BST1)
EFUS103294529(CD38) 103294530(BST1)
DRO112316691(BST1) 112316692(CD38)
SHON118986595(CD38) 118989556(BST1)
AJM119035514(CD38) 119035581(BST1)
PDIC114491309(CD38) 114493375(BST1)
PHAS123815823(CD38) 123815824(BST1)
MMF118615378(BST1) 118641660(CD38)
PPAM129077456(BST1) 129077688(CD38)
HAI109372167(CD38) 109372831(BST1)
RFQ117021922 117021923 117022444(BST1)
PALE102884937(BST1) 102889755(CD38)
PGIG120582708(BST1) 120582820(CD38)
PVP105295961(BST1) 105295966(CD38)
RAY107507351(CD38) 107507352(BST1)
MJV108403411(BST1) 108408183(CD38)
TOD119260627 119260628 119260630 119260888(BST1) 119261103 119261298
SARA101539895(BST1) 101540160(CD38)
SETR126032312(CD38) 126032568(BST1)
LAV100659997(BST1) 100660287(CD38)
TMU101346112 101346368
ETF101649299 101649935 101650242(CD38)
DNM101429299(BST1) 101429735(CD38)
MDO100015733(BST1) 103094598(CD38)
GAS123252450(BST1) 123252910(CD38)
SHR100915627(BST1) 105751033(CD38)
AFZ127540591 127541917
PCW110212831(BST1) 110212844(CD38)
TVP118853509(CD38) 118855327(BST1)
OAA100074315(CD38) 100079912(BST1)
GGA422827(CD38) 422828(BST1)
PCOC116225809(BST1) 116225812
MGP100546297 100548136(CD38)
CJO107313950(BST1) 107313951(CD38)
TPAI128080133 128080300(BST1)
LMUT125691785 125691786
NMEL110398571(CD38) 110398576
ACYG106035386(BST1)
CATA118259455 118259458
AFUL116489206 116489217(CD38)
TGU100224783(BST1) 101232999(CD38)
LSR110484008 110484039
SCAN103824309(BST1) 103824319
PMOA120497359 120497360(CD38)
OTC121335091 121335188
PRUF121348778(BST1) 121365982(CD38)
GFR102032481(BST1) 102032646(CD38)
FAB101808664(BST1) 101813225(CD38)
OMA130252738(CD38) 130252873(BST1)
PHI102100836(CD38) 102101014
PMAJ107203272 107203546
CCAE111928170 111928172
CCW104690721 104690901(CD38)
CBRC103625592(CD38) 103625593
ETL114061133(BST1) 114061141
ZAB102061886 102065942
ZLE135447073(BST1) 135447074
ACHL103810025(BST1) 103810718(CD38)
SVG106857245(BST1) 106857250(CD38)
MMEA130578391 130578393
HRT120753271 120753523
FPG101912278(CD38) 101917967(BST1)
FCH102048375 102048871
CLV102089855(BST1)
EGZ104134476(BST1) 104134477(CD38)
NNI104010763(CD38) 104010764(BST1)
PCRI104026992(CD38) 104030339(BST1)
PLET104613827(CD38) 104619105(BST1)
EHS104508986(BST1) 104515266(CD38)
PCAO104040776(BST1) 104051866(CD38)
ACUN113479380 113479383(BST1)
TALA104357985(CD38) 104360998(BST1)
PADL103916996(CD38) 103916997(BST1)
AFOR103898760 103898761
ACHC115341987(BST1) 115342015(CD38)
HALD104312688(BST1) 104325930(CD38)
HLE104837598(CD38) 104837599(BST1)
AGEN126034359 126034378
GCL127015977 127016135
CCRI104161112(CD38) 104163056(BST1)
CSTI104549352(CD38)
CMAC104473039(CD38) 104475413(BST1)
MUI104534000(CD38) 104536118(BST1)
BREG104629678(CD38) 104631650(BST1)
FGA104080203(CD38)
GSTE104263570(BST1) 104263989(CD38)
LDI104340997(CD38) 104353367(BST1)
MNB103776747(BST1) 103781749(CD38)
OHA104329232(BST1) 104329258(CD38)
NNT104412272(CD38)
SHAB115610662(BST1) 115610663(CD38)
DPUB104309172(BST1) 104309173(CD38)
PGUU104458293(CD38) 104461953(BST1)
ACAR104523532 104523533
CPEA104393586(CD38) 104393587(BST1)
AVIT104267215(CD38) 104272885(BST1)
CVF104288764(BST1) 104288765(CD38)
RTD128910295 128910395
CUCA104067702(BST1) 104067733(CD38)
TEO104376417(BST1) 104376962(CD38)
BRHI104499290(CD38) 104500705(BST1)
AAM106498697 106498751
AROW112970832 112970833
NPD112958511 112958546
TGT104569372(BST1) 104580413(CD38)
DNE112996520 112996530
SCAM104143028(BST1) 104143030(CD38)
ASN102376962(BST1)
AMJ102559494(BST1)
CPOO109322214(BST1) 109322366(CD38)
GGN109303956 109304108
PSS102444728(BST1) 102444963(CD38)
CMY102933631(BST1) 102933862(CD38)
CCAY125636146(BST1) 125636147(CD38)
DCC119855170(BST1) 119855171(CD38)
CPIC101935271 101935553
TST117878308 117878553
CABI116821059(CD38) 116821061(BST1)
MRV120405962 120405963
ACS100566030(cd38)
ASAO132776366
PVT110085956(CD38)
SUND121932151(CD38)
PBI103059310
PMUR107292463
CTIG120300466
TSR106543891(CD38)
PGUT117660712
APRI131203278
PTEX113435891
VKO123017189(CD38)
PMUA114604446
PRAF128420836
ZVI118084020(CD38)
HCG128326526
GJA107120012(CD38)
STOW125439720
EMC129343506
XLA100036901(cd38.L) 101027297(bst1.L)
XTR101733556 496666(cd38)
NPR108799310(BST1) 108799313
RTEM120924334(CD38) 120924335
BBUF120990331 120990332
BGAR122931523 122940253(BST1)
MUO115461420(BST1) 115462162
GSH117367099
DRE101886891
SANH107693813
SGH107568972
CAUA113075268
CGIB128013116
PTET122337612
LROH127158671
OMC131533699
PPRM120495013
MASI127413750 127418175
TROS130550411
TDW130412881 130412937
MANU129425951 129426525
IPU108256685 108259605
IFU128599833 128602611
PHYP113532851 113546708
SMEO124375480 124380174
TFD113634204 113659789
TVC132838678 132840406
TRN134301176 134301219
AMEX103029242
CMAO118798758 118798957
EEE113582404 113582405
CHAR105894086 105900065 105902689 105902690
TRU101074837 101075059 105418447
TFS130514094 130514096 130514097 130514099 130514100 130520404 130520406 130520895 130521000 130521379
TNGGSTEN00025533G001 GSTEN00025534G001
LCO104933795 104933796 104933803
NCC104942392 104946571 104946574
TBEN117496890 117497347 117498409 117498413
CGOB115025235 115025547 115025767
PGEO117465503 117465889 117465962
GACU117544669 117544769 117544771
EMAC134858086 134858088 134858089
ELY117264480 117264955 117265032 117265088
EFO125882281 125882284 125882285
PLEP121940397 121960727 121961001
SLUC116048591 116048593 116048594 116048595
ECRA117937835 117937841
ESP116672165 116672166
PFLV114549402 114549422 114549480 114549609
GAT120811807 120811890 120811891
PPUG119198455 119198456 119198459
AFB129110584 129111088
CLUM117749414 117749895
PSWI130206161 130206628
MSAM119912040 119912049
SCHU122866627 122866628 122866631
CUD121527044 121527105 121527134 121527530 121527535 121527555 121527566 121527740
ALAT119008641 119008766 119008934 119009095 119013827
MZE101478770 101479062 101479335
ONL100696855 100709482 100710024 102077908 102078110 106098852 109194449
OAU116329626 116329633 116329643 120441989 120442012 120442076
OLA101168159 101168658 101168676
OML112151048 112151449
CSAI133423196 133423198 133423381 133445545
XMA102227962 102228215 106699822
XCO114136499 114136564 114137010
XHE116711401 116711499 116711986
PRET103456798 103456800 103456801
PFOR103147559 103147560 103147569
PLAI106951163 106951164 106951165
PMEI106912836 106912857 106912868
GAF122823991 122823992
PPRL129352091 129352097 129352104
CVG107085442 107085455 107099405 107099407
CTUL119798421 119798436 119798439
GMU124857890 124858222 124858405
NFU107382594 107382595
KMR108230245 108230355 108230372
ALIM106515510 106515511
NWH119426679 119426680
AOCE111587679 111587684
MCEP124996073 125024413
CSEM103377367 103377368
POV109629467 109629469
SSEN122766606 122766860
HHIP117753607 117753609
HSP118098756 118098758
PPLT128425478 128425479 128425480 128425481
SMAU118287134 118287137
LCF108900033 108900035
SDU111224346 111224354
SLAL111673629 111673631 111673659
XGL120789958 120790041
HCQ109517521
SSCV125985721
SBIA133492935
PEE133396678
PTAO133470484
BPEC110165536 110165581
BSPL114853868 114854305 114854614 114854615
SJO128382486 128382843
SASA106590199 106590200
STRU115195719 115195720
OTW112227553 112245218
OMY110489876 110489879
OGO124039734 124039735
ONE115130320 115131105
OKI109899432 109899433
OKE118372679 118372691
SALP111953730
SNH120051110 120051113
CCLU121569932 121570630
ELS105031580
SFM108922735 108922775
PKI111850018 111850115
AANG118226015 118226024 118226025
LOC102689984 102690185
PSPA121324556 121324563 121324571 121329920
ARUT117408506 117420417 117421343 117421345 117421349
LCM102364780 106706579
RTP109917306 109917325
CPLA122551973 122555026
HOC132815982 132816861
LERI129699137 129699154
PMRN116941239 116941240
LRJ133345413 133345610
BFO118405736
BBEL109465410
SPU100126187(arc3) 100859964(arc4) 115918149 115918151 115922770 576085(arc2) 580868(arc1)
LPIC129264926 129266004 129279062 129279296 129279449
APLC110977913 110981710
ARUN117298548 117298666 117298782
SKO100370260
HROHELRODRAFT_179637 HELRODRAFT_193621
LGILOTGIDRAFT_150043 LOTGIDRAFT_218611
PVUL126821660 126830888
PCAN112555169 112555726 112555871
GAE121367392
HRF124117015 124117017 124117019 124122531
HRJ124262792 124262799 124262800 124262801 124267312
CRG105319809
CANU128181121
CVN111133847
OED125659704
MYI110451407 110458378
PMAX117342638 117342726
MMER123554776 123556012
RPHI132718611 132734862
DPOL127875390 127878167
MAEA128208242
LJP135479597
LAK106153853 106155009 106155798 106159481 106159482 106169313 106180219
OVIT265_08021 T265_08022
LLON135494596 135498056 135501811
NVE116618638 5503859 5505197
EPA110246357 110251379
ATEN116291709 116302029 116302620
ADF107339424 107340996
AMIL114948060 114961589
PDAM113669069 113675387
SPIS111329655
DGT114519185
XEN124439014
HMG100199121 100199929 100211840 101234797 101241800
HSY130621832 130654748 130654749 130655425 130655865
RES135686012 135686013 135687424
TADTRIADDRAFT_19184 TRIADDRAFT_36890 TRIADDRAFT_51409
AQU105312071 105312710
SREPTSG_13238
 » show all
Reference
1  [PMID:11829748]
  Authors
Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H
  Title
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
  Journal
Biochem J 362:125-30 (2002)
DOI:10.1042/0264-6021:3620125
  Sequence
[mmu:12494]
Reference
2  [PMID:16690024]
  Authors
Moreschi I, Bruzzone S, Melone L, De Flora A, Zocchi E
  Title
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.
  Journal
Biochem Biophys Res Commun 345:573-80 (2006)
DOI:10.1016/j.bbrc.2006.04.096
  Sequence
[hsa:952]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.20
IUBMB Enzyme Nomenclature: 2.4.99.20
ExPASy - ENZYME nomenclature database: 2.4.99.20
BRENDA, the Enzyme Database: 2.4.99.20
LinkDB

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