KEGG ENZYME: 2.5.1.131

ENZYME: 2.5.1.131

Entry

EC 2.5.1.131                Enzyme

Name

(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase;
MfnF

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

[5-(aminomethyl)furan-3-yl]methyl-diphosphate:gamma-L-glutamyltyramine [5-(aminomethyl)furan-3-yl]methyltransferase

Reaction(IUBMB)

[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate [RN:R11040]

Reaction(KEGG)

R11040

Substrate

[5-(aminomethyl)furan-3-yl]methyl diphosphate [CPD:C21069];
gamma-L-glutamyltyramine [CPD:C20926]

Product

(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine [CPD:C21070];
diphosphate [CPD:C00013]

Comment

The enzyme, isolated from the archaeon Methanocaldococcus jannaschii, participates in the biosynthesis of the methanofuran cofactor.

History

EC 2.5.1.131 created 2015

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

Orthology

K07072

(4-(4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl)furan-2-yl)methanamine synthase

Genes

MCA:

MCA2869

METU:

GNH96_03500

MMEO:

OOT43_13985

MEEF:

JWZ97_16245

MMT:	Metme_2271

MDN:	JT25_019365

MDH:	AYM39_08570

MKO:	MKLM6_1784

METL:

U737_14790

MPAD:

KEF85_11445

MELL:

IVG45_03960

MRP:	NM686_014160

MMOT:

QZJ86_13625

MEEP:

JWZ98_13850

MEEC:

PL263_06435

MEUP:

QC632_16075

MAH:	MEALZ_2434

MBUR:

EQU24_09085

MPSY:

CEK71_02035

MMAI:

sS8_3387

MSZE:

MSZNOR_2911

MMOB:

F6R98_18220

MEIN:

methR_P1411

MOZ:	MoryE10_04110

MISZ:

MishRS11D_40190

MESL:

KKZ03_09115

MECH:

Q9L42_015085

MLAU:

ACEPPP_14075

MEIY:

MIN45_P1847

MCAU:

MIT9_P1447

MEJ:

Q7A_51

MEC:

Q7C_1778

MPIN:

LGT42_002825

MTHA:

VSX76_16005

BLEP:

AL038_14875

NOC:

Noc_0256

NHL:

Nhal_3882

NWA:

Nwat_0354

NWR:	E3U44_04645

NTT:

TAO_1760

TSY:	THSYN_31750

NTG:	NSCAC_0078

TBOG:

LT988_22430

SEDS:

AAY24_01685

COX:	E0W60_31980

BUG:	BC1001_3968

BGF:	BC1003_5434

BYI:	BYI23_B014260

BUQ:	AC233_22135

BPH:	Bphy_5937 Bphy_6501

BGE:	BC1002_3203

BCAI:

K788_0001565 K788_0007398

PSPW:

BJG93_19495

PARA:

BTO02_23545

PHS:	C2L64_21770 C2L64_38205

PTER:

C2L65_26225 C2L65_34200

PGP:	CUJ91_21395

PCJ:	CUJ87_23525

PGIS:

I6I06_22570

PSAA:

QEN71_34040

BUE:	BRPE67_BCDS01230

VAP:	Vapar_3070

VPD:	VAPA_1c31350

MPT:

Mpe_A2620

METP:

C1M51_15040

RGE:

RGE_40350

LCH:

Lcho_3139

AON:	DEH84_18950

METR:

BSY238_3385

MFA:

Mfla_1649

MMB:

Mmol_1334

MEH:

M301_1543

MEI:	Msip34_1492

MEP:

MPQ_1555

MBAC:

BN1209_0775

MEU:	ACJ67_07440

MMEC:

FIU01_05905

MEDZ:

MTDW_14990

MPAU:

ZMTM_11930

SPLB:

SFPGR_25900

AZA:	AZKH_p0262

AZD:	CDA09_11450

THU:	AC731_004890

THK:	CCZ27_13205

DDZ:	DSYM_25750

MCI:	Mesci_4265

MCIC:

A4R28_05730

MESW:

A9K65_023645

MESM:

EJ066_29745

MOH:	IHQ72_13850

MMEI:

LRP31_13980

MEAA:

ACG873_04715

PHT:	BLM14_23815

RGA:	RGR602_PC01573

NPM:	QEO92_19245

XAU:

Xaut_1791

STAR:

G3545_09805

LNE:	FZC33_09360

SNO:

Snov_0745

ANC:	GBB76_00725

APRA:

G3A50_16470

APOL:

K9D25_20215

MEA:	Mex_1p1768

MDI:

METDI2520

MEX:

Mext_1836

MCH:

Mchl_2171

MPO:

Mpop_1787

MZA:	B2G69_16840

METQ:

MSPGM_18740

MRD:	Mrad2831_0965

MET:

M446_5788

MNO:

Mnod_6009

MOR:

MOC_1181

META:

Y590_08795

MAQU:

Maq22A_c23990

MPHY:

MCBMB27_00560

MEE:	DA075_05755

METD:

C0214_10550

METX:

A3862_25750

METI:

DK427_13880

MMES:

MMSR116_26060

MTEA:

DK419_10820

MIND:

mvi_43420

MOG:	MMB17_19990

MECL:

CLZ_08315

MFUJ:

ABC766_04265

MENI:

GU700_08315

MENS:

LOK46_05095

MSL:

Msil_2392

MTUN:

MTUNDRAET4_2728

MLG:	CWB41_06070

MEDK:

QEV83_11745

BBAI:

CU048_00810

HDN:

Hden_1472

HDT:	HYPDE_31283

HMC:	HYPMC_1622

HNI:	W911_13200

FIL:	BN1229_v1_0581

FIY:	BN1229_v1_0583

MCG:

GL4_1781

METG:

HT051_10205

MSC:

BN69_1050

MBRY:

B1812_17880

MROS:

EHO51_11435

MHEY:

H2LOC_014915

MPAR:

F7D14_11830

MIWA:

SS37A_10530

MESZ:

LNB28_13665

MTW:	CQW49_13855

MECQ:

MSC49_01130

PLEO:

OHA_1_01030

HDI:

HDIA_2317

AALA:

IGS74_05755

AALM:

LUX29_06510

AUZ:	Sa4125_38580

AUB:	LXB15_00950

MFLG:

ABS361_01845

GBE:	GbCGDNIH1_0768

GBH:	GbCGDNIH2_0768

GBC:	GbCGDNIH3_0768

GBS:	GbCGDNIH4_0768

ALI:	AZOLI_p10883

ABS:	AZOBR_p270077

ABQ:	ABAZ39_25500

ATI:	AL072_21130

AHU:	A6A40_18440

AZT:	TSH58p_01235

AZM:	DM194_17070

AOZ:	HUE56_08890

AARE:

D3093_24930

AZS:	E6C72_18215

AZP:	E6C67_12910

RBA:

RB6209

RHOI:

PSR62_11395

PSL:

Psta_3592

PIR:	VN12_07525

RUL:

UC8_21020

RML:	FF011L_17940

MFF:	MFFC18_12350

ROL:	CA51_35260

RUV:

EC9_39470

RCF:	Poly24_39720

AHEL:

Q31a_27960

LCRE:

Pla8534_39480

AAGG:

ETAA8_35440

BVO:	Pan97_22170

BREM:

PSR63_00210

RLC:	K227x_21220

SMAM:

Mal15_10180

SNEP:

Enr13x_62820

SMAE:

TBK1r_55960

LPAV:

PLANPX_2815

LLH:

I41_29930

AMUC:

Pan181_27100

PND:	Pla175_21260

AMOB:

HG15A2_27270

BMEI:

Spa11_11580

BGOK:

Pr1d_28510

PLM:

Plim_0257

PEH:	Spb1_10160

PBS:	Plabr_4664

PLS:	VT03_12545

PLH:	VT85_05495

FMR:	Fuma_00148

GMR:	GmarT_45470

GIM:	F1728_22320

GPN:	Pan110_43590

GFM:	Enr17x_46100

GAZ:	Pan241w_45180

GAW:	V144x_15810

GAX:	Pan161_45960

MRI:	Mal4_12170

SDYN:

Mal52_29040

PLON:

Pla110_00240

ACAF:

CA12_13930

TPOL:

Mal48_45000

CCOS:

Pan44_38030

PVAR:

SH412_004967

CCOP:

Mal65_36150

SCHL:

QJS52_08110

GES:	VT84_31915

GOG:	C1280_01515

GMS:	SOIL9_58910

TIM:	GMBLW1_24080

LRS:	PX52LOC_03569

FTJ:

FTUN_4763

ULI:	ETAA1_22110

TSPH:

KIH39_02590

IPA:

Isop_3533

SACI:

Sinac_1216

PBOR:

BSF38_00157

AGV:	OJF2_59350

TPLA:

ElP_15650

PJO:	LK449_18550

FWA:	DCMF_03945

HAS:	Halsa_0952

AMO:	Anamo_1254

OCY:	OSSY52_02120

MOX:

DAMO_2658

MJA:

MJ_0840

MFE:	Mefer_0932

MVU:	Metvu_0143

MFS:	MFS40622_1321

MIF:	Metin_1065

MJH:	JH146_1062

MESG:

MLAUSG7_0359(mfnF)

MESA:

MLASG1_1538(mfnF)

MIG:	Metig_1150

MMP:

MMP0072

MMQ:	MmarC5_1605

MMX:	MmarC6_0876

MMZ:	MmarC7_1071

MMD:

GYY_00365

MMAK:

MMKA1_00750

MMAO:

MMOS7_00990

MMAD:

MMJJ_10220

MAE:

Maeo_0623

MVN:	Mevan_1085

MVO:

Mvol_1437

MOK:	Metok_0884

METF:

CFE53_00055

MTH:

MTH_834

MMG:	MTBMA_c12320

MWO:	MWSIV6_1211(mfnF)

MTEE:

MTTB_05410

METC:

MTCT_0748

METE:

tca_00801

METZ:

METMT2_0907

METK:

FVF72_07370

MTHM:

FZP57_05750

METJ:

FZP68_00455

MST:

Msp_0386

METB:

AW729_05140

MEIS:

PXD04_05740

MRU:

mru_1695

MSI:

Msm_0851

MEB:

Abm4_0505

MMIL:

sm9_1778

MEYE:

TL18_07945

MOL:

YLM1_1163

MARO:

MarbSA_18750

METV:

K4897_07225

MEL:	Metbo_1948

MEW:	MSWAN_0671

METH:

MBMB1_0691

MFC:

BRM9_1504

MFI:	DSM1535_2198

MCUB:

MCBB_0702(mfnF)

MSUB:

BK009_01675

METN:

BK008_09250

METT:

CIT01_01985

METO:

CIT02_03315

MEME:

HYG87_03500

MFEG:

GCM10025860_17610

MEER:

NKF70_10445

MRID:

FGU46_01610

MFV:

Mfer_0209

MKA:

MK0113

AFU:

AF_0479

AFG:	AFULGI_00004870

AVE:	Arcve_1963

AST:	Asulf_00362

FPL:

Ferp_0819

GAC:

GACE_1625

GAH:

GAH_00950

MBA:	Mbar_A3437

MBY:	MSBRM_1198

MBW:	MSBRW_1296

MBAR:

MSBR2_1212

MBAK:

MSBR3_1317

MAC:

MA_1474

MMA:

MM_2511

MMAZ:

MmTuc01_2560

MMJ:	MSMAS_2192

MMAC:

MSMAC_2262

MVC:	MSVAZ_1447

MEK:	MSKOL_1392

MLS:	MSLAZ_0911

METM:

MSMTP_0946

MEF:	MSWH1_1889

MEQ:	MSWHS_3184

MSJ:	MSSAC_1476

MSZ:	MSSIH_1483

MSW:	MSSIT_1539

MTHR:

MSTHT_0226

MTHE:

MSTHC_0506

MHOR:

MSHOH_2801

MFZ:	AOB57_001290

MHAB:

RSJ42_09840

METW:

AAY43_12725

MBU:

Mbur_1316

MMET:

MCMEM_1763

MELO:

J7W08_07845

MMH:

Mmah_1620

MHAZ:

BHR79_05625

MPOT:

BKM01_01715

MEV:	Metev_0254

MZH:	Mzhil_1620

MPY:

Mpsy_2545

MZI:	HWN40_09630

MMAV:

RE476_00400

MSEB:

RE474_10145

MHZ:	Metho_0939

MTP:

Mthe_0173

MCJ:

MCON_2321

MHI:

Mhar_2357

MHU:

Mhun_0572

MRTJ:

KHC33_08695

MLA:

Mlab_0269

MEM:	Memar_1383

MBG:	BN140_1325

MEMA:

MMAB1_1686

MCHK:

MchiMG62_15800

MSUM:

OH143_01140

MRC:	R6Y96_05790

MPI:

Mpet_1052

MEFW:

F1737_05570

MAQE:

RJ40_03465

MFK:	E2N92_03520

MOU:	OU421_01760

MESB:

L1S32_05275

MANQ:

L1994_06375

MBN:

Mboo_0921

MFO:	Metfor_1880

MPL:

Mpal_0580

MPD:

MCP_1325

MEZ:

Mtc_1030

RCI:

RCIX2219

MJK:	N2V74_01445 N2V74_04420

MELU:

MTLP_02160

BARB:

AOA66_0933

» show all

Reference

1 [PMID:26100040]

Authors

Wang Y, Xu H, Jones MK, White RH

Title

Identification of the Final Two Genes Functioning in Methanofuran Biosynthesis in Methanocaldococcus jannaschii.

Journal

J Bacteriol 197:2850-8 (2015)
DOI:10.1128/JB.00401-15

Sequence

[mja:MJ_0840]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.131

IUBMB Enzyme Nomenclature:

2.5.1.131

ExPASy - ENZYME nomenclature database:

2.5.1.131

BRENDA, the Enzyme Database:

2.5.1.131

LinkDB

DBGET integrated database retrieval system