KEGG   ENZYME: 2.7.1.146
Entry
EC 2.7.1.146                Enzyme                                 
Name
ADP-specific phosphofructokinase;
ADP-6-phosphofructokinase;
ADP-dependent phosphofructokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ADP:D-fructose-6-phosphate 1-phosphotransferase
Reaction(IUBMB)
ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate [RN:R05805]
Reaction(KEGG)
R05805 > R09084
Substrate
ADP [CPD:C00008];
D-fructose 6-phosphate [CPD:C00085]
Product
AMP [CPD:C00020];
D-fructose 1,6-bisphosphate [CPD:C00354]
Comment
ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective.
History
EC 2.7.1.146 created 2001
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00030  Pentose phosphate pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00918  ADP-dependent phosphofructokinase/glucokinase
Genes
GRC: GI584_20260
TCO: Theco_1176
CSCI: HDCHBGLK_00653
CSH: Closa_0608
QDO: H9Q78_06885
HALS: D7D81_07845
LPIL: LIP_1249
MBAS: ALGA_3097
ASAC: ATHSA_0704
MJA: MJ_1604
MFE: Mefer_1517
MVU: Metvu_0786
MFS: MFS40622_0160
MIF: Metin_0227
MJH: JH146_0031
MESG: MLAUSG7_0561(pfkC)
MESA: MLASG1_0234(pfkC)
MIG: Metig_1734
MMP: MMP1296(pfkC)
MMQ: MmarC5_0297
MMX: MmarC6_1378
MMZ: MmarC7_0541
MMD: GYY_07315
MMAK: MMKA1_15210(pfkC)
MMAO: MMOS7_14030(pfkC)
MMAD: MMJJ_15470
MAE: Maeo_0005
MVN: Mevan_0606
MVO: Mvol_0050 Mvol_0110
MOK: Metok_1190
METF: CFE53_04560
PFU: PF0312 PF1784
PFI: PFC_00640 PFC_09670
PHO: PH0589(PH0589) PH1645(PH1645)
PAB: PAB0967 PAB2013
PYN: PNA2_0229 PNA2_1204
PYA: PYCH_02450 PYCH_10910
PYS: Py04_0618 Py04_1537
PYC: TQ32_02010 TQ32_08590
TKO: TK0376 TK1110
TON: TON_0246 TON_1012
TGA: TGAM_0818(glkA) TGAM_1465(pfkC)
TSI: TSIB_0252 TSIB_1220
TBA: TERMP_00004 TERMP_01160
THE: GQS_04080 GQS_10400
THA: TAM4_1728 TAM4_738
THM: CL1_0470 CL1_1657
TLT: OCC_01044 OCC_09701
THS: TES1_0130 TES1_1218
TNU: BD01_0151 BD01_1045
TEU: TEU_06460 TEU_11110
TGY: X802_00245 X802_07910
THV: ADU37_CDS01920 ADU37_CDS09450
TCH: CHITON_1323 CHITON_1878
TPEP: A0127_02440 A0127_09685
TGG: A3K92_05080 A3K92_05775
TCE: A3L02_00520 A3L02_03710
TBS: A3L01_01790 A3L01_05875
THH: CDI07_01765 CDI07_05830(pfkC)
TSL: A3L11_05625 A3L11_10255
TTD: A3L14_03240 A3L14_08235
TPRF: A3L09_05575 A3L09_08760
TRL: A3L10_00730 A3L10_04695
TPAF: A3L08_05185 A3L08_09265
THY: A3L12_01825 A3L12_06865
TIC: FH039_03970 FH039_09365(pfkC)
TCQ: TIRI35C_0588(glkA) TIRI35C_1487(pfkC)
THEM: FPV09_00340(pfkC) FPV09_05320
THEI: K1720_04385 K1720_09185(pfkC)
PPAC: PAP_01430 PAP_04875
MBA: Mbar_A2004 Mbar_A2005
MBY: MSBRM_2497 MSBRM_2498
MBW: MSBRW_2730 MSBRW_2731
MBAR: MSBR2_2474 MSBR2_2475
MBAK: MSBR3_2515 MSBR3_2516
MAC: MA_3562(glkA) MA_3563(pfk)
MMA: MM_0472 MM_0473
MMJ: MSMAS_0831 MSMAS_0832
MMAC: MSMAC_0811 MSMAC_0812
MVC: MSVAZ_2547 MSVAZ_2548
MEK: MSKOL_2555 MSKOL_2556
MLS: MSLAZ_2352 MSLAZ_2353
METM: MSMTP_2385 MSMTP_2386
MEF: MSWH1_2360 MSWH1_2361
MEQ: MSWHS_2732 MSWHS_2733
MSJ: MSSAC_3156 MSSAC_3157
MSZ: MSSIH_0989 MSSIH_0990
MSW: MSSIT_1026 MSSIT_1027
MTHR: MSTHT_1057 MSTHT_1058
MTHE: MSTHC_2246 MSTHC_2247
MHOR: MSHOH_0977 MSHOH_0978
MFZ: AOB57_011160 AOB57_011165(pfkC)
MBU: Mbur_1338 Mbur_1339
MMET: MCMEM_1827 MCMEM_1828
MELO: J7W08_08075 J7W08_08080(pfkC)
MMH: Mmah_1645 Mmah_1646
MHAZ: BHR79_05490 BHR79_05495
MEV: Metev_0816 Metev_0817
MZH: Mzhil_0819 Mzhil_0820
MPY: Mpsy_1159 Mpsy_1160
MZI: HWN40_02795 HWN40_02800
MHZ: Metho_2034 Metho_2035
MTP: Mthe_1214
MCJ: MCON_0234(pfkC)
MBN: Mboo_1525
HSN: DV733_07550
SRUB: C2R22_19410
HALU: HUG12_09055
NMG: Nmag_3826
NGE: Natgr_2898
HRU: Halru_0715 Halru_2961
HLC: CHINAEXTREME19235
NAJ: B1756_05745
NAG: AArcMg_1072
NAN: AArc1_2551
NBG: DV706_17425
NAS: GCU68_12220
SAWL: NGM29_19280
NAC: AQV86_01495
FLT: Sv326_0933
NCON: LC1Nh_0114
 » show all
Reference
1  [PMID:10409652]
  Authors
Tuininga JE, Verhees CH, van der Oost J, Kengen SW, Stams AJ, de Vos WM.
  Title
Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J Biol Chem 274:21023-8 (1999)
DOI:10.1074/jbc.274.30.21023
  Sequence
[pfu:PF1784]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.146
IUBMB Enzyme Nomenclature: 2.7.1.146
ExPASy - ENZYME nomenclature database: 2.7.1.146
BRENDA, the Enzyme Database: 2.7.1.146
CAS: 237739-62-7
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