KEGG ENZYME: 2.5.1.114

ENZYME: 2.5.1.114

Entry

EC 2.5.1.114                Enzyme

Name

tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase;
TYW2;
tRNA-yW synthesizing enzyme-2;
TRM12 (gene name);
taw2 (gene name)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

S-adenosyl-L-methionine:tRNAPhe (4-demethylwyosine37-C7)-[(3S)-3-amino-3-carboxypropyl]transferase

Reaction(IUBMB)

S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe = S-methyl-5'-thioadenosine + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe [RN:R10611]

Reaction(KEGG)

R10611

Substrate

S-adenosyl-L-methionine [CPD:C00019];
4-demethylwyosine37 in tRNAPhe

Product

S-methyl-5'-thioadenosine [CPD:C00170];
7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe

Comment

The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases. This modification is essential for translational reading-frame maintenance. The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNAPhe.

History

EC 2.5.1.114 created 2013

Orthology

K07055

tRNA wybutosine-synthesizing protein 2

Genes

HSA:	55039(TRMT12)

PTR:	464377(TRMT12)

PPS:	100979722(TRMT12)

GGO:	101124627(TRMT12)

PON:	100447332(TRMT12)

PPYG:

129042728(TRMT12)

NLE:	100582652(TRMT12)

HMH:	116813572(TRMT12)

SSYN:

129486791(TRMT12)

MCC:	705848(TRMT12)

MCF:	101865973(TRMT12)

MTHB:

126961390

MNI:	105468476(TRMT12)

CSAB:

103237404(TRMT12)

CATY:

105598680(TRMT12)

PANU:

101020238(TRMT12)

TGE:	112630768(TRMT12)

MLEU:

105554613(TRMT12)

RRO:	104662794(TRMT12)

RBB:	108538090(TRMT12)

TFN:	117078877(TRMT12)

PTEH:

111550755(TRMT12)

CANG:

105516927(TRMT12)

CJC:	100385176(TRMT12)

SBQ:	101029907(TRMT12)

CIMI:

108305983(TRMT12)

ANAN:

105716801(TRMT12)

MMUR:

105884369(TRMT12)

LCAT:

123644437(TRMT12)

PCOQ:

105823585(TRMT12)

OGA:	100958117(TRMT12)

MMU:	68260(Trmt12)

MCAL:

110310681(Trmt12)

MPAH:

110335044(Trmt12)

RNO:	314999(Trmt12)

MCOC:

116082400(Trmt12)

ANU:	117719407(Trmt12)

ASYL:

127667957(Trmt12)

MUN:	110552425(Trmt12)

CGE:

113837486

MAUA:

101832749(Trmt12)

PROB:

127235378(Trmt12)

PLEU:

114694812(Trmt12)

MORG:

121461067(Trmt12)

MFOT:

126503527

AAMP:

119823230(Trmt12)

NGI:	103743903(Trmt12)

HGL:	101715645(Trmt12)

CPOC:

100734337(Trmt12)

CCAN:

109688115(Trmt12)

DORD:

106001769(Trmt12)

DSP:	122102336(Trmt12)

PLOP:

125361059(Trmt12)

MMMA:

107142906(Trmt12)

ITI:	101961656(Trmt12)

OCU:	100352397 127482590

OPI:	101519993(TRMT12)

TUP:	102500902(TRMT12)

GVR:	103583169(TRMT12)

CFA:	609411(TRMT12)

CLUD:

112662127(TRMT12)

VVP:	112915968(TRMT12)

VLG:	121498782(TRMT12)

AML:	100468536(TRMT12)

UMR:	103661618(TRMT12)

UAH:	113252745(TRMT12)

UAR:	123797720(TRMT12)

ELK:

111146607

LLV:

125096951

MPUF:

101681207(TRMT12)

MNP:	132014286(TRMT12)

MLK:	131826421(TRMT12)

NVS:	122904314(TRMT12)

ORO:	101384928(TRMT12)

EJU:	114211197(TRMT12)

ZCA:	113912492(TRMT12)

MLX:	118015195(TRMT12)

NSU:	110578929(TRMT12)

LWW:	102743104(TRMT12)

FCA:	101090488(RNF139)

PYU:	121042954(TRMT12)

PCOO:

112859522(TRMT12)

PBG:	122495795(TRMT12)

PVIV:

125156265(TRMT12)

LRUF:

124507791

LGF:	123585484(TRMT12)

AJU:

106986564

PTG:	102970870(TRMT12)

PPAD:

109273164(TRMT12)

PUC:

125924741

PLEZ:

122211159(TRMT12)

HHV:	120231767(TRMT12)

BTA:	516516(TRMT12)

BOM:	102277834(TRMT12)

BIU:	109568571(TRMT12)

BBUB:

102406539(TRMT12)

BBIS:

104987830(TRMT12)

CHX:	102189221(TRMT12)

OAS:	101106695(TRMT12)

BTAX:

128059327(TRMT12)

CSUM:

138088568(TRMT12)

ODA:	120878923(TRMT12)

CCAD:

122451232(TRMT12)

MREE:

136145022(TRMT12)

OVR:	110141195(TRMT12)

MBEZ:

129560317(TRMT12)

SSC:	100155406(TRMT12)

CFR:	102519623(TRMT12)

CBAI:

105082926(TRMT12)

CDK:	105096435(TRMT12)

VPC:	102539603(TRMT12)

BACU:

103011113(TRMT12)

LVE:	103086079(TRMT12)

OOR:	101277734(TRMT12)

DLE:	111164382(TRMT12)

PCAD:

102978377

PSIU:

116742288(TRMT12)

NASI:

112396995(TRMT12)

ECB:	100067346(TRMT12)

EPZ:	103564519(TRMT12)

EAI:	106839357(TRMT12)

MYB:	106723536(TRMT12)

MYD:	102770501(TRMT12)

MMYO:

118670979(TRMT12)

MLF:	102424997(TRMT12)

MDT:	132219960(TRMT12)

MYUM:

138992922(TRMT12)

PKL:	118718406(TRMT12)

EFUS:

103287592(TRMT12)

MNA:	107539501(TRMT12)

DRO:	112315491(TRMT12)

SHON:

118988661(TRMT12)

AJM:	119064841(TRMT12)

PDIC:

114514494(TRMT12)

PHAS:

123833115(TRMT12)

MMF:	118631479(TRMT12)

PPAM:

129084319(TRMT12)

RFQ:	117033556(TRMT12)

PALE:

102896712(TRMT12)

PGIG:

120595677(TRMT12)

PVP:	105292545(TRMT12)

RAY:	107521596(TRMT12)

MJV:	108392307(TRMT12)

TOD:	119249369(TRMT12)

SARA:

101544155(TRMT12)

SFUM:

130021586(TRMT12)

SETR:

125997552(TRMT12)

LAV:	100658475(TRMT12)

TMU:

101347238

ETF:	101655489(TRMT12)

DNM:	101438799(TRMT12)

MDO:	100020165(TRMT12) 100023277

GAS:	123231784(TRMT12) 123255422

SHR:	100926005(TRMT12)

AFZ:

127543159

PCW:	110192303(TRMT12)

TVP:	118832587 118844109

PBRV:

138143955(TRMT12)

OAA:	100087951(TRMT12)

TACU:

119929806(TRMT12)

GGA:	422259(TRMT12)

PCOC:

116229661(TRMT12)

MGP:	100538997(TRMT12)

CJO:	107312716(TRMT12)

TPAI:

128075777(TRMT12)

LMUT:

125699556(TRMT12)

NMEL:

110403089(TRMT12)

APLA:

101799970(TRMT12)

ACYG:

106037483(TRMT12)

CATA:

118245385(TRMT12)

AFUL:

116494524(TRMT12)

TGU:	100226909(TRMT12)

LSR:	110469608(TRMT12)

SCAN:

103816584(TRMT12)

PMOA:

120508685(TRMT12)

OTC:	121331765(TRMT12)

PRUF:

121349119(TRMT12)

ATRC:

139597139(TRMT12)

FAB:	101812632(TRMT12)

OMA:	130252989(TRMT12)

PHI:	102114676(TRMT12)

PMAJ:

107204035(TRMT12)

CCAE:

111928720(TRMT12)

CCW:	104691361(TRMT12)

ACOE:

138110292(TRMT12)

ETL:	114060707(TRMT12)

ZLE:	135447674(TRMT12)

ACHL:

103798427(TRMT12)

SVG:	106858364(TRMT12)

MMEA:

130573261(TRMT12)

HRT:	120765449(TRMT12)

SATI:

136374231

CCIC:

134049964(TRMT12)

FPG:	101916683(TRMT12)

FCH:	102054438(TRMT12)

CCRI:

104162575(TRMT12)

SHAB:

115612978(TRMT12)

ACUN:

113480193(TRMT12)

TALA:

116959083(TRMT12)

ACHC:

115333649(TRMT12)

HLE:	104834818(TRMT12)

AGEN:

126050113

HHAR:

128153817(TRMT12)

LDI:	104345837(TRMT12)

DPUB:

104303650(TRMT12)

PPUS:

135183889(TRMT12)

AVIT:

104278056(TRMT12)

EGZ:	104129953(TRMT12)

NNI:	104012948(TRMT12)

AFOR:

103901286(TRMT12)

CLV:

102096517

MUI:	104534454(TRMT12)

PGUU:

104457846(TRMT12)

PLET:

104628371(TRMT12)

EHS:	104515697(TRMT12)

CMAC:

104487697(TRMT12)

CUCA:

104059296(TRMT12)

TEO:	104374729(TRMT12)

BREG:

104636678(TRMT12)

CPEA:

104388392(TRMT12)

CVF:	104283583(TRMT12)

AAM:	106484769(TRMT12)

AROW:

112974121(TRMT12)

NPD:	112944484(TRMT12)

DNE:	112989740(TRMT12)

SCAM:

104150550(TRMT12)

ASN:	102382316(TRMT12)

AMJ:	102563349(TRMT12)

CPOO:

109311027(TRMT12)

GGN:	109300623(TRMT12)

PSS:	102456684(TRMT12)

CMY:	102935765(TRMT12)

CCAY:

125642626(TRMT12)

DCC:	119860891(TRMT12)

CPIC:

101946914(TRMT12)

TST:	117882682(TRMT12)

CABI:

116819983(TRMT12)

MRV:	120372374(TRMT12)

ASAO:

132763044(TRMT12) 132763173

PVT:	110083587(TRMT12)

SUND:

121936220(TRMT12)

PBI:	103062147(TRMT12)

PMUR:

107291575(TRMT12)

CTIG:

120302302(TRMT12)

TSR:	106551718(TRMT12)

PGUT:

117665119(TRMT12)

APRI:

131205157(TRMT12)

PTEX:

113437793(TRMT12)

NSS:	113416723(TRMT12)

VKO:	123021966(TRMT12)

PMUA:

114589041(TRMT12)

PRAF:

128406243(TRMT12)

ZVI:	118084422(TRMT12)

HCG:	128335498(TRMT12)

GJA:	107124532(TRMT12)

STOW:

125442370(TRMT12)

EMC:	129340881(TRMT12)

XLA:	108698285(trmt12.L)

XTR:	100380191(trmt12)

NPR:	108799572(TRMT12)

RTEM:

120913055(TRMT12)

BBUF:

120977596(TRMT12)

BGAR:

122919398(TRMT12)

PWL:	138265490(TRMT12)

MUO:	115474286(TRMT12)

GSH:	117360913(TRMT12)

DRE:	564925(trmt12)

SRX:	107740100(trmt12)

SANH:

107669089(trmt12)

SGH:	107602575(trmt12)

CCAR:

109079186(trmt12)

CAUA:

113113888(trmt12)

CGIB:

127971558

PTET:

122357626(trmt12)

LROH:

127176351(trmt12)

OMC:	131553609(trmt12)

PPRM:

120474346(trmt12)

RKG:	130095145(trmt12)

MAMB:

125259286(trmt12)

CIDE:

127494366

CERY:

137014209(trmt12)

MASI:

127417887

TROS:

130563689(trmt12)

TDW:	130438297(trmt12)

MANU:

129421926(trmt12)

PDAB:

135757773(trmt12)

IPU:

108268801

IFU:	128611144(trmt12)

PHYP:

113529183(trmt12)

SMEO:

124385898(trmt12)

TFD:	113636049(trmt12)

TVC:	132856376(trmt12)

CGAR:

128531445(trmt12)

NGRA:

132890566(trmt12)

TRN:	134318952(trmt12)

AMEX:

103042921(trmt12)

CMAO:

118807119(trmt12)

EEE:	113585203(trmt12)

CHAR:

105893068(trmt12)

SPIL:

134068374(trmt12)

TRU:	101061055(trmt12)

TFS:	130531127(trmt12)

TNG:	GSTEN00031299G001

LCO:	104928726(trmt12)

CGOB:

115014594(trmt12)

EMAC:

134859395(trmt12)

ELY:	117260647(trmt12)

EFO:	125893990(trmt12)

PLEP:

121948109(trmt12)

SLUC:

116052301(trmt12)

ECRA:

117952138(trmt12)

ESP:	116696737(trmt12)

PFLV:

114562320(trmt12)

GAT:	120817855(trmt12)

PPUG:

119210930(trmt12)

AFB:	129090324(trmt12)

CLUM:

117737783(trmt12)

PSWI:

130210213(trmt12)

CANA:

137794611(trmt12)

CVE:	137875645(trmt12)

MSAM:

119889307(trmt12)

SCHU:

122880213(trmt12)

CUD:	121515968(trmt12)

SPUL:

138598548(trmt12)

LMIX:

132982146(trmt12)

ALAT:

119007995(trmt12)

ASTR:

137602284(trmt12)

MZE:	101477717(trmt12)

ONL:	100692074(trmt12)

OAU:	116317612(trmt12)

OLA:	101163092(trmt12)

OML:	112153811(trmt12)

CSAI:

133447628(trmt12)

XMA:	102227936(trmt12)

XCO:	114138657(trmt12)

XHE:	116713895(trmt12)

PRET:

103471570(trmt12)

PFOR:

103150181(trmt12)

PLAI:

106945447(trmt12)

PMEI:

106915283(trmt12)

GAF:	122837506(trmt12)

PPRL:

129360537 129360794

CVG:	107093579(trmt12)

CTUL:

119786245(trmt12)

GMU:	124860136(trmt12)

NFU:	107378195(trmt12)

KMR:	108231272(trmt12)

ALIM:

106514856(trmt12)

NWH:	119408405(trmt12)

AOCE:

111582111(trmt12)

EJA:	138211749(trmt12)

BFRE:

138618532(trmt12)

MCEP:

125008061(trmt12)

CSEM:

103390537(trmt12)

POV:	109625780(trmt12)

SSEN:

122778110(trmt12)

SSOE:

131472574(trmt12)

HHIP:

117769315(trmt12)

HSP:	118111962(trmt12)

PPLT:

128445875(trmt12)

SMAU:

118319270(trmt12)

LCF:

108872492

SDU:	111232645(trmt12)

SLAL:

111648183(trmt12)

XGL:	120785067(trmt12)

HCQ:	109524300(trmt12)

SSCV:

125978323(trmt12)

SBIA:

133508701(trmt12)

PEE:	133407735(trmt12)

PTAO:

133484487(trmt12)

BPEC:

110159037(trmt12)

ENY:	140350970(trmt12)

MALB:

109955755(trmt12)

BSPL:

114864222(trmt12)

SJO:	128363149(trmt12)

SSCO:

133986407(trmt12)

STRU:

115205010(trmt12)

OTW:	112255681(trmt12)

OMY:	110504438(trmt12)

OGO:	124010661(trmt12)

ONE:	115129153(trmt12)

OKI:	109905111(trmt12)

OKE:	118363962(trmt12)

OMM:	135544987(trmt12)

SALP:

111967158(trmt12)

CCLU:

121585941(trmt12)

ELS:	105029873 114828743

OEP:	134032522(trmt12)

SFM:	108923167(trmt12)

PKI:	111836516(trmt12)

AANG:

118223133(trmt12)

AROT:

135251649(trmt12)

CCOG:

133124057(trmt12)

LOC:	102687083(trmt12)

PSPA:

121295211 121317916

ARUT:

117412022 117430509

PSEX:

120537253(trmt12)

LCM:	102350688(TRMT12)

CMK:	103177199(trmt12)

RTP:	109919454(trmt12)

CPLA:

122557175(trmt12)

HOC:	132820483(trmt12)

LERI:

129702204(trmt12)

PMRN:

116956665(TRMT12)

LRJ:	133360474(TRMT12)

BFO:

118431064

BBEL:

109484225

CIN:

100176207

SCLV:

120338208 120343551

SPU:

593691

AJJ:

139982250

APLC:

110982434

ARUN:

117299410

AAMU:

139942850

AFIL:

140139742

SKO:

100379063

PFLL:

139140785

CLEC:

106669520

HHAL:

106684077

NLU:

111056673

MQU:

128996509

PHU:	Phum_PHUM229350

ZNE:

110836641

CSEC:

111870188

BROR:

134542353

IEL:

124170814

HAMR:

139687032

FCD:

110859278

DPX:	DAPPUDRAFT_308692

DMK:

116922965

DPZ:

124341897

AFRA:

136035270 136035276

EAF:

111697572

LSM:

121129251

TCF:

131890322

DSV:

119432359

RSAN:

119405962

RMP:

119180822

DPTE:

113797541

DFR:

124490656

CVS:

136968279

PTEP:

107453812

ABRU:

129959807

UDV:

129216785

SDM:

118197138

LPOL:

106475675

PMEO:

129587028

CEL:	CELE_F40F9.10(F40F9.10)

CBR:

CBG_19351

CRQ:	GCK72_016974

BMY:	BM_BM3972(Bm3972)

LOA:	LOAG_02567

TSP:

Tsp_06313

HRO:	HELRODRAFT_67136

LGI:	LOTGIDRAFT_128178

PVUL:

126823439

PCAN:

112560613

LSAX:

138971824

BGT:

106065493

GAE:

121381844

HRF:

124116850

HRJ:

124267683

HASI:

137261675

HCRA:

139461689

CRG:

105332610

CANU:

128167397

CVN:

111131527

OED:

125683079

MYI:

110445483

PMAX:

117335742

AIRR:

138330405

MCAF:

127705970

MMER:

123536967

RPHI:

132754218

DPOL:

127843841

MAEA:

128229671 128229821

OBI:

106883232

OSN:

115212018

LJP:

135468779

LAK:	106158204 106162049

LLON:

135492423

NVE:

5520372

EPA:

110238807

ATEN:

116297840

ADF:

107333786

AMIL:

114977313

MCAZ:

138021549

MFOO:

138006896

PDAM:

113683052

SPIS:

111341651

HMG:

100209695

HSY:

130629096

RES:

135680794

TAD:	TRIADDRAFT_18638

SMO:	SELMODRAFT_105763 SELMODRAFT_153963

VCN:	VOLCADRAFT_121064

OLU:	OSTLU_34943

SCE:	YML005W(TRM12)

SEUB:

DI49_4085

SPAO:

SPAR_M01220

AGO:	AGOS_ADL199W

LTH:	KLTH0G10780g

VPO:	Kpol_1003p49

ZRO:	ZYRO0A02266g

CGR:	2891692(GVI51_M06765)

NCS:	NCAS_0G03740(NCAS0G03740)

NDI:	NDAI_0G00730(NDAI0G00730)

TPF:	TPHA_0G00810(TPHA0G00810)

TBL:	TBLA_0B06040(TBLA0B06040)

TGB:	HG536_0A02160

TDL:	TDEL_0G02320(TDEL0G02320)

KAF:	KAFR_0H03230(KAFR0H03230)

KNG:	KNAG_0H01920(KNAG0H01920)

ZMK:	HG535_0D01880

DHA:	DEHA2A09988g

PIC:	PICST_40540

PGU:	PGUG_01997

SPAA:

SPAPADRAFT_62286

LEL:	PVL30_003626(TRM12)

LBG:	92208595(LODBEIA_P33990)

CAL:	CAALFM_C305890WA(TRM12)

CTP:	CTRG_02449

COT:	CORT_0C02050

CDU:	CD36_85820

CTEN:

18249206(TRM12)

CLU:	CLUG_04764

CLUS:

A9F13_11g00297

CAUR:

CJI96_0002769

ASAU:

88171761(PUMCH_000693)

PPA:	PAS_chr2-2_0212

PKZ:	C5L36_0E01580

YLI:	2910461(YALI2_D01098g)

SLB:	AWJ20_4217(TRM12)

NCR:

NCU10483

NTE:	NEUTE1DRAFT14617(NEUTE1DRAFT_14617)

SMP:	10801401(SMAC4_08863)

PBEL:

QC761_605237(TRM12)

PPSD:

QC762_605237(TRM12)

PPSP:

QC763_605237(TRM12)

PPSA:

QC764_605237(TRM12)

TTT:	THITE_50004

MTM:	MYCTH_2311624

CTHR:

CTHT_0001960

RTHE:

98127725(VTJ83DRAFT_6377)

MGR:

MGG_12102

PPEI:

PpBr36_04393

PGRI:

PgNI_07006

SSCK:

SPSK_00267

FGR:	FGSG_01465

FPU:	FPSE_08487

FPOA:

FPOAC1_001575

FVN:	FVRRES_01782

FVR:	FVEG_09544

FOX:	FOXG_11249

NHE:	NECHADRAFT_30345

FFC:	NCS54_00037000

FKR:	NCS57_00035100

FMU:	J7337_000419

TRE:	TRIREDRAFT_62780

TRR:	M419DRAFT_79027

TASP:

36618995(TrAFT101_005003)

MAW:	19244382(TRM12)

MAJ:

MAA_01780

MBRN:

26244128(trm12)

PCHM:

VFPPC_02032

CMT:

CCM_05153

AMUS:

LMH87_011058

PLJ:	28889248(PLICBS_008291)

PTKZ:

JDV02_006387(TRM12)

VAL:	VDBG_01523

VDA:	VDAG_02033

CFJ:	CFIO01_07245

CLUP:

CLUP02_01363

CHIG:

CH63R_10285

CDET:

87943382(CDEST_06879)

ELA:	UCREL1_10218

PFY:	PFICI_03564

SSL:	SS1G_02487

BFU:	BCIN_13g03740

MBE:

MBM_06394

PSCO:

LY89DRAFT_573823

GLZ:	GLAREA_01555

ANI:	ANIA_00130

AFM:	AFUA_5G11650

ACT:	ACLA_014720

NFI:	NFIA_075620

AOR:	AO090120000283

ANG:	An18g03090

AFV:	AFLA_009501

ALUC:

AKAW2_31276A

ACHE:

ACHE_41175A

APUU:

APUU_12021A

TMF:	EYB26_001542

TRG:	TRUGW13939_05635

CIM:	CIMG_09168

CPW:	9692603(D8B26_007571)

URE:	UREG_05216

ABE:

ARB_03105

TVE:

TRV_05817

PBL:	PAAG_02406

PBN:	PADG_05548

AJE:	HCAG_00838

BGH:	BDBG_01012

PNO:	SNOG_08634

PTE:

PTT_04003

PTRR:

6347345(PtrM4_035380)

BZE:	COCCADRAFT_8699

BSC:	COCSADRAFT_32516

BOR:	COCMIDRAFT_21718

AALT:

CC77DRAFT_994087

ARAB:

EKO05_0009039

ZTR:	MYCGRDRAFT_87449

PFJ:	MYCFIDRAFT_178656

FFU:	CLAFUR5_10890

CBET:

CB0940_07189

BCOM:

BAUCODRAFT_47065

TML:	GSTUM_00010910001

SPO:	2543551(trm12)

SOM:	SOMG_01666(trm12)

PGR:	PGTG_07536

PTRC:

PtA15_13A231

PSTR:

Pst134EA_024377

MLR:	MELLADRAFT_110558

MBR:	MONBRDRAFT_28161

SRE:	PTSG_03546

PYO:	PY17X_0503900

PCB:	PCHAS_0502900

PBE:	PBANKA_0502800

PKN:	PKNH_0602900

PVX:	PVX_001790

PCY:	PCYB_061290

FCY:	FRACYDRAFT_162398

TPS:	THAPSDRAFT_262512

TBR:	Tb10.70.4420

TBG:	TbgDal_X3900

TCR:	504867.110 510943.180

LMA:	LMJF_03_0060

LIF:	LINJ_03_0050

LDO:	LDBPK_030050

LMI:	LMXM_03_0060

LMAT:

92517901(LSCM1_08046)

LBZ:	LBRM_03_0070

LPAN:

LPMP_030050

LOI:	92364007(LSCM4_08203)

LEIS:

94183396(GH5_08185)

LENR:

94175481(CUR178_08343)

LEIN:

94191766(JIQ42_08205)

PHET:

94293704(JKF63_07696)

EHX:	EMIHUDRAFT_236459 EMIHUDRAFT_449936

GTT:	GUITHDRAFT_71161

BIA:	GMA17_09795

MJA:

MJ_1557

MFE:	Mefer_1490

MVU:	Metvu_0461

MFS:	MFS40622_0731

MIF:	Metin_0073

MJH:	JH146_0117

MESG:

MLAUSG7_1020(taw)

MESA:

MLASG1_0757(taw)

MIG:	Metig_0821

MMP:

MMP0560

MMQ:	MmarC5_1047

MMX:	MmarC6_0333

MMZ:	MmarC7_1579

MMD:

GYY_03680

MMAK:

MMKA1_06070

MMAO:

MMOS7_06020

MMAD:

MMJJ_04250

MAE:

Maeo_0636

MVN:	Mevan_1437

MVO:

Mvol_0432

MOK:	Metok_0862

METF:

CFE53_01555

MTH:

MTH_1200

MMG:	MTBMA_c15780

MWO:	MWSIV6_1593(taw2)

MTEE:

MTTB_02270

METC:

MTCT_1093

METE:

tca_01157

METZ:

METMT2_1202

METK:

FVF72_05620

MTHM:

FZP57_07635

METJ:

FZP68_03040

MST:

Msp_0297

METB:

AW729_05650

MEIS:

PXD04_05285

MRU:

mru_1976

MSI:

Msm_1036

MEB:

Abm4_1548

MMIL:

sm9_2048

MEYE:

TL18_09425

MOL:

YLM1_1413

MARO:

MarbSA_15170

METV:

K4897_06285

MEL:	Metbo_0325

MEW:	MSWAN_2093

METH:

MBMB1_1722(taw2)

MFC:

BRM9_0347

MFI:	DSM1535_0950(taw2)

MCUB:

MCBB_2023(taw2)

MSUB:

BK009_07640

METN:

BK008_03295

METT:

CIT01_03870

METO:

CIT02_09255

MEME:

HYG87_05150

MFEG:

GCM10025860_03380

MEER:

NKF70_05365

MRID:

FGU46_06270

MFV:

Mfer_0394

MKA:

MK0940

AFU:

AF_1973

AFG:	AFULGI_00022330

APO:	Arcpr_0697

AVE:	Arcve_1804

FPL:

Ferp_1396

GAC:

GACE_0368

GAH:

GAH_01121

PFU:

PF0500

PFI:

PFC_01620

PHO:	PH0793(PH0793)

PAB:

PAB1538

PYN:

PNA2_1434

PYA:	PYCH_06810

PYS:

Py04_0683

PYC:	TQ32_03440

TKO:

TK0071

TON:

TON_0748

TGA:

TGAM_0679

TSI:

TSIB_1665

TBA:	TERMP_00791

THE:

GQS_01185

THA:

TAM4_598

THM:

CL1_1935

TLT:

OCC_03207

THS:

TES1_0720

TNU:

BD01_0979

TEU:

TEU_10690

TGY:	X802_06975

THV:	ADU37_CDS16880

TCH:	CHITON_1204

TPEP:

A0127_03555

TPIE:

A7C91_09880

TGG:	A3K92_04860

TCE:	A3L02_08300

TBS:	A3L01_04505

THH:	CDI07_04420

TSL:	A3L11_08610

TTD:	A3L14_06455

TPRF:

A3L09_04985

TRL:	A3L10_02070

TPAF:

A3L08_07405

THY:	A3L12_07840

TIC:	FH039_08765

TCQ:	TIRI35C_1159(taw)

THEM:

FPV09_00915

THEI:

K1720_00970

TAGG:

NF865_05455

PPAC:

PAP_02950

MBA:	Mbar_A2406

MBY:	MSBRM_1684

MBW:	MSBRW_2341

MBAR:

MSBR2_0721

MBAK:

MSBR3_0463

MAC:

MA_2064

MMA:

MM_3150

MMAZ:

MmTuc01_3248

MMJ:	MSMAS_1533

MMAC:

MSMAC_2878

MVC:	MSVAZ_1273

MEK:	MSKOL_1218

MLS:	MSLAZ_1120

METM:

MSMTP_2061

MEF:	MSWH1_1514

MEQ:	MSWHS_1793

MSJ:	MSSAC_2051

MSZ:	MSSIH_1716

MSW:	MSSIT_1771

MTHR:

MSTHT_0440

MTHE:

MSTHC_0281

MHOR:

MSHOH_1874

MFZ:	AOB57_000010

MHAB:

RSJ42_05025

METW:

AAY43_11615

MBU:

Mbur_0655

MMET:

MCMEM_0806

MELO:

J7W08_02195

MMH:

Mmah_1140

MHAZ:

BHR79_07840

MPOT:

BKM01_08520

MEV:	Metev_1614

MZH:	Mzhil_1347

MPY:

Mpsy_3091

MZI:	HWN40_06085

MMAV:

RE476_04510

MSEB:

RE474_00625

MHZ:	Metho_1531

MEHF:

MmiHf6_03440

MEES:

MmiEs2_06230

MTP:

Mthe_0736

MCJ:

MCON_1956

MHI:

Mhar_0127

MHU:

Mhun_0829

MRTJ:

KHC33_09470

MLA:

Mlab_0923

MEM:	Memar_1237

MBG:	BN140_0994

MEMA:

MMAB1_1318

MCHK:

MchiMG62_14330

MSUM:

OH143_00410

MRC:	R6Y96_07630

MPI:

Mpet_0984

MEFW:

F1737_06140

MAQE:

RJ40_04010

MFK:	E2N92_04175

MESB:

L1S32_04030

MANQ:

L1994_06005

MBN:

Mboo_1668

MFO:	Metfor_1346

MPL:

Mpal_1885

MPD:

MCP_0205

MEZ:

Mtc_2504

RCI:

RCIX1355

HAL:

VNG_2475C

HSL:	OE_4468F(taw2)

HANR:

LJ422_10000

HDL:	HALDL1_01855

HHB:	Hhub_3706(taw2)

HAGS:

JT689_11435

HABO:

JRZ79_09720

HNO:	LT974_00355

HLU:	LT972_14355

HANX:

ABSL23_04535

HALH:

HTSR_2016

HHSR:

HSR6_2092

HSU:	HLASF_2096

HSF:	HLASA_2130

HAHS:

HSRCO_2785(trm5-2)

SALR:

FQU85_04360

HALR:

EFA46_003655

HJE:	HacjB3_01325

HALX:

M0R89_05625

HAXZ:

M0R88_05610

HAYC:

NGM10_07820

HAXY:

NGM07_10880

SALI:

L593_09850

SAIM:

K0C01_04640

HARA:

AArcS_0374(tyw2)

HMA:

rrnAC2902

HHI:

HAH_0171

HHN:	HISP_00940

HAB:	SG26_08795

HTA:	BVU17_00815

HALJ:

G9465_03850

HSIN:

KDQ40_13150

NPH:	NP_1360A(taw2)

NMO:	Nmlp_1176(taw2)

NHO:	HWV23_09385

NSAL:

HWV07_12090

HUT:

Huta_1011

HTI:

HTIA_0874

HALA:

Hrd1104_02660

HASV:

SVXHr_0606(tyw2)

HABN:

HBNXHr_0584(tyw2)

HMU:

Hmuk_1200

HALZ:

E5139_09175

HALL:

LC1Hm_0413(tyw2)

HAZP:

GBQ70_09170

HALI:

BV210_07160

HSN:	DV733_09910

HDS:	HSR122_1806(trm5)

HRR:	HZS55_01290

HPEL:

HZS54_07845

HLT:	I7X12_11445

HARC:

HARCEL1_02375

SSAI:

N0B31_15680

HTU:

Htur_0202

HSAL:

JMJ58_08250

HAKZ:

J0X25_07500

NMG:	Nmag_2032(taw2)

HXA:	Halxa_1534

NAT:

NJ7G_0351

NPE:	Natpe_3771

NVR:	FEJ81_18065

NPL:	FGF80_16910

NAY:	HYG81_11080

HALY:

HYG82_12640

HJT:	DVR14_08920

HLO:	J0X27_08645

NGE:	Natgr_1484

HLC:	CHINAEXTREME03815

HRU:	Halru_2763

SAWL:

NGM29_03360

HALV:

NGM15_12985

NOU:	Natoc_0084

HLR:	HALLA_05055

NAJ:	B1756_07545

NAG:	AArcMg_0100

NAN:	AArc1_0103

NARA:

QQ977_08335

NBG:	DV706_05585

NAS:	GCU68_05385

HDA:	BB347_15275

TAC:

Ta0926

TVO:	TVG1132799(TVG1132799)

OMR:	OXIME_000220

PTO:

PTO0680

FAC:	FACI_IFERC01G1166

FAI:

FAD_0193

CDIV:

CPM_1505

TAR:	TALC_00197

MAX:	MMALV_01840

MER:	MMINT_17740

MEAR:

Mpt1_c12780(taw2)

MEUZ:

KRP56_01035

MARC:

AR505_1645

ABI:

Aboo_0011

ACF:	AciM339_0012

SJV:	SJAV_04760

SSO:

SSO2223

SOL:

Ssol_0041

SSOA:

SULA_0039

SSOL:

SULB_0040

SSOF:

SULC_0039

SSHI:

J5U23_01032

SCAS:

SACC_20550

SIS:	LS215_0039

SIA:	M1425_0039

SIM:	M1627_0039

SID:

M164_0039

SIY:	YG5714_0039

SIN:	YN1551_0039

SII:

LD85_0039

SIH:

SiH_0039

SIR:

SiRe_0039

SIC:

SiL_0039

SULE:

GFS03_01730

SAI:

Saci_0030

SACN:

SacN8_00145

SACR:

SacRon12I_00145

SACS:

SUSAZ_00145

SULL:

EWF20_12845

MEMJ:

MJ1HA_0856

MJN:	MjAS7_1514

ACIH:

HS5_12190

CSTY:

KN1_05530

SMET:

RQ359_001632

SAHS:

HS7_11120

CSU:	CSUB_C1650

LOKI:

Lokiarch_25700(taw2_1) Lokiarch_30240(taw2_2)

LOB:	NEF87_003755

» show all

Reference

1 [PMID:19717466]

Authors

Umitsu M, Nishimasu H, Noma A, Suzuki T, Ishitani R, Nureki O

Title

Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2.

Journal

Proc Natl Acad Sci U S A 106:15616-21 (2009)
DOI:10.1073/pnas.0905270106

Sequence

[mja:MJ_1557]

Reference

2 [PMID:22761755]

Authors

Rodriguez V, Vasudevan S, Noma A, Carlson BA, Green JE, Suzuki T, Chandrasekharappa SC

Title

Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA.

Journal

PLoS One 7:e39297 (2012)
DOI:10.1371/journal.pone.0039297

Reference

3 [PMID:20382657]

Authors

de Crecy-Lagard V, Brochier-Armanet C, Urbonavicius J, Fernandez B, Phillips G, Lyons B, Noma A, Alvarez S, Droogmans L, Armengaud J, Grosjean H

Title

Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea.

Journal

Mol Biol Evol 27:2062-77 (2010)
DOI:10.1093/molbev/msq096

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.114

IUBMB Enzyme Nomenclature:

2.5.1.114

ExPASy - ENZYME nomenclature database:

2.5.1.114

BRENDA, the Enzyme Database:

2.5.1.114

LinkDB

DBGET integrated database retrieval system