KEGG   ENZYME: 2.7.11.8
Entry
EC 2.7.11.8                 Enzyme                                 
Name
Fas-activated serine/threonine kinase;
FAST;
FASTK;
STK10
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:[Fas-activated serine/threonine protein] phosphotransferase
Reaction(IUBMB)
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
Reaction(KEGG)
(other) R00162
Substrate
ATP [CPD:C00002];
[Fas-activated serine/threonine protein]
Product
ADP [CPD:C00008];
[Fas-activated serine/threonine phosphoprotein]
Comment
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
History
EC 2.7.11.8 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K08290  Fas-activated serine/threonine kinase
Genes
HSA: 10922(FASTK)
PTR: 472626(FASTK)
PPS: 100978359(FASTK)
GGO: 101150125(FASTK)
PON: 100171584(FASTK)
NLE: 100593928(FASTK)
MCC: 714020(FASTK)
MCF: 101926723(FASTK)
CSAB: 103227240(FASTK)
CATY: 105584741(FASTK)
PANU: 100998246(FASTK)
TGE: 112620081(FASTK)
RRO: 104675400(FASTK)
RBB: 108532532(FASTK)
TFN: 117072836(FASTK)
PTEH: 111551518(FASTK)
CJC: 100409995(FASTK)
SBQ: 101037716(FASTK)
CSYR: 103275287(FASTK)
MMUR: 105883174(FASTK)
LCAT: 123647513(FASTK)
OGA: 100955654(FASTK)
MMU: 66587(Fastk)
MCAL: 110293884(Fastk)
MPAH: 110315921(Fastk)
RNO: 296741(Fastk)
MCOC: 116097549(Fastk)
MUN: 110562562(Fastk)
CGE: 100762130(Fastk)
MAUA: 101835825(Fastk)
PLEU: 114700084(Fastk)
MORG: 121439977(Fastk)
AAMP: 119808143(Fastk)
NGI: 103745309(Fastk)
HGL: 101707658(Fastk)
CCAN: 109694452(Fastk)
DORD: 105993877(Fastk)
DSP: 122105952(Fastk)
NCAR: 124990772
OCU: 100343065(FASTK)
OPI: 101518654(FASTK)
TUP: 102498075(FASTK)
CFA: 482802(FASTK)
VVP: 112916212(FASTK)
VLG: 121489294(FASTK)
AML: 100482824(FASTK)
UMR: 103660954(FASTK)
UAH: 113241480(FASTK)
UAR: 123788775(FASTK)
ELK: 111154327
LLV: 125081333
MPUF: 101681299(FASTK)
ORO: 101384446(FASTK)
EJU: 114198016(FASTK) 114213868
ZCA: 113911331(FASTK) 113925854
MLX: 118026803(FASTK)
FCA: 101082140(FASTK)
PYU: 121022887(FASTK)
PBG: 122488533(FASTK)
PTG: 102956491(FASTK)
PPAD: 109252377(FASTK)
AJU: 106969574(FASTK)
HHV: 120230912(FASTK)
BTA: 509781(FASTK)
BOM: 102266409(FASTK)
BIU: 109557800(FASTK)
BBUB: 102388980(FASTK)
CHX: 102186744 108635865(FASTK)
OAS: 101103314(FASTK)
ODA: 120877889(FASTK)
CCAD: 122438873(FASTK)
SSC: 100233181(FASTK)
CFR: 102523278(FASTK)
CBAI: 105067015(FASTK)
CDK: 105105644(FASTK)
VPC: 102529432(FASTK)
BACU: 103019324(FASTK)
LVE: 103084660(FASTK)
OOR: 101282680(FASTK)
DLE: 111176805(FASTK)
PCAD: 102987574(FASTK)
PSIU: 116759264(FASTK)
ECB: 100063473(FASTK)
EPZ: 103564176(FASTK)
EAI: 106823328(FASTK)
MYB: 102254535(FASTK)
MYD: 102755949(FASTK)
MMYO: 118679404(FASTK)
MLF: 102432778(FASTK)
MNA: 107524906(FASTK)
PKL: 118704770(FASTK)
HAI: 109389645(FASTK)
DRO: 112308283(FASTK)
SHON: 118975548(FASTK)
AJM: 119039239(FASTK)
PDIC: 114507784(FASTK)
PHAS: 123817939(FASTK)
MMF: 118619784(FASTK)
RFQ: 117018039(FASTK) 117025120
PALE: 102878349(FASTK)
PGIG: 120601500(FASTK)
RAY: 107520316(FASTK)
MJV: 108391845(FASTK)
TOD: 119248884(FASTK)
SARA: 101548353(FASTK)
LAV: 100672710(FASTK)
TMU: 101358568
DNM: 101436971(FASTK)
OAA: 114816161(FASTK)
GGA: 426636(FASTK)
PCOC: 116242826(FASTK)
MGP: 100544059(FASTK)
CJO: 107308708(FASTK)
NMEL: 110390744(FASTK)
AFUL: 116485986(FASTK)
TGU: 100227496(FASTK)
LSR: 110475124(FASTK)
SCAN: 103824487(FASTK)
PMOA: 120510557(FASTK)
OTC: 121334865(FASTK)
PRUF: 121355532(FASTK)
GFR: 102034598(FASTK)
FAB: 101814009(FASTK)
PHI: 102100505(FASTK)
PMAJ: 107200647(FASTK)
CCAE: 111944798(FASTK)
CCW: 104684261(FASTK)
ETL: 114067997(FASTK)
FPG: 101913183(FASTK)
FCH: 102058389(FASTK)
CLV: 102096109(FASTK)
EGZ: 104127868(FASTK)
NNI: 104011535(FASTK)
PLET: 104627183(FASTK)
ACUN: 113477571(FASTK)
TALA: 116959979(FASTK)
PADL: 103922139(FASTK)
ACHC: 115339075(FASTK)
AAM: 106491561(FASTK)
AROW: 112976165(FASTK)
NPD: 112956375(FASTK)
DNE: 112994028(FASTK)
ASN: 102382446(FASTK)
AMJ: 102570632(FASTK)
CPOO: 109305652(FASTK)
CMY: 102940414(FASTK)
CPIC: 101930899(FASTK)
TST: 117871962(FASTK)
CABI: 116834487(FASTK)
MRV: 120397575(FASTK)
ACS: 103282002(fastk)
PVT: 110082558(FASTK)
SUND: 121932798(FASTK)
PMUA: 114607669(FASTK)
ZVI: 118092036(FASTK)
GJA: 107108218(FASTK)
STOW: 125440705(FASTK)
DRE: 564534(fastk)
SRX: 107709854 107718024
SANH: 107657442 107701011
SGH: 107557009 107599878
CCAR: 109047574 109088211
CAUA: 113045685 113118459 113118466
PPRM: 120482099(fastk)
MAMB: 125250388(fastk)
IPU: 108267814(fastk)
PHYP: 113540273(fastk)
SMEO: 124387612(fastk)
TFD: 113657462(fastk)
AMEX: 103039878(fastk)
EEE: 113590303(fastk)
TRU: 101064436(fastk)
TNG: GSTEN00004492G001
LCO: 104932655(fastk)
ELY: 117272384(fastk)
PLEP: 121967003
SLUC: 116065601 116065877(fastk)
PFLV: 114566069(fastk)
GAT: 120816511(fastk)
PPUG: 119209125(fastk)
MSAM: 119902774(fastk)
CUD: 121519821(fastk)
ALAT: 119011428(fastk)
MZE: 101476418(fastk)
ONL: 100691686(fastk)
OAU: 116320456(fastk)
OLA: 111949112(fastk)
OML: 112144253(fastk)
XMA: 102236288(fastk)
XCO: 114146143(fastk)
XHE: 116721449(fastk)
PRET: 103460488(fastk)
PFOR: 103129941(fastk)
PLAI: 106960303(fastk)
PMEI: 106903891(fastk)
GAF: 122841513(fastk)
CVG: 107080741(fastk)
CTUL: 119776811(fastk)
GMU: 124869497(fastk)
NFU: 107383684(fastk)
KMR: 108228222(fastk)
ALIM: 106534218(fastk)
NWH: 119415305(fastk)
AOCE: 111576067(fastk)
CSEM: 103398754(fastk)
POV: 109645871(fastk)
SSEN: 122775989(fastk)
HHIP: 117777830(fastk)
HSP: 118117430(fastk)
LCF: 108884940(fastk)
SDU: 111237341(fastk)
SLAL: 111659187(fastk)
XGL: 120800230(fastk)
HCQ: 109518860
BPEC: 110173952(fastk)
MALB: 109965944(fastk)
BSPL: 114844236(fastk)
SASA: 106568668 106597078
OTW: 112227246(fastk) 112260156
OMY: 110509102(fastk) 110529976
OGO: 124042155(fastk)
ONE: 115103360 115114246
SALP: 111957211 111979512
SNH: 120020707 120055453
ELS: 105025013(fastk)
SFM: 108937493(fastk)
PKI: 111837192(fastk)
AANG: 118234100(fastk)
LOC: 102694158
PSPA: 121313456 121314399(fastk)
ARUT: 117394833(fastk) 117399961
LCM: 102349276(FASTK)
CMK: 103190094(fastk)
RTP: 109925014
SKO: 102804167
 » show all
Reference
1  [PMID:7544399]
  Authors
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P.
  Title
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
  Journal
J Exp Med 182:865-74 (1995)
DOI:10.1084/jem.182.3.865
  Sequence
[hsa:10922]
Reference
2  [PMID:15572676]
  Authors
Li W, Simarro M, Kedersha N, Anderson P.
  Title
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.
  Journal
Mol Cell Biol 24:10718-32 (2004)
DOI:10.1128/MCB.24.24.10718-10732.2004
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.8
IUBMB Enzyme Nomenclature: 2.7.11.8
ExPASy - ENZYME nomenclature database: 2.7.11.8
BRENDA, the Enzyme Database: 2.7.11.8
CAS: 170347-50-9
LinkDB

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