Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy

L-methionine:2-oxo-acid aminotransferase

L-methionine + a 2-oxo carboxylate = 4-(methylsulfanyl)-2-oxobutanoate + an L-amino acid [RN:R08618]

R08618
Reaction

L-methionine [CPD:C00073];
2-oxo carboxylate [CPD:C00161]

The enzyme is most active with L-methionine. It participates in the L-methionine salvage pathway from S-methyl-5'-thioadenosine, a by-product of polyamine biosynthesis. The enzyme from the bacterium Klebsiella pneumoniae can use several different amino acids as amino donor, with aromatic amino acids being the most effective [1]. The enzyme from the plant Arabidopsis thaliana is also a part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates [3].

EC 2.6.1.88 created 2011