KEGG   ENZYME: 2.8.1.9
Entry
EC 2.8.1.9                  Enzyme                                 
Name
molybdenum cofactor sulfurtransferase;
molybdenum cofactor sulfurase;
ABA3;
HMCS;
MoCo sulfurase;
MoCo sulfurtransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
Sysname
L-cysteine:molybdenum cofactor sulfurtransferase
Reaction(IUBMB)
molybdenum cofactor + L-cysteine + reduced acceptor + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O + oxidized acceptor [RN:R11583]
Reaction(KEGG)
R11583
Substrate
molybdenum cofactor [CPD:C18237];
L-cysteine [CPD:C00097];
reduced acceptor [CPD:C00030];
H+ [CPD:C00080]
Product
thio-molybdenum cofactor [CPD:C21486];
L-alanine [CPD:C00041];
H2O [CPD:C00001];
oxidized acceptor
Comment
Contains pyridoxal phosphate. Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide. The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes. In prokaryotes the reaction is catalysed by two enzymes: cysteine desulfurase (EC 2.8.1.7), which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein.
History
EC 2.8.1.9 created 2011, modified 2015
Pathway
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K15631  molybdenum cofactor sulfurtransferase
Genes
HSA55034(MOCOS)
PTR455379(MOCOS)
PPS100980622(MOCOS)
GGO101144098(MOCOS)
PON100437474(MOCOS)
NLE100603055(MOCOS)
MCC715633(MOCOS)
MCF102120844(MOCOS)
CSAB103222528(MOCOS)
CATY105592572(MOCOS)
PANU101013787(MOCOS)
TGE112611441(MOCOS)
RRO104661881(MOCOS)
RBB108530893(MOCOS)
TFN117063971(MOCOS)
PTEH111539595(MOCOS)
CJC100394299(MOCOS)
SBQ101048496(MOCOS)
CSYR103257820(MOCOS)
MMUR105858775(MOCOS)
LCAT123621757(MOCOS)
OGA100950381(MOCOS)
MMU68591(Mocos)
MCAL110284811(Mocos)
MPAH110333396(Mocos)
RNO361300(Mocos)
MCOC116086927(Mocos)
MUN110555784(Mocos)
CGE113834026
MAUA101825284(Mocos)
PLEU114691673(Mocos)
MORG121441869 121453495
AAMP119814527(Mocos)
NGI103733624(Mocos)
HGL101714313(Mocos)
CPOC100731216(Mocos)
CCAN109693507
DORD105984611(Mocos)
DSP122104404(Mocos)
NCAR124965861
OCU100353426(MOCOS)
OPI101532996(MOCOS)
TUP102477563(MOCOS)
CFA490482(MOCOS)
VVP112918830(MOCOS)
VLG121485467(MOCOS)
AML100471952(MOCOS)
UMR103665067(MOCOS)
UAH113253347(MOCOS)
UAR123779589(MOCOS)
ELK111142621
LLV125082141
MPUF101683553(MOCOS)
ORO101376236(MOCOS)
EJU114205015(MOCOS)
ZCA113913126(MOCOS)
MLX118004413(MOCOS)
FCA101098093(MOCOS)
PYU121032717(MOCOS)
PBG122470711(MOCOS)
PTG102960562(MOCOS)
PPAD109276403(MOCOS)
AJU106984131(MOCOS)
HHV120236267(MOCOS)
BTA281226(MOCOS)
BOM102271668(MOCOS)
BIU109577802(MOCOS)
BBUB102408736(MOCOS)
CHX102184109(MOCOS)
OAS101115591(MOCOS)
ODA120881207(MOCOS)
CCAD122425751(MOCOS)
SSC100621611(MOCOS)
CFR102519803(MOCOS)
CBAI105062816(MOCOS)
CDK105086901(MOCOS)
VPC102537794(MOCOS)
BACU103013287(MOCOS)
LVE103077536(MOCOS)
OOR101270096(MOCOS)
DLE111181529(MOCOS)
PCAD102993509(MOCOS)
PSIU116739177(MOCOS)
ECB100067480(MOCOS)
EPZ103557043(MOCOS)
EAI106823547(MOCOS)
MYB102247364(MOCOS)
MYD102753138(MOCOS)
MMYO118662947(MOCOS)
MLF102429870(MOCOS)
MNA107524197(MOCOS)
PKL118707374(MOCOS)
HAI109380405(MOCOS)
SHON118977950(MOCOS)
AJM119056158(MOCOS)
PDIC114506495(MOCOS)
PHAS123826385(MOCOS)
MMF118619271(MOCOS)
RFQ117011751(MOCOS)
PALE102880788(MOCOS)
PGIG120586630(MOCOS)
PVP105293691(MOCOS)
RAY107501299(MOCOS)
MJV108400427(MOCOS)
TOD119243093(MOCOS)
SARA101553248(MOCOS)
LAV100677256(MOCOS)
TMU101346589
DNM101437444(MOCOS)
MDO100013356(MOCOS)
GAS123237826(MOCOS)
SHR100930485(MOCOS)
PCW110207936(MOCOS)
OAA100075210(MOCOS)
GGA420964(MOCOS)
PCOC116226505
MGP100545875(MOCOS)
CJO107309449(MOCOS)
NMEL110394276(MOCOS)
APLA101790101(MOCOS)
ACYG106045026(MOCOS)
AFUL116485618(MOCOS)
TGU100221503(MOCOS)
LSR110469724(MOCOS)
SCAN103815511(MOCOS)
PMOA120503004(MOCOS)
OTC121337803(MOCOS)
PRUF121362009(MOCOS)
GFR102035844(MOCOS)
FAB101818369(MOCOS)
PHI102107851(MOCOS)
PMAJ107200520(MOCOS)
CCAE111925340(MOCOS)
CCW104685912(MOCOS)
ETL114056572(MOCOS)
ZAB102064349(MOCOS)
FPG101916617(MOCOS)
FCH102048214(MOCOS)
CLV102094081(MOCOS)
EGZ104127290(MOCOS)
NNI104013414(MOCOS)
PLET104617391
ACUN113476074(MOCOS)
TALA104366658(MOCOS)
PADL103922355(MOCOS)
ACHC115340523(MOCOS)
AAM106492843(MOCOS)
AROW112976472(MOCOS)
NPD112949451(MOCOS)
DNE112983036(MOCOS)
ASN102371402(MOCOS)
AMJ102570986(MOCOS)
CPOO109313838(MOCOS)
GGN109291971(MOCOS)
PSS102456094(MOCOS)
CMY102946540(MOCOS)
CPIC101945849(MOCOS)
TST117872675(MOCOS)
CABI116827864(MOCOS)
MRV120399278(MOCOS)
ACS100552531(mocos)
PVT110075377(MOCOS)
SUND121934961(MOCOS)
PMUR107289459(MOCOS)
TSR106537962(MOCOS)
PGUT117664912(MOCOS)
VKO123034673(MOCOS)
PMUA114581985(MOCOS)
ZVI118094560(MOCOS)
GJA107118425(MOCOS)
STOW125441267(MOCOS)
XLA108720028
XTR100490959(mocos)
NPR108790410(MOCOS)
RTEM120940556(MOCOS)
BBUF121001325(MOCOS)
BGAR122939394(MOCOS)
DRE100331902(mocos)
SRX107708374 107721213(mocos)
SANH107678503 107698156
SGH107582499
CCAR109064480
CAUA113057181(mocos)
PPRM120479732(mocos)
MAMB125276646(mocos)
IPU108263722(mocos)
PHYP113545829(mocos)
SMEO124376037(mocos)
TFD113639839(mocos)
AMEX103041534(mocos)
EEE113587070(mocos)
TRU101076796(mocos)
TNGGSTEN00005422G001
LCO104921895(mocos)
NCC104941688(mocos)
CGOB115020221(mocos)
ELY117248419(mocos)
PLEP121954316(mocos)
SLUC116039382(mocos)
ECRA117960601(mocos)
PFLV114571620(mocos)
GAT120820428(mocos)
PPUG119214360(mocos)
MSAM119917069(mocos)
CUD121511478(mocos)
ALAT119034081(mocos)
MZE101482613(mocos)
ONL100704498(mocos)
OAU116318768(mocos)
OLA101157481(mocos)
OML112162127(mocos)
XMA102225677(mocos)
XCO114138556(mocos)
XHE116712846(mocos)
PRET103477143(mocos)
PFOR103130016(mocos)
PLAI106939875(mocos)
PMEI106930743(mocos)
GAF122842848(mocos)
CVG107088186(mocos)
CTUL119781076(mocos)
GMU124859610(mocos)
NFU107375543(mocos)
KMR108247154(mocos)
ALIM106525590(mocos)
NWH119410849(mocos)
AOCE111573104(mocos)
CSEM103387498(mocos)
POV109630009(mocos)
SSEN122782238(mocos)
HHIP117775157(mocos)
HSP118119417(mocos)
LCF108886273(mocos)
SDU111220745(mocos)
SLAL111669563(mocos)
XGL120796436(mocos)
HCQ109523029(mocos)
BPEC110173521(mocos)
MALB109960038
BSPL114841890(mocos)
SASA106576810 106604730
OTW112252794(mocos) 112252819
OMY110502287(mocos) 110526526
OGO124038125 124041425
ONE115113373 115135291
SALP111951948 111978108
SNH120017531 120046475
ELS105026557(mocos)
SFM108923697(mocos)
PKI111851161(mocos)
AANG118232797(mocos)
LOC102689001(mocos)
PSPA121312952(mocos)
ARUT117400134
LCM102345152(MOCOS)
CMK103181183(mocos)
RTP109935896(mocos)
BFO118403654
BBEL109469487
CIN100181096 100182548
SCLV120339539
SPU581966 583644
APLC110975000
SKO102802829
DMEDmel_CG1692(mal)
DER6549751
DSE6615133
DSIDsimw501_GD19688(Dsim_GD19688)
DYADyak_GE17883
DAN6501972
DSR110175938
DPODpse_GA14218
DPE6599378
DMN108164580
DWI6644650
DGR6569472
DMODmoj_GI15478
DAZ108619921
DNV108656644
DHE111593031
CCAT101462819
BOD106621143
MDE101890540
SCAC106088032
LCQ111680597
LSQ119611500
HIS119658348
AGAAgaP_AGAP000555(MOCOS_ANOGA)
ACOZ120949618
AARA120905783
ASTE118517503
AAG5575262 5575265
AALB109415228 109415232 109428357 115256654
CQUCpipJ_CPIJ009938 CpipJ_CPIJ009941
CPII120427567 120430610
CNS116343532
BCOO119068857
AME411261
ACER107993378
ALAB122718518
BIM100747497
BBIF117215784
BVK117235846
BVAN117159976
BTER100647735
BPYO122570006
CCAL108628293
OBB114877673
MGEN117222011
NMEA116429487
CGIG122396146
SOC105193848
MPHA105836664
AEC105144204 105144207
ACEP105618350 105618460
PBAR105432349
VEM105566386
HST105192250
DQU106752064
CFO105259179
FEX115239755
LHU105672589
PGC109856555
OBO105275142
PCF106784086
PFUC122520974
VPS122637586
NVI100122104
CSOL105362341
TPRE106651372
MDL103570737
CGLO123265691
FAS105265509
DAM107048757
AGIF122849501
CCIN107274016
TCA655996
DPA109532846
SOY115890590
ATD109598745
CSET123318816
AGB108908317
NVL108569660
APLN108742945
PPYR116167908
OTU111428111
BMOR100134930(mal)
BMAN114239841
MSEX115449232
DPLKGM_211280
BANY112056437
PMAC106716247 106720641
PPOT106103738
PXU106115917
PRAP110996467
ZCE119838400
HAW110374298
TNL113500505
SLIU111361979
OFU114360088
PXY105390609
DNX107168202
AGS114132067
RMD113559166
BTAB109033495
DCI108254548
CLEC106669371
HHAL106684658
NLU111060434
PHUPhum_PHUM354400
FOC113212030
TPAL117649250
ZNE110840571
CSEC111868230
FCD110849036
DPXDAPPUDRAFT_198784
DMK116927687 123469423
PVM113801631 113806761
PJA122246228
PCHN125032960
HAME121861190
PCLA123762028
PTRU123511801
HAZT108665630
EAF111695368
LSM121121863
PPOI119103164
CELCELE_R03A10.3(mocs-1)
CBRCBG_07703(Cbr-mocs-1)
NAINECAME_00680
TSPTsp_00269
HROHELRODRAFT_77660
LGILOTGIDRAFT_235545
PCAN112556609
GAE121366672 121385065
HRF124135961
HRJ124291095
CRG105333152
MYI110445086
PMAX117321770
MMER123561594
LAK106161604 106179355
NVE5521332
EPA110238345
ATEN116296706
ADF107334248
AMIL114970125
PDAM113666540
SPIS111328372
DGT114533918
XEN124439948
TADTRIADDRAFT_20006
AQU100632714
ATHAT1G16540(ABA3)
ALY9328977
CRB17900233
CSAT104740338 104759250 104775752
EUSEUTSA_v10006808mg
BRP103872446
BNA106346761 106365599
BOE106295608
RSZ108834777 108840016
THJ104812356
CIT102577967
CICCICLE_v10004324mg
PVY116119195 116133565
MINC123206669 123224980
TCC18594558
GRA105775773
GHI107932693 107936180
GAB108483764
DZI111276021 111288351
EGR104448676
GMX100787334
GSJ114366909
PVUPHAVU_011G216100g
VRA106756103
VAR108340378
VUN114168999
CCAJ109817449
APRC113865931
MTRMTR_4g030930
CAM101491274
LJALj3g3v0461990.1(Lj3g3v0461990.1) Lj3g3v0462260.1(Lj3g3v0462260.1)
ADU107470927
AIP107622615
AHF112716207 112782737
LANG109325633
FVE101310007
RCN112166909
PPER18780634
PMUM103325694
PAVI110769002
PDUL117624659
MDM103435418
PXB103952011
ZJU107417969
MNT21399319
CSV101220625
CMO103496300
BHJ120088439
MCHA111017992
CMAX111469677
CMOS111451282
CPEP111795061
RCU8272616
JCU105646197
HBR110662033
MESC110617318
POP7483072
PEU105116451
PALZ118049660
JRE108998007
QSU111992871 111992875 112002665 112011399 112038259
QLO115983195
TWL119985636
VVI100247369
VRI117908824 117908905
SLY543832(FLACCA)
SPEN107026467
SOT102580056
CANN107878893
NTA107762786 107822877
NSY104216382 104217977
NTO104115990
NAU109234201
INI109178270
ITR116021132
SIND105175074
OEU111385378
EGT105969020
SSPL121755847 121759606
HAN110890120
ECAD122590888
LSV111904522
CCAV112506408
DCR108214967
CSIN114267032
BVG104904512
SOE110784245
CQI110698612 110704929
NNU104608087
MING122062908
TSS122639954
PSOM113280759
NCOL116264250
OSA4341801
DOSAOs06t0670000-01(Os06g0670000)
OBR102708066
BDI100833860
ATS109764490
TDC119329666 119336827
TAES123149141 123155915 123164562
TUA125525153
SBI8061592
ZMA103629655 103638882
SITA101770290
SVS117852199
PVIR120671603 120704182
PHAI112888995
PDA103722368
EGU105047545 105049235
MUS103993636
DCT110109869 110116593
PEQ110038799
AOF109844527
ATR18443110
SMOSELMODRAFT_123676 SELMODRAFT_173762 SELMODRAFT_180197 SELMODRAFT_446104
PPP112277529 112282503 112283195 112289964 112292332 112293898
CRECHLRE_02g142351v5 CHLRE_03g152000v5
VCNVOLCADRAFT_40621 VOLCADRAFT_64703
MNGMNEG_7052 MNEG_8999
CSLCOCSUDRAFT_19457
CVRCHLNCDRAFT_143919 CHLNCDRAFT_54300
APROF751_4011 F751_5508
BPGBathy10g01940
MISMICPUN_64112
GSLGasu_62000
CCPCHC_T00004572001
PPAPAS_chr4_0951
SLBAWJ20_3753
BBRXBRETT_005034
NCRNCU02777
NTENEUTE1DRAFT106582(NEUTE1DRAFT_106582)
SMPSMAC_00395 SMAC_04825 SMAC_09753
PANPODANSg10035 PODANSg5761
TTTTHITE_2048359 THITE_2121818
MTMMYCTH_2075738 MYCTH_2294998
CTHRCTHT_0053620
MGRMGG_01613 MGG_05759
PPEIPpBr36_01132
SSCKSPSK_05938
FGRFGSG_01107 FGSG_11787
FPUFPSE_03133 FPSE_09064
FVRFVEG_01032 FVEG_01234
FOXFOXG_00283 FOXG_00475
NHENECHADRAFT_90012
TRETRIREDRAFT_56614
TRRM419DRAFT_72279
MAWMAC_05269
MAJMAA_03960
CMTCCM_07073
PLJVFPFJ_03537
VALVDBG_04857
VDAVDAG_04397
CFJCFIO01_02220
CHIGCH63R_00566
ELAUCREL1_1191
PFYPFICI_01191 PFICI_01351
SSLSS1G_02848 SS1G_04269
BFUBCIN_01g03840 BCIN_06g03130
MBEMBM_06139 MBM_08333
PSCOLY89DRAFT_574838 LY89DRAFT_693745 LY89DRAFT_702279
GLZGLAREA_00427 GLAREA_09272
ANIAN1637.2 AN5314.2
AFMAFUA_4G08990
ACTACLA_048350
NFINFIA_107180
AORAO090023000633
ANGANI_1_1786184(An04g03890)
AFVAFLA_006978
ALUCAKAW2_51402S
ACHEACHE_10624S
APUUAPUU_10108A APUU_21485A
PCSPc18g03430
PDPPDIP_72590
TMFPMAA_056490 PMAA_090880
TRGTRUGW13939_00715 TRUGW13939_06840
CIMCIMG_08337
CPWCPC735_061080
UREUREG_02511
PBLPAAG_01323 PAAG_03275
PBNPADG_00444 PADG_03145
ABEARB_00349 ARB_05175
TVETRV_03588 TRV_04189
AJEHCAG_07088 HCAG_08188
BGHBDBG_00558 BDBG_06982
PNOSNOG_03754 SNOG_08868
PTEPTT_11897 PTT_17229
BZECOCCADRAFT_82416 COCCADRAFT_97443
BSCCOCSADRAFT_123521 COCSADRAFT_162629
BORCOCMIDRAFT_3523 COCMIDRAFT_95895
AALTCC77DRAFT_844885 CC77DRAFT_985777
ZTRMYCGRDRAFT_58203 MYCGRDRAFT_74083 MYCGRDRAFT_76893
PFJMYCFIDRAFT_156097 MYCFIDRAFT_160506 MYCFIDRAFT_191255
FFUCLAFUR5_00448 CLAFUR5_12394
BCOMBAUCODRAFT_30361 BAUCODRAFT_39552
NPAUCRNP2_5638
TMLGSTUM_00001509001 GSTUM_00008546001
PPLPOSPLDRAFT_100883
TVSTRAVEDRAFT_154197
DSQDICSQDRAFT_107133
PCOPHACADRAFT_260279
SHSSTEHIDRAFT_162619
HIRHETIRDRAFT_429587 HETIRDRAFT_68211
PSQPUNSTDRAFT_72094
ADLAURDEDRAFT_73914 AURDEDRAFT_73944
FMEFOMMEDRAFT_16749
GTRGLOTRDRAFT_129648
LBCLACBIDRAFT_296314
MPRMPER_12679
MRRMoror_15305
CCICC1G_06870
SCMSCHCODRAFT_32583 SCHCODRAFT_57784
ABPAGABI1DRAFT37315(AGABI1DRAFT_37315)
ABVAGABI2DRAFT70376(AGABI2DRAFT_70376)
UMAUMAG_03149 UMAG_03628
PFPPFL1_02705
PGRPGTG_09358
MLRMELLADRAFT_78150
MBRMONBRDRAFT_26864
SREPTSG_00019
DDIDDB_G0272935(mocos)
DPPDICPUDRAFT_59401
DFADFA_00843(mocos)
EIVEIN_079600 EIN_284440
ACANACA1_241830 ACA1_263000 ACA1_263020
CPVcgd2_30
CHOChro.20011
TGOTGME49_300350
SMINv1.2.036207.t1(symbB.v1.2.036207.t1)
PTIPHATR_46641
FCYFRACYDRAFT_207845
TPSTHAPSDRAFT_261324
PIFPITG_04515
PSOJPHYSODRAFT_480999
SPARSPRG_02564
EHXEMIHUDRAFT_456573 EMIHUDRAFT_458486
GTTGUITHDRAFT_114790
TVATVAG_038390 TVAG_104740 TVAG_246630 TVAG_286130 TVAG_302460 TVAG_357440 TVAG_395270 TVAG_482220
GLAGL50803_0014200
PCTPC1_2018
PARII2D83_10960
SMTSmal_2080
STEMCLM74_11605
SINCDAIF1_22590(sufS_2)
LCPLC55x_5316 LC55x_5356
LGULG3211_0318
MFBMFUL124B02_13225
SSPBCP982_03085
 » show all
Reference
1  [PMID:11553608]
  Authors
Bittner F, Oreb M, Mendel RR
  Title
ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana.
  Journal
J Biol Chem 276:40381-4 (2001)
DOI:10.1074/jbc.C100472200
  Sequence
[ath:AT1G16540]
Reference
2  [PMID:15561708]
  Authors
Heidenreich T, Wollers S, Mendel RR, Bittner F
  Title
Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
  Journal
J Biol Chem 280:4213-8 (2005)
DOI:10.1074/jbc.M411195200
  Sequence
[ath:AT1G16540]
Reference
3  [PMID:18258600]
  Authors
Wollers S, Heidenreich T, Zarepour M, Zachmann D, Kraft C, Zhao Y, Mendel RR, Bittner F
  Title
Binding of sulfurated molybdenum cofactor to the C-terminal domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
  Journal
J Biol Chem 283:9642-50 (2008)
DOI:10.1074/jbc.M708549200
  Sequence
[ath:AT1G16540]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.1.9
IUBMB Enzyme Nomenclature: 2.8.1.9
ExPASy - ENZYME nomenclature database: 2.8.1.9
BRENDA, the Enzyme Database: 2.8.1.9
LinkDB

DBGET integrated database retrieval system