KEGG ENZYME: 2.7.1.119

ENZYME: 2.7.1.119

Entry

EC 2.7.1.119                Enzyme

Name

hygromycin-B 7''-O-kinase;
hygromycin B phosphotransferase;
hygromycin-B kinase (ambiguous)

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:hygromycin-B 7''-O-phosphotransferase

Reaction(IUBMB)

ATP + hygromycin B = ADP + 7''-O-phosphohygromycin B [RN:R03770]

Reaction(KEGG)

R03770

Substrate

ATP [CPD:C00002];
hygromycin B [CPD:C01925]

Product

ADP [CPD:C00008];
7''-O-phosphohygromycin B

Comment

Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7''-hydroxy group in the destomic acid ring.

History

EC 2.7.1.119 created 1989, modified 2009, modified 2011

Orthology

K17880

hygromycin-B 7''-O-kinase

Genes

XHY:	FZ025_02925

XAS:	HEP74_01321

XAI:	HEP75_01355

SDN:

Sden_2943

SSE:

Ssed_4380

SPL:

Spea_2805

SVO:

SVI_4227

SPSW:

Sps_05479

SBK:	SHEWBE_0404

SPSH:

FM037_27200

SEUR:

FM038_024410

LSD:	EMK97_14005

TACT:

SG35_009525

TVD:	SG34_019720

PSPO:

PSPO_a1848(hyg)

LCAD:

PXX05_02805

CUU:	BKK79_15750

BURT:

BTHE68_56560

ADK:	Alide2_1935

UNY:	UNDYM_0645

NEN:	NCHU2750_17050

SHZ:

shn_08510

BJA:	blr1035(blr1035)

BJU:	BJ6T_10600

BJP:	RN69_05170

BRA:

BRADO6829

BBT:

BBta_0715

BRS:

S23_67720

AOL:

S58_06400

BRC:	BCCGELA001_34480

BRAD:

BF49_7151

BIC:	LMTR13_36535

BRO:	BRAD285_6968

BRK:	CWS35_10000

BOT:	CIT37_09125

BRQ:	CIT40_30270

BGQ:	X265_34860

BGZ:	XH91_33225

BSYM:

CIT39_29375

BBET:

F8237_13200

BARH:

WN72_46410

BVZ:	BRAD3257_8692

BEL:	BE61_90630

BDG:	LPJ38_02350

BSEP:

HAP48_0012130

BQB:	J4P68_0015995

BSEI:

KMZ68_03295

BBAN:

J4G43_050905

BCAN:

BcanWSM471_35650

BAUT:

QA635_04680

BBRA:

QA636_04155

BGK:	IC762_32665

BCOU:

IC761_34840

BPAH:

QA639_04100

BXN:	I3J27_37815

BRAZ:

LRP30_02140

BOY:	LQG66_26915

BRAY:

ML401_32865

BVV:	BHK69_21860

BOP:	AXW83_14650

BOSE:

RMR04_11990

PLIA:

E4191_15325

PSAP:

JHX88_06905

PSHQ:

F3W81_08540

SCU:	SCE1572_39530

OLE:	K0B96_00120

OBA:	ASA1KI_05840

PBAP:

Pla133_31260

BLE:	BleG1_3378

CSUA:

IM538_08060

VNE:	CFK40_16370

GAJ:	MY490_17370

LWI:	UE46_12585

PPY:

PPE_01320

PPOL:

X809_07440

PTA:	HPL003_15155

PBD:	PBOR_13235

POW:	IJ21_42000

PXL:	BS614_06340

PKB:	B4V02_18125

PAIH:

ASL14_04465

PLUT:

EI981_15230

PBAC:

HUB98_20000

AFX:	JZ786_16100

PMAR:

B0X71_15750

VIJ:	JNUCC6_05980

CSH:	Closa_2823

NAH:	F5544_16105

SCO:	SCO3277(SCE39.27c)

SMA:	SAVERM_4746

SGRF:

SGFS_069420

SCB:	SCAB_38991

SVE:

SVEN_5979

SDV:	BN159_8349

SLV:	SLIV_21400

SLD:

T261_3533

SRW:	TUE45_pSRc_0512(TUE45_pSRTUE45c_0512)

SGS:	AVL59_19560

SALW:

CP975_10190

SGM:	GCM10017557_47320

SGRS:

V9K83_13930

SLS:	SLINC_1212

SSIA:

A7J05_25520

SGV:	B1H19_24140

SLAU:

SLA_6338

SALF:

SMD44_02510(hyg)

STRO:

STRMOE7_24175

SFK:

KY5_2295c

SCYA:

EJ357_44140

SNQ:	CP978_19285

SKA:	CP970_31000

SRK:	FGW37_32675

SVR:	CP971_25275

SPHV:

F9278_29505

SSPB:

CP982_13355

SPLA:

CP981_22790

SCYG:

S1361_02065

SDW:	K7C20_21555

SXN:	IAG42_00620

SHK:	J2N69_10010

SANU:

K7396_15240

SINE:

KI385_26640

SLF:	JEQ17_26470

SDEC:

L3078_27040

SAOV:

G3H79_26560

SDUR:

M4V62_29520

SAKB:

K1J60_18325

SCAE:

IHE65_18645

SCIR:

STRCI_000323

SLON:

LGI35_38975

SDRZ:

NEH16_14175

STUD:

STRTU_002915

SCYN:

N8I84_23005

SOV:	QZH56_04505

SCOA:

QU709_39560

SFP:	QUY26_28585

KBU:	Q4V64_48445

STPB:

QR97_36705

SRPA:

HEP86_23855

KAU:	B6264_19840

ACIT:

HPK19_12600

SPIQ:

OHA34_37355

ACTQ:

OG417_03835 OG417_35105

NOA:	BKM31_23170

NOW:	GBF35_13400

KRA:

Krad_2754

SACC:

EYD13_04715

AOI:

AORI_1717

AJA:	AJAP_30905

AMYC:

CU254_28415

AMYB:

BKN51_00795

AAB:	A4R43_37900

AMYY:

YIM_40145

AORI:

SD37_32605

APRT:

MUY14_01420

AROO:

NQK81_14440

ATHM:

L1857_30105

AMOG:

QRX60_23895

ACOR:

LCL61_22495

ANW:	QP939_27015

AMYE:

MJQ72_32460

AMYS:

CVV72_20565

APRE:

CNX65_11050

AMI:

Amir_2164

SESP:

BN6_18860

KAL:

KALB_4352

AHM:	TL08_06760

ACTI:

UA75_06520

ACAD:

UA74_06520

PMAD:

BAY61_06195

CROS:

N8J89_34390

ASIC:

Q0Z83_062300

AFS:

AFR_32445

DVC:	Dvina_09130

PBF:	CFX0092_A0744

KBS:	EPA93_38635

» show all

Reference

1 [PMID:3026811]

Authors

Zalacain M, Pardo JM, Jimenez A.

Title

Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus.

Journal

Eur J Biochem 162:419-22 (1987)
DOI:10.1111/j.1432-1033.1987.tb10618.x

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.119

IUBMB Enzyme Nomenclature:

2.7.1.119

ExPASy - ENZYME nomenclature database:

2.7.1.119

BRENDA, the Enzyme Database:

2.7.1.119

CAS:	88361-67-5

LinkDB

DBGET integrated database retrieval system