Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
BRITE hierarchy

[protein]-S-sulfanyl-L-cysteine:sulfoacetaldehyde sulfurtransferase

a [protein]-S-sulfanyl-L-cysteine + sulfoacetaldehyde + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ = a [protein]-L-cysteine + coenzyme M + 4 oxidized ferredoxin [iron-sulfur] cluster [RN:R09153]

R09153
Reaction

[protein]-S-sulfanyl-L-cysteine [CPD:C21440];
sulfoacetaldehyde [CPD:C00593];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]

The enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyses the last step in the biosynthesis of coenzyme M. The enzyme carries two [4Fe-4S] clusters. The reaction involves two L-cysteine residues, one of which receives a sulfane sulfur from a donor protein.

EC 2.8.1.17 created 2025

1  [PMID:30932481]