KEGG ENZYME: 2.6.1.127

ENZYME: 2.6.1.127

Entry

EC 2.6.1.127                Enzyme

Name

spermidine---8-amino-7-oxononanoate transaminase;
BIO3-BIO1 (gene name)

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

spermidine:8-amino-7-oxononanoate aminotransferase

Reaction(IUBMB)

spermidine + 8-amino-7-oxononanoate = N-(3-aminopropyl)-4-aminobutanal + 7,8-diaminononanoate [RN:R13517]

Reaction(KEGG)

R13517

Substrate

spermidine [CPD:C00315];
8-amino-7-oxononanoate [CPD:C01092]

Product

N-(3-aminopropyl)-4-aminobutanal [CPD:C23055];
7,8-diaminononanoate [CPD:C01037]

Comment

A pyridoxal 5'-phosphate enzyme. The enzyme, characterized from the plant Arabidopsis thaliana, differs from enzymes that catalyse a similar reaction by using spermidine as the amino group donor. The enzyme from Arabidopsis thaliana is bifunctional and also catalyses EC 6.3.3.3, dethiobiotin synthase. cf. EC 2.6.1.62, adenosylmethionine---8-amino-7-oxononanoate transaminase, and EC 2.6.1.105, lysine---8-amino-7-oxononanoate transaminase

History

EC 2.6.1.127 created 2025

Reference

1 [PMID:40028677]

Authors

Noble CG, Hollinshead T, Kende A, Langford MP, Lim PP, Linney E, Mattocks J, Swindale LY, Green K.

Title

The plant Diaminopelargonic acid aminotransferase uses spermidine as its amino donor.

Journal

Plant J 121:e70076 (2025)
DOI:10.1111/tpj.70076

Sequence

[ath:AT5G57590]