KEGG ENZYME: 2.5.1.51

ENZYME: 2.5.1.51

Entry

EC 2.5.1.51                 Enzyme

Name

beta-pyrazolylalanine synthase;
beta-(1-pyrazolyl)alanine synthase;
beta-pyrazolealanine synthase;
beta-pyrazolylalanine synthase (acetylserine);
O3-acetyl-L-serine acetate-lyase (adding pyrazole);
BPA-synthase;
pyrazolealanine synthase;
pyrazolylalaninase;
3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase;
O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase

Reaction(IUBMB)

O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate [RN:R03134]

Reaction(KEGG)

R03134

Substrate

O-acetyl-L-serine [CPD:C00979];
pyrazole [CPD:C00481]

Product

3-(pyrazol-1-yl)-L-alanine [CPD:C01162];
acetate [CPD:C00033]

Comment

The enzyme is highly specific for acetylserine and pyrazole. Not identical with EC 2.5.1.52 L-mimosine synthase.

History

EC 2.5.1.51 created 1989 as EC 4.2.99.14 (EC 4.2.99.17 incorporated 1992), transferred 2002 to EC 2.5.1.51

Reference

Authors

Murakoshi I, Ikegami F, Hinuma Y, Hanma Y.

Title

Purification and characterization of beta-(pyrazol-1-yl)-L-alanine synthase from Citrullus vulgaris.

Journal

Phytochemistry 23:973-977 (1984)

Reference

Authors

Murakoshi I, Ikegami F, Hinuma Y, Hanma Y.

Title

Purification and characterization of L-mimosine synthase from Leucaena leucocephala.

Journal

Phytochemistry 23:1905-1908 (1984)

Reference

Authors

Murakoshi I, Kuramoto H, Haginiwa J.

Title

The enzymic synthesis of beta-substituted alanines.

Journal

Phytochemistry 11:177-182 (1972)

Reference

4 [PMID:8280125]

Authors

Noji M, Murakoshi I, Saito K

Title

Evidence for identity of beta-pyrazolealanine synthase with cysteine synthase in watermelon: formation of beta-pyrazole-alanine by cloned cysteine synthase in vitro and in vivo.

Journal

Biochem Biophys Res Commun 197:1111-7 (1993)
DOI:10.1006/bbrc.1993.2592

Sequence

[ag:BAA05965]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.51

IUBMB Enzyme Nomenclature:

2.5.1.51

ExPASy - ENZYME nomenclature database:

2.5.1.51

BRENDA, the Enzyme Database:

2.5.1.51

CAS:	37290-81-6

LinkDB

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