tryprostatin B synthase;
ftmPT1 (gene name);
brevianamide F prenyltransferase (ambiguous);
dimethylallyl-diphosphate:brevianamide-F dimethylallyl-C-2-transferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
prenyl diphosphate [CPD:C00235];
brevianamide F [CPD:C20563]
Product
diphosphate [CPD:C00013];
tryprostatin B [CPD:C20512]
Comment
The enzyme from the fungus Aspergillus fumigatus can also prenylate other tryptophan-containing cyclic dipeptides. Prenylation occurs mainly at C-2 [1], but also at C-3 [2]. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, cyclotryprostatins, spirotryprostatins, fumitremorgins and verruculogen.
Breaking the regioselectivity of indole prenyltransferases: identification of regular C3-prenylated hexahydropyrrolo[2,3-b]indoles as side products of the regular C2-prenyltransferase FtmPT1.
