KEGG   ENZYME: 2.7.1.145
Entry
EC 2.7.1.145                Enzyme                                 
Name
deoxynucleoside kinase;
multispecific deoxynucleoside kinase;
ms-dNK;
multisubstrate deoxyribonucleoside kinase;
multifunctional deoxynucleoside kinase;
D. melanogaster deoxynucleoside kinase;
Dm-dNK;
ATP:deoxynucleoside 5'-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:deoxyribonucleoside 5'-phosphotransferase
Reaction(IUBMB)
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate [RN:R05806]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
2'-deoxyribonucleoside [CPD:C02269]
Product
ADP [CPD:C00008];
2'-deoxyribonucleoside 5'-phosphate [CPD:C00676]
Comment
The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2'-deoxyribonucleosides.
History
EC 2.7.1.145 created 2001
Pathway
ec00230  Purine metabolism
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K05961  deoxynucleoside kinase
Genes
DMEDmel_CG5452(dnk)
DER6554072
DSE6620705
DSIDsimw501_GD19261(Dsim_GD19261)
DYADyak_GE25572
DAN6505870
DSR110186665
DPO4801838
DPE6588091
DMN108156402
DWI6647251
DGR6568426
DMODmoj_GI10047
DAZ108620993
DNV108658836
DHE111602690
DVI6631195
CCAT101450470
BOD106617808
BDR105231069
RZE108355448
AOQ129236198
TDA119680404 119681378
MDE101896877
SCAC106090041
LCQ111680959
LSQ119613191
GFS119639424
ECOE129942128
CLON129605891 129612847
HIS119650996
AGA1281587
ACOZ120953957
AARA120898076
AMER121590743
ASTE118505597 118516567
AFUN125774874
AMOU128297035
AALI118461083
AAG5579214
AALB109405935 109417111 115266522
CQUCpipJ_CPIJ003276
CPII120424947
CNS116347604 116350021 116351806
BCOO119069920 119070619 119075577 119079253 119085227
AME552840
ACER107998280
ALAB122714892
ADR102672898
AFLR100871899
BIM100744576
BBIF117205012
BVK117230963
BVAN117153269
BTER100648317
BAFF126921834
BPYO122567739
BPAS132912725
FVI122537787
CCAL108626754
OBB114878736
OLG117602966
MGEN117221411
NMEA116423874
CGIG122398991
SOC105196060 105207545
MPHA105836053 105837551
AEC105144858 105146649
ACEP105623946 105626028
PBAR105422323 105427465
VEM105564478 105567866
HST105187065 105188611
DQU106741152 106749991
CFO105248838 105257645
FEX115238243 115243702
LHU105672005 105672239
PGC109856640 109858340
OBO105275914 105281382
PCF106784413
PFUC122519186
VPS122630646
VCRB124424167
VVE124950789 124950790
LHT122513012
LBD127284996
FAS105270889
DAM107041802
AGIF122861087
VCAN122412197
CCIN107262785
DSM124410894 124416581
NPT124215415
NFB124179224
NLO107219391
NVG124300585
AROA105684234
TCA659303 659935 660567
DPA109542197 109546462
SOY115876628 115880872 115880987 115883471
AGRG126746792 126747076 126747310
ATD109602144
CSET123319946 123321861
AGB108907401 108911548 108915258
LDC111501828 111511326
NVL108559729 108561321 108567605
APLN108736123 108740527
PPYR116171896 116172019 116178371 116181669 116182896
OTU111416219 111424509 111429051
BMOR101741300 692569
BMAN114244024 114245792
MSEX115448679 115450116
DPLKGM_201543 KGM_210835
BANY112044401 112051943
MJU123871697 123871853
NIQ126769380 126770645
VCD124529800 124532529
MCIX123655306 123657209
PMAC106707992 106716895
PPOT106109692 106111772
PXU106121104 106124000
PRAP111000809 111002863
PBX123708340 123714501
PNAP125049648 125059630
ZCE119829693 119832290
CCRC123694796 123695479
LSIN126976424 126979176
HAW110376532 110377523
HZE124633059 124633234
TNL113494794 113496714
SLIU111353352 111359721
OFU114357187 114361976
PXY105393061
PGW126369271 126372417
CFEL113376318 113377350
API100165338 100165639 100573648
DNX107163678 107166092
AGS114125562
RMD113555271 113560575
ACOO126837273 126839223
DVT126901113
BTAB109030166 109030645 109042887
NLU111045781 111048849
HVI124355318
PHUPhum_PHUM399920 Phum_PHUM407830
TPAL117642345 117644223 117644227 117644838 117645549 117646362 117646570 117647020 117647901 117648133 117650702 117650881 117652427 117652670 117653641
ZNE110827391 110835653
CSEC111866426 111875651
SGRE126273169
IEL124165263
FCD110842433
DPXDAPPUDRAFT_305834 DAPPUDRAFT_99663
PVM113805250 113818333
PMOO119596870
HAME121868408
HAZT108665785
EAF111699873 111704998 111706452 111718376
LSM121121677 121122856
TCF131878958 131879683 131882528 131885170 131889936
PPOI119101655
VDE111249878 111253427
VJA111260459 111269325
DPTE113789910
DFR124499059
PMEO129588944 129593989
DPOL127865105
 » show all
Reference
1  [PMID:9461577]
  Authors
Munch-Petersen B, Piskur J, Sondergaard L.
  Title
Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase.
  Journal
J Biol Chem 273:3926-31 (1998)
DOI:10.1074/jbc.273.7.3926
  Sequence
Reference
2  [PMID:10692477]
  Authors
Munch-Petersen B, Knecht W, Lenz C, Sondergaard L, Piskur J
  Title
Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants.
  Journal
J Biol Chem 275:6673-9 (2000)
DOI:10.1074/jbc.275.9.6673
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.145
IUBMB Enzyme Nomenclature: 2.7.1.145
ExPASy - ENZYME nomenclature database: 2.7.1.145
BRENDA, the Enzyme Database: 2.7.1.145
CAS: 52227-81-3
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