Entry
Name
lipid A phosphoethanolamine transferase;
lipid A PEA transferase;
LptA
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
diacylphosphatidylethanolamine:lipid-A ethanolaminephosphotransferase
Reaction(IUBMB)
(1) diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 1-(2-aminoethyl diphosphate);
(2) diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate);
(3) diacylphosphatidylethanolamine + lipid A 1-(2-aminoethyl diphosphate) = diacylglycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)
Reaction(KEGG)
Substrate
diacylphosphatidylethanolamine;
lipid A;
lipid A 1-(2-aminoethyl diphosphate)
Product
diacylglycerol [CPD:
C00165 ];
lipid A 1-(2-aminoethyl diphosphate);
lipid A 4'-(2-aminoethyl diphosphate);
lipid A 1,4'-bis(2-aminoethyl diphosphate)
Comment
The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC
2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-beta-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A.
History
EC 2.7.8.43 created 2015 as EC 2.7.4.30, transferred 2016 to EC 2.7.8.43
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K03760 lipid A ethanolaminephosphotransferase
Genes
ECE : Z1140 Z1579 Z5716(yjdB)
ECS : ECs_1317(eptA) ECs_5096(eptA)
ECF : ECH74115_1318 ECH74115_5627
ETW : ECSP_1246 ECSP_5213(eptA)
ELX : CDCO157_1261 CDCO157_4781
EOI : ECO111_1223 ECO111_4984(eptA)
EOJ : ECO26_1276 ECO26_5226(eptA)
EOH : ECO103_3792 ECO103_4866(eptA)
ECOO : ECRM13514_1217 ECRM13514_4007(eptA) ECRM13514_5329(yjdB)
ECOH : ECRM13516_1177(eptA) ECRM13516_4997(yjdB)
EUN : UMNK88_1196 UMNK88_4978
ECQ : ECED1_3549 ECED1_4848(eptA)
EDJ : ECDH1ME8569_3973(yjdB)
ECOI : ECOPMV1_04574(eptA)
SEEC : CFSAN002050_00980 CFSAN002050_04715
SALZ : EOS98_20840(eptA) EOS98_24540(mcr-1)
SHIG : LXH19_20270(eptA) LXH19_23780
ECLE : ECNIH2_10205 ECNIH2_25895
ECLY : LI62_012865 LI62_10345
ECLA : ECNIH3_09380 ECNIH3_23210
EKB : BFV64_09680 BFV64_17340
ENX : NI40_009650 NI40_012280
ENZ : G0034_09400(eptA) G0034_11885
EAX : AAHF05_09615(eptA) AAHF05_23615
KGR : JJJ10_19170(eptA) JJJ10_28595
KLC : K7H21_19200(eptA) K7H21_21135
REE : electrica_03535(eptA)
RTG : NCTC13098_05222(eptA)
CFAR : CI104_23015 CI104_26315
CTEL : GBC03_06895(eptA) GBC03_17550
CLAP : NCTC11466_02584(eptA)
KSA : C813_07855 C813_24320
KPSE : IP581_06985(eptA) IP581_12680
KIE : NCTC12125_02202(eptA)
LEI : C2U54_15095 C2U54_23870
LEE : DVA44_13660 DVA44_24905
BSEL : RHD99_10435 RHD99_10560(eptA)
KIN : AB182_03170 AB182_17345
PSHI : SAMEA2665130_0988(eptA_1) SAMEA2665130_1535(eptA_2)
PVJ : LMA04_05785(eptA) LMA04_21445
MPHG : MPHASIOC01_001092(eptA) MPHASIOC01_004681
SMW : SMWW4_v1c22330(eptA)
SFJ : SAMEA4384070_2270(eptA)
SOF : NCTC11214_04616(eptA)
SSAR : SSARUM_002131(eptA)
PARI : I2D83_02190(eptA) I2D83_11430
PAQU : DMB82_0018455(eptA)
PARL : PEC302110_03390(eptA)
DIC : Dpoa569_0000408(eptA)
PAGG : AL522_00845 AL522_15640
PANS : FCN45_08790(eptA) FCN45_20055(eptA)
PEY : EE896_07970(eptA) EE896_19775(eptA)
PJI : KTJ90_07775(eptA) KTJ90_21475(eptA)
KPIE : N5580_09675(eptA) N5580_18860(eptA) N5580_19590(eptA)
PANE : P6287_08665(eptA) P6287_20895(eptA)
PAMT : IAI47_08265(eptA) IAI47_21225(eptA)
PANZ : NR302_08645(eptA) NR302_20685(eptA)
LPV : HYN51_01275 HYN51_04835
LRI : NCTC12151_01782(eptA)
AVT : NCTC3438_00838(eptA)
RPNE : NCTC8284_03305(eptA_2)
PAET : NCTC13378_00211(eptA)
XFU : XFF4834R_chr33220(eptA)
XPH : XppCFBP6546_05400(XppCFBP6546P_05400)
XHD : LMG31886_31170(eptA)
XHA : PG878_05380 PG878_10445
XAZ : XSP_001208 XSP_003635
STEK : AXG53_03970 AXG53_19320
SINC : DAIF1_21660(eptA_1) DAIF1_31190(eptA_2)
SPAQ : STNY_R24640 STNY_R31670
SGEN : RKE57_12050(eptA) RKE57_15595
SARC : PDM28_16380 PDM28_17795
STEJ : FQS62_013195(eptA) FQS62_016620
STEO : PEM_09745 PEM_12405
STEZ : ACEPA4_11490 ACEPA4_14830
SLAB : AB9L18_05345 AB9L18_10080
PMEX : H4W19_09970 H4W19_14235
PSSE : OY559_01230 OY559_10010
LLZ : LYB30171_01367(eptA)
VVM : VVMO6_03206 VVMO6_04270
VVL : VV93_v1c32340 VV93_v1c42720
VAU : VANGNB10_cI0578c VANGNB10_cI1784
VFL : AL536_09360 AL536_11305
VGA : BSQ33_18825 BSQ33_20530
VSR : Vspart_03726(eptA_1) Vspart_04286(eptA_2) Vspart_04490(eptA_3)
VZI : G5S32_07910 G5S32_18255
VRU : RND59_16690 RND59_17540
AWD : AWOD_II_1102 AWOD_I_1090
PDS : CAY62_07215 CAY62_16620
PGH : FH974_16515 FH974_16690
SALY : E8E00_15070 E8E00_15190
PAEV : N297_2034 N297_3429
PAEI : N296_2034 N296_3429
PAU : PA14_21210 PA14_39020
PAG : PLES_17551 PLES_33511
PAF : PAM18_1655 PAM18_3073
PNC : NCGM2_2944 NCGM2_4440
PAEB : NCGM1900_2966 NCGM1900_4516
PDK : PADK2_07720 PADK2_15795
PSG : G655_08210 G655_15250
PRP : M062_10280 M062_17690
PAEP : PA1S_08795 PA1S_15835
PAEM : U769_08295 U769_15420
PAEL : T223_08795 T223_17115
PAES : SCV20265_1739 SCV20265_3421
PAEU : BN889_03678 BN889_06907
PAEG : AI22_17935 AI22_25090
PAEC : M802_2032 M802_3428
PAEO : M801_2033 M801_3294
SECH : B18_21755 B18_29555
PAP : PSPA7_1810 PSPA7_3323
PPAA : B7D75_08420 B7D75_15130
PPG : PputGB1_0039 PputGB1_4122
PPW : PputW619_0042 PputW619_2985
PPUH : B479_00445 B479_19645
PPUT : L483_16105 L483_25065
PPUN : PP4_00170(eptA) PP4_12080(eptA)
PMON : X969_19295 X969_26150
PMOT : X970_18930 X970_25770
PPJ : RK21_00537 RK21_05115
PALD : LU682_007045 LU682_028870
PMOS : O165_002085 O165_023650
PST : PSPTO_3923 PSPTO_5584
PVD : CFBP1590__1088(eptA) CFBP1590__3935(eptA)
PFO : Pfl01_1387 Pfl01_3156
PKR : AYO71_02840 AYO71_09585
PLUL : FOB45_01195 FOB45_12035
PDR : H681_13255 H681_18285
PSV : PVLB_00190 PVLB_18440
PCH : EY04_06915 EY04_19100
PCZ : PCL1606_24260 PCL1606_46340
PCP : JM49_12125 JM49_22945
PCHP : C4K32_1555 C4K32_3850
PSES : PSCI_1547 PSCI_4925
PSEM : TO66_07365 TO66_19465
PGG : FX982_02665 FX982_04549
PGY : AWU82_12415 AWU82_23315
PZE : HU754_008440 HU754_017030
PMOE : HV782_007905 HV782_013245
PXN : HU772_013700 HU772_018115
PTW : TUM18999_01540 TUM18999_29600
PGF : J0G10_08215 J0G10_14000
PJU : L1P09_18230 L1P09_25280
PFIT : KJY40_08105 KJY40_16550
PASI : LG197_05040 LG197_26615
PNB : NK667_13330 NK667_20130
PTRL : OU419_07935 OU419_13415
PSJY : AA098_20755 AA098_27575
PFOU : OZ911_00085 OZ911_21740
PDEU : QEP73_05225 QEP73_11110
ABC : ACICU_01072 ACICU_03004
ABZ : ABZJ_01217 ABZJ_03184
ABR : ABTJ_00710 ABTJ_02705
ABAD : ABD1_10510(eptA) ABD1_26990(eptA)
ABJ : BJAB07104_01209 BJAB07104_03087
ABAB : BJAB0715_01217 BJAB0715_03131
ABAZ : P795_12185 P795_3380
ABW : BL01_05330 BL01_12130
ABAL : ABLAC_07320 ABLAC_18280
ACUM : C9E88_016040 C9E88_16945
AGYL : FPL18_11090 FPL18_13605
APRL : PY247_01195 PY247_19915
AVIV : LF296_03095 LF296_14685
ACIE : KIP84_03780 KIP84_12380
MCAT : MC25239_01256(eptA)
MORA : NGM44_01910(mcr-1.35)
SPC : Sputcn32_1978 Sputcn32_2097
SEUR : FM038_011285 FM038_019750
SHEJ : MZ182_10505 MZ182_10905
IDI : CWC33_08205 CWC33_10325
COLA : DBO93_06495 DBO93_08650
COV : EKO29_02930 EKO29_15440
TVD : SG34_004285 SG34_007925
PART : PARC_a0362(eptA) PARC_p0107(eptA)
PTU : PTUN_b0497(eptA) PTUN_b0637(eptA)
PNG : PNIG_a2272(eptA) PNIG_a2289(eptA) PNIG_a3534(eptA)
AMC : MADE_000001020715 MADE_1001850
ASQ : AVL57_00105 AVL57_00110
GAG : Glaag_3264 Glaag_4539 Glaag_4542
GPS : C427_1983(eptA) C427_2883
MARQ : MARGE09_P0550 MARGE09_P0557
ZAL : AZF00_08765 AZF00_08830
LSH : CAB17_02375 CAB17_16545
LCJ : NCTC11976_02094(eptA)
MTHA : VSX76_01250 VSX76_10765
GAI : IMCC3135_11270(eptA)
HAK : KO116_02473 KO116_P100086
HAAH : HALA3H3_400024(eptA) HALA3H3_870020(eptA)
HNP : SR894_01230 SR894_21070
HTT : HZS52_05875 HZS52_11280
MMW : Mmwyl1_0677 Mmwyl1_1916 Mmwyl1_3642 Mmwyl1_4448
MPRI : MP3633_0619 MP3633_3785
AHY : AHML_08455 AHML_14160
AHD : AI20_06105 AI20_11555
AHR : V428_08685 V428_14650
AHP : V429_08690 V429_14670
AHJ : V469_08440 V469_14805
AHH : RY45_08285 RY45_13840
AHI : VU14_08400 VU14_14945
AAJ : BOQ57_07370 BOQ57_13675
ASA : ASA_2842 ASA_P5G157 ASA_P5G158
ADH : CK627_12485 CK627_18465
AEM : CK911_01010 CK911_09965
AES : C2U30_06415 C2U30_06825
AEL : NCTC12917_01378(eptA)
AJD : I6H43_03415 I6H43_19925
ASAA : KXJ75_08080 KXJ75_20760 KXJ75_20765
AEJ : E5E97_11670(mcr-3) E5E97_11675 E5E97_12710 E5E97_18670(mcr-3)
ABES : IU367_08340(mcr-3) IU367_14345
AERO : CK910_14145 CK910_20355
AERZ : E5E96_15090 E5E96_21290(mcr-3)
CHJ : NCTC10426_01814(eptA)
CDIZ : CEDIAZO_01382(eptA)
CGD : CR3_1310(eptA) CR3_1335(eptA)
CCAX : KZ686_24630 KZ686_24775
CUPR : IC580_06910 IC580_07060
PLG : NCTC10937_02019(eptA)
LMIR : NCTC12852_00640(eptA)
ASAH : AVXHC19_27460(eptA) AVXHC19_31110
DAC : Daci_1142 Daci_1718 Daci_2705
DLA : I6G47_15685 I6G47_18855
VAA : AX767_01165 AX767_09600
CTT : CtCNB1_2468 CtCNB1_4336
CTES : O987_10245 O987_14535 O987_25760
AANT : HUK68_02855 HUK68_13295
COMB : MJ205_10850 MJ205_13490
LIM : L103DPR2_01460(eptA)
LIH : L63ED372_01161(eptA)
HPSE : HPF_11450(eptA1) HPF_22550(eptA2)
DIH : G7047_08170 G7047_25380
DAER : H9K75_01150 H9K75_10435
DIA : Dtpsy_1756 Dtpsy_2213
SMIO : CATMQ487_42400(yjdB)
ATER : MW290_03760 MW290_23175
MMS : mma_0057(yjdB) mma_1764
MTIM : DIR46_18215 DIR46_26050
MASY : DPH57_24220 DPH57_25255
MEI : Msip34_1258 Msip34_2098
MEU : ACJ67_00830 ACJ67_02185 ACJ67_13510
UPL : DSM104440_01398(eptA)
THAG : CKCBHOJB_02754(eptA)
RBS : RHODOSMS8_01808(eptA)
SFD : USDA257_c11240(eptA)
SAME : SAMCFNEI73_pC0998(eptA)
ESJ : SJ05684_a37360 SJ05684_b51680
RHL : LPU83_2061 LPU83_3077 LPU83_3872
RHV : BA939_15380 BA939_20990
RGR : FZ934_08735 FZ934_23585
ROY : G3A56_22285 G3A56_26310 G3A56_27605
RRHO : PR018_05905 PR018_18490
RTU : PR017_06030 PR017_27190
NEN : NCHU2750_41830(eptA)
SZO : K8M09_10960 K8M09_22935
SSUM : Q9314_03050 Q9314_16915
BMC : BAbS19_I18270 BAbS19_I18280
BAA : BAA13334_I00871 BAA13334_I00873
BABO : DK55_1885 DK55_1886
BABR : DO74_2088 DO74_2089
BABT : DK49_1643 DK49_1644
BABU : DK53_1870 DK53_1871
BABS : DK51_1672 DK51_1673
BABC : DO78_1790 DO78_1791
BRU : BFS01_09280 BFS01_09285
PSCQ : KHQ08_07500 KHQ08_08900
PSXF : LDL70_05225 LDL70_06735
SPSE : SULPSESMR1_00523(eptA)
LALG : LentiSH36_02590(eptA_1) LentiSH36_02596(eptA_2)
HCL : NCTC13205_00719(eptA)
HPUL : NCTC13154_00143(hopA_1)
HFI : NHP21005_17910(eptA)
HGA : NHP190012_08830(eptA)
HGS : NHP190003_06870(eptA)
CJV : MTVDSCj20_0232(eptA)
CFV : CFVI03293_1746(eptC)
CAMP : CFT03427_1669(eptA)
CCOC : CCON33237_1243(eptC)
CLR : UPTC16701_0053(eptC)
CLM : UPTC16712_0055(eptC)
CAMR : CAQ16704_0043(eptA)
CHV : CHELV3228_1751(eptC)
SULS : Sdiek1_0125 Sdiek1_2580
SULJ : SJPD1_0126 SJPD1_2486
SULT : FA592_05185 FA592_07720
KAN : IMCC3317_15060(eptA)
CJG : NCTC13459_01898(eptA)
PARH : I5S86_00840 I5S86_16485
» show all
Taxonomy
Reference
Authors
Tran AX, Karbarz MJ, Wang X, Raetz CR, McGrath SC, Cotter RJ, Trent MS
Title
Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A.
Journal
Sequence
Reference
Authors
Herrera CM, Hankins JV, Trent MS
Title
Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides.
Journal
Reference
Authors
Cullen TW, Trent MS
Title
A link between the assembly of flagella and lipooligosaccharide of the Gram-negative bacterium Campylobacter jejuni.
Journal
Sequence
Reference
Authors
Anandan A, Piek S, Kahler CM, Vrielink A
Title
Cloning, expression, purification and crystallization of an endotoxin-biosynthesis enzyme from Neisseria meningitidis.
Journal
Reference
Authors
Wanty C, Anandan A, Piek S, Walshe J, Ganguly J, Carlson RW, Stubbs KA, Kahler CM, Vrielink A
Title
The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.43
ExPASy - ENZYME nomenclature database: 2.7.8.43
LinkDB
All DBs