Entry
Name
molybdenum cofactor sulfurtransferase;
molybdenum cofactor sulfurase;
ABA3;
HMCS;
MoCo sulfurase;
MoCo sulfurtransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
BRITE hierarchy
Sysname
L-cysteine:molybdenum cofactor sulfurtransferase
Reaction(IUBMB)
molybdenum cofactor + L-cysteine + reduced acceptor + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O + oxidized acceptor [RN:
R11583 ]
Reaction(KEGG)
Substrate
Product
thio-molybdenum cofactor [CPD:
C21486 ];
L-alanine [CPD:
C00041 ];
H2O [CPD:
C00001 ];
oxidized acceptor
Comment
Contains pyridoxal phosphate. Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide. The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes. In prokaryotes the reaction is catalysed by two enzymes: cysteine desulfurase (EC
2.8.1.7 ), which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein.
History
EC 2.8.1.9 created 2011, modified 2015
Pathway
Orthology
K15631 molybdenum cofactor sulfurtransferase
Genes
MORG : 121441869 121453495
PWL : 138280770 138280797(MOCOS)
SRX : 107708374 107721213(mocos)
SANH : 107678503 107698156
SASA : 106576810 106604730
STRU : 115153023 115193986
OTW : 112252794(mocos) 112252819
OMY : 110502287(mocos) 110526526
OCLA : 139381837 139409944
SALP : 111951948 111978108
CCLU : 121553425 121568181
DSI : Dsimw501_GD19688(Dsim_GD19688)
AALB : 109415228 109415232 109428357 115256654
ASUA : 134203582 134203589 134207822 134216783
CQU : CpipJ_CPIJ009938 CpipJ_CPIJ009941
CPII : 120427567 120430610
ACEP : 105618350 105618460
PMAC : 106716247 106720641
AAGE : 121727222 121727302
CEL : CELE_R03A10.3(mocs-1)
CBR : CBG_07703(Cbr-mocs-1)
DPOL : 127831470 127832135
CSAT : 104740338 104759250 104775752
MINC : 123206669 123224980
HSYR : 120114118 120160761
SSPL : 121755847 121759606
TAES : 123149141 123155915 123164562
PVIR : 120671603 120704182
SMO : SELMODRAFT_123676 SELMODRAFT_173762 SELMODRAFT_180197 SELMODRAFT_446104
PPP : 112277529 112282503 112283195 112292332 112293898
CRE : CHLRE_02g142351v5 CHLRE_03g152000v5
VCN : VOLCADRAFT_40621 VOLCADRAFT_64703
CVR : CHLNCDRAFT_143919 CHLNCDRAFT_54300
APRO : F751_4011 F751_5508
NTE : NEUTE1DRAFT106582(NEUTE1DRAFT_106582)
SMP : 10799978(SMAC4_09753) 10804952(SMAC4_04825)
PAN : PODANSg10035 PODANSg5761
TTT : THITE_2048359 THITE_2121818
MTM : MYCTH_2075738 MYCTH_2294998
RTHE : 98127117(VTJ83DRAFT_583)
FGR : FGSG_01107 FGSG_11787
FPU : FPSE_03133 FPSE_09064
FVR : FVEG_01032 FVEG_01234
FOX : FOXG_00283 FOXG_00475
TATV : 25775147(TrAtP1_003891)
TASP : 36607365(TrAFT101_003387)
MAW : 19249580(J3458_003362)
PLJ : 28885668(PLICBS_007201)
CDET : 87939271(CDEST_02768)
PFY : PFICI_01191 PFICI_01351
SSL : SS1G_02848 SS1G_04269
BFU : BCIN_01g03840 BCIN_06g03130
PSCO : LY89DRAFT_574838 LY89DRAFT_693745 LY89DRAFT_702279
GLZ : GLAREA_00427 GLAREA_09272
ANI : ANIA_01637 ANIA_05314
APUU : APUU_10108A APUU_21485A
TMF : EYB26_007455 EYB26_008040
TRG : TRUGW13939_00715 TRUGW13939_06840
CPW : 9695875(D8B26_004554)
PBL : PAAG_01323 PAAG_03275
PBN : PADG_00444 PADG_03145
AJE : HCAG_07088 HCAG_08188
BGH : BDBG_00558 BDBG_06982
PNO : SNOG_03754 SNOG_08868
PTRR : 6340424(PtrM4_008820) 6347062(PtrM4_032370)
BZE : COCCADRAFT_82416 COCCADRAFT_97443
BSC : COCSADRAFT_123521 COCSADRAFT_162629
BOR : COCMIDRAFT_3523 COCMIDRAFT_95895
AALT : CC77DRAFT_844885 CC77DRAFT_985777
ADAC : 96088425(ACET3X_008103)
ARAB : EKO05_0008257 EKO05_0009054
ZTR : MYCGRDRAFT_58203 MYCGRDRAFT_74083 MYCGRDRAFT_76893
PFJ : MYCFIDRAFT_156097 MYCFIDRAFT_160506 MYCFIDRAFT_191255
FFU : CLAFUR5_00448 CLAFUR5_12394
CBET : CB0940_01437 CB0940_05655 CB0940_11476
BCOM : BAUCODRAFT_30361 BAUCODRAFT_39552
TML : GSTUM_00001509001 GSTUM_00008546001
HIR : HETIRDRAFT_429587 HETIRDRAFT_68211
ADL : AURDEDRAFT_73914 AURDEDRAFT_73944
ABP : AGABI1DRAFT37315(AGABI1DRAFT_37315)
ABV : AGABI2DRAFT70376(AGABI2DRAFT_70376)
SCM : SCHCO_01202278(SCHCODRAFT_01202278) SCHCO_02508441(SCHCODRAFT_02508441)
UMA : UMAG_03149 UMAG_03628
RIE : OCT59_001960 OCT59_013069
EIV : EIN_079600 EIN_284440
ACAN : ACA1_241830 ACA1_263000 ACA1_263020
TVA : 4751147(TVAGG3_0655740) 4751499(TVAGG3_0418640) 4759106(TVAGG3_0075330) 4766057(TVAGG3_0172830) 4767879(TVAGG3_0588680) 4772726(TVAGG3_0960880) 5464506(TVAGG3_0561400)
SSAO : 94296516(SS50377_22493)
EHX : EMIHUDRAFT_456573 EMIHUDRAFT_458486
SINC : DAIF1_22590(sufS_2)
LCP : LC55x_5316 LC55x_5356
ยป show all
Taxonomy
Reference
Authors
Bittner F, Oreb M, Mendel RR
Title
ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana.
Journal
Sequence
Reference
Authors
Heidenreich T, Wollers S, Mendel RR, Bittner F
Title
Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
Journal
Sequence
Reference
Authors
Wollers S, Heidenreich T, Zarepour M, Zachmann D, Kraft C, Zhao Y, Mendel RR, Bittner F
Title
Binding of sulfurated molybdenum cofactor to the C-terminal domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.1.9
ExPASy - ENZYME nomenclature database: 2.8.1.9
BRENDA, the Enzyme Database: 2.8.1.9
LinkDB
All DBs