KEGG   ENZYME: 2.5.1.116
Entry
EC 2.5.1.116                Enzyme                                 
Name
homogentisate geranylgeranyltransferase;
HGGT;
slr1736 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranylgeranyl-diphosphate:homogentisate geranylgeranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + homogentisate = diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 [RN:R10708]
Reaction(KEGG)
R10708
Substrate
geranylgeranyl diphosphate [CPD:C00353];
homogentisate [CPD:C00544]
Product
diphosphate [CPD:C00013];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737];
CO2 [CPD:C00011]
Comment
Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2].
History
EC 2.5.1.116 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09833  homogentisate phytyltransferase / homogentisate geranylgeranyltransferase
Genes
ATHAT2G18950(HPT1)
ALY9322319
CRB17890967
CSAT104700961 104747741 104767264 104767267
EUSEUTSA_v10022720mg
BRP103828352
BNA106357630 106435342
BOE106301964
RSZ108807240
THJ104819975
CPAP110811069 110820895
CIT102608087 102608968 102609326 102613589 102614431 102614532 102614569 102615381 102617448 102617739 102617831 102618022 102618067 102618351 102618884 102619418 102623927 102625279 102625410 102630921 107176028 107177609 112497290 112497612 112498822 112498888
CICCICLE_v10001398mg CICLE_v10003300mg CICLE_v10004028mg CICLE_v10005871mg CICLE_v10008442mg CICLE_v10008503mg CICLE_v10008872mg CICLE_v10009274mg CICLE_v10010224mg CICLE_v10010546mg CICLE_v10010573mg CICLE_v10010789mg CICLE_v10017775mg CICLE_v10018121mg CICLE_v10027291mg CICLE_v10027365mg CICLE_v10031740mg CICLE_v100327301m CICLE_v10033551mg
PVY116114802 116114832 116119517 116119520 116138172
MINC123194989 123200832 123206129
TCC18589276
GRA105783372
GHI121225293
GAB108450426
DZI111284703 111303440
EGR104437423
GMX100301896(G4DT) 100777408(PT10B) 100777517(PT01) 100777935(PT10D) 100786181(PT11A) 100786739 100787246(PT11C) 100787771(PT11B) 100809827(PT03) 100812378(G2DT) 100819685(VTE2-1) 732648(HPT1)
GSJ114369277 114370024 114370328 114370845 114380950 114382242 114382243 114382547 114392266 114403916 114405649 114417018 114424576
PVUPHAVU_003G143900g PHAVU_007G227700g PHAVU_007G227800g PHAVU_007G227900g PHAVU_007G228000g PHAVU_007G2281001 PHAVU_007G228200g PHAVU_007G228300g PHAVU_007G228400g PHAVU_007G228500g PHAVU_010G008800g
VRA106755177 106755178 106755189 106755193 106755196 106768988 106770232 106770233 106770235 106770239 106770244 106770249 106770250 106770252 106771301 106771454 106771704 106779908 106780050 106780051
VAR108322189 108322537 108324509 108324510 108324512 108324513 108324514 108324515 108324517 108324519 108324521 108325334 108325650 108325763
VUN114166371 114167335 114175608 114189465 114189466 114189467 114189468 114190375 114190504 114190505 114190554 114192583 114192765
CCAJ109789231 109791030 109791554 109791815 109792084 109792131 109792275 109792904 109795581 109802283 109806854 109814853 109814854 109815140 109818324 109818329
APRC113845942 113868741
MTRMTR_4g127800
CAM101500582
LJALj0g3v0082139.1(Lj0g3v0082139.1) Lj0g3v0207399.1(Lj0g3v0207399.1) Lj0g3v0207399.2(Lj0g3v0207399.2) Lj0g3v0271809.1(Lj0g3v0271809.1) Lj0g3v0361429.2(Lj0g3v0361429.2) Lj2g3v3133590.1(Lj2g3v3133590.1) Lj4g3v2120440.1(Lj4g3v2120440.1) Lj6g3v2116900.1(Lj6g3v2116900.1)
ADU107460208 107462706 107462797 107462798 107462801 107462854 107462886 107473062 107483497 107488249
AIP107611433 107611439 107613081 107613594 107614303 107614405 107624847 107642500 107646183 107646191 110266040
AHF112697918 112705387 112707566 112707567 112707569 112707570 112707571 112707661 112710990 112720242 112720245 112720246 112723572 112769080 112770351 112770354 112771257 112771258 112771259 112772563 112773029 112773196 112773269 112790139 112790167 112790178 114924330 114924763
LANG109329674 109330257 109330259 109330260 109339484 109342123 109345051 109347120 109355698 109359165 109359166 109361934
FVE101291897 101307294
RCN112174207 112198516
PPER18788573 18792275
PMUM103320912 103323537
PAVI110753464 110762569
PDUL117615596 117618110
MDM103440854 103453838 103453843
PXB103934858
ZJU107403648
MNT21399785
CSV101221791
CMO103492819
BHJ120079349
MCHA111020832
CMAX111468615 111492342
CMOS111436184 111444351
CPEP111786258 111798810 111806101
RCU8287864
JCU105636458 105638319
HBR110635723 110641326 110662933
MESC110603510 110617361
POP18108989 7458405 7488957
PEU105134140 105139265
PALZ118051289 118051583
JRE108980432 109005530
QSU111987085 111996280
QLO115977448 115978355
TWL119992541 119996354
VVI100232967(HGGT) 100257787
VRI117913606 117925549
SLY101252610 101263529
SPEN107024007 107028106
SOT102582366 102585030
CANN107850218
NTA107761331 107762790 107763873 107769769
NSY104224034 104245594
NTO104111194 104113048
NAU109212945 109239654
INI109162896 109177213
ITR116002375 116003107
SIND105155709 105162836
OEU111402203
EGT105976586
SSPL121746567 121751031 121804873
HAN110875595 110877485 110883007 110883031 110886147 110894007 110901342 110901343
ECAD122595497 122597626 122597627 122598875 122608611
LSV111897952 111906151 111906153 111906157 111913868 111914015 111917917
CCAV112516610
DCR108197709 108197735 108198300 108198922 108199087 108199988 108200042 108200043 108207058 108207059 108208293 108208950 108223968 108226481
CSIN114266844 114275415 114295325
BVG104884339 104902388
SOE110785014 110798399
CQI110690856 110692271 110704786 110706467 110733734 110734883
NNU104603204 104603366
MING122063411 122071717 122071803 122072625 122075717 122083709 122093628
TSS122649845 122654634 122657820 122659397 122661786
PSOM113299270 113355629 113358337
NCOL116250791
OSA4341663 4341727
DOSAOs06t0658900-01(Os06g0658900)
OBR102714653 102721852
BDI100821283 100840598
ATS109738157 109751933 109781124
TDC119333974 119338341 119340497 119365656
TAES123149361 123165791 123166512 543094 780685
TUA125519393 125520233
SBI8058455 8069332
ZMA100192568 103638712 103651727 732789
SITA101759318 101784031
SVS117851826 117854003
PVIR120669429 120670931 120671478 120702243 120704939
PHAI112889148 112890206
PDA103696389 103707082
EGU105050383 105052944
MUS103980015 103981284 104000151
DCT110092574 110114682 110114683
PEQ110027871 110034181
AOF109839507 109839522 109843662
ATR18435574 18438637
SMOSELMODRAFT_34021 SELMODRAFT_34027
PPP112284137 112289018 112295124
CRECHLRE_09g414000v5
VCNVOLCADRAFT_45120
MNGMNEG_12636
CSLCOCSUDRAFT_31305
CVRCHLNCDRAFT_52381
APROF751_6870
OLUOSTLU_119481(hpt1)
OTAOT_ostta02g02710
BPGBathy14g02200
MISMICPUN_83621
MPPMICPUCDRAFT_13055
CMECYME_CMN202C
GSLGasu_32880
SMINv1.2.025201.t1(symbB.v1.2.025201.t1)
PTIPHATRDRAFT_47601
FCYFRACYDRAFT_291522(VTE2)
AAFAURANDRAFT_67156
EHXEMIHUDRAFT_55059 EMIHUDRAFT_56139
GTTGUITHDRAFT_52966
MBDMEBOL_007651
MSAKMSAS_37510
DVCDvina_33755
EUZDVS28_a0161
SYNslr1736
SYZMYO_112080
SYYSYNGTS_1198(ubiA)
SYTSYNGTI_1198(ubiA)
SYSSYNPCCN_1197(ubiA)
SYQSYNPCCP_1197(ubiA)
SYJD082_16900
SYOC7I86_06210
SYPSYNPCC7002_A0703(hggT)
CYACYA_1788
CYBCYB_2237
SYNESyn6312_2666
SYNPSyn7502_02738
SYVAWQ23_03665(ubiA)
SYLAWQ21_03525
DSLDacsa_1480
CMPCha6605_5220
AMRAM1_4541
LEPLepto7376_3018
LENLEP3755_11140
LETO77CONTIG1_03944
LBOLBWT_42290
KOVK9N68_24365
LSCKIK02_06040
LSKJ5X98_20990
HHGXM38_037660
PSEUPse7367_1120
THEUHPC62_10915
GLPGlo7428_4759
CHONNIES4102_16090
MARMAE_41250
MPKVL20_3746
MIQB5D77_08130
MVZmyaer102_16000
HAOPCC7418_1398
ENNFRE64_10075
CYTcce_0241
CWACwatDRAFT_2769
CYPPCC8801_0012
CYHCyan8802_0010
CYCPCC7424_0002
CYJCyan7822_0002
CYNCyan7425_0726
TERTery_3881
ARPNIES39_E01300
PAGHNIES204_22010
PPSUNO713_03650
OXYHCG48_01375
MVAGD0A34_10565
LFSHFV01_23285
MICMic7113_1561
GEIGEI7407_0066
OACOscil6304_3681
ONIOsc7112_4374
MPROBJP34_19295
PHORJWS08_01930
CEPCri9333_1618
GVIgll0283
GLJGKIL_2663(ubiA)
GMLISF26_11285
ANAalr3448
NPUNpun_R1870
NOSNos7107_4224
NOPNos7524_4365
NONNOS3756_12030(ubiA_1)
NFLCOO91_06216
NOECLI64_25765
NSHGXM_00460
NEDHUN01_03280
AVAAva_3472
NAZAazo_3462
ANBANA_C20682(ubiA)
ACYAnacy_5289
AWAAA650_08020(ubiA)
ANNEH233_11625
CSGCylst_2833
RSINB6N60_00406
CALOCal7507_0601
CALTCal6303_2078
CALHIJ00_11015(ubiA)
RIVRiv7116_6707
FISFIS3754_01280
NSPHBDGGKGIB_04207
DOUBMF77_00885
DFSHGD76_15825
CCURIAR63_17065
CRKL3I90_10970
AFLOHEQ12_05005
TOQHCG51_14310
NCNBZZ01_25560
CTHEChro_0306
PLPPle7327_1939
SCSSta7437_3668
STANSTA3757_38870
CAUCaur_3427
CHLChy400_3688
CAGCagg_0386
 » show all
Reference
1  [PMID:11706191]
  Authors
Collakova E, DellaPenna D
  Title
Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis.
  Journal
Plant Physiol 127:1113-24 (2001)
DOI:10.1104/pp.010421
  Sequence
[ath:AT2G18950] [syn:slr1736]
Reference
2  [PMID:12897790]
  Authors
Cahoon EB, Hall SE, Ripp KG, Ganzke TS, Hitz WD, Coughlan SJ
  Title
Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content.
  Journal
Nat Biotechnol 21:1082-7 (2003)
DOI:10.1038/nbt853
  Sequence
[osa:4341663]
Reference
3  [PMID:21223386]
  Authors
Yang W, Cahoon RE, Hunter SC, Zhang C, Han J, Borgschulte T, Cahoon EB
  Title
Vitamin E biosynthesis: functional characterization of the monocot homogentisate  geranylgeranyl transferase.
  Journal
Plant J 65:206-17 (2011)
DOI:10.1111/j.1365-313X.2010.04417.x
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.116
IUBMB Enzyme Nomenclature: 2.5.1.116
ExPASy - ENZYME nomenclature database: 2.5.1.116
BRENDA, the Enzyme Database: 2.5.1.116
LinkDB

DBGET integrated database retrieval system