KEGG   ENZYME: 2.5.1.2
Entry
EC 2.5.1.2                  Enzyme                                 

Name
thiamine pyridinylase;
pyrimidine transferase;
thiaminase I;
thiamin hydrolase;
thiamin pyridinolase;
thiaminase (ambiguous);
thiamine pyridinolase;
thiamin pyridinylase;
thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Reaction(IUBMB)
thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole [RN:R02863]
Reaction(KEGG)
R02863
Substrate
thiamine [CPD:C00378];
pyridine [CPD:C00747]
Product
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium [CPD:C02691];
4-methyl-5-(2-hydroxyethyl)thiazole [CPD:C04294]
Comment
Various bases and thiol compounds can act instead of pyridine.
History
EC 2.5.1.2 created 1961, modified 1976, modified 2001
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K10811  thiamine pyridinylase
Genes
SRR: SerAS9_2400
SRS: SerAS12_2400
SRA: SerAS13_2401
BPS: BPSS1103
BPM: BURPS1710b_A0059
BPL: BURPS1106A_A1472
BPD: BURPS668_A1560
BPSE: BDL_4389
BPSM: BBQ_5068
BPSU: BBN_4528
BPSD: BBX_6232
BPK: BBK_6008
BPSH: DR55_4224
BPSA: BBU_4959
BPSO: X996_4304
BUT: X994_6054
BTQ: BTQ_4590
BTJ: BTJ_5573
BTZ: BTL_4040
BTD: BTI_3614
BTV: BTHA_3841
BTHE: BTN_3627
BTHM: BTRA_4326
BTHA: DR62_3661
BTHL: BG87_4047
BOK: DM82_5265
BOC: BG90_5344
BGU: KS03_4180
BUL: BW21_5615
DDE: Dde_0637
MXA: MXAN_4523
SCL: sce5380
HOH: Hoch_1390
RPOD: E0E05_16885(bcmE)
LABP: FJ695_26280(bcmE)
CBO: CBO0770
CBA: CLB_0812
CBH: CLC_0826
CBY: CLM_0920
CBL: CLK_0178
CBB: CLD_3794
CBI: CLJ_B0819
CBF: CLI_0856
CBM: CBF_0826
MED: MELS_1668
SFB: CP974_10120(bcmE)
 » show all
Reference
1  [PMID:13158184]
  Authors
FUJITA A.
  Title
Thiaminase.
  Journal
Adv Enzymol Relat Subj Biochem 15:389-421 (1954)
DOI:10.1002/9780470122600.ch9
Reference
2  [PMID:13471505]
  Authors
KENTEN RH.
  Title
[Pteridium aquilinum (L.) Kuhn.]
  Journal
Biochem J 67:25-33 (1957)
DOI:10.1042/bj0670025
Reference
3  [PMID:4966932]
  Authors
Wittliff JL, Airth RL.
  Title
The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties.
  Journal
Biochemistry 7:736-44 (1968)
DOI:10.1021/bi00842a032
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.2
IUBMB Enzyme Nomenclature: 2.5.1.2
ExPASy - ENZYME nomenclature database: 2.5.1.2
BRENDA, the Enzyme Database: 2.5.1.2
CAS: 9030-35-7
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