KEGG   ENZYME: 2.8.3.26
Entry
EC 2.8.3.26                 Enzyme                                 
Name
succinyl-CoA:mesaconate CoA transferase;
mct (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
Sysname
succinyl-CoA:mesaconate CoA transferase
Reaction(IUBMB)
succinyl-CoA + mesaconate = 2-methylfumaryl-CoA + succinate [RN:R10904]
Reaction(KEGG)
R10904
Substrate
succinyl-CoA [CPD:C00091];
mesaconate [CPD:C01732]
Product
2-methylfumaryl-CoA [CPD:C06028];
succinate [CPD:C00042]
Comment
The enzyme participates in the methylaspartate cycle, an anaplerotic pathway that operates in some members of the haloarchaea and forms malate from acetyl-CoA.
History
EC 2.8.3.26 created 2020
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K19280  succinyl-CoA:mesaconate CoA transferase
Genes
HALXM0R89_18065
SALIL593_04685
HMArrnAC0683
HHIHAH_1336(caiB)
HHNHISP_06840
HABSG26_14685
HTABVU17_06510
HALJG9465_08560
HSINKDQ40_06790
HMUHmuk_2979
HALZE5139_02170
HALLLC1Hm_2316(mct)
HAZPGBQ70_02170
HRRHZS55_20010
HPELHZS54_23510
HTUHtur_1595
HDABB347_04035
HSALJMJ58_00660
HLOJ0X27_02320
HAKZJ0X25_14785
NMGNmag_3333(mct)
HXAHalxa_3154
NATNJ7G_3294
NPENatpe_2595
NVRFEJ81_11905
NPLFGF80_10945
NAYHYG81_14715
HALYHYG82_17335
HJTDVR14_02960
NGENatgr_3389
HRUHalru_1553
NOUNatoc_1514
HLRHALLA_10860
HLCCHINAEXTREME16100
NAJB1756_12000
NAGAArcMg_1650
NANAArc1_1989
NBGDV706_13005
NASGCU68_13750
SAWLNGM29_08795
 » show all
Reference
1  [PMID:21252347]
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
  Sequence
[hma:rrnAC0683]
Reference
2  [PMID:28932214]
  Authors
Borjian F, Johnsen U, Schonheit P, Berg IA
  Title
Succinyl-CoA:Mesaconate CoA-Transferase and Mesaconyl-CoA Hydratase, Enzymes of the Methylaspartate Cycle in Haloarcula hispanica.
  Journal
Front Microbiol 8:1683 (2017)
DOI:10.3389/fmicb.2017.01683
  Sequence
[hhi:HAH_1336]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.26
IUBMB Enzyme Nomenclature: 2.8.3.26
ExPASy - ENZYME nomenclature database: 2.8.3.26
BRENDA, the Enzyme Database: 2.8.3.26
LinkDB

DBGET integrated database retrieval system