KEGG   ENZYME: 2.7.1.174
Entry
EC 2.7.1.174                Enzyme                                 
Name
diacylglycerol kinase (CTP);
DAG kinase;
CTP-dependent diacylglycerol kinase;
diglyceride kinase (ambiguous);
DGK1 (gene name);
diacylglycerol kinase (CTP dependent)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase
Reaction(IUBMB)
CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R09944]
Reaction(KEGG)
R09944
Substrate
CTP [CPD:C00063];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
CDP [CPD:C00112];
1,2-diacyl-sn-glycerol 3-phosphate [CPD:C00416]
Comment
Requires Ca2+ or Mg2+ for activity. Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Unlike the diacylglycerol kinases from bacteria, plants, and animals [cf. EC 2.7.1.107, diacylglycerol kinase (ATP)], the enzyme from Saccharomyces cerevisiae utilizes CTP. The enzyme can also use dCTP, but not ATP, GTP or UTP.
History
EC 2.7.1.174 created 2012, modified 2013
Pathway
ec00564  Glycerophospholipid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16368  diacylglycerol kinase (CTP)
Genes
SCE: YOR311C(DGK1)
SEUB: DI49_5130
SPAO: SPAR_O04210
AGO: AGOS_AFR329C
ERC: Ecym_1490
KLA: KLLA0_F08635g
KMX: KLMA_20319(DGK1)
LTH: KLTH0H15356g
VPO: Kpol_1010p4
ZRO: ZYRO0F12540g
CGR: 2889272(GVI51_I09669)
NCS: NCAS_0B00880(NCAS0B00880)
NDI: NDAI_0E00540(NDAI0E00540)
TPF: TPHA_0G01150(TPHA0G01150)
TBL: TBLA_0B02820(TBLA0B02820) TBLA_0D00720(TBLA0D00720)
TGB: HG536_0H01130
TDL: TDEL_0B01100(TDEL0B01100)
KAF: KAFR_0D01590(KAFR0D01590)
KNG: KNAG_0G03200(KNAG0G03200)
ZMK: HG535_0F00810
SLUD: SCDLUD_000729
DHA: DEHA2D18436g DEHA2D18502g
PIC: PICST_56382
PGU: PGUG_05218
SPAA: SPAPADRAFT_60969
LEL: PVL30_001209(DGK1)
LBG: 92209763(LODBEIA_P45670)
CAL: CAALFM_C200790CA(CaO19.2045)
CTP: CTRG_01144
COT: CORT_0A12290
CDU: CD36_15730
CTEN: 18248194(DGK1)
CLU: CLUG_04390
CLUS: A9F13_04g01188
CAUR: CJI96_0001861
ASAU: 88172939(PUMCH_001874)
PPA: PAS_chr3_0072
PKZ: C5L36_0A08970
BNN: FOA43_004690
BBRX: BRETT_001722
OPA: HPODL_01418
YLI: 2909033(YALI2_F00589g)
SLB: AWJ20_3255(DGK1)
NCR: NCU03381
NTE: NEUTE1DRAFT84553(NEUTE1DRAFT_84553)
SMP: 10802586(SMAC4_08256)
PAN: PODANSg7049
PBEL: QC761_605160(DGK1)
PPSD: QC762_605160(DGK1)
PPSP: QC763_605160(DGK1)
PPSA: QC764_605160(DGK1)
TTT: THITE_2171517
MTM: MYCTH_2311577
CTHR: CTHT_0006610
RTHE: 98127691(VTJ83DRAFT_6346)
MGR: MGG_02416
PPEI: PpBr36_06995
PGRI: PgNI_05557
TMN: UCRPA7_812
SSCK: SPSK_01155
FGR: FGSG_10897
FPU: FPSE_09806
FPOA: FPOAC1_009630
FVN: FVRRES_10272
FVR: FVEG_11577
FOX: FOXG_12833
NHE: NECHADRAFT_4054
FFC: NCS54_00650300
FKR: NCS57_00690300
FMU: J7337_009978
TRE: TRIREDRAFT_77915
TRR: M419DRAFT_9055
TATV: 25780450(TrAtP1_004788)
TASP: 36618799(TrAFT101_004213)
MAW: 19247918(DGK1_1)
MAJ: MAA_02579
MBRN: 26241923(DGK1)
PCHM: VFPPC_12955
CMT: CCM_00191
AMUS: LMH87_000419
PLJ: 28888923(PLICBS_008594)
PTKZ: JDV02_006035(DGK1)
CFJ: CFIO01_08444
CLUP: CLUP02_02221
CHIG: CH63R_10913
CDET: 87943993(CDEST_07490)
PFY: PFICI_09234
SSL: SS1G_12219
BFU: BCIN_05g05750(Bcdgk1)
MBE: MBM_04096
PSCO: LY89DRAFT_783476
GLZ: GLAREA_05179
ANI: ANIA_03177
AFM: AFUA_3G13270
ACT: ACLA_040980
NFI: NFIA_064080
AOR: AO090012000806
ANG: An02g09160
AFV: AFLA_002520
ALUC: AKAW2_10782A AKAW2_80531A
ACHE: ACHE_20191S
APUU: APUU_30355S
PCS: N7525_002587
PDP: PDIP_23570
POU: POX_b02834
TMF: EYB26_000413
TRG: TRUGW13939_04470
CIM: CIMG_03494
CPW: 9694204(D8B26_003034)
URE: UREG_07293
ABE: ARB_05368
TVE: TRV_01710
PBL: PAAG_02107
PBN: PADG_00789
BGH: BDBG_03109
PNO: SNOG_06468
PTE: PTT_18596
PTRR: 6338562(PtrM4_018990)
BZE: COCCADRAFT_3592
BSC: COCSADRAFT_178032
BOR: COCMIDRAFT_109291
ADAC: 96082127(ACET3X_001805)
ARAB: EKO05_0005731
ZTR: MYCGRDRAFT_34966
PFJ: MYCFIDRAFT_203374
FFU: CLAFUR5_04245
CBET: CB0940_11816
BCOM: BAUCODRAFT_28994
NPA: UCRNP2_7212
TML: GSTUM_00010292001
SPO: 2540998(ptp4)
SOM: SOMG_01296(ptp4)
CNE: CNA08270
CNB: CNBA8100
CNG: CNAG_00852
CGI: CGB_A9630W
CDEU: CNBG_1091
CDEP: 91088949(L203_104739)
KMG: 30162311(I203_100854)
KNE: 92181520(IAR55_004262)
TMS: TREMEDRAFT_73615
TASA: A1Q1_01060
CCAC: CcaHIS019_0109300(DGK1)
TVS: TRAVEDRAFT_155258
DSQ: DICSQDRAFT_89106
PCO: PHACADRAFT_254155
SHS: STEHIDRAFT_121170
HIR: HETIRDRAFT_446249
PSQ: PUNSTDRAFT_57981
ADL: AURDEDRAFT_56616
FME: FOMMEDRAFT_124258
GTR: GLOTRDRAFT_50706
RSX: RhiXN_10847
LBC: LACBIDRAFT_303651 LACBIDRAFT_307204 LACBIDRAFT_316889 LACBIDRAFT_317349
CCI: CC1G_11851
ABP: AGABI1DRAFT116813(AGABI1DRAFT_116813)
ABV: AGABI2DRAFT195012(AGABI2DRAFT_195012)
PCUB: JR316_0013368
MPR: MPER_10629
MRR: Moror_15923
MORE: E1B28_006263
SCM: SCHCO_02702080(SCHCODRAFT_02702080)
CPUT: CONPUDRAFT_86032
SLA: SERLADRAFT_414556
WSE: WALSEDRAFT_60470
WIC: J056_002927
UMA: UMAG_04898
PFP: PFL1_02740
SGRA: EX895_005769
MGL: MGL_1278
MRT: MRET_2866
MSYM: MSY001_0629
PGR: PGTG_20746
PTRC: PtA15_10A511
PSTR: Pst134EA_019480
MLR: MELLADRAFT_29397
RIE: OCT59_029449
 » show all
Reference
1  [PMID:18458075]
  Authors
Han GS, O'Hara L, Carman GM, Siniossoglou S
  Title
An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth.
  Journal
J Biol Chem 283:20433-42 (2008)
DOI:10.1074/jbc.M802903200
  Sequence
[sce:YOR311C]
Reference
2  [PMID:18458076]
  Authors
Han GS, O'Hara L, Siniossoglou S, Carman GM
  Title
Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase.
  Journal
J Biol Chem 283:20443-53 (2008)
DOI:10.1074/jbc.M802866200
  Sequence
[sce:YOR311C]
Reference
3  [PMID:21071438]
  Authors
Fakas S, Konstantinou C, Carman GM
  Title
DGK1-encoded diacylglycerol kinase activity is required for phospholipid synthesis during growth resumption from stationary phase in Saccharomyces cerevisiae.
  Journal
J Biol Chem 286:1464-74 (2011)
DOI:10.1074/jbc.M110.194308
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.174
IUBMB Enzyme Nomenclature: 2.7.1.174
ExPASy - ENZYME nomenclature database: 2.7.1.174
BRENDA, the Enzyme Database: 2.7.1.174
LinkDB

DBGET integrated database retrieval system