KEGG ENZYME: 2.7.11.8

ENZYME: 2.7.11.8

Entry

EC 2.7.11.8                 Enzyme

Name

Fas-activated serine/threonine kinase;
FAST;
FASTK;
STK10

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:[Fas-activated serine/threonine protein] phosphotransferase

Reaction(IUBMB)

ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]

Reaction(KEGG)

(other) R00162

Substrate

ATP [CPD:C00002];
[Fas-activated serine/threonine protein]

Product

ADP [CPD:C00008];
[Fas-activated serine/threonine phosphoprotein]

Comment

This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.

History

EC 2.7.11.8 created 2005 (EC 2.7.1.37 part-incorporated 2005)

Orthology

K08290

Fas-activated serine/threonine kinase

Genes

HSA:	10922(FASTK)

PTR:	472626(FASTK)

PPS:	100978359(FASTK)

GGO:	101150125(FASTK)

PON:	100171584(FASTK)

PPYG:

129040250(FASTK)

NLE:	100593928(FASTK)

HMH:	116814539(FASTK)

SSYN:

129485213(FASTK)

MCC:	714020(FASTK)

MCF:	101926723(FASTK)

MTHB:

126951601

MNI:	105474907(FASTK)

CSAB:

103227240(FASTK)

CATY:

105584741(FASTK)

PANU:

100998246(FASTK)

TGE:	112620081(FASTK)

MLEU:

105542701(FASTK)

RRO:	104675400(FASTK)

RBB:	108532532(FASTK)

TFN:	117072836(FASTK)

PTEH:

111551518(FASTK)

CANG:

105511334(FASTK)

CJC:	100391071 100409995(FASTK)

SBQ:	101037716(FASTK)

CIMI:

108297674(FASTK)

ANAN:

105710656(FASTK)

CSYR:

103275287(FASTK)

MMUR:

105883174(FASTK)

LCAT:

123647513(FASTK)

PCOQ:

105824603(FASTK)

OGA:	100955654(FASTK)

MMU:	66587(Fastk)

MCAL:

110293884(Fastk)

MPAH:

110315921(Fastk)

RNO:	296741(Fastk)

MCOC:

116097549(Fastk)

ANU:	117721024(Fastk)

ASYL:

127678217(Fastk)

MUN:	110562562(Fastk)

CGE:	100762130(Fastk)

MAUA:

101835825(Fastk)

PROB:

127235674(Fastk)

PLEU:

114700084(Fastk)

MORG:

121439977(Fastk)

MFOT:

126489456

AAMP:

119808143(Fastk)

NGI:	103745309(Fastk)

HGL:	101707658(Fastk)

CCAN:

109694452(Fastk)

DORD:

105993877(Fastk)

DSP:	122105952(Fastk)

DMER:

138809940(Fastk)

PLOP:

125345707(Fastk)

NCAR:

124990772

MMMA:

107148931(Fastk)

ITI:	101954734(Fastk)

OCU:	100343065 127488312

OPI:	101518654(FASTK)

TUP:	102498075(FASTK)

GVR:	103585100(FASTK)

CFA:	482802(FASTK)

CLUD:

112663739(FASTK)

VVP:	112916212(FASTK)

VLG:	121489294(FASTK)

NPO:	129516219(FASTK)

AML:	100482824(FASTK)

UMR:	103660954(FASTK)

UAH:	113241480(FASTK)

UAR:	123788775(FASTK)

ELK:

111154327

LLV:

125081333

MPUF:

101681299(FASTK)

MNP:	132015567(FASTK)

MLK:	131829943(FASTK)

NVS:	122897905 122905202(FASTK)

ORO:	101384446(FASTK)

EJU:	114198016(FASTK) 114213868

ZCA:	113911331(FASTK) 113925854

MLX:	118026803(FASTK)

NSU:	110582838(FASTK)

LWW:	102732660(FASTK)

FCA:	101082140(FASTK)

PYU:	121022887(FASTK)

PCOO:

112866590(FASTK)

PBG:	122488533(FASTK)

PVIV:

125159292(FASTK)

LRUF:

124523525

LGF:	123607122(FASTK)

AJU:

106969574

PTG:	102956491(FASTK)

PPAD:

109252377(FASTK)

PUC:

125930308

PLEZ:

122213010(FASTK)

HHV:	120230912(FASTK)

BTA:	509781(FASTK)

BOM:	102266409(FASTK)

BIU:	109557800(FASTK)

BBUB:

102388980(FASTK)

BBIS:

105001104(FASTK)

CHX:	102186744 108635865(FASTK)

OAS:	101103314(FASTK)

BTAX:

128046397(FASTK)

CSUM:

138079806(FASTK)

ODA:	120877889(FASTK)

CCAD:

122438873(FASTK)

MREE:

136170881(FASTK)

OVR:	110124502(FASTK)

MBEZ:

129552786(FASTK)

SSC:	100233181(FASTK)

CFR:	102523278(FASTK)

CBAI:

105067015(FASTK)

CDK:	105105644(FASTK)

VPC:	102529432(FASTK)

BACU:

103019324(FASTK)

BMUS:

118901147(FASTK)

LVE:	103084660(FASTK)

OOR:	101282680(FASTK)

LALB:

132524456(FASTK)

GMF:	115851856(FASTK)

DDP:	132431302(FASTK)

DLE:	111176805(FASTK)

PCAD:

102987574(FASTK)

PSIU:

116759264(FASTK)

PPHC:

136127858(FASTK)

NASI:

112405916(FASTK)

ECB:	100063473(FASTK)

EPZ:	103564176(FASTK)

EAI:	106823328(FASTK)

MYB:	102254535(FASTK)

MYD:	102755949(FASTK)

MMYO:

118679404(FASTK)

MLF:	102432778(FASTK)

MDT:	132242617(FASTK)

MYUM:

139016073(FASTK)

PKL:	118704770(FASTK)

EFUS:

103301759(FASTK)

MNA:	107524906(FASTK)

DRO:	112308283(FASTK)

SHON:

118975548(FASTK)

AJM:	119039239(FASTK)

PDIC:

114507784(FASTK)

PHAS:

123817939(FASTK)

MMF:	118619784(FASTK)

PPAM:

129086741(FASTK)

HAI:	109389645(FASTK)

RFQ:	117018039(FASTK) 117025120

PALE:

102878349(FASTK)

PGIG:

120601500(FASTK)

RAY:	107520316(FASTK)

MJV:	108391845(FASTK)

TOD:	119248884(FASTK)

SARA:

101548353(FASTK)

SFUM:

130042647(FASTK)

SETR:

126014970(FASTK)

LAV:	100672710(FASTK)

TMU:

101358568

ETF:	101661712(FASTK)

DNM:	101436971(FASTK)

OAA:	114816161(FASTK)

TACU:

119936095(FASTK)

GGA:	426636(FASTK)

PCOC:

116242826(FASTK)

MGP:	100544059(FASTK)

CJO:	107308708(FASTK)

TPAI:

128087186(FASTK)

LMUT:

125696127(FASTK)

NMEL:

110390744(FASTK)

APLA:

119715809(FASTK)

ACYG:

125180893(FASTK)

CATA:

118251771(FASTK)

AFUL:

116485986(FASTK)

TGU:	100227496(FASTK)

LSR:	110475124(FASTK)

SCAN:

103824487(FASTK)

PMOA:

120510557(FASTK)

OTC:	121334865(FASTK)

PRUF:

121355532(FASTK)

ATRC:

139605042(FASTK)

GFR:	102034598(FASTK)

FAB:	101814009(FASTK)

OMA:	130249315(FASTK)

PHI:	102100505(FASTK)

PMAJ:

107200647(FASTK)

CCAE:

111944798(FASTK)

CCW:	104684261(FASTK)

CBRC:

103617019(FASTK)

ACOE:

138106090(FASTK)

ETL:	114067997(FASTK)

ZLE:	135443473(FASTK)

SVG:	106861778(FASTK)

MMEA:

130574587(FASTK)

HRT:	120760753(FASTK)

SATI:

136357590(FASTK)

CCIC:

134051556(FASTK)

FPG:	101913183(FASTK)

FCH:	102058389(FASTK)

CCRI:

104164299(FASTK)

NNT:	104410871(FASTK)

SHAB:

115610719(FASTK)

ACUN:

113477571(FASTK)

TALA:

116959979(FASTK)

ACHC:

115339075(FASTK)

HLE:	104828484(FASTK)

AGEN:

126037981

HHAR:

128139426(FASTK)

GCL:

127012729

DPUB:

104298511(FASTK)

PPUS:

135185526(FASTK)

EGZ:	104127868(FASTK)

NNI:	104011535(FASTK)

PADL:

103922139(FASTK)

AFOR:

103897135(FASTK)

CBOY:

140648662(FASTK)

CLV:	102096109(FASTK)

CNIC:

135986198(FASTK)

PLET:

104627183(FASTK)

CUCA:

104061721(FASTK)

CPEA:

104389088(FASTK)

CVF:	104290123(FASTK)

RTD:	128904777(FASTK)

CRID:

134510932(FASTK)

AAM:	106491561(FASTK)

AROW:

112976165(FASTK)

NPD:	112956375(FASTK)

DNE:	112994028(FASTK)

SCAM:

104141276(FASTK)

ASN:	102382446(FASTK)

AMJ:	102570632(FASTK)

CPOO:

109305652(FASTK)

CMY:	102940414(FASTK)

CCAY:

125632967(FASTK)

DCC:	119850590(FASTK)

CPIC:

101930899(FASTK)

TST:	117871962(FASTK)

CABI:

116834487(FASTK)

MRV:	120397575(FASTK)

ACS:	103282002(fastk)

ASAO:

132779733(FASTK)

PVT:	110082558(FASTK)

SUND:

121932798(FASTK)

PMUA:

114607669(FASTK)

PRAF:

128424006(FASTK)

ZVI:	118092036(FASTK)

HCG:	128329353(FASTK)

GJA:	107108218(FASTK)

STOW:

125440705(FASTK)

EMC:	129337722(FASTK)

DRE:	564534(fastk)

SRX:	107709854 107718024

SANH:

107657442 107701011

SGH:	107557009 107599878

CCAR:

109047574 109088211

CAUA:

113045685 113118459 113118466

CGIB:

127950709 128030564

PTET:

122362623(fastk)

LROH:

127181638(fastk)

GRF:	141344393(fastk)

OMC:	131529731(fastk)

PPRM:

120482099(fastk)

RKG:	130074003(fastk)

MAMB:

125250388(fastk)

CIDE:

127504457

CERY:

137002598(fastk)

MASI:

127441421 127442123

TROS:

130554897(fastk)

TDW:	130418248(fastk)

MANU:

129442053(fastk)

PDAB:

135766996(fastk)

IPU:

108267814

IFU:	128609556(fastk)

PHYP:

113540273(fastk)

SMEO:

124387612(fastk)

TFD:	113657462(fastk)

TVC:	132848383(fastk)

CGAR:

128527078(fastk)

NGRA:

132893503(fastk)

TRN:	134312164(fastk)

AMEX:

103039878(fastk)

CMAO:

118826747(fastk)

EEE:	113590303(fastk)

CHAR:

105891392(fastk)

SPIL:

134070016(fastk)

TRU:	101064436(fastk)

TFS:	130539169(fastk)

TNG:	GSTEN00004492G001

LCO:	104932655(fastk)

EMAC:

134865903(fastk)

ELY:	117272384(fastk)

EFO:	125902720(fastk)

PLEP:

121967003

SLUC:

116065601 116065877(fastk)

PFLV:

114566069(fastk)

GAT:	120816511(fastk)

PPUG:

119209125(fastk)

AFB:	129116094(fastk)

CLUM:

117745976(fastk)

CANA:

137779875(fastk)

CVE:	137871457(fastk) 137891896

MSAM:

119902774(fastk)

SCHU:

122886833(fastk)

CUD:	121519821(fastk)

SPUL:

138611071(fastk)

LMIX:

132979638(fastk)

ALAT:

119011428(fastk)

ASTR:

137612039(fastk)

MZE:	101476418(fastk)

ONL:	100691686(fastk)

OAU:	116320456(fastk)

OLA:	111949112(fastk)

OML:	112144253(fastk)

CSAI:

133452238(fastk)

XMA:	102236288(fastk)

XCO:	114146143(fastk)

XHE:	116721449(fastk)

PRET:

103460488(fastk)

PFOR:

103129941(fastk)

PLAI:

106960303(fastk)

PMEI:

106903891(fastk)

GAF:	122841513(fastk)

PPRL:

129351678

CVG:	107080741(fastk)

CTUL:

119776811(fastk)

GMU:	124869497(fastk)

NFU:	107383684(fastk)

KMR:	108228222(fastk)

ALIM:

106534218(fastk)

NWH:	119415305(fastk)

AOCE:

111576067 129347264

EJA:	138193949(fastk)

BFRE:

138633177(fastk)

MCEP:

125010899(fastk)

CSEM:

103398754(fastk)

POV:	109645871(fastk)

SSEN:

122775989(fastk)

SSOE:

131461283(fastk)

HHIP:

117777830(fastk)

HSP:	118117430(fastk)

PPLT:

128454593(fastk)

SMAU:

118311719(fastk)

LCF:

108884940

SDU:	111237341(fastk)

SLAL:

111659187(fastk)

XGL:	120800230(fastk)

HCQ:

109518860

SSCV:

125985365(fastk)

SBIA:

133510653(fastk)

PEE:	133411399(fastk)

PTAO:

133488733(fastk)

BPEC:

110173952(fastk)

ENY:	140376946(fastk)

MALB:

109965944(fastk)

BSPL:

114844236(fastk)

SJO:	128369311(fastk)

SSCO:

133991057(fastk)

GMH:	115548654(fastk)

SASA:

106568668 106597078

STRU:

115156573 115170161

OTW:	112227246(fastk) 112260156

OMY:	110509102(fastk) 110529976

OGO:	124042155(fastk)

ONE:	115103360 115114246

OKI:	109871629 109875109

OKE:	118394382(fastk)

OMM:	135518261 135558364(fastk)

OCLA:

139375813 139387592

SALP:

111957211 111979512

SNH:	120020707 120055453

CCLU:

121534771 121554836 121580592

ELS:	105025013(fastk)

OEP:	134036697(fastk)

SFM:	108937493(fastk)

PKI:	111837192(fastk)

AANG:

118234100(fastk)

AROT:

135260732(fastk)

CCOG:

133136210(fastk)

LOC:

102694158

PSPA:

121313456 121314399(fastk)

ARUT:

117394833(fastk) 117399961

PSEX:

120529429(fastk)

LCM:	102349276(FASTK)

CMK:	103190094(fastk)

RTP:	109925014(fastk)

CPLA:

122548785(fastk)

HOC:	132815149(fastk)

LERI:

129696096(fastk)

HAKA:

140727531(fastk)

PMRN:

116946338(FASTK)

LRJ:

133345048

SKO:

102804167

PFLL:

139117173

» show all

Reference

1 [PMID:7544399]

Authors

Tian Q, Taupin J, Elledge S, Robertson M, Anderson P.

Title

Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.

Journal

J Exp Med 182:865-74 (1995)
DOI:10.1084/jem.182.3.865

Sequence

[hsa:10922]

Reference

2 [PMID:15572676]

Authors

Li W, Simarro M, Kedersha N, Anderson P.

Title

FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.

Journal

Mol Cell Biol 24:10718-32 (2004)
DOI:10.1128/MCB.24.24.10718-10732.2004

Other DBs

ExplorEnz - The Enzyme Database:

2.7.11.8

IUBMB Enzyme Nomenclature:

2.7.11.8

ExPASy - ENZYME nomenclature database:

2.7.11.8

BRENDA, the Enzyme Database:

2.7.11.8

CAS:	170347-50-9

LinkDB

DBGET integrated database retrieval system