Entry
Name
1,4-dihydroxy-2-naphthoate polyprenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
all-trans-polyprenyl-diphosphate:1,4-dihydroxy-2-naphthoate polyprenyltransferase
Reaction(IUBMB)
an all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate = a demethylmenaquinone + diphosphate + CO2 [RN:
R10757 ]
Reaction(KEGG)
Substrate
all-trans-polyprenyl diphosphate [CPD:
C05847 ];
1,4-dihydroxy-2-naphthoate [CPD:
C03657 ]
Product
Comment
This enzyme catalyses a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphate synthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA). The bacterial enzyme is an inner membrane protein [1], with the C-terminus located in the periplasm [3]. It is highly specific for DHNA but not for a specific length of the prenyl chain [2].
History
EC 2.5.1.74 created 2009
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K02548 1,4-dihydroxy-2-naphthoate polyprenyltransferase
Genes
ECOO : ECRM13514_5046(menA)
ECOH : ECRM13516_4782(menA)
ECW : EcE24377A_4466(menA)
EDJ : ECDH1ME8569_3799(menA)
ECOI : ECOPMV1_04329(menA)
REE : electrica_04958(menA)
RTG : NCTC13098_07107(menA)
CLAP : NCTC11466_04493(menA)
KIE : NCTC12125_03686(menA)
AHN : NCTC12129_04832(menA)
METY : MRY16398_55240(menA)
PSHI : SAMEA2665130_2854(menA)
MPHG : MPHASIOC01_005309(menA)
YPG : YpAngola_A0111(menA)
YPI : YpsIP31758_0111(menA)
SMW : SMWW4_v1c47250(menA)
SFJ : SAMEA4384070_4728(menA)
SOF : NCTC11214_01533(menA)
PHEI : NCTC12003_03848(menA)
PRJ : NCTC6933_03876(menA)
LRI : NCTC12151_00100(menA)
HIC : NTHIC486_00481(menA)
HPIT : NCTC13334_00051(menA)
HHZ : NCTC10839_00634(menA)
HAEG : NCTC8502_00628(menA)
PDAG : 4362423_02135(menA)
ADP : NCTC12871_01060(menA)
ALIG : NCTC10568_01764(menA)
ASEG : NCTC10977_01942(menA)
AVT : NCTC3438_00810(menA)
RPNE : NCTC8284_03485(menA)
PAET : NCTC13378_00024(menA)
VAU : VANGNB10_cI2423c(menA)
VPL : SA104470976_00162(menA)
VIB : VspSTUT11_27080(menA)
VIS : VspSTUT16_28290(menA)
MSHE : MAALD49_37980(menA)
SCAA : TUM17387_13460(menA)
COZ : A3Q34_01920 A3Q34_05270
MYA : MORIYA_1703(menA) MORIYA_2432
MMAA : FR932_11435(menA) FR932_14995
HALC : EY643_14780 EY643_17885
CVB : R0135_04575 R0135_14070
TIB : THMIRHAM_12500(menA)
TZO : THMIRHAT_13620(menA)
TANI : J8380_02925 J8380_05785
TFRI : Thiofri_02990(menA)
TNI : TVNIR_2061(menA_[H])
GAI : IMCC3135_15025(menA)
HPIS : P1P91_03810 P1P91_03825
HAAH : HALA3H3_490050(menA)
BACZ : KFF03_05735 KFF03_06610(menA)
AEL : NCTC12917_00435(menA)
CHJ : NCTC10426_01750(menA)
CDIZ : CEDIAZO_00458(menA)
NWE : SAMEA3174300_2030(menA)
NZO : SAMEA4504057_0560(menA)
NCI : NCTC10296_00123(menA)
NANI : NCTC12227_00215(menA)
ECOR : SAMEA4412678_0158(menA)
LMIR : NCTC12852_01767(menA)
RAC : RA876_00950 RA876_05095
SMIO : CATMQ487_46690(menA)
UPL : DSM104440_01900(menA_1) DSM104440_02435(menA_2)
AIQ : Azoinq_08155 Azoinq_13330(menA)
THAG : CKCBHOJB_03435(menA)
FPHO : SHINM1_011930(menA)
MAGN : WV31_11930 WV31_18515
LIP : LI0757(menA) LI0759(menA)
LIR : LAW_00783(menA) LAW_00785
SAT : SYN_00445 SYN_02527 SYN_02622
DTI : Desti_1136 Desti_5083
CCX : COCOR_04513(menA) COCOR_04736(menA1)
MBD : MEBOL_005167 MEBOL_006860
BBA : Bd0546(menA) Bd0558(menA)
BBAT : Bdt_0526(menA) Bdt_0536(menA)
BBAC : EP01_17080 EP01_17130
BDQ : CIK05_02725 CIK05_02750
BDC : DOE51_02755(menA) DOE51_02800
BDZ : DOM22_02415(menA) DOM22_02455
BDK : HW988_02520(menA) HW988_02560
BREY : MNR06_09350 MNR06_09390(menA)
OBG : Verru16b_02594(menA)
BTHO : Btheta7330_01033(menA)
BCEL : BcellWH2_01449(menA_1) BcellWH2_04084(menA_2)
BIS : DXK01_009935 DXK01_021930(menA)
BUN : Bun01g_16350(menA_1) Bun01g_37290(menA_2)
BHUM : JXR92_007480 JXR92_016915(menA)
BACE : H1A11_01055 H1A11_11485(menA)
PCRE : NCTC12858_01850(menA)
PCAG : NCTC12856_00541(menA)
PSOE : CE91St14_04670(menA)
PET : PEIBARAKI_5237 PEIBARAKI_5515
PSAC : PSM36_1309 PSM36_2089
PROJ : KDN43_09875 KDN43_14155(menA)
COPR : Cop2CBH44_14660(menA)
PMZ : HMPREF0659_A7120(menA)
PDN : HMPREF9137_0214(menA)
PHER : prwr041_22720(menA)
POC : NCTC13071_01607(menA)
ADA : A5CPEGH6_14450(menA_1) A5CPEGH6_20530(menA_2)
APUT : L6V35_01195 L6V35_05080(menA)
BLQ : L21SP5_01360(menA_1) L21SP5_01784(menA_2)
PSEZ : HME7025_01703(menA)
FOK : KK2020170_22410(menA)
PHG : KCTC32516_00050(menA)
AALG : AREALGSMS7_04209(menA)
AANR : KCTC52924_03757(menA_2)
KOS : KORDIASMS9_04141(menA)
KAN : IMCC3317_11920(menA_2)
SPON : HME9304_02956(menA)
OHM : MSHRCOH1_04160(menA)
CGLE : NCTC11432_00904(menA)
CTAI : NCTC12078_00662(menA)
CTAK : 4412677_00520(menA)
CHRJ : CHRYMOREF3P_0674(menA)
CJG : NCTC13459_00783(menA)
CANT : NCTC13489_00846(menA)
KFA : Q73A0000_02725(menA)
PTAN : CRYO30217_00675(menA)
PROC : Ptc2401_00599(menA)
BAZ : BAMTA208_19470(menA)
BSON : S101395_01267(menA)
BAN : BA_3186(menA) BA_5113
BAH : BAMEG_1425 BAMEG_5147
BAI : BAA_3236(menA) BAA_5125
BAX : H9401_3040 H9401_4883
BANT : A16_32140 A16_51090
BANR : A16R_32570 A16R_51720
BANS : BAPAT_3057 BAPAT_4905
BANH : HYU01_15690 HYU01_24895
BANV : DJ46_1938(menA) DJ46_3770(menA)
BAL : BACI_c31310(menA1) BACI_c48630(menA2)
BCZ : BCE33L2885(menA) BCE33L4612(menA)
BCR : BCAH187_A3206 BCAH187_A4999
BCB : BCB4264_A3180 BCB4264_A4988
BCU : BCAH820_3193 BCAH820_4970
BCG : BCG9842_B0250 BCG9842_B2068
BCQ : BCQ_2986(menA) BCQ_4675(menA)
BCER : BCK_10850 BCK_19200
BTK : BT9727_2949(menA) BT9727_4590(menA)
BTL : BALH_2841(menA) BALH_4423(menA)
BTB : BMB171_C2859 BMB171_C4496
BTHR : YBT1520_13805 YBT1520_25645
BTHI : BTK_13935 BTK_25515
BTC : CT43_CH3111 CT43_CH4882
BTF : YBT020_15755 YBT020_23965
BTG : BTB_c32420(menA1) BTB_c50180(menA2)
BTN : BTF1_13270 BTF1_22915
BTHT : H175_ch3164 H175_ch4965
BTHU : YBT1518_17215 YBT1518_26890
BTW : BF38_4340(menA) BF38_613(menA)
BTHY : AQ980_05525 AQ980_17040
BWE : BcerKBAB4_2914 BcerKBAB4_4699
BWW : bwei_0024(menA) bwei_1872
BMYO : BG05_1166(menA) BG05_2906(menA)
BTY : Btoyo_0421 Btoyo_2100
BBY : CY96_14755 CY96_23455
BWD : CT694_16795 CT694_25985
BTRO : FJR70_03430(menA) FJR70_18260
BMOB : MLA2C4_16715 MLA2C4_25280
BNT : GSN03_15100(menA) GSN03_23185
BPAC : LMD38_02565 LMD38_11340(menA)
BPAN : NLJ82_14910(menA) NLJ82_23860
BALU : QRY64_18090(menA) QRY64_27220
BFD : NCTC4823_01164(menA)
BASD : LCG60_05330 LCG60_07080(menA)
LFU : HR49_05765 HR49_13440
VIM : GWK91_00425(menA) GWK91_12225
LEX : Len3610_09295 Len3610_10035
SJE : AAV35_004045 AAV35_009000
SAPL : U0355_04940 U0355_10610
GRC : GI584_07055 GI584_09595
MEKU : HUW50_02940 HUW50_08840
MSEM : GMB29_09080 GMB29_21610
MEBZ : LPC09_13105 LPC09_19605
MRL : WCV66_03860 WCV66_09940
BLEN : NCTC4824_02908(menA_1) NCTC4824_03200(menA_2)
GTE : GTCCBUS3UF5_32360 GTCCBUS3UF5_38420
GTK : GT3570_14070 GT3570_16800
GGH : GHH_c29520(menA) GHH_c35160
GJF : M493_14905 M493_17890
GSR : GS3922_01870 GS3922_16165
PARG : PspKH34_06240(menA)
PCAL : BV455_01876(menA_1) BV455_02459(menA_2)
SAX : USA300HOU_0989(menA)
SUQ : HMPREF0772_12194(menA)
SDP : NCTC12225_02007(menA)
SPIC : SAMEA4384060_1914(menA)
SSH : NCTC13712_00987(menA)
SSIM : SAMEA4384339_0956(menA)
SSTE : SAMEA4384403_1821(menA)
LMOC : LMOSLCC5850_1740(menA)
LMW : LMOSLCC2755_1689(menA)
LMX : LMOSLCC2372_1742(menA)
LMZ : LMOSLCC2482_1741(menA)
LMON : LMOSLCC2376_1636(menA)
LMOS : LMOSLCC7179_1650(menA)
LMOO : LMOSLCC2378_1698(menA)
LMOY : LMOSLCC2479_1740(menA)
LMOT : LMOSLCC2540_1760(menA)
LMOA : LMOATCC19117_1692(menA)
LGZ : NCTC10812_01199(menA)
GMO : NCTC11323_00292(menA)
GHA : NCTC10459_00325(menA)
PNK : AASFL403_11365(ubiA)
SOB : CSE16_13600 CSE16_16480
LJF : FI9785_1108 FI9785_1765
LCR : LCRIS_01619 LCRIS_01634(menA)
LPW : LpgJCM5343_02430(menA) LpgJCM5343_17670(menA)
LTA : H1A07_01325 H1A07_09015
LIQ : KBW87_07200 KBW87_09445
LPT : zj316_1166 zj316_1712
LPS : LPST_C0909 LPST_C1371
LPR : LBP_cg0898 LBP_cg1320 LBP_p7g017
LPB : SH83_04710 SH83_07145
LPX : ASU28_00625 ASU28_07145
LPG : BB562_08915 BB562_11685
LARG : LPA65_04585 LPA65_06850
LBS : MH1LPH_08970 MH1LPH_20620
LOR : AYI71_04490 AYI71_13430
LFN : LF145_04845 LF145_04905
LFV : LF543_00325 LF543_00460 LF543_00465
LKF : DNL43_03785 DNL43_12075
LBK : LVISKB_1562 LVISKB_2354
LKO : ABN16_05840 ABN16_10365
LANI : FAX13_07915 FAX13_08995
LMUR : CPS94_00465 CPS94_10670
LOL : LACOL_0076 LACOL_0100
LROS : LROSL1_0850 LROSL1_1931
LGN : ABM34_03870 ABM34_09375
LHI : JP39_07445 JP39_11960
LCT : BI355_0033 BI355_0747 BI355_2277
LALW : BTM29_02800 BTM29_08100
LALI : LA20249_04505 LA20249_08145 LA20249_09380
LFM : LF20184_00170 LF20184_04905
LZH : D1B17_00145 D1B17_08110
LFT : FG051_04460 FG051_12545
CPAB : G6534_07140 G6534_10545
WEI : EQG49_05420 EQG49_07375
EGV : EGCR1_01030 EGCR1_05110
EAV : EH197_09620 EH197_14935
ERAF : J9537_02880 J9537_07310
VAH : G7081_00900 G7081_02415 G7081_05295
VHY : G7082_06495 G7082_09305
VFV : K5K99_00800 K5K99_03535 K5K99_06245
VLC : G314FT_02190(menA_1)
VIE : OL234_01825 OL234_10260
CARC : NY10_1813 NY10_1919 NY10_1963
JDA : BW727_101919(menA_2)
CBEI : LF65_03348 LF65_03382
CSR : Cspa_c28660(menA1) Cspa_c37580(menA2)
CDY : F3K33_15120(menA) F3K33_15280
DFG : B0537_02885 B0537_07315
MAS : Mahau_0760 Mahau_1244
NCD : ACONDI_01366(menA_1) ACONDI_01627(menA_2)
VRM : 44547418_00427(menA)
VDN : NCTC11831_00394(menA)
TFC : T23_13740(menA) T23_20060
TUK : VXM77_00875 VXM77_04785
MBO : BQ2027_MB0548C(menA)
MCZ : BN45_10520 BN45_10601(menA)
MAVM : MAA44156_04052(menA)
MMAE : MMARE11_08300(menA)
MHAD : B586_19350 B586_19665
MXE : MYXE_41770(menA) MYXE_43040
MNV : MNVI_22760 MNVI_23430(menA)
MCOO : MCOO_39090 MCOO_39850(menA)
MBAI : MB901379_00749(menA)
MHEK : JMUB5695_04114(menA_1) JMUB5695_04189(menA_2)
MLJ : MLAC_36190(menA) MLAC_36870
MBRD : MBRA_08230(menA) MBRA_09310
MSHJ : MSHI_29040(menA) MSHI_29670
MMAM : K3U93_20715 K3U93_21030
MPAA : MKK62_21060 MKK62_21420
MKY : IWGMT90018_08670(menA)
MWU : PT015_21000 PT015_21375
MPHL : MPHLCCUG_04453(menA)
MTHN : 4412656_00632(menA)
MHAS : MHAS_04530(menA_1) MHAS_04905(menA_2)
MAUU : NCTC10437_00737(menA)
MFLV : NCTC10271_04434(menA)
MHOL : K3U96_01795 K3U96_22865
MSAL : DSM43276_03770(menA)
MTER : 4434518_00523(menA)
CDIP : ERS451417_00340(menA)
CUN : Cul210932_0351(menA)
CUQ : Cul210931_0339(menA)
CMIN : NCTC10288_02201(menA)
CRL : NCTC7448_01176(menA)
CCYS : SAMEA4530656_2145(menA)
NFR : ERS450000_04740(menA)
NAD : NCTC11293_00058(menA)
NWL : NWFMUON74_65490(menA)
NSPU : IFM12276_57120(menA)
RCR : NCTC10994_03597(menA)
TPUL : TPB0596_07040(menA)
CUF : KM842_02310 KM842_07495
FSB : GCM10025867_40140(menA)
AMAU : DSM26151_03310(menA)
AMAV : GCM10025877_19620(menA)
MALK : MalAC0309_2599(menA)
PSEV : USB125703_00875(menA)
AAGI : NCTC2676_1_02533(menA)
GCR : GcLGCM259_2195(menA)
KVR : CIB50_0000194(menA_1)
RDN : HMPREF0733_10424(menA)
SERJ : SGUI_0854 SGUI_1416
DCO : SAMEA4475696_0691(menA)
DSS : GCM25873_24780(menA)
PAK : HMPREF0675_5005(menA)
CGRN : 4412665_00123(menA)
PAUS : NCTC13651_02008(menA)
PPC : HMPREF9154_2424(menA)
NAQU : ENKNEFLB_04141(menA_2)
PSDS : K1T35_22630 K1T35_44270
ACTI : UA75_02485 UA75_12815
ACAD : UA74_02480 UA74_12735
AHG : AHOG_02425(menA1) AHOG_12010(menA2)
MCU : HMPREF0573_10959(menA)
TBW : NCTC13354_01409(menA)
ANE : ATCC27039_17270(menA)
AHW : NCTC11636_02284(menA)
ASLA : NCTC11923_02643(menA)
AVC : NCTC10951_01639(menA)
ACAP : MANAM107_06200(menA)
BBV : HMPREF9228_1625(menA)
BAST : BAST_1278 BAST_1279
GVA : HMPREF0424_0615(menA)
BNK : KIM372_04700(menA) KIM372_04890
ABAI : IMCC26256_111875 IMCC26256_111893
BALA : DSM104299_02595(menA)
PARQ : DSM112329_02076(menA_1) DSM112329_02364(menA_2)
SBAE : DSM104329_02657(menA)
ATM : ANT_03090 ANT_04940 ANT_31450(menA)
LEK : hrd7_15010(menA_1) hrd7_24960(menA_2)
CAP : CLDAP_23320(menA) CLDAP_30590(menA)
KBS : EPA93_20655 EPA93_22100(menA) EPA93_27945(menA)
KBB : ccbrp13_28460(menA) ccbrp13_43640
TBH : Tbon_06370(menA) Tbon_07085
TFLA : O0235_06200 O0235_06930(menA)
THUG : KNN16_04725 KNN16_12890
MEL : Metbo_2001 Metbo_2002
MEW : MSWAN_0617 MSWAN_0618
MEER : NKF70_10145 NKF70_10150
RCI : RCIX2436(menA-1) RCIX2657(menA-2)
HALH : HTSR_1293(menA) HTSR_1583
HHSR : HSR6_1366(menA2) HSR6_1652
NPH : NP_2734A(menA1) NP_3556A(menA2)
HSN : DV733_00840 DV733_15465
HLT : I7X12_04050 I7X12_19835
SSAI : N0B31_01240 N0B31_04850
HWA : HQ_1426A(menA2) HQ_1875A(menA1)
HWC : Hqrw_1503(menA2) Hqrw_2013(menA1)
HLS : KU306_12365 KU306_14495
HBO : Hbor_12860 Hbor_17690
HALP : DOS48_04720 DOS48_08250
HALB : EKH57_01460 EKH57_06430
HEZZ : EO776_06100 EO776_09900
HSAI : HPS36_00885 HPS36_15060
HAH : Halar_1505 Halar_3325
NAY : HYG81_18255 HYG81_19205
HLC : CHINAEXTREME13700 CHINAEXTREME15260
MER : MMINT_07430 MMINT_10730
MEUZ : KRP56_05375 KRP56_05700(menA)
ABRI : DFR85_03470 DFR85_03760
VMO : VMUT_0544 VMUT_0842 VMUT_2236
THB : N186_05275 N186_09455
TCB : TCARB_0121 TCARB_1008
ASC : ASAC_0242 ASAC_0632 ASAC_1391
ACIA : SE86_02020 SE86_03620 SE86_04680
CLG : Calag_0160 Calag_0428 Calag_1290
» show all
Taxonomy
Reference
Authors
Shineberg B, Young IG
Title
Biosynthesis of bacterial menaquinones: the membrane-associated 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli.
Journal
Reference
Authors
Saito Y, Ogura K
Title
Biosynthesis of menaquinones. Enzymatic prenylation of 1,4-dihydroxy-2-naphthoate by Micrococcus luteus membrane fractions.
Journal
Reference
Authors
Suvarna K, Stevenson D, Meganathan R, Hudspeth ME
Title
Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli.
Journal
Sequence
Reference
Authors
Daley DO, Rapp M, Granseth E, Melen K, Drew D, von Heijne G
Title
Global topology analysis of the Escherichia coli inner membrane proteome.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.74
ExPASy - ENZYME nomenclature database: 2.5.1.74
LinkDB
All DBs