KEGG   ENZYME: 2.7.1.166
Entry
EC 2.7.1.166                Enzyme                                 
Name
3-deoxy-D-manno-octulosonic acid kinase;
kdkA (gene name);
Kdo kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:(Kdo)-lipid IVA 3-deoxy-alpha-D-manno-oct-2-ulopyranose 4-phosphotransferase
Reaction(IUBMB)
alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP [RN:R09767]
Reaction(KEGG)
R09767
Substrate
alpha-Kdo-(2->6)-lipid IVA;
ATP [CPD:C00002]
Product
4-O-phospho-alpha-Kdo-(2->6)-lipid IVA [CPD:C19877];
ADP [CPD:C00008]
Comment
The enzyme phosphorylates the 4-OH position of Kdo in (Kdo)-lipid IVA.
History
EC 2.7.1.166 created 2010, modified 2011
Pathway
ec00540  Lipopolysaccharide biosynthesis
Orthology
K11211  3-deoxy-D-manno-octulosonic acid kinase
Genes
HINHI_0260.1
HITNTHI0367(kdkA)
HIPCGSHiEE_01760
HIQCGSHiGG_04085
HIFHIBPF_02040
HILHICON_12130
HIUHIB_03190
HIER2846_0325(kdkA)
HIZR2866_0324(kdkA)
HIKHifGL_000012(kdkA)
HIAH733_0155
HIHNF38_04100
HIWNTHI477_01300(kdkA)
HICNTHIC486_00733(kdkA)
HIXNTHI723_01437(kdkA)
HPRPARA_02570
HDUHD_1101(kdkA)
HAYC3V42_03380
HPITNCTC13334_00281(kdkA)
HHZNCTC10839_00212(kdkA)
HAEGNCTC8502_00965(kdkA)
HPAAE5Q53_00110
HSEML3077_01085
HAPHAPS_0211(kdkA)
HPAZK756_05480
HPASJL26_04970
HPAKJT17_02525
GLECJD39_05465
PMUPM1303
PMVPMCN06_1970(kdtA)
PULNT08PM_2157
PMPPmu_19660(kdkA)
PMULDR93_551(kdkA)
PDAG4362423_01452(kdkA)
PSKYA6B44_07010
PATLKGI96_00170
PCAIK7G93_001891
MSUMS1964(sPS1)
BSUNA4G13_07090
MHTD648_17510
MHQD650_8630
MHATB824_17690
MHXMHH_c26070(kdkA)
MHAEF382_03790
MHAMJ450_02825
MHAOJ451_04035
MHALN220_09890
MHAQWC39_04305
MHAYVK67_04305
MVRX781_7490
MVIX808_14960
MVGX874_13890
MVEX875_6110
MANNGM695_05575
MGRAA4G16_01935
MBOSICJ55_05910
MPEGHV560_06080
APLAPL_0904(kdkA)
APJAPJL_0916(kdkA)
APAAPP7_0963(kdkA)
ASUAsuc_1985
ASIASU2_02140
ASSASU1_02145
AEUACEE_02145
APORDDU33_08995
AIOEXH44_01685
ADPNCTC12871_01303(kdkA)
ALIGNCTC10568_00387(kdkA)
AAPNT05HA_1635
AAZADJ80_00875
AATD11S_0381
AAOANH9381_0701
AAND7S_00859
AAHCF65_01398
AACNAANUM_0597
AACTACT75_04355
ASEGNCTC10977_00651(kdkA)
GANUMN179_01502
BTOWQG_13700
BTREF542_8340
BTRHF543_9630
BTRAF544_14090
APAGEIA51_01030
AVTNCTC3438_00405(kdkA_1)
RHEYFEE42_09705
RHAEIHV77_08905
OOIA6A10_03290
FCLA4G17_06585
BHUDA6A11_08585
PAETNCTC13378_01959(kdkA)
XFAXF_2153
XFTPD_1213
XFMXfasm12_1357
XFNXfasM23_1292
XFFXFLM_00085
XFLP303_05730
XFSD934_12540
XFHXFHB_08245
XTWAB672_05400
XCCXCC0993
XCBXC_3251
XCAxcc-b100_3366(waaP)
XCPXCR_1193
XCVXCV1103(kdkA)
XAXXACM_1053(kdkA)
XACXAC1095
XCIXCAW_01193(sPS1)
XCTJ151_01229
XCJJ158_01226
XCUJ159_01226
XCNJ169_01225
XCWJ162_01225
XCRJ163_01225
XCMJ164_01225
XCFJ172_01220
XFUXFF4834R_chr10760(kdkA)
XAOXAC29_05515
XOMXOO0957(XOO0957)
XOOXOO1057
XOPPXO_02451
XOYAZ54_19250
XORXOC_1150
XOZBE73_18695
XALXALC_0604(kdkA)
XSASB85_07640
XTNFD63_04360
XFRBER92_14125
XVEBJD12_18605
XPEBJD13_11360
XHRXJ27_09710
XGABI317_06440
XPHXppCFBP6546_06085(XppCFBP6546P_06085)
XVAC7V42_05790
XANAC801_05415
XARXB05_00215
XHYFZ025_14820
XCZEBN15_04310
XTHG4Q83_06175
XEUXSP_001113
XHDLMG31886_32720(kdkA)
XPRMUG10_04405
SMLSmlt1004
SMTSmal_0850
BUJBurJV3_0856
SMZSMD_0942
SACZAOT14_09660(kdkA)
STEKAXG53_12685
SRHBAY15_1019
SLMBIZ42_13700
STENCCR98_04625
STEMCLM74_04580
STESMG068_04325
SINCDAIF1_09170(kdkA)
SPAQSTNY_R09750
PSUPsesu_2026
PSUWWQ53_02115
PSDDSC_11970
PMEXH4W19_01445
PJPLAG73_10440
PDDMNQ95_01205
LABLA76x_3535
LAQGLA29479_4877
LCPLC55x_3489
LGULG3211_1704
LEZGLE_1666
LEMLEN_3300
LMBC9I47_1245
LYTDWG18_08595
LUEDCD74_02790
LYJFKV23_10930
LSOLGOY17_12740
LSXH8B22_01985
LAREHIV01_001860
LHXLYSHEL_02540(kdkA)
LCASLYSCAS_02540(kdkA)
LCICINQ41_09820
LAVIINQ42_09265
LLZLYB30171_01801(kdkA)
LUMCNR27_07800
LUSE5843_10530
LUGFPZ22_11365
THESFHQ07_03240
THEHG7079_09885
TCNH9L16_10590
TBVH9L17_04565
XBCELE36_07845
FAUFraau_1379
RHDR2APBS1_1430
RGLCS053_09060
RTHLRK53_08790
DJICH75_05215
DJAHY57_10780
DTXATSB10_05430
DYEEO087_07785
DCSISN74_06790
DTLH8F01_17405
DTADYST_04875
DKOI596_1882
LRZBJI69_21545
LPYFIV34_13595
LANHKR767_21200
XBAC7S18_14055
RBDALSL_1797
VCHVC_0227
VCFIR04_06060
VCSMS6_0095
VCEVch1786_I2510
VCQEN18_18030
VCJVCD_001390
VCIO3Y_01040
VCOVC0395_A2607
VCRVC395_0259
VCMVCM66_0215
VCLVCLMA_A0198
VCXVAA049_3475
VCZVAB027_3624
VVUVV1_0814
VVYVV0297
VVMVVMO6_02810
VVLVV93_v1c02880
VPAVP0196
VPBVPBB_0203
VPKM636_20765
VPFM634_02995
VPHVPUCM_0196
VHAVIBHAR_00664
VCAM892_09525
VAGN646_2384
VEXVEA_001809
VDBAL552_09335
VHRAL538_10580
VNAPN96_12390
VOWA9237_07235
VROBSZ04_22360
VSPVS_0192(waaP)
VEJVEJY3_00920
VFUvfu_A00144
VNIVIBNI_A3729(kdkA)
VANVAA_02464
LAGN175_02015
VAUVANGNB10_cI2539c(wavC)
VCYIX92_15360
VCTJV59_38620
VTUIX91_00605
VEUIXK98_09290
VSIMTO69_00570
VFLAL536_19690
VMIAL543_10235
VBRA6E01_00860
VSCVSVS12_00339(kdkA)
VGABSQ33_09720
VSHBSZ05_05320
VQICCZ37_12560
VTAA3101(kdkA)
VAFD1115_14270
VNLD3H41_01000
VCCFAZ90_14280
VASGT360_13665
VAQFIV01_00770(kdkA)
VSRVspart_00152(kdkA)
VKABTD91_05540
VZIG5S32_14080
VNVIF132_14130
VGIMID13_00865
VSLLTQ54_07870
VPLSA104470976_02518(kdkA)
VFIVF_0136(wavC)
VFMVFMJ11_0134
VSAVSAL_I0182(wavC) VSAL_I0241(wavC)
AWDAWOD_I_0133(wavC)
PPRPBPRA0210(WAVC)
PGBH744_2c0477
PDSCAY62_13460
PGHFH974_00760
GHOAL542_08700
PMAICF386_02835
SALYE8E00_12715
SKSFCN78_00930
SCOTHBA18_00805
MAQMaqu_0778
MHCMARHY0647
MADHP15_439
MBSMRBBS_0656(kdkA)
MSRAU15_20845
MSXAU14_13690
MPQABA45_03435
MARIACP86_13305
MLQASQ50_14980
MSQBKP64_12140
MARAD0851_15980
MARJMARI_22710(kdkA)
SONSO_4677(kdkA)
SDNSden_3612
SFRSfri_3935
SAZSama_0101
SBLSbal_0061
SBMShew185_4337
SBNSbal195_4477
SBPSbal223_4282
SBTSbal678_4506
SBSSbal117_0061
SBBSbal175_4266
SLOShew_3706
SPCSputcn32_3898
SHPSput200_0053
SSESsed_0105
SPLSpea_0110
SHEShewmr4_3897
SHMShewmr7_3989
SHNShewana3_4101
SHWSputw3181_0053
SHLShal_4212
SWDSwoo_0068
SWPswp_5062
SVOSVI_0097(kdkA)
SHFCEQ32_15990
SJASJ2017_0057
SPSWSps_00146
SBJCF168_20690
SMAVCFF01_18355
SHEWCKQ84_07405
SALGBS332_07560
SLJEGC82_00425
SMAIEXU30_10925
SPOLFH971_19850
SBKSHEWBE_0685(kdkA)
SKHSTH12_03771(kdkA)
SAESHBH39_16990
SLITJQC75_00485
SDKKHX94_09215
SCAATUM17387_00560(kdkA)
SPSHFM037_00550
SEURFM038_000565
SYKKDN34_17130
SCYPJYB88_00515
SAVIJYB87_18280
SSEMJYB85_00545
SGLAFJ709_18920
SINVK8B83_01335
SXMMKD32_20350
CPSCPS_0117(kdkA)
COMCMT41_00465
COZA3Q34_11035
COLWA3Q33_09300
COLADBO93_17650
COVEKO29_19370
CBERB5D82_07335
LSDEMK97_10795
THTE2K93_06355
THAPFNC98_15080
THABLP316_03995
PHAPSHAa2319
PTNPTRA_a2809(kdkA)
PATPatl_0055
PSMPSM_A0767
PSEOOM33_06550
PIAPI2015_0748
PPHEPP2015_713
PBWD172_014165
PRRAT705_15665
PLZS4054249_04730
PALNB0W48_11655
PPISB1L02_02450
PEAPESP_a0948(kdkA)
PSPOPSPO_a0739(kdkA)
PARTPARC_a3116(kdkA)
PTUPTUN_a3545(kdkA)
PNGPNIG_a3002(kdkA)
PTDPTET_a0865(kdkA)
PSENPNC201_14500(kdkA)
PDJD0907_03165
PAGAPAGA_a2962(kdkA)
PCARPC2016_2506
PMAACPA52_03600
PVBJ5X90_09110
PSAZPA25_07590(kdkA)
PDVFFU37_11725
PSYMJ1N51_09255
AMCMADE_1000290
AMHI633_00320
AMAAamad1_00285
AMALI607_00275
AMAEI876_00290
AMAOI634_00275
AMADI636_00280
AMAII635_00280
AMAGI533_00275
AMACMASE_00280
AMBAMBAS45_00285
AMGAMEC673_00280
AMKAMBLS11_00275
ALTambt_18695
AALEP13_00305
AAUSEP12_00315
ASPAOR13_3456
ASQAVL57_01520
AAWAVL56_00300
ALRDS731_00305
ALEAV939_00305
ALZAV940_00305
APELCA267_009700
SALMD0Y50_19110
SALKFBQ74_00300
SMAAIT774_16960
GAGGlaag_0060
GNIGNIT_0061(kdkA)
GPSC427_0070
PMESFX988_02557
LALAT746_18730
CATEC2869_10335
SALHHMF8227_00049(kdkA)
HMIsoil367_03135
AGZM0C34_20450
PINPing_0330
PSYPCNPT3_02610
FBLFbal_0149
FESHER31_16505
MVSMVIS_0149(wavC)
MYAMORIYA_3161(kdkA)
MMAAFR932_16945
MARQMARGE09_P1743
MAGAMag101_02630
MHYDGTQ55_03155
MCELLPW13_18105
KIMG3T16_08335
TWNL2Y54_10655
TEETel_02945
AEHMlg_2807
HHAHhal_2259
HHKHH1059_01980(kdkA)
TKMTK90_0306
TNITVNIR_2695(kdkA_[H])
TTITHITH_02440
SSALSPISAL_00690
SPIUSPICUR_00625
SROSBBH56_09285
SPIZGJ672_00785
NAXHC341_17625
WMAWM2015_1098
WEZIC757_11845
WOCBA177_03070
GAIIMCC3135_06860(kdkA)
CSACsal_0015
HELHELO_1016A(kdkA)
HCSFF32_06335
HAKKO116_04282
HAMHALO4511
HHUAR456_00095
HCOLOKO_01073(kdkA_1)
HSIBOX17_08010
HALOBWR19_00070
HHHCLM76_05335
HBEBEI_0014(kdkA)
HAGBB497_03780
HAFC8233_11060
HALKCUU95_05805
HVNEI420_00070
HOLHORIV_00280(kdkA)
HSRHSBAA_00370
HMDCTT34_00070
HAXIHAALTHF_08960n
HTTHZS52_04290
HCAMI4484_00070
HPIZGYM47_00070
HSXHNO51_00070
HSVHNO53_00070
HTXEKK97_00075
HPROLMS44_00085
ZPLZBT109_0138
HAAA5892_03320
CMAIBFX80_17105
CAMHLCW13_00075
KUSB9G99_06940
KMAB9H00_08065
KUYFY550_00170
PAURFGL86_04350
MMWMmwyl1_1694
MMEMarme_2846
MPCMar181_2116
MPRIMP3633_2378
MARDIBG28_13115
MFOIJSY38_02755
MPRFJ8N69_00895
VCWGJQ55_00735
AHAAHA_0043(kdkA)
AHYAHML_00195
AHDAI20_19570
AHRV428_00215
AHPV429_00215
AHJV469_00215
AHHRY45_00210
AHIVU14_00415
AAJBOQ57_22060
ASAASA_0038(kdtA)
AEOO23A_p3595
AVRB565_0032
AVOAMS64_00240
AMEDB224_5297
ASRWL1483_2189(kdkA)
ADHCK627_03690
ACAVVI35_00185
AEMCK911_17485
AEAC2U39_22425
ARVC7N77_03915
AESC2U30_13765
AELNCTC12917_00038(kdkA)
ASIMFE240_00240
AALLI6G90_15605
AJDI6H43_10875
ARIVKYK33_00315
TAUTola_0135
OCEGU3_03195
OCMCBP12_09415
OPFCBP31_06655
ZDFAN401_00740
KKOKkor_2338
KGETQ33_0240
KSDKS2013_266
KPDCW740_10945
SDFACG33_02960
SINIGT972_06325
FCEJN531_006500
SALNSALB1_0115
CDIZCEDIAZO_00367(kdkA)
BPEBP2349
BPCBPTD_2308
BPERBN118_2274
BPETB1917_2262
BPEUQ425_22790
BPARBN117_1708
BPABPP1690
BBHBN112_1221
BBRBB3418
BBMBN115_3205
BBXBBS798_3250
BPTBpet1947
BAVBAV2255
BHOD560_2547
BHMD558_2530
BHZACR54_03019(kdkA)
BTRMSAMEA390648703800(kdkA)
BBROBAU06_17030
BFZBAU07_09155
BPDZBBN53_06945
BOHAKI39_16320
BGMCAL15_15650
BOJCBF45_11060
AXYAXYL_01990
AXONH44784_001021
AXNAX27061_1876
AXXERS451415_01875(kdkA)
ADTAPT56_08965
AISBUW96_00655
ASWCVS48_26260
ACHRC2U31_15585
ACHBDVB37_08045
ADYHLG70_13135
PUTPT7_0485
PUSCKA81_07805
PUDG9Q38_12685
AKATKWG_15535
AMIMMIM_c15070(kdkA)
CDNBN940_12431
BPSIIX83_02325
AFAUZ73_05000
AFQAFA_05310
AAQUD3M96_06855
AAMMFE795_05450
PHNPAEH1_12705
ODIODI_R1614
BOZDBV39_01575
OURCEQ07_07400
OUEI6G29_12290
KGYEHF36_11310
PARKLSG25_08355
DAKDaAHT2_1099
DEKDSLASN_49520
DHRLGS26_06445
TALXFOF52_14305
OBGVerru16b_01924(kdkA)
BROCIPI25_06435
BPITBPIT_34380
JETL3J17_06615
SCORJ3U87_07070
GGRHKW67_02385
MOAI6I89_07495
CHYDH4K34_16245
DINSelin_1025
 » show all
Reference
1  [PMID:10952982]
  Authors
Brabetz W, Muller-Loennies S, Brade H
  Title
3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout  mutation of Escherichia coli.
  Journal
J Biol Chem 275:34954-62 (2000)
DOI:10.1074/jbc.M005204200
  Sequence
[hin:HI_0260.1]
Reference
2  [PMID:17517879]
  Authors
Harper M, Boyce JD, Cox AD, St Michael F, Wilkie IW, Blackall PJ, Adler B
  Title
Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: identification of two acceptor-specific heptosyl I transferases.
  Journal
Infect Immun 75:3885-93 (2007)
DOI:10.1128/IAI.00212-07
Reference
3  [PMID:9195966]
  Authors
White KA, Kaltashov IA, Cotter RJ, Raetz CR
  Title
A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae.
  Journal
J Biol Chem 272:16555-63 (1997)
DOI:10.1074/jbc.272.26.16555
  Sequence
[hin:HI_0260.1]
Reference
4  [PMID:10531340]
  Authors
White KA, Lin S, Cotter RJ, Raetz CR
  Title
A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence.
  Journal
J Biol Chem 274:31391-400 (1999)
DOI:10.1074/jbc.274.44.31391
  Sequence
[hin:HI_0260.1]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.166
IUBMB Enzyme Nomenclature: 2.7.1.166
ExPASy - ENZYME nomenclature database: 2.7.1.166
BRENDA, the Enzyme Database: 2.7.1.166
LinkDB

DBGET integrated database retrieval system