Entry
Name
inositol-pentakisphosphate 2-kinase;
IP5 2-kinase;
Gsl1p;
Ipk1p;
inositol polyphosphate kinase;
inositol 1,3,4,5,6-pentakisphosphate 2-kinase;
Ins(1,3,4,5,6)P5 2-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase
Reaction(IUBMB)
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate [RN:
R05202 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:
C01284 ]
Product
ADP [CPD:
C00008 ];
1D-myo-inositol hexakisphosphate [CPD:
C01204 ]
Comment
The enzyme can also use Ins(1,4,5,6)P4 [2] and Ins(1,4,5)P3 [3] as substrate. Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolysed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment [5].
History
EC 2.7.1.158 created 2006
Pathway
ec00562 Inositol phosphate metabolism
Orthology
K10572 inositol-pentakisphosphate 2-kinase
K19786 inositol-pentakisphosphate 2-kinase
Genes
MORG : 121434062 121443255
LWW : 102736953 115944008(IPPK)
XLA : 108714575(ippk.L) 108715809(ippk.S)
SRX : 107731322(ippk) 107755999
SANH : 107658385 107704449(ippk)
SGH : 107586979 107593095(ippk)
CAUA : 113040243 113064709 113077411 113079543
CGIB : 127942931 127988584
MASI : 127438556 127439247
CHAR : 105893519 122129934
TRU : 101061368(ippk) 115246760
CGOB : 115007737 115008119(ippk)
SASA : 106566244 106583802(ippk)
STRU : 115149959(ippk) 115207217
OTW : 112222097 112235151(ippk)
OMY : 110494838 110529060(ippk)
OGO : 124004218 124024933(ippk)
ONE : 115121083(ippk) 115127830
OKI : 109880438 109891672(ippk)
OMM : 135540437 135541293(ippk)
OCLA : 139369957 139414491
SNH : 120037983(ippk) 120058264
CCLU : 121556603 121577876(ippk)
SFM : 108925514 108929817(ippk)
PKI : 111837462(ippk) 111855777
PSPA : 121298141 121329262
ARUT : 117412602 117414128
DSI : Dsimw501_GD11544(Dsim_GD11544)
ACOO : 126838935 126845623
CLEC : 106664712 112127226
PCLA : 123772428 138365551
DPOL : 127832562 127881646
LLON : 135491129 135491452
ATH : AT1G22100 AT1G58643 AT1G58936 AT1G59312 AT5G42810(IPK1)
ALY : 9299810 9322751 9326556
CRB : 17876676 17896255 17896736
CSAT : 104700825 104700828 104740911 104753487 104756557 104760678 104771419 104776328 104787222 109124944
EUS : EUTSA_v10003206mg EUTSA_v10007647mg
BNA : 106406633 106425972 106447074 125591737
RSZ : 108818639 108823470 130498333
CPAP : 110810565 110810798
GHI : 107905450 107935047 107943428 107957935
HSYR : 120113600 120168240 120169119 120216679
GMX : 100127406(IPK1) 100782468 100807360
GSJ : 114385136 114408628 114414640
CCAJ : 109801800 109817489
APRC : 113847706 113864758
TPRA : 123886621 123898766
PSAT : 127080301 127092378 127093084
VVO : 131596623 131628601 131654837
AHF : 112696319 112705565 112758039 112765731
LANG : 109339489 109343173 109363302
QSA : O6P43_016200 O6P43_018603
PMUM : 103319310 103320876
PAVI : 110771216 110771569
PDUL : 117612294 117615298
MSYL : 126601893 126632348
MCHA : 111012378 111013962
CMAX : 111480854 111491850 111496203
CMOS : 111446613 111454721 111462600
CPEP : 111789184 111799273 111805829
MESC : 110606531 110615744
PALZ : 118052793 118062117
SSTN : 125855047 125877433
INI : 109149147 109155313 109170253
ITR : 116023042 116031524 116033948
SSPL : 121760092 121765702 121792747 121802903
SMIL : 130991680 131010508 131010562
SHIS : 125192899 125202745 125222767
ECAD : 122579302 122585126
CCAV : 112504518 112525351
CSIN : 114279944 114288632 114302543
RVL : 131330993 131333938 131333939
CQI : 110686597 110702215 110724786
ATRI : 130797689 130809791
PSOM : 113288466 113288681
TAES : 123046991 123054827 123190668
ZOF : 122012864 122014526 122018050 122049721
SMO : SELMODRAFT_111972 SELMODRAFT_136205
CGR : 2888465(GVI51_H07183)
NCS : NCAS_0F02820(NCAS0F02820)
NDI : NDAI_0C04280(NDAI0C04280)
TPF : TPHA_0D02010(TPHA0D02010)
TBL : TBLA_0A03060(TBLA0A03060)
TDL : TDEL_0E02850(TDEL0E02850)
KAF : KAFR_0K02240(KAFR0K02240)
KNG : KNAG_0B02000(KNAG0B02000)
LBG : 92210388(LODBEIA_P51920)
CAL : CAALFM_C403330WA(IPK1)
ASAU : 88172738(PUMCH_001673)
YLI : 2912429(YALI2_E01618g)
NTE : NEUTE1DRAFT146520(NEUTE1DRAFT_146520)
SMP : 10801547(SMAC4_06466)
RTHE : 98129301(VTJ83DRAFT_957)
TATV : 25783147(TrAtP1_000710)
TASP : 36611911(TrAFT101_001697)
PLJ : 28887702(PLICBS_002934)
CDET : 87937705(CDEST_01202)
PTRR : 6340248(PtrM4_006370)
ADAC : 96083974(ACET3X_003652)
TML : GSTUM_00004198001 GSTUM_00010933001
ABP : AGABI1DRAFT35200(AGABI1DRAFT_35200)
ABV : AGABI2DRAFT63616(AGABI2DRAFT_63616)
SCM : SCHCO_02608225(SCHCODRAFT_02608225)
» show all
Taxonomy
Reference
Authors
York JD, Odom AR, Murphy R, Ives EB, Wente SR.
Title
A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
Journal
Sequence
Reference
Authors
Phillippy BQ, Ullah AH, Ehrlich KC.
Title
Purification and some properties of inositol 1,3,4,5,6-Pentakisphosphate 2-kinase from immature soybean seeds.
Journal
J Biol Chem 269:28393-9 (1994)
Reference
3
Authors
Phillippy BQ, Ullah AH, Ehrlich KC.
Title
Additions and corrections to Purification and some properties of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from immature soybean seeds.
Journal
J Biol Chem 270:7782 (1997)
Reference
Authors
Ongusaha PP, Hughes PJ, Davey J, Michell RH.
Title
Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation.
Journal
Reference
Authors
Miller AL, Suntharalingam M, Johnson SL, Audhya A, Emr SD, Wente SR.
Title
Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway.
Journal
Reference
Authors
Stevenson-Paulik J, Odom AR, York JD
Title
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.158
LinkDB
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