Entry
Name
Kdo2-lipid A phosphotransferase;
lipid A undecaprenyl phosphotransferase;
LpxT;
YeiU
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
ditrans-octacis-undecaprenyl-diphosphate:alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid-A phosphotransferase
Reaction(IUBMB)
ditrans-octacis-undecaprenyl diphosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A = ditrans-octacis-undecaprenyl phosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate [RN:
R11186 ]
Reaction(KEGG)
Substrate
ditrans,octacis-undecaprenyl diphosphate [CPD:
C04574 ];
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A [CPD:
C06026 ]
Product
ditrans,octacis-undecaprenyl phosphate [CPD:
C17556 ];
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate [CPD:
C21157 ]
Comment
An inner-membrane protein. The activity of the enzyme is regulated by PmrA. In vitro the enzyme can use diacylglycerol 3-diphosphate as the phosphate donor.
History
EC 2.7.4.29 created 2015
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K19803 Kdo2-lipid A phosphotransferase
Genes
EDJ : ECDH1ME8569_2111(yeiU)
ECOI : ECOPMV1_02335(yeiU)
REE : electrica_01534(yeiU)
RTG : NCTC13098_02095(yeiU)
CLAP : NCTC11466_01379(yeiU)
KIE : NCTC12125_00477(yeiU)
AHN : NCTC12129_01666(yeiU)
METY : MRY16398_16840(lpxT)
SMW : SMWW4_v1c33400(lpxT)
SFJ : SAMEA4384070_3355(yeiU)
SOF : NCTC11214_03478(yeiU)
TPTY : NCTC11468_02449(yeiU_2)
LRI : NCTC12151_01317(yeiU)
ZPL : ZBT109_1836 ZBT109_1837
KUS : B9G99_09770 B9G99_09775
KMA : B9H00_05065 B9H00_05070
KUY : FY550_03130 FY550_03135
AEL : NCTC12917_03497(yeiU)
ASIM : FE240_03925 FE240_09805
OPE : PU634_14020 PU634_14560
OCM : CBP12_09165 CBP12_11925
OPF : CBP31_06150 CBP31_09430
ZDF : AN401_01035 AN401_16620
PFAC : PFJ30894_00421(yeiU)
» show all
Taxonomy
Reference
Authors
Touze T, Tran AX, Hankins JV, Mengin-Lecreulx D, Trent MS
Title
Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate.
Journal
Sequence
Reference
Authors
Herrera CM, Hankins JV, Trent MS
Title
Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.29
ExPASy - ENZYME nomenclature database: 2.7.4.29
LinkDB
All DBs