Entry
Name
3-deoxy-D-manno-octulosonic acid kinase;
kdkA (gene name);
Kdo kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:(Kdo)-lipid IVA 3-deoxy-alpha-D-manno-oct-2-ulopyranose 4-phosphotransferase
Reaction(IUBMB)
alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP [RN:
R09767 ]
Reaction(KEGG)
Substrate
alpha-Kdo-(2->6)-lipid IVA;
ATP [CPD:
C00002 ]
Product
4-O-phospho-alpha-Kdo-(2->6)-lipid IVA [CPD:
C19877 ];
ADP [CPD:
C00008 ]
Comment
The enzyme phosphorylates the 4-OH position of Kdo in (Kdo)-lipid IVA.
History
EC 2.7.1.166 created 2010, modified 2011
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K11211 3-deoxy-D-manno-octulosonic acid kinase
Genes
HIC : NTHIC486_00733(kdkA)
HPIT : NCTC13334_00281(kdkA)
HHZ : NCTC10839_00212(kdkA)
HAEG : NCTC8502_00965(kdkA)
PDAG : 4362423_01452(kdkA)
ADP : NCTC12871_01303(kdkA)
ALIG : NCTC10568_00387(kdkA)
ASEG : NCTC10977_00651(kdkA)
AVT : NCTC3438_00405(kdkA_1)
PAET : NCTC13378_01959(kdkA)
XFU : XFF4834R_chr10760(kdkA)
XPH : XppCFBP6546_06085(XppCFBP6546P_06085)
XHD : LMG31886_32720(kdkA)
LLZ : LYB30171_01801(kdkA)
VAU : VANGNB10_cI2539c(wavC)
VPL : SA104470976_02518(kdkA)
VIB : VspSTUT11_27700(kdkA)
VIS : VspSTUT16_28950(kdkA)
VSA : VSAL_I0182(wavC) VSAL_I0241(wavC)
MSHE : MAALD49_07650(kdkA)
SCAA : TUM17387_00560(kdkA)
SALH : HMF8227_00049(kdkA)
TNI : TVNIR_2695(kdkA_[H])
GAI : IMCC3135_06860(kdkA)
HAAH : HALA3H3_360025(kdkA)
HAAZ : HaloA020_11980(kdkA)
AEL : NCTC12917_00038(kdkA)
CDIZ : CEDIAZO_00367(kdkA)
BTRM : SAMEA390648703800(kdkA)
AXX : ERS451415_01875(kdkA)
OBG : Verru16b_01924(kdkA)
» show all
Taxonomy
Reference
Authors
Brabetz W, Muller-Loennies S, Brade H
Title
3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout mutation of Escherichia coli.
Journal
Sequence
Reference
Authors
Harper M, Boyce JD, Cox AD, St Michael F, Wilkie IW, Blackall PJ, Adler B
Title
Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: identification of two acceptor-specific heptosyl I transferases.
Journal
Reference
Authors
White KA, Kaltashov IA, Cotter RJ, Raetz CR
Title
A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae.
Journal
Sequence
Reference
Authors
White KA, Lin S, Cotter RJ, Raetz CR
Title
A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.166
LinkDB
All DBs