KEGG   ENZYME: 2.7.7.64
Entry
EC 2.7.7.64                 Enzyme                                 
Name
UTP-monosaccharide-1-phosphate uridylyltransferase;
UDP-sugar pyrophosphorylase;
PsUSP
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Reaction(IUBMB)
UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide [RN:R08845]
Reaction(KEGG)
Substrate
UTP [CPD:C00075];
monosaccharide 1-phosphate [CPD:C00991]
Product
diphosphate [CPD:C00013];
UDP-monosaccharide [CPD:C05227]
Comment
Requires Mg2+ or Mn2+ for maximal activity. The reaction can occur in either direction and it has been postulated that MgUTP and Mg-diphosphate are the actual substrates [1,2]. The enzyme catalyses the formation of UDP-Glc, UDP-Gal, UDP-GlcA, UDP-L-Ara and UDP-Xyl, showing broad substrate specificity towards monosaccharide 1-phosphates. Mannose 1-phosphate, L-Fucose 1-phosphate and glucose 6-phosphate are not substrates and UTP cannot be replaced by other nucleotide triphosphates [1].
History
EC 2.7.7.64 created 2006
Pathway
ec00040  Pentose and glucuronate interconversions
ec00052  Galactose metabolism
ec00053  Ascorbate and aldarate metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12447  UDP-sugar pyrophosphorylase
Genes
PCAD112062722 114486214
ATHAT5G52560(USP)
ALY9301995
CRB17875462
CSAT104725768 104727645 104761268 109127935
EUSEUTSA_v10000457mg
BRP103842186
BNA106368564 106415929
BOE106307311 106336398
RSZ108805857 108805896
THJ104808371
CPAP110813513
CIT102628031
CICCICLE_v10000592mg
PVY116116047 116140087
MINC123203258 123206225
TCC18592423
GRA105783427 105792654
GHI107897588 107938693 107939552 107949516
GAB108462975 108467534
DZI111298632 111312249
EGR104450548
GMX100793599 778158(USP1)
GSJ114410378 114415459
PVUPHAVU_009G130500g
VRA106762599
VAR108332148
VUN114164681
CCAJ109796895
APRC113869536
MTRMTR_3g088650
CAM101505137
LJALj0g3v0214629.1(Lj0g3v0214629.1) Lj0g3v0214629.2(Lj0g3v0214629.2)
ADU107460668
AIP107606001
AHF112706017 112764737 114927234
LANG109344323
FVE101297604
RCN112172726
PPER18790905
PMUM103319759
PAVI110766413
PDUL117614229
MDM103456258
PXB103945204 103946766
ZJU107421126
MNT21387354
CSV101202798
CMO103485690(UGGPase)
BHJ120075699
MCHA111011819
CMAX111487149
CMOS111462581
CPEP111802306
RCU8270969
JCU105639006
HBR110632622 110647558
MESC110606169
POP7467856
PEU105127743
PALZ118061551
JRE109004826 109012130
QSU111984090 111999283
QLO115960014
TWL119996987 120017142
VVI100259254
VRI117906610
SLY101247010
SPEN107018439
SOT102596087
CANN107852493
NTA107804078 107808766
NSY104232978
NTO104119089
NAU109234273
INI109170461
ITR116014919
SIND105180105
OEU111397495 111408714
EGT105963411
SSPL121783004 121785967 121810605
HAN110904244 110927044
ECAD122603150 122609402
LSV111901456
CCAV112522223 112523107
DCR108204601
CSIN114267052
BVG104894442
SOE110782013
CQI110685928 110725744
NNU104606683
MING122072129 122094797
TSS122655413 122657876 122670080
PSOM113291734 113326815 113332494 113358220
NCOL116261024
OSA4341967
DOSAOs06t0701200-01(Os06g0701200)
OBR102704348
BDI100845164
ATS109751835
TDC119329157 119337370
TAES123148643 123157133 123163925
TUA125519710
SBI8065566
ZMA100285949 100382378 103625925 109939773
SITA101760295 101768879
SVS117854042 117863004
PVIR120668692 120704388
PHAI112888690
PDA103713110
EGU105049301
MUS103985547 103997892
DCT110114106
PEQ110033390
AOF109850719
ATR18424675
SMOSELMODRAFT_100378 SELMODRAFT_118485
PPP112284456 112291294
CRECHLRE_14g621751v5
VCNVOLCADRAFT_120799
CSLCOCSUDRAFT_53808
CVRCHLNCDRAFT_35169
APROF751_3978
OLUOSTLU_51241 OSTLU_52106
OTAOT_ostta13g02030
BPGBathy17g01210
MISMICPUN_106965
MPPMICPUCDRAFT_60817
PFAPF3D7_0517500
PFDPFDG_01194
PFHPFHG_00237
PREIPRSY57_0008200
PGABPGSY75_0517500
PYOPY17X_1235700
PCBPCHAS_123290(PC301053.00.0)
PBEPBANKA_1232300
PVVPVVCY_1203320
PKNPKNH_1015800
PVXPVX_080375
PCYPCYB_102430
CPVcgd7_1830
CHOChro.70213
TGOTGME49_218200
TETTTHERM_00929520 TTHERM_00951720
PTMGSPATT00032995001
SMINv1.2.004770.t1(symbB.v1.2.004770.t1) v1.2.004770.t2(symbB.v1.2.004770.t2) v1.2.011414.t1(symbB.v1.2.011414.t1)
PTIPHATRDRAFT_23639 PHATRDRAFT_54493
FCYFRACYDRAFT_211962(USP2) FRACYDRAFT_237242(USP1)
TPSTHAPSDRAFT_13482 THAPSDRAFT_42326
AAFAURANDRAFT_22705 AURANDRAFT_23667 AURANDRAFT_28944 AURANDRAFT_70780
PIFPITG_10315
PSOJPHYSODRAFT_312734
EHXEMIHUDRAFT_426133 EMIHUDRAFT_427850 EMIHUDRAFT_454930 EMIHUDRAFT_51739 EMIHUDRAFT_68020 EMIHUDRAFT_74985
GTTGUITHDRAFT_115181 GUITHDRAFT_157482 GUITHDRAFT_159419
TCR503493.10 511761.10
LMALMJF_17_1160(USP)
LIFLINJ_17_1260(USP)
LDOLDBPK_171260
LMILMXM_17_1160
LBZLBRM_17_1270(USP)
LPANLPMP_171130(USP)
CAACaka_1908
VBSEGM51_17175
 » show all
Reference
1  [PMID:15326166]
  Authors
Kotake T, Yamaguchi D, Ohzono H, Hojo S, Kaneko S, Ishida HK, Tsumuraya Y
  Title
UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts.
  Journal
J Biol Chem 279:45728-36 (2004)
DOI:10.1074/jbc.M408716200
  Sequence
Reference
2  [PMID:4430676]
  Authors
Rudick VL, Weisman RA.
  Title
Uridine diphosphate glucose pyrophosphorylase of Acanthamoeba castellanii. Purification, kinetic, and developmental studies.
  Journal
J Biol Chem 249:7832-40 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.64
IUBMB Enzyme Nomenclature: 2.7.7.64
ExPASy - ENZYME nomenclature database: 2.7.7.64
BRENDA, the Enzyme Database: 2.7.7.64
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