KEGG   ENZYME: 2.7.1.218
Entry
EC 2.7.1.218                Enzyme                                 
Name
fructoselysine 6-kinase;
frlD (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:D-fructosyl-L-lysine 6-phosphotransferase
Reaction(IUBMB)
ATP + N6-(D-fructosyl)-L-lysine = ADP + N6-(6-phospho-D-fructosyl)-L-lysine [RN:R08124]
Reaction(KEGG)
R08124
Substrate
ATP [CPD:C00002];
N6-(D-fructosyl)-L-lysine [CPD:C16488]
Product
ADP [CPD:C00008];
N6-(6-phospho-D-fructosyl)-L-lysine
Comment
The enzyme, characterized from the bacterium Escherichia coli, has very little activity with fructose.
History
EC 2.7.1.218 created 2017
Orthology
K10710  fructoselysine 6-kinase
Genes
ECOb3374(frlD)
ECJJW3337(frlD)
ECDECDH10B_3549(frlD)
EBWBWG_3065(frlD)
ECOKECMDS42_2820(frlD)
ECEZ4734 Z4735
ELXCDCO157_3965
EOIECO111_4183(frlD)
EOJECO26_4462(frlD)
EOHECO103_4092(frlD)
ESLO3K_02200
ESOO3O_23450
ESMO3M_02245
ECKEC55989_3779(frlD)
ELHETEC_3624
ECWEcE24377A_3843
EUNUMNK88_4139
ECOAAPECO78_20660
ECXEcHS_A3569
ECYECSE_3635
ECRECIAI1_3512(frlD)
EBRECB_03224(yhfQ)
EBLECD_03224(frlD)
EBEB21_03176(frlD)
EBDECBD_0375
ELOEC042_3635(frlD)
ECLEcolC_0339
EKOEKO11_0371
EKFKO11_05930(frlD)
EDHEcDH1_0339
EDJECDH1ME8569_3253(frlD)
ELWECW_m3629(frlD)
ELLWFL_17725(frlD)
ELPP12B_c3472(yhfQ)
ECOLLY180_17300
STMSTM3600
SEOSTM14_4330
SEVSTMMW_35891
SEYSL1344_3565
SEJSTMUK_3585
SEBSTM474_3768
SEFUMN798_3905
SETUSTU288_18185
SETCCFSAN001921_22450
SENRSTMDT2_34851
SENDDT104_35831
SENICY43_18685
SEENSE451236_02915
SPQSPAB_04469
SEISPC_3674
SECSCH_3534(yurL)
SEHSeHA_C3914
SHBSU5_04074
SENHCFSAN002069_14055
SEEHSEEH1578_04070
SEESNSL254_A3872
SENNSN31241_2880
SEWSeSA_A3794
SEASeAg_B3806
SENSQ786_17580
SEDSeD_A3975
SEGSG3837
SELSPUL_3973
SEGASPUCDC_3959
SETSEN3423
SENAAU38_17465
SENOAU37_17655
SENVAU39_17660
SENQAU40_19660
SENLIY59_18095
SENJCFSAN001992_15640
SEECCFSAN002050_24955
SEEBSEEB0189_001880
SEEPI137_19040
SENBBN855_36780
SENEIA1_17465
SENCSEET0819_01720
SESSARI_04036
SBGSBG_3195(frlD)
SBZA464_3678
SBVN643_15885
SALZEOS98_01305
SFLSF3392(yhfQ)
SFXS4370(yhfQ)
SFVSFV_3379(yhfQ)
SFESFxv_3703(frlD)
SFNSFy_4820
SFSSFyv_4895
SFTNCTC1_03673(frlD)
SSNSSON_3505(yhfQ)
SBOSBO_3361(yhfQ)
SBCSbBS512_E3751
SHQA0259_20615
ESAESA_04362
CSKES15_0289(frlD)
CSZCSSP291_20090
CSJCSK29544_01247
CCONAFK62_18485
CDMAFK67_19050
CSIP262_00432
CMJAFK66_001490
CUIAFK65_18220
CMWAFK63_00180
CTUCTU_38900(frlD)
KPMKPHS_05080
KPHKPNIH24_02610
KPVKPNIH29_27125
KPWKPNIH30_02745
KPGKPNIH32_02755
KPCKPNIH10_02595
KPQKPR0928_02600
KPTVK055_2804
KPOKPN2242_01360
KPJN559_4635
KPID364_23700
KPAKPNJ1_04959
KPSKPNJ2_04908
KPBFH42_19675
KPNEKU54_023990
KPNULI86_23830
KQUAVR78_26505
KQVB8P98_28500
CFDCFNIH1_05180
CFARCI104_00385 CI104_01830
CIEAN232_05650
KORAWR26_23150
KRDA3780_00625
SYMK6K13_17755
METYMRY16398_04130(frlD) MRY16398_49900
AHNNCTC12129_00401(frlD_1) NCTC12129_00624(frlD_2)
KINAB182_27495
PDZHHA33_04270(frlD) HHA33_25110
IZHFEM41_17955
EBCC2U52_04405 C2U52_10300
SFWWN53_23555
RAHRahaq_1897
RAQRahaq2_1680
RAAQ7S_09315
GQUAWC35_07295 AWC35_23960
PARII2D83_01700
BGJAWC36_18630
BRBEH207_07775
BNGEH206_12000
BIZHC231_23640
LBQCKQ53_05705
LPOPI6N93_00345
PANTPSNIH1_p00420
PAGCBEE12_20910
PVDCFBP1590__2976
PLULFOB45_03630
PVKEPZ47_17040
PBZGN234_29555
PALVKSS97_17475
LGTE4T54_11445
WOCBA177_05455
BUMAXG89_20480
MAMMesau_02913
AAKAA2016_1157
SMESMc03138
SMKSinme_3010
SMQSinmeB_2784
SMXSM11_chr3126
SMIBN406_02811 BN406_03672
SMEGC770_GR4Chr3084
SMELSM2011_c03138
SMERDU99_16275
SMDSmed_2845 Smed_5455
RHINGR_b21930
SFDUSDA257_c23170(frlD)
SIXBSY16_5367
SAMESAMCFNEI73_pC0439(frlD)
SINOSS05631_b62630
EADOV14_b0619
EAHFA04_29325
ESJSJ05684_b42990
EAKEKH55_4762
ATFAch5_51770
AVIAvi_9147
AGTEYD00_23585
ALFCFBP5473_24035
RPUSCFBP5875_23630 CFBP5875_23705
ROYG3A56_16560
RBANJ2J98_24605
NGLRG1141_PA11750
NGGRG540_PA11150
SOJK6301_18200
OINIAR37_21955
OPSA8A54_22965
OCRHGK82_23085
BVVBHK69_06580
BOFFQV39_06035
NOHG5V57_10130
SULDB5M07_17975
SINLDSM14862_03568(frlD)
RSPRSP_3945
RSQRsph17025_3647
RSKRSKD131_4343
CAZTLV780_17510
RCPRCAP_rcp00007(frlD)
PARSDRW48_05625
PARREOJ32_19800
DAAAKL17_2269
THASC6Y53_19120 C6Y53_19130
HTQFRZ44_02800(frlD)
HADHFRZ61_03170(frlD)
BSUBSU32570(frlD)
BSRI33_3361
BSLA7A1_2473
BSHBSU6051_32570(frlD)
BSYI653_15710
BSUTBSUB_03476(frlD)
BSULBSUA_03476(frlD)
BSUSQ433_17825
BSOBSNT_09743(yurL)
BSNBSn5_07185
BSQB657_32570(frlD)
BSXC663_3116(frlD)
BSPU712_16250
BSSBSUW23_15905(frlD)
BSTGYO_3557
BAYRBAM_029630
BAQBACAU_2990(yurL)
BYABANAU_3149(yurL)
BAMPB938_15170
BQYMUS_3551(yhfQ1)
BAMLBAM5036_2876(frlD)
BAMARBAU_3092(frlD)
BAMNBASU_2880(frlD)
BAMBBAPNAU_3140(frlD)
BAMTAJ82_16770
BAMYV529_32240(yurL)
BMPNG74_03111(frlD)
BAOBAMF_3052(frlD)
BAZBAMTA208_16450(frlD)
BQLLL3_03329(frlD)
BXHBAXH7_03356(yurL)
BAMIKSO_004340
BAMCU471_30700
BAMFU722_15945
BSIACWD84_04375
BAEBATR1942_14215
BVMB9C48_15130
BSONS101395_04163(frlD)
BHTDIC78_14910
BMOJHC660_31390(frlD)
BTEQG4P54_16645
BIQAN935_16355
BJSMY9_3292
BIFN288_10525 N288_22675
BACPSB24_13925
BACBOY17_18135
BACYQF06_14605
BACLBS34A_35540(frlD)
BALMBsLM_3254
BGYBGLY_3826
BACSAUL54_14855
BITBIS30_05865
BACQDOE78_04980 DOE78_09260 DOE78_10715 DOE78_24360
BCOHBC6307_07045 BC6307_07415
BCIRC2I06_15325 C2I06_21500 C2I06_21525
BMQBMQ_2407(yurL)
BMDBMD_2372(yurL)
BMEGBG04_4781(frlD) BG04_614(frlD)
BEOBEH_13920 BEH_25895
BGIBGM20_10395
CGOTJ1899_20170
APAKAP3564_15310
BSJUP17_08925
POFGS400_06225
MEKUHUW50_22125 HUW50_22160(frlD) HUW50_22225
BOUI5818_04375
GAJMY490_01360(frlD)
STEAC0679_02850
BCHSJNE38_06905 JNE38_13550
PPMPPSC2_02775(yhfQ) PPSC2_03815(frlD1) PPSC2_08135(frlD3)
PPOPPM_0496(yhfQ) PPM_0707(frlD1) PPM_1541(frlD3)
PPOLX809_03340
PPQPPSQR21_005290(rbsK) PPSQR21_007400
PPOYRE92_04045 RE92_08170 RE92_09170
PMSKNP414_05710 KNP414_07065
PMQPM3016_5052 PM3016_6656
PMWB2K_26185 B2K_33630
PGMPGRAT_06025 PGRAT_06570 PGRAT_22600 PGRAT_32010
PODPODO_22805
PRIPRIO_1384(frlD) PRIO_4583 PRIO_4875 PRIO_4891 PRIO_6652
PSONJI735_07935 JI735_07940 JI735_08235(frlD) JI735_15030 JI735_30680 JI735_32030 JI735_32105
PPEOABE82_03575
PDHB9T62_22420
PIBBBD41_28615
PCHIPC41400_26465
PTRIKDC22_26585(frlD) KDC22_26610
EFFskT53_15460
PGQFK545_05430
LKLDKL58_02655
LAPIDKL56_02075
LPAIGYM71_03010
LCALSEI_2086
LCZLCAZH_2049
LCSLCBD_2246
LCELC2W_2227
LCWBN194_22240(frlD)
LCLLOCK919_2265
LPQAF91_03305
LPILBPG_02008
LPAPLBPC_2027
LCBLCABL_22650(mocE)
LCXLCA12A_0197
LRHLGG_02086
LRGLRHM_2005
LRLLC705_02081
LRALRHK_2086
LROLOCK900_2035
LRCLOCK908_2147
LCHIKG086_09145
LZEKG087_09730
LVALV515_01340
LNGBSQ50_11615
LHWBSQ49_12120 BSQ49_12375
LFMLF20184_06305
CPABG6534_05555
EFUHMPREF0351_12786 HMPREF0351_12897
EAVEH197_08835
ESGEsVE80_03190
ERAFJ9537_17635
CACCA_C3498
CAESMB_G3536(frlD)
CAYCEA_G3502
CBECbei_0960 Cbei_4798
CBZCbs_0960 Cbs_4798
CBEILF65_05347
CDYF3K33_05065 F3K33_24485
CMAHC1I91_18280 C1I91_18315
AMTAmet_1349
GFEGferi_09760
ESRES1_09720
ESUEUS_03950
RALRumal_2339
RCHRUM_11890
RUMCK1_13150
CAPREQM14_03780
OBJEIO64_04090
CFEMHCR03_02570 HCR03_02575(frlD) HCR03_07435(frlD) HCR03_07465(frlD)
CCTCC1_07220
CCOMI6K69_13935
CEVLK421_04375
BYLA4V09_17710
BPROPMF13cell1_00269(frlD)
BLABEYS05_04870
BLIQINP51_14435
LACYA4V08_03760 A4V08_11195 A4V08_11255 A4V08_13840
CSHClosa_1463 Closa_1470 Closa_3643 Closa_4036
CSOCLS_33460 CLS_33560
ACHTbsdcttw_02030(frlD_1) bsdcttw_02040 bsdcttw_19450(frlD_2) bsdcttw_19510 bsdcttw_19710
RGNRGna_06845
CBOLCGC65_02995 CGC65_24950 CGC65_24955
DLOK5I24_08000
LBWC3V36_02990 C3V36_08220
CSTCLOST_1206(frlD)
IBUIB211_00949c
VPYHZI73_11500
LASAL9O85_11450
BPRSCK3_35120
HASHalsa_0744
HALSD7D81_02955 D7D81_15635
IFNGM661_00255 GM661_12770
SHYSHJG_1054 SHJG_1747
SHOSHJGH_0887 SHJGH_1512
SCTSCAT_p1059
SCYSCATT_p06770
SCIB446_03110
SRIMCP984_37660
SDDD9753_34795
MIPAXH82_02795
MCWA8L33_05035
MAURBOH66_14855
MLVCVS47_02163(frlD)
MCHNHCR76_13515 HCR76_15755 HCR76_15785
MRNK8F61_14385
CPHYB5808_17065
HUMDVJ78_03895
LEULeucomu_00575 Leucomu_00595
HEAHL652_14610
ARRARUE_c04100
AAGINCTC2676_1_00619(frlD)
AAUAAur_0441
BLUTEW640_07195
AJIC0Z10_01365
MPHMLP_21790 MLP_21820
MGGMPLG2_2639
SROSros_0298
NOABKM31_09000
NOWGBF35_46635
NGNLCN96_32450
BCORBCOR_0209
BIIBINDI_0145
OLSOlsu_0626 Olsu_1405 Olsu_1406
ATBJ4859_01715
TIOINP52_03690
CGOCorgl_0707 Corgl_0708
CAERCSV91_01210 CSV91_08930
ABAOBEQ56_11695
KBSEPA93_13655
DDRDeide_3p00190
DMRDeima_0079
DFCDFI_15970
TSCTSC_p800050
BHCJFL75_10480
EPOEpro_0778(pfkB)
FVAFV113G1_03710
KOSKORDIASMS9_03201(frlD)
MIBUY43_C0001G0083
 » show all
Reference
1  [PMID:12147680]
  Authors
Wiame E, Delpierre G, Collard F, Van Schaftingen E
  Title
Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli.
  Journal
J Biol Chem 277:42523-9 (2002)
DOI:10.1074/jbc.M200863200
  Sequence
[eco:b3374]
Reference
2  [PMID:14641112]
  Authors
Wiame E, Van Schaftingen E
  Title
Fructoselysine 3-epimerase, an enzyme involved in the metabolism of the unusual Amadori compound psicoselysine in Escherichia coli.
  Journal
Biochem J 378:1047-52 (2004)
DOI:10.1042/BJ20031527
  Sequence
[eco:b3374]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.218
IUBMB Enzyme Nomenclature: 2.7.1.218
ExPASy - ENZYME nomenclature database: 2.7.1.218
BRENDA, the Enzyme Database: 2.7.1.218
LinkDB

DBGET integrated database retrieval system