KEGG   ENZYME: 2.7.2.16
Entry
EC 2.7.2.16                 Enzyme                                 
Name
2-phosphoglycerate kinase;
pgk2 (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor
Sysname
ATP:2-phosphoglycerate 3-phosphotransferase
Reaction(IUBMB)
ATP + 2-phospho-D-glycerate = ADP + 2,3-diphospho-D-glycerate [RN:R02664]
Reaction(KEGG)
R02664
Substrate
ATP [CPD:C00002];
2-phospho-D-glycerate [CPD:C00631]
Product
ADP [CPD:C00008];
2,3-diphospho-D-glycerate [CPD:C01159]
Comment
The enzyme, found in a number of methanogenic archaeal genera, is involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant. Activity is stimulated by potassium ions.
History
EC 2.7.2.16 created 2019
Orthology
K05715  2-phosphoglycerate kinase
Genes
FRAFrancci3_2383
FRIFraEuI1c_1617
RXYRxyl_0777
RRDRradSPS_0650
RUBGBA63_06080
RMARGBA65_14470
DRADR_1514
DGEDgeo_1765
DDRDeide_06610
DMRDeima_2799
DPTDeipr_0721
DGODGo_CA0902
DPDDeipe_0950
DSWQR90_06485
DCHSY84_00360
DPUSU48_12650
DEZDKM44_05645
DWUDVJ83_03475
DFCDFI_08620
DEINDAAJ005_13615
DGADEGR_17140
DPHEHF33_12505
DRDLMT64_03035
TRATrad_0850 Trad_2028
TTHTT_C0121
TTJTTHA0495(TTHA0495)
TTSThthe16_0495
TTLTtJL18_1583
TSCTSC_c19610
THCTCCBUS3UF1_17550
TOSTheos_1814
TAQTO73_1841
TPARAV541_08230
TBCA0O31_01897
TANTKNN15_01315
MRBMrub_0491 Mrub_1022
MREK649_02080 K649_04755
MSVMesil_1353
MTAIMtai_v1c04270
OPROcepr_1323
MHDMarky_1499
RBARAWN76_018125
TAMTheam_0110
DTEDester_0088
NFTFBF37_03295
CGWUR58_C0001G0492
MJAMJ_1482
MFEMefer_1456
MVUMetvu_1257
MFSMFS40622_0982
MIFMetin_1099
MJHJH146_1500
MESGMLAUSG7_1394(pgk)
MESAMLASG1_0821(pgk)
MIGMetig_0799
MMPMMP1431(2pgk)
MMQMmarC5_0147
MMXMmarC6_1242
MMZMmarC7_0676
MMDGYY_07990
MMAKMMKA1_16550(pgk2)
MMAOMMOS7_15380(pgk2)
MMADMMJJ_14080
MAEMaeo_0251
MVNMevan_0742
MVOMvol_1490
MOKMetok_0252
METFCFE53_05275
MTHMTH_1883
MMGMTBMA_c04540(pgk1)
MWOMWSIV6_0414(pgk2_3)
MTEEMTTB_11730
METCMTCT_1721
METEtca_01819
METZMETMT2_0217
METKFVF72_02290
MTHMFZP57_01945
METJFZP68_06975
MSTMsp_0443(pgk2-1)
METBAW729_03330
MRUmru_0822(pgk2B)
MSIMsm_0791
MEBAbm4_1302(pgk2)
MMILsm9_1712(pgk2B)
MEYETL18_07615
MOLYLM1_0409
MAROMarbSA_07000
METVK4897_07540
MELMetbo_0705
MEWMSWAN_1548
METHMBMB1_1270(pgk2)
MFCBRM9_0486(pgk2B)
MFIDSM1535_0467(pgk2)
MCUBMCBB_1485(pgk2_1)
MSUBBK009_05265
METNBK008_00810
METTCIT01_08490
METOCIT02_11705
MEMEHYG87_08930
MFVMfer_0247
MKAMK0868
PFUPF0078
PFIPFC_07810
PHOPH0149(PH0149)
PABPAB2253
PYNPNA2_0684
PYAPYCH_14390
PYSPy04_0159
PYCTQ32_06565
TKOTK1038
TONTON_0742
TGATGAM_0724
TSITSIB_0159
TBATERMP_00451
THEGQS_01215
THATAM4_889
THMCL1_1941
TLTOCC_11507
TNUBD01_0985
TEUTEU_10720
TGYX802_06790
THVADU37_CDS00760
TCHCHITON_0180
TPEPA0127_10025
TPIEA7C91_09855
TGGA3K92_03150
TCEA3L02_08270
TBSA3L01_04475
THHCDI07_04390
TSLA3L11_08575
TTDA3L14_06425
TPRFA3L09_05020
TRLA3L10_02100
TPAFA3L08_07435
THYA3L12_07810
TICFH039_08730
TCQTIRI35C_1152(pgk)
THEMFPV09_00950
THEIK1720_03860
PPACPAP_01540
 » show all
Reference
1  [PMID:2226838]
  Authors
Lehmacher A, Vogt AB, Hensel R
  Title
Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus.
  Journal
FEBS Lett 272:94-8 (1990)
DOI:10.1016/0014-5793(90)80456-s
Reference
2  [PMID:8159166]
  Authors
Lehmacher A, Hensel R
  Title
Cloning, sequencing and expression of the gene encoding 2-phosphoglycerate kinase from Methanothermus fervidus.
  Journal
Mol Gen Genet 242:163-8 (1994)
DOI:10.1007/bf00391009
  Sequence
[mfv:Mfer_0247]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.2.16
IUBMB Enzyme Nomenclature: 2.7.2.16
ExPASy - ENZYME nomenclature database: 2.7.2.16
BRENDA, the Enzyme Database: 2.7.2.16
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