KEGG ENZYME: 2.7.1.204

ENZYME: 2.7.1.204

Entry

EC 2.7.1.204                Enzyme

Name

protein-Npi-phosphohistidine---D-galactose phosphotransferase;
D-galactose PTS permease;
EIIGal;
Enzyme IIGal

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

protein-Npi-phospho-L-histidine:D-galactose Npi-phosphotransferase

Reaction(IUBMB)

[protein]-Npi-phospho-L-histidine + D-galactose[side 1] = [protein]-L-histidine + D-galactose 6-phosphate[side 2] [RN:R11171]

Reaction(KEGG)

R11171

Substrate

[protein]-Npi-phospho-L-histidine [CPD:C04261];
D-galactose[side 1] [CPD:C00124]

Product

[protein]-L-histidine [CPD:C00615];
D-galactose 6-phosphate[side 2] [CPD:C01113]

Comment

This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.

History

EC 2.7.1.204 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.204

Orthology

K20112

galactose PTS system EIIA component

K20113

galactose PTS system EIIB component

Genes

CTEL:

GBC03_22350

DMS:	E8L03_12365

BSON:

S101395_04912 S101395_04913

OJD:	NP439_07320 NP439_07325

VIG:	BKP57_12195 BKP57_12200

VPN:	A21D_01074 A21D_01075

VPT:	KBP50_01775 KBP50_01780

LEX:	Len3610_12830 Len3610_12835

SFOR:

QNH23_14005

SCA:

SCA_1696

SSIF:

AL483_01340

SCV:	A4G25_11645

SCHR:

DWB92_02185 DWB92_02190

SPIC:

SAMEA4384060_0832 SAMEA4384060_0834 SAMEA4384060_0835

SDB:	CNQ82_10445

LWI:	UE46_12420

SPY:	SPy_1710 SPy_1711

SPZ:	M5005_Spy1400 M5005_Spy1401

SPYM:

M1GAS476_1479 M1GAS476_1480

SPYA:

A20_1449c A20_1450c

SPM:	spyM18_1720 spyM18_1721

SPG:	SpyM3_1487 SpyM3_1488

SPS:	SPs0379 SPs0380

SPH:	MGAS10270_Spy1521 MGAS10270_Spy1522

SPI:	MGAS10750_Spy1513 MGAS10750_Spy1514

SPJ:	MGAS2096_Spy1427 MGAS2096_Spy1428

SPK:	MGAS9429_Spy1403 MGAS9429_Spy1404

SPF:	SpyM50389 SpyM50390

SPA:	M6_Spy1449 M6_Spy1450

SPB:	M28_Spy1443 M28_Spy1444

STG:	MGAS15252_1298 MGAS15252_1299

STX:	MGAS1882_1359 MGAS1882_1360

SOZ:	Spy49_1328c Spy49_1329c

STZ:	SPYALAB49_001445 SPYALAB49_001446

SPYH:

L897_07010 L897_07015

SPYO:

STAB901_07045 STAB901_07050

SPN:	SP_0645 SP_0646 SP_1197 SP_1198

SPD:	SPD_0559 SPD_0560 SPD_1057

SPR:	spr0562(PTS-EII) spr0563 spr1080 spr1081

SPW:	SPCG_0600 SPCG_0601 SPCG_1101 SPCG_1102

SJJ:	SPJ_0593 SPJ_0594 SPJ_1114 SPJ_1115

SNV:	SPNINV200_05670 SPNINV200_05680 SPNINV200_10320

SPX:	SPG_0585 SPG_0586 SPG_1092 SPG_1093

SNT:	SPT_0667 SPT_0668 SPT_1028 SPT_1029

SND:	MYY_0689 MYY_0690 MYY_1037 MYY_1038

SPNN:

T308_03030 T308_03035 T308_04775 T308_04780

SNE:	SPN23F05800 SPN23F05810 SPN23F10980

SPV:	SPH_0738 SPH_0739 SPH_1315

SNC:	HMPREF0837_10934 HMPREF0837_10935 HMPREF0837_11301 HMPREF0837_11302

SNM:	SP70585_0703 SP70585_0704 SP70585_1247 SP70585_1248

SPP:	SPP_0661 SPP_0662 SPP_1238 SPP_1239

SNI:	INV104_05370 INV104_05380

SPNG:

HMPREF1038_00669 HMPREF1038_00670 HMPREF1038_01204 HMPREF1038_01205

SNB:	SP670_0700 SP670_0701 SP670_1078 SP670_1079

SNP:	SPAP_0631 SPAP_0632 SPAP_1224

SNX:	SPNOXC05900 SPNOXC05910 SPNOXC10740

SNU:	SPNA45_00986 SPNA45_00987 SPNA45_01458 SPNA45_01459

SPNE:

SPN034156_01620 SPN034156_16390 SPN034156_16400

SPNU:

SPN034183_05910 SPN034183_05920 SPN034183_10740

SPNM:

SPN994038_05800 SPN994038_05810 SPN994038_10630

SPNO:

SPN994039_05810 SPN994039_05820 SPN994039_10640

SAG:	SAG1934 SAG1935

SAN:	gbs1921 gbs1922

SAK:	SAK_1894 SAK_1895

SGC:	A964_1793(gatB) A964_1794(gatA)

SAGS:

SaSA20_1590 SaSA20_1591

SAGL:

GBS222_1595

SAGM:

BSA_19510 BSA_19520

SAGI:

MSA_20200 MSA_20210

SAGR:

SAIL_19540 SAIL_19550

SAGP:

V193_08465 V193_08470

SAGC:

DN94_08465 DN94_08470

SAGT:

GBSCOH1_1729 GBSCOH1_1730

SAGE:

EN72_10145 EN72_10150

SAGG:

EN73_09235 EN73_09240

SAGN:

W903_1870 W903_1871

SAGJ:

ID870_00265 ID870_00270

SMJ:	SMULJ23_0624 SMULJ23_0625

SGO:	SGO_1521 SGO_1522

SUB:	SUB1459 SUB1460

SDS:	SDEG_1765 SDEG_1766

SDG:	SDE12394_08800 SDE12394_08805

SDA:	GGS_1588 GGS_1589

SDC:	SDSE_1860 SDSE_1861

SDQ:	SDSE167_1823 SDSE167_1824

SGA:	GALLO_0181 GALLO_0182

SGG:	SGGBAA2069_c01990 SGGBAA2069_c02000

SGT:	SGGB_0225 SGGB_0226

SMB:	smi_1022 smi_1023

SGW:	D7D53_04710 D7D53_04715

STOY:

STYK_09290 STYK_09300

SOR:	SOR_1093(sgaB) SOR_1094

STK:	STP_0242 STP_0243

STB:	SGPB_0168 SGPB_0169

SCP:	HMPREF0833_10696 HMPREF0833_10697

SCF:	Spaf_1260(gatB) Spaf_1261(gatA)

STD:	SPPN_03375 SPPN_03380

SMN:	SMA_0202 SMA_0203

SIE:	SCIM_1147 SCIM_1148

SIB:	SIR_0444 SIR_0445

SIU:	SII_0428 SII_0429

SANG:

SAIN_1272

SANC:

SANR_1496

SANS:

DK43_03195 DK43_03200

SCG:	SCI_1412 SCI_1413

SCON:

SCRE_1369 SCRE_1370

SCOS:

SCR2_1369 SCR2_1370

SOI:	I872_06865 I872_06870

SLU:	KE3_0131 KE3_0132

SIG:	N596_00795 N596_00800

SIP:	N597_02500 N597_02505

STV:	V470_05090 V470_05095

STRA:

ATM98_00880 ATM98_00885

STRN:

SNAG_1091 SNAG_1092

SKI:	D7D50_09700 D7D50_09705

SPEI:

EHW89_06420 EHW89_06425

SRAT:

FY406_10225 FY406_10230

SCAI:

NCTC12191_01055 NCTC12191_01056

SPSU:

NCTC13786_01581 NCTC13786_01582

SPOC:

NCTC10925_01575 NCTC10925_01576

SLAT:

J4854_06625 J4854_06630

SAUP:

NCTC3168_00084 NCTC3168_00085(gatA_1)

SACO:

SAME_02069 SAME_02070

SVF:	NCTC3166_00688(gatA_1) NCTC3166_00689

SMIE:

NCTC11169_01286 NCTC11169_01287

SRUN:

LPB404_03990 LPB404_03995

SPAM:

SP4011_09920(PTS-EII_2) SP4011_09930

SDID:

N1495_08205 N1495_08210

SDEN:

SM121_05995 SM121_06000

SLIN:

SM123_04835 SM123_04840

SNID:

AAFQ93_07170 AAFQ93_07175

LJO:

LJ_0125

LJF:	FI9785_193 FI9785_566 FI9785_567

LJH:

LJP_0131

LJN:	T285_00695

LAC:

LBA0146

LAD:

LA14_0147

LAF:

SD55_0144

LDB:

Ldb0199

LBU:

LBUL_0173

LDE:	LDBND_0179 LDBND_1641 LDBND_1642

LDL:

LBU_0153

LGA:	LGAS_0125 LGAS_0495 LGAS_0496

LHE:

lhv_0154

LHL:

LBHH_0154

LHR:	R0052_00835

LHV:

lhe_0161

LHH:

LBH_0126

LHD:

HUO_01745

LCR:	LCRIS_00142

LAM:

LA2_00810

LAI:	LAC30SC_00675

LAY:	LAB52_00755

LKE:

WANG_1702

LAE:

LBAT_0166

LGL:	AO203_02210

LAMY:

B1745_00735

LPW:	LpgJCM5343_01250 LpgJCM5343_04870 LpgJCM5343_04880

LKL:	DKL58_01965 DKL58_01970

LTA:	H1A07_00690

LUU:	H4B44_00840

LPAI:

GYM71_02170

LIQ:	KBW87_00675

LACH:

LDX54_09420 LDX54_09425

LCA:	LSEI_0671 LSEI_0672

LCZ:	LCAZH_0603 LCAZH_0604 LCAZH_2648

LCS:	LCBD_0742 LCBD_0743 LCBD_2865

LCE:	LC2W_0742 LC2W_0743 LC2W_2838

LCW:	BN194_07420 BN194_07430 BN194_27910

LCL:	LOCK919_0414 LOCK919_0772 LOCK919_0773 LOCK919_2901

LPQ:	AF91_02390 AF91_02395

LPI:	LBPG_01243 LBPG_02737 LBPG_02738

LPAP:

LBPC_0592 LBPC_0593

LCB:	LCABL_07380(PTS-EII) LCABL_07390 LCABL_28420(pts36B)

LCX:	LCA12A_0343 LCA12A_1703 LCA12A_1704

LRL:	LC705_00631(pts) LC705_00632(pts) LC705_02666(gatB)

LRA:	LRHK_2774 LRHK_650 LRHK_651

LRO:	LOCK900_2665

LRC:	LOCK908_0642 LOCK908_0643 LOCK908_2745

LCHI:

KG086_12185

LZE:	KG087_03095 KG087_13445

LHN:	LHUE1_000795

LPAB:

PQ472_00270 PQ472_00275

LPAH:

LACPH_000603 LACPH_000604 LACPH_002546

LSB:	LACSTY_002627

LNG:	BSQ50_09225 BSQ50_09230

LACA:

LAC1533_0038 LAC1533_0039

LBT:	AYR52_00505

PACI:

A4V11_07380 A4V11_07385

PIO:	PI20285_01630 PI20285_01635

LHI:	JP39_11240 JP39_11245

LCT:	BI355_2105 BI355_2106

LALW:

BTM29_03610 BTM29_03615

LFM:	LF20184_00970 LF20184_00975

LZH:	D1B17_12105 D1B17_12110

LFT:	FG051_00595 FG051_00600

CPAB:

G6534_11255 G6534_11260

LAH:	LA20533_03270 LA20533_03385 LA20533_03390

EFA:	EF1836 EF1837

EFI:	OG1RF_11557 OG1RF_11558

ETH:	CK496_07790 CK496_07795

EGV:	EGCR1_15210 EGCR1_15215

EAV:	EH197_02520 EH197_02525

EMS:	P3T75_02095 P3T75_02105

THL:	TEH_04450 TEH_04460 TEH_24190 TEH_24200 TEH_24980 TEH_24990

TEY:	GLW17_07135 GLW17_07140

TOO:	C7K38_04710 C7K38_04715

TKR:	C7K43_09015 C7K43_09020

AUI:	APT62_01835 APT62_01840

IRU:	M0R79_02835 M0R79_02840

CVD:	LHA31_08635 LHA31_08640

DPM:	FNV33_06570 FNV33_06575

DST:	VUQ06_07075 VUQ06_07080

CAC:	CA_C2957 CA_C2958

CAE:	SMB_G2993 SMB_G2994

CAY:	CEA_G2964 CEA_G2965

CBUT:

ATN24_02870 ATN24_02875

CLOL:

ONV75_01465 ONV75_01470

SCLA:

SCLARK_001174

DVA:	DAD186_12990

STR:	Sterm_1732 Sterm_3753

HALN:

B4589_004345

» show all

Reference

1 [PMID:22660715]

Authors

Zeng L, Martino NC, Burne RA

Title

Two gene clusters coordinate galactose and lactose metabolism in Streptococcus gordonii.

Journal

Appl Environ Microbiol 78:5597-605 (2012)
DOI:10.1128/AEM.01393-12

Sequence

[sgo:SGO_1521 SGO_1522]

Reference

2 [PMID:23421335]

Authors

Zeng L, Xue P, Stanhope MJ, Burne RA

Title

A galactose-specific sugar: phosphotransferase permease is prevalent in the non-core genome of Streptococcus mutans.

Journal

Mol Oral Microbiol 28:292-301 (2013)
DOI:10.1111/omi.12025

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.204

IUBMB Enzyme Nomenclature:

2.7.1.204

ExPASy - ENZYME nomenclature database:

2.7.1.204

BRENDA, the Enzyme Database:

2.7.1.204

LinkDB

DBGET integrated database retrieval system