KEGG   ENZYME: 2.7.1.189
Entry
EC 2.7.1.189                Enzyme                                 
Name
autoinducer-2 kinase;
lsrK (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:(S)-4,5-dihydroxypentane-2,3-dione 5-phosphotransferase
Reaction(IUBMB)
ATP + (S)-4,5-dihydroxypentane-2,3-dione = ADP + (S)-4-hydroxypentane-2,3-dione 5-phosphate [RN:R11183]
Reaction(KEGG)
R11183
Substrate
ATP [CPD:C00002];
(S)-4,5-dihydroxypentane-2,3-dione [CPD:C11838]
Product
ADP [CPD:C00008];
(S)-4-Hydroxy-5-phosphonooxypentane-2,3-dione [CPD:C20959]
Comment
The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.
History
EC 2.7.1.189 created 2015
Orthology
K11216  autoinducer-2 kinase
Genes
ECO: b1511(lsrK)
ECJ: JW1504(ydeV)
ECD: ECDH10B_1642(lsrK)
EBW: BWG_1330(lsrK)
ECOK: ECMDS42_1222(ydeV)
ECOC: C3026_08740
ECE: Z2194(ydeV)
ECS: ECs_2118(lsrK)
ECF: ECH74115_2124(lsrK)
ETW: ECSP_1996(lsrK)
ELX: CDCO157_1958
EOH: ECO103_1641(lsrK)
ECOO: ECRM13514_1880(lsrK)
ECOH: ECRM13516_1876(lsrK)
ESL: O3K_12925
ESO: O3O_12710
ESM: O3M_12885
ECK: EC55989_1644(lsrK)
EOK: G2583_1876(lsrK)
ELR: ECO55CA74_09195
ELH: ETEC_1581
ECW: EcE24377A_1712(lsrK)
EUN: UMNK88_1929
ECOA: APECO78_11300
ECX: EcHS_A1593(lsrK)
ECM: EcSMS35_1661(lsrK)
ECY: ECSE_1601
ECR: ECIAI1_1523(lsrK)
EUM: ECUMN_1779(lsrK)
EOC: CE10_1700(lsrK)
ELO: EC042_1644
ECL: EcolC_2147
EKF: KO11_15610(lsrK)
EDH: EcDH1_2135
EDJ: ECDH1ME8569_1454(lsrK)
ELW: ECW_m1640(lsrK)
ELL: WFL_08030(lsrK)
ELP: P12B_c1565
EFE: EFER_1566(lsrK)
ESZ: FEM44_22660(lsrK)
STY: STY3798
STT: t3546(ydeV)
SEX: STBHUCCB_37290
SENT: TY21A_17915
STM: STM4072(ydeV)
SEO: STM14_4896(ydeV)
SEV: STMMW_40371
SEY: SL1344_4021(ydeV)
SEM: STMDT12_C42190(lsrK)
SEJ: STMUK_4057(ydeV)
SEB: STM474_4254(lsrk)
SEF: UMN798_4415(ydeV)
SETU: STU288_20510
SETC: CFSAN001921_20060
SENR: STMDT2_39351(ydeV)
SEND: DT104_40811(ydeV)
SENI: CY43_21295
SEEN: SE451236_00530
SPT: SPA3915(ydeV)
SEK: SSPA3643
SPQ: SPAB_05045
SEI: SPC_4178(ydeV)
SEC: SCH_3962(ydeV)
SEH: SeHA_C4403
SHB: SU5_0169
SENH: CFSAN002069_11710
SEEH: SEEH1578_06620
SEE: SNSL254_A4400
SENN: SN31241_46160
SEW: SeSA_A4288
SEA: SeAg_B4318
SENS: Q786_19995
SED: SeD_A4470
SEG: SG3348(ydeV)
SET: SEN3862(ydeV)
SENA: AU38_19965
SENO: AU37_19980
SENV: AU39_20000
SENQ: AU40_22305
SENL: IY59_20460
SENJ: CFSAN001992_13330
SEEB: SEEB0189_021985
SENB: BN855_41470
SENE: IA1_19815
SENC: SEET0819_04205
SALZ: EOS98_21950
SFE: SFxv_1776(lsrK)
SFN: SFy_2267
SFS: SFyv_2321
SFT: NCTC1_01714(lsrK)
SHIG: LXH19_11265(lsrK)
ENC: ECL_04484
ENL: A3UG_19815
ECLG: EC036_38630
ECLE: ECNIH2_20295
ECLN: ECNIH4_03410
ECLI: ECNIH5_18835
ECLX: LI66_19540
ECLY: LI62_21540
ECLO: ENC_33410
EHM: AB284_05830
EXF: BFV63_19040
ECLA: ECNIH3_18925
ECLC: ECR091_18850
EAU: DI57_21445
EKB: BFV64_20405
ENO: ECENHK_19245
EEC: EcWSU1_03900(lsrK)
ELG: BH714_20295
ECAN: CWI88_02980
ERN: BFV67_19075
ECHG: FY206_21405(lsrK)
ESH: C1N69_19905
EPT: HWQ17_16520(lsrK)
ENT: Ent638_3538
EAS: Entas_3763
ENR: H650_12050
ENX: NI40_019330
ENF: AKI40_0665(ydeV)
LNI: CWR52_15660
EBG: FAI37_09790(lsrK)
END: A4308_03910
ENZ: G0034_19830(lsrK)
ENS: HWQ15_04810(lsrK)
ENK: LOC22_07585(lsrK)
EHU: D5067_0003170(lsrK)
EMOR: L6Y89_19115(lsrK)
ENB: ELK40_19690
EQU: OM418_19250(lsrK)
EPU: QVH39_20150(lsrK)
EDY: F0320_18680(lsrK)
EAX: AAHF05_19485(lsrK)
KPN: KPN_03509(ydeV)
KPU: KP1_4807(ydeV)
KPM: KPHS_46420
KPP: A79E_0608
KPH: KPNIH24_05685
KPZ: KPNIH27_22165
KPV: KPNIH29_23060
KPW: KPNIH30_23385
KPY: KPNIH31_22570
KPG: KPNIH32_24235
KPC: KPNIH10_23115
KPQ: KPR0928_22635
KPT: VK055_3959(lsrK)
KPO: KPN2242_20680
KPR: KPR_4713(lsrK)
KPJ: N559_0662
KPI: D364_18080
KPA: KPNJ1_00650
KPS: KPNJ2_00692
KPX: PMK1_01027(lsrK)
KPB: FH42_13830
KPNE: KU54_003200
KPNU: LI86_03205
KPNK: BN49_0598(lsrK)
KVA: Kvar_0591
KPE: KPK_0603(lsrK)
KPK: A593_07795
KVD: KR75_05060
KVQ: SP68_11695
KQU: AVR78_01390
KQV: B8P98_03245
KOX: KOX_03320
KOE: A225_5112
KOY: J415_06445
KOM: HR38_01880
KMI: VW41_02420
KOK: KONIH1_25840
KOC: AB185_10485
EAE: EAE_03960
EAR: CCG33200
KLL: BJF97_25495
KLW: DA718_03685
KAR: LGL98_03110(lsrK)
KGR: JJJ10_03310(lsrK)
KPAS: LUW96_03215(lsrK)
KLC: K7H21_03300(lsrK)
KLM: BWI76_24670
REE: electrica_00586(lsrK)
KLP: GUC22_03210(lsrK)
ROR: RORB6_21810
RON: TE10_24545
RPLN: B1209_03080
RAO: DSD31_03250
RTG: NCTC13098_00809(lsrK_1)
CAMA: F384_16515
CAF: AL524_06550
CFAR: CI104_21680
CIR: C2U53_13435
CTEL: GBC03_08085(lsrK)
CIY: HAP28_21700(lsrK)
CNT: JT31_09750
CEM: LH23_08020
CEN: LH86_07885
CLAP: NCTC11466_04017(lsrK_2)
ESC: Entcl_0612
KLE: AO703_18380
KSA: C813_18605
KOR: AWR26_03075(lsrK)
KRD: A3780_21660
KPSE: IP581_20150(lsrK)
KOO: O9K67_03275(lsrK)
KOU: C0557_23050
KCA: AAEY27_03115(lsrK)
LAX: APT61_03105
LEI: C2U54_01625
LEH: C3F35_15035
LEE: DVA44_03100
LER: GNG29_19910(lsrK)
LEA: GNG26_19100(lsrK)
LPNU: KQ929_02545(lsrK)
LEY: DVA43_21120
LAZ: A8A57_18305
LEF: LJPFL01_3640
LEW: DAI21_07760
BUF: D8682_18505
BAGE: BADSM9389_05500
BFT: MNO13_02830(lsrK)
BSEL: RHD99_02780(lsrK)
AHN: NCTC12129_00634(lsrK)
ASUB: NLZ15_02795(lsrK)
YRE: HEC60_14960(lsrK)
SGOE: A8O29_003680(lsrK)
KIN: AB182_28890
PDZ: HHA33_05595(lsrK)
METY: MRY16398_06750(lsrK)
SUPE: P0H77_00625(lsrK)
TOE: QMG90_18685(lsrK)
MPHG: MPHASIOC01_000754(lsrK)
FPUL: ACBV55_19795(lsrK)
EBC: C2U52_11780
EBU: CUC76_18715
YPE: YPO0415
YPK: y3764
YPH: YPC_4186
YPA: YPA_3869
YPN: YPN_0286
YPM: YP_3766(xylB3)
YPP: YPDSF_3216
YPG: YpAngola_A0855
YPZ: YPZ3_0407
YPT: A1122_03025
YPD: YPD4_0359
YPX: YPD8_0361
YPW: CH59_1446(lsrK)
YPJ: CH55_2394(lsrK)
YPV: BZ15_3156(lsrK)
YPL: CH46_499(lsrK)
YPS: YPTB0554(ydeV)
YPO: BZ17_2005(lsrK)
YPI: YpsIP31758_3518
YPY: YPK_3648
YPB: YPTS_0578
YPQ: DJ40_1813(lsrK)
YPU: BZ21_3934(lsrK)
YPR: BZ20_1539(lsrK)
YPC: BZ23_34(lsrK)
YPF: BZ19_4061(lsrK)
YEN: YE0530
YEP: YE105_C0543
YEY: Y11_37641
YEW: CH47_2946(lsrK)
YET: CH48_1068(lsrK)
YEF: FORC2_3559
YEE: YE5303_27971
YSI: BF17_11045
YAL: AT01_3048(lsrK)
YFR: AW19_3889(lsrK)
YIN: CH53_1158(lsrK)
YKR: CH54_1901
YRO: CH64_3163(lsrK)
YAK: ACZ76_11850
YMA: DA391_19395
YHI: D5F51_03000
YEL: LC20_08735
YCA: F0T03_03270(lsrK)
YMO: HRD69_08400(lsrK)
YAS: N0H69_02890(lsrK)
YKI: HRD70_07610(lsrK)
SMAR: SM39_0819(lsrK)
SMAC: SMDB11_0647(lsrK)
SMW: SMWW4_v1c13610(lsrK)
SPE: Spro_1382
SRR: SerAS9_1357
SRL: SOD_c12740(lsrK)
SRY: M621_07075
SPLY: Q5A_006945(lsrK)
SRS: SerAS12_1357
SRA: SerAS13_1358
SMAF: D781_1308
SLQ: M495_06365
SERF: L085_21655
SERS: SERRSCBI_06430
SFW: WN53_22830
SFG: AV650_18660
SRZ: AXX16_3787
SERM: CLM71_06390
SQU: E4343_09245(lsrK)
SFJ: SAMEA4384070_1443(lsrK)
SOF: NCTC11214_05537(lsrK)
SSUR: ATE40_003610
SURI: J0X03_16955(lsrK)
SENP: KHA73_07160(lsrK)
SNEM: NLX84_06830(lsrK)
SNEV: OI978_26930(lsrK)
SGRI: SGBXF1_01331(lsrK)
SSAR: SSARUM_001313(lsrK)
SERB: QEP77_15685(lsrK)
RAH: Rahaq_2588
RACE: JHW33_04245(lsrK)
RAQ: Rahaq2_2601
RAA: Q7S_12885
ROX: BV494_07330
RVC: J9880_17045(lsrK)
RIU: I2123_14440(lsrK)
EAME: GXP68_13195(lsrK)
RBAD: H2866_22225(lsrK)
SERA: Ser39006_021920
SERQ: CWC46_21930
PROD: PCO85_03530(lsrK)
SOD: Sant_3797(lsrK)
SLIG: GTU79_26090(lsrK)
PAO: Pat9b_2709
KLN: LH22_09040
KPIE: N5580_06470(lsrK)
PPHO: CTZ24_15050
PMAK: PMPD1_2972
PLU: plu3141
PLUM: A4R40_15690
PAY: PAU_01471
PTT: VY86_00280
PAKH: B0X70_16185
PLUI: CE143_16175
XBO: XBJ1_4109(ydeV)
XBV: XBW1_0353(lsrK)
XNE: XNC1_4323(ydeV)
XNM: XNC2_4172(ydeV)
XDO: XDD1_3684(lsrK)
XHO: A9255_16410
XBU: HGO23_01285(lsrK)
XGR: QL128_01470(lsrK)
MMK: MU9_2083
EHO: A9798_12225
HIP: CGSHiEE_08190
HIA: H733_1673(lsrK)
HIC: NTHIC486_00200(lsrK)
HSO: HS_0049
HSM: HSM_1942
PMU: PM1272
PMV: PMCN06_1937(lsrK)
PUL: NT08PM_2193
PMP: Pmu_19330(lsrK)
PMUL: DR93_516(lsrK)
PATL: KGI96_03300(lsrK)
PCAI: K7G93_001861(lsrK)
PSKY: A6B44_08080
AAT: D11S_1398
AAO: ANH9381_1746
AAN: D7S_00013
AAH: CF65_02230
AACN: AANUM_1694(lsrK)
AACT: ACT75_11325
AVT: NCTC3438_00380(lsrK)
SWD: Swoo_3745
SVO: SVI_3479
SPSW: Sps_04498
SBK: SHEWBE_4117(lsrK)
SPSH: FM037_22275(lsrK)
SEUR: FM038_25915(lsrK)
SHEM: HWQ47_05735(lsrK)
HMAR: HVMH_2034(lsrK)
TZO: THMIRHAT_03020(lsrK)
CDIZ: CEDIAZO_00808(lsrK)
SME: SM_b21022
SMK: Sinme_5078
SMQ: SinmeB_4065
SMX: SM11_pD0954
SMI: BN406_06009(lsrK)
SMEG: C770_GR4pD0990
SMEL: SM2011_b21022
SMER: DU99_30215
ECAA: J3R84_32490(lsrK)
SZO: K8M09_14840(lsrK)
SOJ: K6301_14505(lsrK)
SSUM: Q9314_11270(lsrK)
KAI: K32_08850
DEA: FPZ08_01350
SIW: GH266_09415(lsrK)
CID: P73_1373
CEH: CEW89_15560
CBAK: DA792_09715
YPAC: CEW88_20215
RSP: RSP_3506
RSH: Rsph17029_3151
RSK: RSKD131_3672
PAMI: JCM7686_pAMI4p038
RMB: K529_019155
THW: BMG03_15435
GCE: KYE46_14165(lsrK)
RCP: RCAP_rcc02884
PMAS: NCF86_15900(lsrK)
THAC: CSC3H3_20685
TTB: MACH01_07240
THGO: M9H61_09325(lsrK)
TDN: Suden_1477
SUA: Saut_1517
SULG: FJR48_03670(lsrK)
SPAL: FM071_07130(lsrK)
SSEI: FJR45_04305(lsrK)
SBAL: HUE88_02930(lsrK)
SMAS: HUE87_09425(lsrK)
SMAX: FJR03_03600(lsrK)
SAQT: GJV85_04675(lsrK)
SKU: Sulku_2327
SULR: B649_11025
ANT: Arnit_1320
HEBR: AEBR_0249
HTM: RZR91_09550(lsrK)
SUN: SUN_0119
SLH: YH65_01130
TPI: TREPR_3784
TRM: JO41_06345
TMED: DWB79_02640
TSK: HRI97_08155(lsrK)
SSM: Spirs_3576
BAT: BAS2768
BAH: BAMEG_1624
BAX: H9401_2842
BANS: BAPAT_2858
BANH: HYU01_14740
BANV: DJ46_1742
BAL: BACI_c29350(ydeV)
BCE: BC2965
BCA: BCE_3017
BCZ: BCE33L2698
BCR: BCAH187_A3019
BCB: BCB4264_A2981
BCU: BCAH820_2977
BCG: BCG9842_B2261
BCQ: BCQ_2801(ydeV)
BCX: BCA_3051
BNC: BCN_2825
BCF: bcf_14535
BCER: BCK_20020
BCEF: BcrFT9_02335
BTK: BT9727_2718(ydeV)
BTL: BALH_2666
BTB: BMB171_C2668
BTT: HD73_3008
BTHR: YBT1520_14795
BTHI: BTK_14895
BTC: CT43_CH2966
BTF: YBT020_14835
BTM: MC28_2165
BTG: BTB_c30940(lsrK)
BTI: BTG_04510
BTN: BTF1_12355
BTHT: H175_ch3017
BTHU: YBT1518_16390
BTW: BF38_4133(lsrK)
BTHY: AQ980_16100
BWE: BcerKBAB4_2774
BWW: bwei_2047(lsrK)
BMYO: BG05_3047
BTY: Btoyo_0261
BMYC: DJ92_62(lsrK)
BBY: CY96_13670
BWD: CT694_15910
BTRO: FJR70_04285(lsrK)
BMOB: MLA2C4_15680
BNT: GSN03_14360(lsrK)
BPAC: LMD38_12215(lsrK)
BPAN: NLJ82_13985(lsrK)
BALU: QRY64_16955(lsrK)
BARD: QRY57_14970(lsrK)
BASD: LCG60_08015(lsrK)
CSOA: LIS82_25980(lsrK)
OCN: CUC15_15715
VIM: GWK91_10945(lsrK)
PPSR: I6J18_09100(lsrK)
NMK: CHR53_25605
NDT: L1999_27395(lsrK)
NCM: QNK12_16635(lsrK)
NNV: QNH39_14485(lsrK)
MDG: K8L98_05150(lsrK)
VAO: FA707_08160(lsrK)
FCT: NRE15_11630(lsrK)
GAD: K8O88_08710(lsrK)
CSB: CLSA_c21380(lsrK)
CAH: CAETHG_3998(lsrK)
ACOL: K5I23_11485(lsrK)
AIM: PYS61_00890(lsrK)
ANQ: PYS63_01830(lsrK)
CFEM: HCR03_10800(lsrK)
CBAF: JS518_10795(lsrK)
LACY: A4V08_30740
CHYL: CE91St63_19830
ECLF: QMP25_16125(lsrK)
LBP: V1224_14370(lsrK)
AHAD: FRZ06_01605(lsrK)
GFE: Gferi_19735
PCAT: Pcatena_00660(glpK_1)
MIP: AXH82_08925
MLV: CVS47_03274(lsrK)
MLZ: F6J85_02865
MRN: K8F61_15475
MSUF: KV394_07570
ASOI: MTP13_04780
GRY: D7I44_11695
LEU: Leucomu_13335
AGG: C1N71_13045
ACIT: HPK19_06240(lsrK)
OFA: NF556_16290(lsrK)
TPY: CQ11_07240
TPYO: X956_00445
ACTT: DDD63_02055
RMAR: GBA65_18055
PSUB: Pelsub_P2245
DPH: EHF33_19240
DMB: E5F05_01055(lsrK)
OPR: Ocepr_1035
 » show all
Reference
1  [PMID:17274596]
  Authors
Xavier KB, Miller ST, Lu W, Kim JH, Rabinowitz J, Pelczer I, Semmelhack MF, Bassler BL
  Title
Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.
  Journal
ACS Chem Biol 2:128-36 (2007)
DOI:10.1021/cb600444h
  Sequence
[stm:STM4072]
Reference
2  [PMID:20025244]
  Authors
Roy V, Fernandes R, Tsao CY, Bentley WE
  Title
Cross species quorum quenching using a native AI-2 processing enzyme.
  Journal
ACS Chem Biol 5:223-32 (2010)
DOI:10.1021/cb9002738
  Sequence
[eco:b1511]
Reference
3  [PMID:23672516]
  Authors
Zhu J, Hixon MS, Globisch D, Kaufmann GF, Janda KD
  Title
Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation.
  Journal
J Am Chem Soc 135:7827-30 (2013)
DOI:10.1021/ja4024989
  Sequence
[stm:STM4072]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.189
IUBMB Enzyme Nomenclature: 2.7.1.189
ExPASy - ENZYME nomenclature database: 2.7.1.189
BRENDA, the Enzyme Database: 2.7.1.189
LinkDB

DBGET integrated database retrieval system