KEGG ENZYME: 2.5.1.93

ENZYME: 2.5.1.93

Entry

EC 2.5.1.93                 Enzyme

Name

4-hydroxybenzoate geranyltransferase;
PGT1;
PGT2;
4HB geranyltransferase;
4HB:geranyltransferase;
p-hydroxybenzoate geranyltransferase;
PHB geranyltransferase;
geranyl diphosphate:4-hydroxybenzoate geranyltransferase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

geranyl-diphosphate:4-hydroxybenzoate 3-geranyltransferase

Reaction(IUBMB)

geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate [RN:R09040]

Reaction(KEGG)

R09040

Substrate

geranyl diphosphate [CPD:C00341];
4-hydroxybenzoate [CPD:C00156]

Product

3-geranyl-4-hydroxybenzoate;
diphosphate [CPD:C00013]

Comment

The enzyme is involved in shikonin biosynthesis. It has a strict substrate specificity for geranyl diphosphate and an absolute requirement for Mg2+ [2].

History

EC 2.5.1.93 created 2010

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K13565

4-hydroxybenzoate geranyltransferase

Reference

1 [PMID:19392660]

Authors

Ohara K, Muroya A, Fukushima N, Yazaki K

Title

Functional characterization of LePGT1, a membrane-bound prenyltransferase involved in the geranylation of p-hydroxybenzoic acid.

Journal

Biochem J 421:231-41 (2009)
DOI:10.1042/BJ20081968

Sequence

[ag:BAB84122]

Reference

2 [PMID:9640665]

Authors

Muhlenweg A, Melzer M, Li SM, Heide L

Title

4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon: purification of a plant membrane-bound prenyltransferase.

Journal

Planta 205:407-13 (1998)
DOI:10.1007/s004250050337

Sequence

[ag:BAB84122 BAB84123]

Reference

3 [PMID:11744717]

Authors

Yazaki K, Kunihisa M, Fujisaki T, Sato F

Title

Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis.

Journal

J Biol Chem 277:6240-6 (2002)
DOI:10.1074/jbc.M106387200

Sequence

[ag:BAB84122 BAB84123]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.93

IUBMB Enzyme Nomenclature:

2.5.1.93

ExPASy - ENZYME nomenclature database:

2.5.1.93

BRENDA, the Enzyme Database:

2.5.1.93

LinkDB

DBGET integrated database retrieval system