KEGG   ENZYME: 2.7.2.15
Entry
EC 2.7.2.15                 Enzyme                                 
Name
propionate kinase;
PduW;
TdcD;
propionate/acetate kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor
Sysname
ATP:propanoate phosphotransferase
Reaction(IUBMB)
ATP + propanoate = ADP + propanoyl phosphate [RN:R01353]
Reaction(KEGG)
R00315 R01353
Substrate
ATP [CPD:C00002];
propanoate [CPD:C00163]
Product
ADP [CPD:C00008];
propanoyl phosphate [CPD:C02876]
Comment
Requires Mg2+. Acetate can also act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria [1]. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate [1].
History
EC 2.7.2.15 created 2005
Pathway
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
Orthology
K00932  propionate kinase
K19697  propionate kinase
Genes
ECO: b3115(tdcD)
ECJ: JW5806(tdcD)
ECD: ECDH10B_3289(tdcD)
EBW: BWG_2823(tdcD)
ECOK: ECMDS42_2583(tdcD)
ECOC: C3026_16990
ECE: Z4467(tdcD)
ECS: ECs_3995(tdcD)
ECF: ECH74115_4428(tdcD)
ETW: ECSP_4087(tdcD)
ELX: CDCO157_3736
EOI: ECO111_3939(tdcD)
EOJ: ECO26_4220(tdcD)
EOH: ECO103_3862(tdcD)
ECOO: ECRM13514_4076(tdcD)
ECOH: ECRM13516_3879(tdcD)
ESL: O3K_03365
ESO: O3O_22280
ESM: O3M_03405
ECK: EC55989_3532(tdcD)
ECG: E2348C_3405(tdcD)
EOK: G2583_3837(tdcD)
ELR: ECO55CA74_18300
ELH: ETEC_3383
ECW: EcE24377A_3589(tdcD)
EUN: UMNK88_3870(ackA)
ECP: ECP_3208
ENA: ECNA114_4344(tdcD)
ECOS: EC958_3518(tdcD)
ECV: APECO1_2288 APECO1_3309(tdcD)
ECOA: APECO78_19410
ECX: EcHS_A3303(tdcD)
ECM: EcSMS35_3411(tdcD)
ECY: ECSE_3399
ECR: ECIAI1_3264(tdcD)
ECQ: ECED1_3455 ECED1_3780(tdcD)
EUM: ECUMN_3599(tdcD)
ECT: ECIAI39_3616(tdcD)
EOC: CE10_3647(tdcD)
EBR: ECB_02982(tdcD)
ECOB: C3029_19575
EBL: ECD_02982(tdcD)
EBE: B21_02933(tdcD)
EBD: ECBD_0625
ECI: UTI89_C3550(tdcD)
EIH: ECOK1_3542(tdcD)
ECZ: ECS88_3508(tdcD) ECS88_4678
ECC: c3873 c4530(tdcD)
ELO: EC042_3407(tdcD)
ELN: NRG857_15490
ESE: ECSF_2955
ECL: EcolC_0583
EKF: KO11_07110(tdcD)
EAB: ECABU_c35320(tdcD)
EDH: EcDH1_0588
EDJ: ECDH1ME8569_3008(tdcD)
ELU: UM146_00755
ELW: ECW_m3384(tdcD)
ELL: WFL_16540(tdcD)
ELC: i14_3561(tdcD)
ELD: i02_3561(tdcD)
ELP: P12B_c3231(tdcD)
ELF: LF82_2233(tdcD)
ECOL: LY180_16090
ECOI: ECOPMV1_03429(tdcD)
ECOJ: P423_17570
EFE: EFER_2027
EAL: EAKF1_ch2818(tdcD)
EMA: C1192_19945
ESZ: FEM44_06640(tdcD)
ERUY: OSH18_16035(tdcD)
STY: STY2262 STY3424(tdcD)
STT: t0817 t3162(tdcD)
SEX: STBHUCCB_33440 STBHUCCB_8720
SENT: TY21A_04150 TY21A_16025
STM: STM2057(pduW) STM3242(tdcD)
SEO: STM14_2546(pduW) STM14_3924(tdcD)
SEV: STMMW_20871 STMMW_32421
SEY: SL1344_2033(pduW) SL1344_3214(tdcD)
SEM: STMDT12_C20790 STMDT12_C33000
SEJ: STMUK_2087(pduW) STMUK_3231(tdcD)
SEB: STM474_2142(pduW) STM474_3396(tdcD)
SEF: UMN798_2223(pduW) UMN798_3526(tdcD)
SETU: STU288_06675 STU288_16420
SETC: CFSAN001921_00795 CFSAN001921_06500
SENR: STMDT2_20301(pduW) STMDT2_31341(tdcD)
SEND: DT104_21141(pduW) DT104_32371(tdcD)
SENI: CY43_11100 CY43_16895
SEEN: SE451236_16495 SE451236_22340
SPT: SPA0814(pduW) SPA3111(tdcD)
SEK: SSPA0761 SSPA2905
SPQ: SPAB_01047 SPAB_04045
SEI: SPC_1657(pduW) SPC_3318(tdcD)
SEC: SCH_2066(pduW) SCH_3188(tdcD)
SEH: SeHA_C2280(ackA) SeHA_C3537(ackA)
SHB: SU5_02651 SU5_03736
SENH: CFSAN002069_15925 CFSAN002069_21535
SEEH: SEEH1578_02355 SEEH1578_19565
SEE: SNSL254_A2234(ackA) SNSL254_A3504(ackA)
SENN: SN31241_31580 SN31241_43720
SEW: SeSA_A2227(ackA) SeSA_A3433(ackA)
SEA: SeAg_B2180(ackA) SeAg_B3430(ackA)
SENS: Q786_10155 Q786_15815
SED: SeD_A2393(ackA) SeD_A3600(ackA)
SEG: SG2086(pduW) SG3139(tdcD)
SEL: SPUL_0843(pduW) SPUL_3255(tdcD)
SEGA: SPUCDC_0843(pduW) SPUCDC_3241(tdcD)
SET: SEN2055(pduW) SEN3083(tdcD)
SENA: AU38_10370 AU38_15700
SENO: AU37_10380 AU37_15900
SENV: AU39_10380 AU39_15895
SENQ: AU40_11625 AU40_17685
SENL: IY59_10665 IY59_16300
SENJ: CFSAN001992_01150 CFSAN001992_17325
SEEC: CFSAN002050_17245 CFSAN002050_23200
SEEB: SEEB0189_003655 SEEB0189_009180
SEEP: I137_03800 I137_15530
SENB: BN855_21420(ackA) BN855_33230
SENE: IA1_10265 IA1_15685
SENC: SEET0819_17430 SEET0819_23220
SES: SARI_00830 SARI_04377
SBG: SBG_2879(tdcD)
SBZ: A464_3326
SBV: N643_14175
SALZ: EOS98_03080 EOS98_08725
SFL: SF3155(tdcD)
SFX: S3367(tdcD)
SFV: SFV_3156(tdcD)
SFE: SFxv_3462(tdcD)
SFN: SFy_4506
SFS: SFyv_4580
SFT: NCTC1_03420(tdcD)
SSN: SSON_3272(tdcD)
SBO: SBO_2980(tdcD)
SBC: SbBS512_E3242(tdcD)
SDY: SDY_3307(tdcD)
SDZ: Asd1617_04413
SHQ: A0259_19315
SHIG: LXH19_03125(tdcD)
ENC: ECL_04509
ENL: A3UG_19935
ECLG: EC036_38890
ECLE: ECNIH2_20420
ECLN: ECNIH4_03280
ECLI: ECNIH5_19030
ECLX: LI66_19690
ECLY: LI62_21665
ECLZ: LI64_18805
ECLO: ENC_33660
EHM: AB284_05705
EXF: BFV63_19165
ECLA: ECNIH3_19130
ECLC: ECR091_19055
EAU: DI57_21325
EKB: BFV64_20550
ENO: ECENHK_19385
EEC: EcWSU1_03927(tdcD)
ELG: BH714_20165
ECAN: CWI88_02855
ERN: BFV67_19230
ECLS: LI67_021105
ECHG: FY206_21550(tdcD)
ESH: C1N69_20045
EPT: HWQ17_16385(tdcD)
ENT: Ent638_3562
EAS: Entas_3790
ENX: NI40_019450
LNI: CWR52_15515
EBG: FAI37_09660(tdcD)
END: A4308_04045
ENZ: G0034_19960(tdcD)
ENS: HWQ15_04935(tdcD)
ENK: LOC22_07710(tdcD)
EHU: D5067_0003025(tdcD)
EMOR: L6Y89_19245(tdcD)
ENB: ELK40_19810
EQU: OM418_19380(tdcD)
EPU: QVH39_20280(tdcD)
EDY: F0320_18800(tdcD)
EAX: AAHF05_19615(tdcD)
KPN: KPN_02293(tdcD) KPN_03222(pduW)
KPU: KP1_3409(tdcD) KP1_4491(pduW)
KPM: KPHS_33000 KPHS_42850
KPP: A79E_0888 A79E_1945
KPH: KPNIH24_07365 KPNIH24_12035
KPZ: KPNIH27_15965 KPNIH27_20765
KPV: KPNIH29_16420 KPNIH29_21535
KPW: KPNIH30_16740 KPNIH30_21555
KPY: KPNIH31_15840 KPNIH31_20820
KPG: KPNIH32_16635 KPNIH32_22415
KPC: KPNIH10_16215 KPNIH10_21350
KPQ: KPR0928_16190 KPR0928_20840
KPT: VK055_0163(ackA) VK055_4303(ackA2)
KPO: KPN2242_14410 KPN2242_19060
KPR: KPR_1811(pduW) KPR_3203(tdcD)
KPJ: N559_1017 N559_1981
KPI: D364_11650 D364_16355
KPA: KPNJ1_01022 KPNJ1_02140
KPS: KPNJ2_01053 KPNJ2_02101
KPX: PMK1_00703(pduW) PMK1_04654(tdcD)
KPB: FH42_07540 FH42_12070
KPNE: KU54_005015 KU54_009880
KPNU: LI86_05025 LI86_09835
KPNK: BN49_0886(pduW) BN49_3394(tdcD)
KVA: Kvar_0848 Kvar_1910
KPE: KPK_0893(pduW) KPK_2016(tdcD)
KPK: A593_01005 A593_06240
KVD: KR75_03690 KR75_24715
KVQ: SP68_05075 SP68_10235
KQU: AVR78_20465 AVR78_25860
KQV: B8P98_04945 B8P98_10940
KOX: KOX_01540
KOE: A225_4773
KOY: J415_08155
KOM: HR38_27675
KMI: VW41_20010
KOK: KONIH1_23980
KOC: AB185_12410
EAE: EAE_22040
EAR: CCG29523
KLL: BJF97_23810
KLW: DA718_05380
KAR: LGL98_04525 LGL98_09490(tdcD)
KGR: JJJ10_05400
KPAS: LUW96_01635
KLC: K7H21_05065
KLM: BWI76_23200
REE: electrica_01998(tdcD)
KLP: GUC22_04635
ROR: RORB6_03475 RORB6_03645
RPLN: B1209_10130
RAO: DSD31_09915 DSD31_10085
CRO: ROD_21431(pduW) ROD_47621(tdcD)
CKO: CKO_00779 CKO_04515
CFD: CFNIH1_02830 CFNIH1_21280
CBRA: A6J81_01030 A6J81_20315
CWE: CO701_00875 CO701_07945
CYO: CD187_02965 CD187_09130
CPOT: FOB25_14320(tdcD) FOB25_20440
CFQ: C2U38_15400 C2U38_22495
CSED: JY391_03185(tdcD) JY391_08705
CAMA: F384_10495 F384_17135
CAF: AL524_12185 AL524_23530
CIF: AL515_09965 AL515_20455
CFAR: CI104_03160 CI104_16280
CIR: C2U53_06265 C2U53_26090
CIE: AN232_07665 AN232_13910
CPAR: CUC49_05340 CUC49_16185
CTEL: GBC03_14200 GBC03_27720(tdcD)
CITZ: E4Z61_02770 E4Z61_19980(tdcD)
CARS: E1B03_16810 E1B03_23075(tdcD)
CIX: M4I31_03090(tdcD) M4I31_09055
CIB: HF677_002790(tdcD) HF677_009305
CENS: P2W74_02770(tdcD)
CITR: GUC46_02900(tdcD) GUC46_08995
CIQ: FD428_02905(tdcD) FD428_08205
CIY: HAP28_03235(tdcD) HAP28_16020
CNT: JT31_15955
CEM: LH23_01775
CEN: LH86_01770
ESC: Entcl_0583 Entcl_1740
KLE: AO703_13245 AO703_18520
KCA: AAEY27_08435
KIE: NCTC12125_04515(tdcD)
KAS: KATP_35580(tdcD)
KCY: RIN60_03015(tdcD)
LAX: APT61_02980
LEH: C3F35_14895
LAZ: A8A57_18455
LEF: LJPFL01_3665
LEW: DAI21_07615
BUF: D8682_02415 D8682_19420
BAGE: BADSM9389_07280
BFT: MNO13_03720(tdcD) MNO13_13055(tdcD)
BSEL: RHD99_03645(tdcD)
AHN: NCTC12129_00736(tdcD_1)
ASUB: NLZ15_11360(tdcD) NLZ15_18920(tdcD)
YRE: HEC60_15105(tdcD)
SGOE: A8O29_005410(tdcD)
KIN: AB182_08055
PDZ: HHA33_11180
METY: MRY16398_18410(pduW)
PSGC: G163CM_41900(tdcD)
SUPE: P0H77_17580(tdcD) P0H77_19655(tdcD)
TOE: QMG90_18840(tdcD)
EBF: D782_0577
EBC: C2U52_18640
EBU: CUC76_20200 CUC76_25145
EBB: F652_3201 F652_943
YEN: YE0338(tdcD) YE2747(pduW)
YEP: YE105_C0366 YE105_C1538
YEY: Y11_16341 Y11_35781
YEW: CH47_2096(ackA) CH47_3136(ackA)
YET: CH48_1252(ackA) CH48_3134(ackA)
YEF: FORC2_2728 FORC2_3741
YEE: YE5303_31801(pduW)
YAL: AT01_2860(ackA) AT01_4016(ackA)
YFR: AW19_702(ackA)
YIN: CH53_1391(ackA) CH53_3350(ackA)
YKR: CH54_960(ackA)
YRU: BD65_1333(ackA)
YRB: UGYR_07395
YAK: ACZ76_01750
YMA: DA391_08055
YHI: D5F51_11595
YEL: LC20_07360
YCA: F0T03_14065
YMO: HRD69_13070
YAS: N0H69_17175
YKI: HRD70_00825(tdcD) HRD70_18715
YEG: PL78_08375
GQU: AWC35_20630
PWA: Pecwa_4098
PPAR: A8F97_20995
PEC: W5S_4257
PWS: A7983_05625
SOD: Sant_2126(tdcD)
SLIG: GTU79_14980
MINT: C7M51_00180(tdcD)
MTHI: C7M52_02539(tdcD)
ETD: ETAF_0836
ETE: ETEE_2779(tdcD)
ETR: ETAE_0896(tdcD)
ETC: ETAC_04285
EDW: QY76_15705
EDL: AAZ33_04750(tdcD)
EHO: A9798_12290
HAV: AT03_21325
HPAR: AL518_05445 AL518_16415
OPO: DSM2777_04090
XBC: ELE36_10260 ELE36_12825
VEJ: VEJY3_08465
VZI: G5S32_07755
VIB: VspSTUT11_17440(tdcD)
EMO: DM558_02430
SHEM: HWQ47_24240
APRS: BI364_08950
RFO: REIFOR_01380
AVR: B565_1141
AVO: AMS64_07500
AEM: CK911_02465
AALL: I6G90_09750(tdcD)
AJD: I6H43_17035(tdcD)
TAU: Tola_1703
PAGI: ABHF91_07930
KKO: Kkor_1315
SLIM: SCL_1777
BOK: DM82_5787(ackA)
BOC: BG90_4841(ackA)
CABA: SBC2_35140(tdcD)
NEN: NCHU2750_31760(ackA)
NHA: Nham_4372
AHEL: Q31a_48310(pduW)
TRS: Terro_3746
SSA: SSA_0541
LNG: BSQ50_09355
EAV: EH197_11740
ERAF: J9537_04870
VCP: H9L18_05065
VLU: M2919_01940
VIE: OL234_05815
 » show all
Reference
1  [PMID:9484901]
  Authors
Hesslinger C, Fairhurst SA, Sawers G
  Title
Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate.
  Journal
Mol Microbiol 27:477-92 (1998)
DOI:10.1046/j.1365-2958.1998.00696.x
  Sequence
[eco:b3115]
Reference
2  [PMID:12700259]
  Authors
Palacios S, Starai VJ, Escalante-Semerena JC.
  Title
Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol.
  Journal
J Bacteriol 185:2802-10 (2003)
DOI:10.1128/JB.185.9.2802-2810.2003
Reference
3  [PMID:10498722]
  Authors
Wei Y, Miller CG.
  Title
Characterization of a group of anaerobically induced, fnr-dependent genes of Salmonella typhimurium.
  Journal
J Bacteriol 181:6092-7 (1999)
DOI:10.1128/JB.181.19.6092-6097.1999
  Sequence
[stm:STM3242]
Reference
4  [PMID:15774882]
  Authors
Ingram-Smith C, Gorrell A, Lawrence SH, Iyer P, Smith K, Ferry JG.
  Title
Characterization of the acetate binding pocket in the Methanosarcina thermophila acetate kinase.
  Journal
J Bacteriol 187:2386-94 (2005)
DOI:10.1128/JB.187.7.2386-2394.2005
Reference
5  [PMID:16508089]
  Authors
Simanshu DK, Murthy MR.
  Title
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of propionate kinase (TdcD) from Salmonella typhimurium.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:52-5 (2005)
DOI:10.1107/S1744309104026429
Reference
6  [PMID:16139298]
  Authors
Simanshu DK, Savithri HS, Murthy MR.
  Title
Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily.
  Journal
J Mol Biol 352:876-92 (2005)
DOI:10.1016/j.jmb.2005.07.069
  Sequence
[stm:STM3242]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.2.15
IUBMB Enzyme Nomenclature: 2.7.2.15
ExPASy - ENZYME nomenclature database: 2.7.2.15
BRENDA, the Enzyme Database: 2.7.2.15
CAS: 39369-28-3
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