KEGG   ENZYME: 2.7.1.189
Entry
EC 2.7.1.189                Enzyme                                 
Name
autoinducer-2 kinase;
lsrK (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:(S)-4,5-dihydroxypentane-2,3-dione 5-phosphotransferase
Reaction(IUBMB)
ATP + (S)-4,5-dihydroxypentane-2,3-dione = ADP + (S)-4-hydroxypentane-2,3-dione 5-phosphate [RN:R11183]
Reaction(KEGG)
R11183
Substrate
ATP [CPD:C00002];
(S)-4,5-dihydroxypentane-2,3-dione [CPD:C11838]
Product
ADP [CPD:C00008];
(S)-4-Hydroxy-5-phosphonooxypentane-2,3-dione [CPD:C20959]
Comment
The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.
History
EC 2.7.1.189 created 2015
Orthology
K11216  autoinducer-2 kinase
Genes
ECOb1511(lsrK)
ECJJW1504(ydeV)
ECDECDH10B_1642(lsrK)
EBWBWG_1330(lsrK)
ECOKECMDS42_1222(ydeV)
ECOCC3026_08740
ECEZ2194(ydeV)
ECSECs_2118(lsrK)
ECFECH74115_2124(lsrK)
ETWECSP_1996(lsrK)
ELXCDCO157_1958
EOHECO103_1641(lsrK)
ECOOECRM13514_1880(lsrK)
ECOHECRM13516_1876(lsrK)
ESLO3K_12925
ESOO3O_12710
ESMO3M_12885
ECKEC55989_1644(lsrK)
EOKG2583_1876(lsrK)
ELRECO55CA74_09195
ELHETEC_1581
ECWEcE24377A_1712(lsrK)
EUNUMNK88_1929
ECOAAPECO78_11300
ECXEcHS_A1593(lsrK)
ECMEcSMS35_1661(lsrK)
ECYECSE_1601
ECRECIAI1_1523(lsrK)
EUMECUMN_1779(lsrK)
EOCCE10_1700(lsrK)
ELOEC042_1644
ECLEcolC_2147
EKOEKO11_2305
EKFKO11_15610(lsrK)
EDHEcDH1_2135
EDJECDH1ME8569_1454(lsrK)
ELWECW_m1640(lsrK)
ELLWFL_08030(lsrK)
ELPP12B_c1565
EFEEFER_1566(lsrK)
ESZFEM44_22660(lsrK)
STYSTY3798(ydeV)
STTt3546(ydeV)
SEXSTBHUCCB_37290
SENTTY21A_17915
STMSTM4072(ydeV)
SEOSTM14_4896(ydeV)
SEVSTMMW_40371
SEYSL1344_4021(ydeV)
SEMSTMDT12_C42190(lsrK)
SEJSTMUK_4057(ydeV)
SEBSTM474_4254(lsrk)
SEFUMN798_4415(ydeV)
SETUSTU288_20510
SETCCFSAN001921_20060
SENRSTMDT2_39351(ydeV)
SENDDT104_40811(ydeV)
SENICY43_21295
SEENSE451236_00530
SPTSPA3915(ydeV)
SEKSSPA3643
SPQSPAB_05045
SEISPC_4178(ydeV)
SECSCH_3962(ydeV)
SEHSeHA_C4403
SHBSU5_0169
SENHCFSAN002069_11710
SEEHSEEH1578_06620
SEESNSL254_A4400
SENNSN31241_46160
SEWSeSA_A4288
SEASeAg_B4318
SENSQ786_19995
SEDSeD_A4470
SEGSG3348(ydeV)
SETSEN3862(ydeV)
SENAAU38_19965
SENOAU37_19980
SENVAU39_20000
SENQAU40_22305
SENLIY59_20460
SENJCFSAN001992_13330
SEEBSEEB0189_021985
SENBBN855_41470
SENEIA1_19815
SENCSEET0819_04205
SALZEOS98_21950
SFESFxv_1776(lsrK)
SFNSFy_2267
SFSSFyv_2321
SFTNCTC1_01714(lsrK)
ENCECL_04484
ENLA3UG_19815
ECLGEC036_38630
ECLEECNIH2_20295
ECLNECNIH4_03410
ECLIECNIH5_18835
ECLXLI66_19540
ECLYLI62_21540
ECLOENC_33410
EHMAB284_05830
EXFBFV63_19040
ECLAECNIH3_18925
ECLCECR091_18850
EAUDI57_21445
EKBBFV64_20405
ENOECENHK_19245
EECEcWSU1_03900(lsrK)
ELGBH714_20295
ECANCWI88_02980
ERNBFV67_19075
ECHGFY206_21405(lsrK)
ESHC1N69_19905
EPTHWQ17_16520(lsrK)
ENTEnt638_3538
EASEntas_3763
ENRH650_12050
ENXNI40_019330
ENFAKI40_0665(ydeV)
LNICWR52_15660
EBGFAI37_09790(lsrK)
ENDA4308_03910
ENZG0034_19830(lsrK)
ENSHWQ15_04810(lsrK)
ENKLOC22_07585(lsrK)
EHUD5067_0003170(lsrK)
EMORL6Y89_19115(lsrK)
ENBELK40_19690
EQUOM418_19250(lsrK)
EPUQVH39_20150(lsrK)
KPNKPN_03509(ydeV)
KPUKP1_4807(ydeV)
KPMKPHS_46420
KPPA79E_0608
KPHKPNIH24_05685
KPZKPNIH27_22165
KPVKPNIH29_23060
KPWKPNIH30_23385
KPYKPNIH31_22570
KPGKPNIH32_24235
KPCKPNIH10_23115
KPQKPR0928_22635
KPTVK055_3959(lsrK)
KPOKPN2242_20680
KPRKPR_4713(lsrK)
KPJN559_0662
KPID364_18080
KPAKPNJ1_00650
KPSKPNJ2_00692
KPXPMK1_01027(lsrK)
KPBFH42_13830
KPNEKU54_003200
KPNULI86_03205
KPNKBN49_0598(lsrK)
KVAKvar_0591
KPEKPK_0603(lsrK)
KPKA593_07795
KVDKR75_05060
KVQSP68_11695
KOXKOX_03320
KOEA225_5112
KOYJ415_06445
KOMHR38_01880
KMIVW41_02420
KOKKONIH1_25840
KOCAB185_10485
KQUAVR78_01390
EAEEAE_03960
EARCCG33200
KQVB8P98_03245
KLLBJF97_25495
KLWDA718_03685
KARLGL98_03110(lsrK)
KGRJJJ10_03310(lsrK)
KPASLUW96_03215(lsrK)
KLCK7H21_03300(lsrK)
KLMBWI76_24670
REEelectrica_00586(lsrK)
RORRORB6_21810
RONTE10_24545
RPLNB1209_03080
RAODSD31_03250
RTGNCTC13098_00809(lsrK_1)
CAMAF384_16515
CAFAL524_06550
CFARCI104_21680
CIRC2U53_13435
CTELGBC03_08085(lsrK)
CNTJT31_09750
CEMLH23_08020
CENLH86_07885
CLAPNCTC11466_04017(lsrK_2)
ESCEntcl_0612
KLEAO703_18380
KSAC813_18605
KORAWR26_03075(lsrK)
KRDA3780_21660
KPSEIP581_20150(lsrK)
KOOO9K67_03275(lsrK)
LAXAPT61_03105
LEIC2U54_01625
LEHC3F35_15035
LEEDVA44_03100
LERGNG29_19910(lsrK)
LEAGNG26_19100(lsrK)
LPNUKQ929_02545(lsrK)
LEYDVA43_21120
LAZA8A57_18305
LEFLJPFL01_3640
LEWDAI21_07760
BUFD8682_18505
BAGEBADSM9389_05500
BFTMNO13_02830(lsrK)
AHNNCTC12129_00634(lsrK)
ASUBNLZ15_02795(lsrK)
YREHEC60_14960(lsrK)
SGOEA8O29_003680(lsrK)
KINAB182_28890
PDZHHA33_05595(lsrK)
METYMRY16398_06750(lsrK)
SUPEP0H77_00625(lsrK)
TOEQMG90_18685(lsrK)
EBCC2U52_11780
EBUCUC76_18715
YPEYPO0415
YPKy3764
YPHYPC_4186
YPAYPA_3869
YPNYPN_0286
YPMYP_3766(xylB3)
YPPYPDSF_3216
YPGYpAngola_A0855
YPZYPZ3_0407
YPTA1122_03025
YPDYPD4_0359
YPXYPD8_0361
YPWCH59_1446(lsrK)
YPJCH55_2394(lsrK)
YPVBZ15_3156(lsrK)
YPLCH46_499(lsrK)
YPSYPTB0554(ydeV)
YPOBZ17_2005(lsrK)
YPIYpsIP31758_3518
YPYYPK_3648
YPBYPTS_0578
YPQDJ40_1813(lsrK)
YPUBZ21_3934(lsrK)
YPRBZ20_1539(lsrK)
YPCBZ23_34(lsrK)
YPFBZ19_4061(lsrK)
YENYE0530
YEPYE105_C0543
YEYY11_37641
YELLC20_08735
YEWCH47_2946(lsrK)
YETCH48_1068(lsrK)
YEFFORC2_3559
YEEYE5303_27971
YSIBF17_11045
YALAT01_3048(lsrK)
YFRAW19_3889(lsrK)
YINCH53_1158(lsrK)
YKRCH54_1901
YROCH64_3163(lsrK)
YAKACZ76_11850
YMADA391_19395
YHID5F51_03000
YCAF0T03_03270(lsrK)
YMOHRD69_08400(lsrK)
YASN0H69_02890(lsrK)
YKIHRD70_07610(lsrK)
SMARSM39_0819(lsrK)
SMACSMDB11_0647(lsrK)
SMWSMWW4_v1c13610(lsrK)
SPESpro_1382
SRRSerAS9_1357
SRLSOD_c12740(lsrK)
SRYM621_07075
SPLYQ5A_006945(lsrK)
SRSSerAS12_1357
SRASerAS13_1358
SMAFD781_1308
SLQM495_06365
SERFL085_21655
SERSSERRSCBI_06430
SFWWN53_22830
SFGAV650_18660
SRZAXX16_3787
SERMCLM71_06390
SQUE4343_09245(lsrK)
SFJSAMEA4384070_1443(lsrK)
SOFNCTC11214_05537(lsrK)
SSURATE40_003610
SURIJ0X03_16955(lsrK)
SENPKHA73_07160(lsrK)
SNEMNLX84_06830(lsrK)
SNEVOI978_26930(lsrK)
RAHRahaq_2588
RACEJHW33_04245(lsrK)
RAQRahaq2_2601
RAAQ7S_12885
ROXBV494_07330
RVCJ9880_17045(lsrK)
RIUI2123_14440(lsrK)
EAMEGXP68_13195(lsrK)
RBADH2866_22225(lsrK)
PRODPCO85_03530(lsrK)
SERASer39006_021920
SERQCWC46_21930
SODSant_3797(lsrK)
SLIGGTU79_26090(lsrK)
PAOPat9b_2709
KLNLH22_09040
KPIEN5580_06470(lsrK)
PLUplu3141
PLUMA4R40_15690
PAYPAU_01471
PTTVY86_00280
PAKHB0X70_16185
PLUICE143_16175
XBOXBJ1_4109(ydeV)
XBVXBW1_0353(lsrK)
XNEXNC1_4323(ydeV)
XNMXNC2_4172(ydeV)
XDOXDD1_3684(lsrK)
XHOA9255_16410
XBUHGO23_01285(lsrK)
XGRQL128_01470(lsrK)
MMKMU9_2083
EHOA9798_12225
HIPCGSHiEE_08190
HIAH733_1673(lsrK)
HICNTHIC486_00200(lsrK)
HSOHS_0049
HSMHSM_1942
PMUPM1272
PMVPMCN06_1937(lsrK)
PULNT08PM_2193
PMPPmu_19330(lsrK)
PMULDR93_516(lsrK)
PSKYA6B44_08080
PATLKGI96_03300(lsrK)
PCAIK7G93_001861(lsrK)
AATD11S_1398
AAOANH9381_1746
AAND7S_00013
AAHCF65_02230
AACNAANUM_1694(lsrK)
AACTACT75_11325
AVTNCTC3438_00380(lsrK)
SWDSwoo_3745
SVOSVI_3479
SPSWSps_04498
SBKSHEWBE_4117(lsrK)
SPSHFM037_22275(lsrK)
SEURFM038_25915(lsrK)
HMARHVMH_2034(lsrK)
TZOTHMIRHAT_03020(lsrK)
CDIZCEDIAZO_00808(lsrK)
SMESM_b21022
SMKSinme_5078
SMQSinmeB_4065
SMXSM11_pD0954
SMIBN406_06009(lsrK)
SMEGC770_GR4pD0990
SMELSM2011_b21022
SMERDU99_30215
ECAAJ3R84_32490(lsrK)
SZOK8M09_14840(lsrK)
SOJK6301_14505(lsrK)
SSUMQ9314_11270(lsrK)
KAIK32_08850
DEAFPZ08_01350
SIWGH266_09415(lsrK)
CIDP73_1373
CEHCEW89_15560
YPACCEW88_20215
RSPRSP_3506
RSHRsph17029_3151
RSKRSKD131_3672
RCPRCAP_rcc02884
PAMIJCM7686_pAMI4p038
RMBK529_019155
THWBMG03_15435
GCEKYE46_14165(lsrK)
PMASNCF86_15900(lsrK)
THACCSC3H3_20685
TTBMACH01_07240
TDNSuden_1477
SUASaut_1517
SULGFJR48_03670(lsrK)
SPALFM071_07130(lsrK)
SSEIFJR45_04305(lsrK)
SBALHUE88_02930(lsrK)
SMASHUE87_09425(lsrK)
SMAXFJR03_03600(lsrK)
SAQTGJV85_04675(lsrK)
SKUSulku_2327
SULRB649_11025
ANTArnit_1320
HEBRAEBR_0249
HTMRZR91_09550(lsrK)
SUNSUN_0119
SLHYH65_01130
BATBAS2768
BAHBAMEG_1624
BAXH9401_2842
BANSBAPAT_2858
BANHHYU01_14740
BANVDJ46_1742
BCEBC2965
BCABCE_3017
BCZBCE33L2698
BCRBCAH187_A3019
BCBBCB4264_A2981
BCUBCAH820_2977
BCGBCG9842_B2261
BCQBCQ_2801(ydeV)
BCXBCA_3051
BALBACI_c29350(ydeV)
BNCBCN_2825
BCFbcf_14535
BCERBCK_20020
BCEFBcrFT9_02335
BTKBT9727_2718(ydeV)
BTLBALH_2666
BTBBMB171_C2668
BTTHD73_3008
BTHRYBT1520_14795
BTHIBTK_14895
BTCCT43_CH2966
BTFYBT020_14835
BTMMC28_2165
BTGBTB_c30940(lsrK)
BTIBTG_04510
BTNBTF1_12355
BTHTH175_ch3017
BTHUYBT1518_16390
BTWBF38_4133(lsrK)
BTHYAQ980_16100
BWEBcerKBAB4_2774
BWWbwei_2047(lsrK)
BMYOBG05_3047
BTYBtoyo_0261
BMYCDJ92_62(lsrK)
BBYCY96_13670
BWDCT694_15910
BTROFJR70_04285(lsrK)
BMOBMLA2C4_15680
BNTGSN03_14360(lsrK)
BPACLMD38_12215(lsrK)
BPANNLJ82_13985(lsrK)
BALUQRY64_16955(lsrK)
BARDQRY57_14970(lsrK)
CSOALIS82_25980(lsrK)
OCNCUC15_15715
VIMGWK91_10945(lsrK)
PPSRI6J18_09100(lsrK)
NMKCHR53_25605
NDTL1999_27395(lsrK)
NCMQNK12_16635(lsrK)
NNVQNH39_14485(lsrK)
MDGK8L98_05150(lsrK)
VAOFA707_08160(lsrK)
FCTNRE15_11630(lsrK)
GADK8O88_08710(lsrK)
CSBCLSA_c21380(lsrK)
CAHCAETHG_3998(lsrK)
ACOLK5I23_11485(lsrK)
AIMPYS61_00890(lsrK)
ANQPYS63_01830(lsrK)
CFEMHCR03_10800(lsrK)
CBAFJS518_10795(lsrK)
LACYA4V08_30740
CHYLCE91St63_19830
GFEGferi_19735
PCATPcatena_00660(glpK_1)
MIPAXH82_08925
MLVCVS47_03274(lsrK)
MLZF6J85_02865
MRNK8F61_15475
ASOIMTP13_04780
GRYD7I44_11695
LEULeucomu_13335
AGGC1N71_13045
ACITHPK19_06240(lsrK)
TPYCQ11_07240
TPYOX956_00445
ACTTDDD63_02055
RMARGBA65_18055
PSUBPelsub_P2245
DPHEHF33_19240
OPROcepr_1035
TPITREPR_3784
TRMJO41_06345
TMEDDWB79_02640
TSKHRI97_08155(lsrK)
SSMSpirs_3576
 » show all
Reference
1  [PMID:17274596]
  Authors
Xavier KB, Miller ST, Lu W, Kim JH, Rabinowitz J, Pelczer I, Semmelhack MF, Bassler BL
  Title
Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.
  Journal
ACS Chem Biol 2:128-36 (2007)
DOI:10.1021/cb600444h
  Sequence
[stm:STM4072]
Reference
2  [PMID:20025244]
  Authors
Roy V, Fernandes R, Tsao CY, Bentley WE
  Title
Cross species quorum quenching using a native AI-2 processing enzyme.
  Journal
ACS Chem Biol 5:223-32 (2010)
DOI:10.1021/cb9002738
  Sequence
[eco:b1511]
Reference
3  [PMID:23672516]
  Authors
Zhu J, Hixon MS, Globisch D, Kaufmann GF, Janda KD
  Title
Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation.
  Journal
J Am Chem Soc 135:7827-30 (2013)
DOI:10.1021/ja4024989
  Sequence
[stm:STM4072]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.189
IUBMB Enzyme Nomenclature: 2.7.1.189
ExPASy - ENZYME nomenclature database: 2.7.1.189
BRENDA, the Enzyme Database: 2.7.1.189
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